Detailed information for compound 1103094

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 372.379 | Formula: C17H20N6O4
  • H donors: 4 H acceptors: 7 LogP: -0.35 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1OC([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCCc1ccncc1
  • InChi: 1S/C17H20N6O4/c24-7-11-13(25)14(26)17(27-11)23-9-22-12-15(20-8-21-16(12)23)19-6-3-10-1-4-18-5-2-10/h1-2,4-5,8-9,11,13-14,17,24-26H,3,6-7H2,(H,19,20,21)/t11-,13-,14-,17?/m1/s1
  • InChiKey: HQEBOZPDIQMCOD-IKYDMHQPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0057 0.0089
Brugia malayi nuclear hormone receptor 0.0077 0.0374 0.0686
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0165 0.0622
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0077 0.0374 0.0686
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0077 0.0374 0.0686
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0077 0.0374 0.0686
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0749 0.4058 0.4058
Schistosoma mansoni nuclear hormone receptor 0.0077 0.0374 0.0996
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0077 0.0374 0.0686
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.015 0.037
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0245
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0077 0.0374 0.0374
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0077 0.0374 0.0374
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0271 0.1437 0.7926
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0165 0.0853 0.1963
Echinococcus multilocularis dna polymerase kappa 0.002 0.0057 0.0057
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0037 0.015 0.0399
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0318
Brugia malayi nuclear hormone receptor family member nhr-6 0.0037 0.015 0.0274
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0231 0.1217 0.2234
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0225 0.0248
Brugia malayi MH1 domain containing protein 0.0017 0.0043 0.0076
Schistosoma mansoni hypothetical protein 0.0117 0.0591 0.1573
Loa Loa (eye worm) mbt repeat family protein 0.0055 0.0251 0.046
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0077 0.0374 0.0996
Schistosoma mansoni tar DNA-binding protein 0.0351 0.1876 0.4991
Schistosoma mansoni tar DNA-binding protein 0.0351 0.1876 0.4991
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0077 0.0374 0.0374
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0077 0.0374 0.0686
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0274
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0369 0.1976 0.363
Schistosoma mansoni nuclear receptor 0.0037 0.015 0.0399
Brugia malayi hypothetical protein 0.0231 0.122 0.2239
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.122 0.122
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0041 0.0174 0.0429
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0271 0.1437 0.7926
Brugia malayi Nuclear hormone receptor-like 1 0.0077 0.0374 0.0686
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0318
Echinococcus granulosus Smad4 0.0017 0.0043 0.0105
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0165 0.0165
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0043 0.0043
Echinococcus granulosus thyroid hormone receptor alpha 0.0037 0.015 0.037
Loa Loa (eye worm) acetyltransferase 0.0166 0.0858 0.1575
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0117 0.0591 0.0591
Loa Loa (eye worm) hypothetical protein 0.012 0.0608 0.1114
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0185 0.0456
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0077 0.0374 0.0686
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0077 0.0374 0.0686
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0694 0.3758 1
Echinococcus multilocularis geminin 0.0382 0.2048 0.2048
Brugia malayi MH2 domain containing protein 0.0249 0.1316 0.2415
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0063 0.0293 0.0722
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0077 0.0374 0.0686
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0057 0.0057
Brugia malayi MH1 domain containing protein 0.0017 0.0043 0.0076
Echinococcus multilocularis dnaJ subfamily B 0.0455 0.2449 0.2449
Echinococcus multilocularis ecdysone induced protein 78C 0.0077 0.0374 0.0374
Brugia malayi mbt repeat family protein 0.0055 0.0251 0.046
Echinococcus multilocularis histone acetyltransferase MYST2 0.0063 0.0293 0.0293
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.1798 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0329 0.0874
Loa Loa (eye worm) hypothetical protein 0.0077 0.0374 0.0686
Leishmania major dihydroorotate dehydrogenase 0.0694 0.3758 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0055 0.0251 0.0669
