Detailed information for compound 1103248

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 584.568 | Formula: C30H32O12
  • H donors: 4 H acceptors: 7 LogP: 0.67 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@H]1[C@@H](O[C@@H]([C@H]([C@@H]1O)O)COC(=O)c1ccccc1)O[C@]12C[C@H]3[C@@]2(COC(=O)c2ccccc2)C(=O)O[C@@]1(C)C[C@H]3O
  • InChi: 1S/C30