Loa Loa (eye worm) hypothetical protein 0.0252 0.1335 0.2451
Trypanosoma brucei unspecified product 0.002 0.0057 0.0089
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0274
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0077 0.0374 0.0996
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0037 0.015 0.0274
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0694 0.3758 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0185 0.0734
Schistosoma mansoni inositol monophosphatase 0.0039 0.0165 0.044
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0077 0.0374 0.0686
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0077 0.0374 0.0686
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0165 0.0622
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0077 0.0374 0.0686
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0037 0.015 0.015
Schistosoma mansoni hypothetical protein 0.0117 0.0591 0.1573
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0192 0.0774
Schistosoma mansoni nuclear receptor 0.0037 0.015 0.0399
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0694 0.3758 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0057 0.0089
Brugia malayi CXXC zinc finger family protein 0.0032 0.0125 0.0228
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1001 0.5443 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0185 0.0431
Schistosoma mansoni myelin transcription factor 1 myt1 0.0063 0.0293 0.078
Brugia malayi Latrophilin receptor protein 2 0.0117 0.0591 0.1084
Schistosoma mansoni survival motor neuron protein 0.0047 0.0209 0.0555
Brugia malayi hypothetical protein 0.0037 0.015 0.0274
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0322 0.0516
Brugia malayi follicle stimulating hormone receptor 0.0491 0.2644 0.4856
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0165 0.0622
Echinococcus granulosus CREB binding protein 0.0019 0.0053 0.013
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0057 0.0141
Brugia malayi MH2 domain containing protein 0.0017 0.0043 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0077 0.0374 0.0686
Echinococcus granulosus tar DNA binding protein 0.0351 0.1876 0.4623
Echinococcus granulosus GPCR family 2 0.0117 0.0591 0.1457
Echinococcus multilocularis CREB binding protein 0.0082 0.0402 0.0402
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0274
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0165 0.0293
Schistosoma mansoni lamin 0.0057 0.0263 0.0701
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0225 0.0554
Onchocerca volvulus 0.0037 0.015 0.0196
Loa Loa (eye worm) hypothetical protein 0.0077 0.0374 0.0686
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0185 0.0345
Schistosoma mansoni hypothetical protein 0.0117 0.0591 0.1573
Brugia malayi latrophilin 2 splice variant baaae 0.0252 0.1335 0.2451
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0057 0.0089
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0271 0.1437 0.7926
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0124 0.0306
Loa Loa (eye worm) inositol-1 0.0039 0.0165 0.0302
Onchocerca volvulus Protein ultraspiracle homolog 0.0077 0.0374 0.1967
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0057 0.0089
Schistosoma mansoni hypothetical protein 0.0382 0.2048 0.545
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0185 0.0734
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0077 0.0374 0.0374
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0077 0.0374 0.0686
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0174 0.0318
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0055 0.0251 0.0996
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.015 0.015
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0077 0.0374 0.0686
Loa Loa (eye worm) TAR-binding protein 0.0351 0.1876 0.3445
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0117 0.0591 0.1457
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0077 0.0374 0.0996
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0057 0.0089
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0185 0.0345
Brugia malayi nuclear receptor RXR 0.0037 0.015 0.0274
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.122 0.3006
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0694 0.3758 1
Schistosoma mansoni hypothetical protein 0.0252 0.1335 0.3553
Loa Loa (eye worm) hypothetical protein 0.0077 0.0374 0.0686
Loa Loa (eye worm) Smad1 0.0017 0.0043 0.0076
Echinococcus multilocularis lamin 0.0057 0.0263 0.0263
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0271 0.1437 0.7926
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0057 0.0089
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0274
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0318
Schistosoma mansoni hypothetical protein 0.0382 0.2048 0.545
Echinococcus multilocularis thyroid hormone receptor alpha 0.0077 0.0374 0.0374
Brugia malayi nuclear hormone receptor family member odr-7 0.0037 0.015 0.0274
Brugia malayi intermediate filament protein 0.0057 0.0263 0.0482
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0117 0.0591 0.1084
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0337 0.1798 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0185 0.0492
Brugia malayi nuclear receptor NHR-67 0.0037 0.015 0.0274
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0135 0.0359
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.1798 1
Schistosoma mansoni intermediate filament proteins 0.0057 0.0263 0.0701
Brugia malayi steroid hormone receptor 0.0077 0.0374 0.0686
Brugia malayi photoreceptor-specific nuclear receptor 0.0077 0.0374 0.0686
Schistosoma mansoni dihydroorotate dehydrogenase 0.0694 0.3758 1
Onchocerca volvulus Huntingtin homolog 0.012 0.0608 0.3809
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0209 0.0381
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0118 0.0214
Schistosoma mansoni cpg binding protein 0.0032 0.0125 0.0333
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0077 0.0374 0.0923
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0174 0.0463
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0005
Echinococcus multilocularis CREB binding protein 0.0019 0.0053 0.0053
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0166 0.0858 0.2284
Onchocerca volvulus Bile acid receptor homolog 0.0077 0.0374 0.1967
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0263 0.0482
Echinococcus granulosus dna polymerase eta 0.002 0.0057 0.0141
Schistosoma mansoni DNA polymerase eta 0.002 0.0057 0.0152
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0043 0.0105
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0694 0.3758 0.6904
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0491 0.2644 0.4856
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.1798 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0041 0.0174 0.0318
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0165 0.0622
Loa Loa (eye worm) hypothetical protein 0.0077 0.0374 0.0686
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0077 0.0374 0.0923
Giardia lamblia Fructose-bisphosphate aldolase 0.0337 0.1798 1
Echinococcus granulosus lamin dm0 0.0057 0.0263 0.0649
Schistosoma mansoni zinc finger protein 0.0037 0.015 0.0399
Echinococcus granulosus polycomb protein SCMH1 0.0055 0.0251 0.0619
Echinococcus multilocularis CREB binding protein 0.0019 0.0053 0.0053
Schistosoma mansoni tar DNA-binding protein 0.0351 0.1876 0.4991
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0165 0.0293
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0165 0.0853 0.2149
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0125 0.0228
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0077 0.0374 0.0923
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0185 0.0734
Schistosoma mansoni tar DNA-binding protein 0.0351 0.1876 0.4991
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0185 0.0492
Echinococcus granulosus histone acetyltransferase MYST2 0.0063 0.0293 0.0722
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0043 0.0114
Schistosoma mansoni CREB-binding protein 2 0.0118 0.0599 0.1594
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0217 0.1138 0.1138
Brugia malayi hypothetical protein 0.0037 0.015 0.0274
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0043 0.0076
Schistosoma mansoni coup transcription factor 0.0077 0.0374 0.0996
Loa Loa (eye worm) MH2 domain-containing protein 0.0249 0.1316 0.2415
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0057 0.0089
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0077 0.0374 0.0923
Brugia malayi ecdysteroid receptor 0.0077 0.0374 0.0686
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0077 0.0374 0.0686
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0271 0.1437 0.7926
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0037 0.015 0.037
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0185 0.0337
Schistosoma mansoni inositol monophosphatase 0.0039 0.0165 0.044
Brugia malayi Steroid receptor seven-up type 2 0.0077 0.0374 0.0686
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0057 0.0103
Brugia malayi tailless protein 0.0037 0.015 0.0274
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.1798 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0165 0.0085
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0057 0.0103
Brugia malayi Calcitonin receptor-like protein seb-1 0.0369 0.1976 0.363
Loa Loa (eye worm) hypothetical protein 0.0077 0.0374 0.0686
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0057 0.0152
Brugia malayi Pre-SET motif family protein 0.0034 0.0135 0.0245
Schistosoma mansoni nuclear receptor nhr-48 0.0037 0.015 0.0399
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0185 0.0734
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0011 0.0026
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0271 0.1437 0.3728
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0118 0.0214
Schistosoma mansoni tar DNA-binding protein 0.0351 0.1876 0.4991
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0185 0.0456
Echinococcus granulosus histone acetyltransferase KAT2B 0.0159 0.0822 0.2026
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0217 0.1138 0.2805
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0185 0.0734
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.015 0.0196
Brugia malayi acetyltransferase, GNAT family protein 0.0166 0.0858 0.1575
Loa Loa (eye worm) hypothetical protein 0.0028 0.0101 0.0184
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0225 0.0248
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0749 0.4058 1
Echinococcus multilocularis musashi 0.0057 0.0263 0.0263
Schistosoma mansoni smad1 5 8 and 0.0017 0.0043 0.0114
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0043 0.0076
Schistosoma mansoni steroid hormone receptor ad4bp 0.0077 0.0374 0.0996
Brugia malayi hypothetical protein 0.0041 0.0174 0.0318
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0694 0.3758 1
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0174 0.0318
Echinococcus multilocularis tar DNA binding protein 0.0351 0.1876 0.1876
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0057 0.0089
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0271 0.1437 0.1437
Schistosoma mansoni hypothetical protein 0.0047 0.0209 0.0555
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0274
Schistosoma mansoni RAR-like nuclear receptor 0.0077 0.0374 0.0996
Echinococcus granulosus smad 0.0017 0.0043 0.0105
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0135 0.0359
Schistosoma mansoni hypothetical protein 0.0334 0.1783 0.4745
Echinococcus granulosus CREB binding protein 0.0118 0.0599 0.1477
Echinococcus multilocularis lamin dm0 0.0057 0.0263 0.0263
Echinococcus multilocularis Smad4 0.0017 0.0043 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0057 0.0089
Schistosoma mansoni nuclear hormone receptor 0.0037 0.015 0.0399
Loa Loa (eye worm) DR-78 0.0037 0.015 0.0274
Onchocerca volvulus 0.0057 0.0263 0.1091
Loa Loa (eye worm) hypothetical protein 0.0077 0.0374 0.0686
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0351 0.1876 0.3445
Loa Loa (eye worm) hypothetical protein 0.0063 0.0293 0.0536
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0694 0.3758 1
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0694 0.3758 1
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0694 0.3758 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0077 0.0374 0.0923
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0077 0.0374 0.0686
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0271 0.1437 0.3541
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0185 0.0185
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0185 0.0456
Brugia malayi nuclear receptor RXR 0.0041 0.0174 0.0318
Loa Loa (eye worm) steroid hormone receptor 0.0077 0.0374 0.0686
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0185 0.0185
Brugia malayi nuclear receptor NHR-88 0.0037 0.015 0.0274
Brugia malayi RNA binding protein 0.0351 0.1876 0.3445
Loa Loa (eye worm) hypothetical protein 0.0077 0.0374 0.0686
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0135 0.0359
Echinococcus granulosus CREB binding protein 0.0075 0.0359 0.0884
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0143 0.0232
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.015 0.037
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0118 0.0599 0.1594
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0225 0.0248
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0043 0.0105
Echinococcus granulosus geminin 0.0382 0.2048 0.5048
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0063 0.0293 0.0293
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.1798 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0263 0.0482
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0135 0.0332
Loa Loa (eye worm) hypothetical protein 0.0043 0.0185 0.0337
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0103
Brugia malayi hypothetical protein 0.0171 0.0886 0.1625
Onchocerca volvulus 0.0037 0.015 0.0196
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0274
Onchocerca volvulus 0.0077 0.0374 0.1967
Loa Loa (eye worm) hypothetical protein 0.0117 0.0591 0.1084
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0057 0.0152
Echinococcus multilocularis CREB binding protein 0.0019 0.0053 0.0053
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0037 0.015 0.0399
Loa Loa (eye worm) CBP-B 0.0083 0.0407 0.0747
Loa Loa (eye worm) hypothetical protein 0.0055 0.0251 0.046
Treponema pallidum fructose-bisphosphate aldolase 0.0337 0.1798 0.5
Loa Loa (eye worm) RNA binding protein 0.0351 0.1876 0.3445
Schistosoma mansoni cpg binding protein 0.0034 0.0135 0.036
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0037 0.015 0.0274
Onchocerca volvulus 0.0055 0.0251 0.0996
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0037 0.015 0.015
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0077 0.0374 0.0923
Brugia malayi TAR-binding protein 0.0351 0.1876 0.3445
Echinococcus multilocularis FTZ F1 alpha 0.0077 0.0374 0.0374
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0077 0.0374 0.0374
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.015 0.037
Brugia malayi mbt repeat family protein 0.0055 0.0251 0.046
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.015 0.015
Brugia malayi hypothetical protein 0.0041 0.0174 0.0318
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0077 0.0374 0.1967
Schistosoma mansoni hypothetical protein 0.0117 0.0591 0.1573
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0063 0.0293 0.0536
Loa Loa (eye worm) hypothetical protein 0.0054 0.0244 0.0447
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0173
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0274
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0271 0.1437 0.1437
Echinococcus granulosus intermediate filament protein 0.0057 0.0263 0.0649
Onchocerca volvulus 0.0047 0.0209 0.0659
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0101 0.0249
Brugia malayi nuclear receptor NHR-88 0.0077 0.0374 0.0686
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0011 0.0011
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0077 0.0374 0.0374
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0165 0.0379
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0225 0.0963
Onchocerca volvulus Huntingtin homolog 0.012 0.0608 0.3809
Loa Loa (eye worm) hypothetical protein 0.0171 0.0886 0.1625
Trichomonas vaginalis set domain proteins, putative 0.0263 0.1392 0.7666
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0274
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0274
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0274
Brugia malayi conserved hypotetical protein 0.0037 0.015 0.0274
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0274
Schistosoma mansoni thyroid hormone receptor 0.0077 0.0374 0.0996
Brugia malayi MH2 domain containing protein 0.0017 0.0043 0.0076
Loa Loa (eye worm) MBCTL1 0.0063 0.0293 0.0536
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0694 0.3758 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0117 0.0591 0.1084
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0077 0.0374 0.0923
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0165 0.0293
Echinococcus granulosus dnaJ subfamily B 0.0455 0.2449 0.6035
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.015 0.0196
Loa Loa (eye worm) nuclear hormone receptor 0.0037 0.015 0.0274
Echinococcus granulosus CREB binding protein 0.0019 0.0053 0.013
Brugia malayi nuclear hormone receptor 0.0037 0.015 0.0274
Onchocerca volvulus 0.0263 0.1392 1
Brugia malayi RNA recognition motif domain containing protein 0.0351 0.1876 0.3445
Schistosoma mansoni hypothetical protein 0.0455 0.2449 0.6516
Echinococcus granulosus dna polymerase kappa 0.002 0.0057 0.0141
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0251 0.0669
Loa Loa (eye worm) nuclear receptor NHR-67 0.0037 0.015 0.0274
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0057 0.0103
Brugia malayi Nuclear hormone receptor E75 0.0037 0.015 0.0274
Echinococcus multilocularis nuclear receptor nhr 48 0.0037 0.015 0.015
Schistosoma mansoni lamin 0.0057 0.0263 0.0701
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0057 0.0089
Brugia malayi orphan nuclear receptor NR2E1 0.0037 0.015 0.0274
Echinococcus multilocularis SAM and MBT domain containing protein 0.0055 0.0251 0.0251
Echinococcus multilocularis dna polymerase eta 0.002 0.0057 0.0057
Schistosoma mansoni thyroid hormone receptor 0.0077 0.0374 0.0996
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0318
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0185 0.0185
Echinococcus granulosus lamin 0.0057 0.0263 0.0649
Loa Loa (eye worm) hypothetical protein 0.0077 0.0374 0.0686
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0077 0.0374 0.0686
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0101 0.0101
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0271 0.1437 0.7926
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0057 0.0089
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0337 0.1798 1
Brugia malayi Pre-SET motif family protein 0.0231 0.1217 0.2234
Schistosoma mansoni nuclear hormone receptor 0.0037 0.015 0.0399
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.015 0.015
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0694 0.3758 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0135 0.0135
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0225 0.0963
Schistosoma mansoni smad 0.0017 0.0043 0.0114
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0043 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0057 0.0089
Echinococcus multilocularis cpg binding protein 0.0034 0.0135 0.0135
Echinococcus granulosus cpg binding protein 0.0034 0.0135 0.0333
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0166 0.0858 0.0858
Onchocerca volvulus 0.0057 0.0263 0.1091
Echinococcus multilocularis polycomb protein SCMH1 0.0055 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.1001 0.5443 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0271 0.1437 0.3541
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0011 0.0017
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0165 0.0293
Loa Loa (eye worm) hypothetical protein 0.0231 0.122 0.2239
Echinococcus multilocularis smad 0.0017 0.0043 0.0043
Schistosoma mansoni retinoic acid receptor RXR 0.0077 0.0374 0.0996
Schistosoma mansoni smad1 5 8 and 0.0017 0.0043 0.0114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0077 0.0374 0.0686
Brugia malayi Zinc finger, C2H2 type family protein 0.0271 0.1437 0.2638
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.1798 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0258 0.0471
Loa Loa (eye worm) hypothetical protein 0.012 0.0608 0.1114
Brugia malayi Nuclear hormone receptor E75 0.0037 0.015 0.0274
Echinococcus granulosus ecdysone induced protein 78C 0.0077 0.0374 0.0923
Brugia malayi TAZ zinc finger family protein 0.0118 0.0599 0.1099
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0173
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0263 0.0482
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0077 0.0374 0.0686
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0135 0.0359
Onchocerca volvulus 0.0171 0.0886 0.6005
Schistosoma mansoni Smad4 0.0017 0.0043 0.0114
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0041 0.0174 0.0463
Schistosoma mansoni smad1 5 8 and 0.0017 0.0043 0.0114
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0185 0.0345
Echinococcus multilocularis GPCR, family 2 0.0117 0.0591 0.0591
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0274
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0263 0.0482
Echinococcus granulosus nuclear receptor nhr 48 0.0037 0.015 0.037
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0077 0.0374 0.0996
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0077 0.0374 0.0996
Brugia malayi ecdysone receptor 0.0037 0.015 0.0274
Plasmodium falciparum dihydroorotate dehydrogenase 0.0694 0.3758 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0165 0.0853 0.2149
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0077 0.0374 0.0996
Brugia malayi Inositol-1 0.0039 0.0165 0.0302
Echinococcus granulosus FTZ F1 alpha 0.0077 0.0374 0.0923
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0165 0.0408
Brugia malayi Smad1 0.0017 0.0043 0.0076
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.001 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0077 0.0374 0.0686
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0274
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0057 0.0089
Echinococcus granulosus SAM and MBT domain containing protein 0.0055 0.0251 0.0619
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0192 0.0774
Onchocerca volvulus 0.0034 0.0135 0.0076
Schistosoma mansoni cpg binding protein 0.0034 0.0135 0.036
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0271 0.1437 0.7926
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.1798 1
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0251 0.0669
Loa Loa (eye worm) transcription factor SMAD2 0.0249 0.1316 0.2415
Brugia malayi hypothetical protein 0.012 0.0608 0.1114
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.1798 1
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0694 0.3758 0.6904
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0318
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0041 0.0174 0.0174
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0057 0.0089

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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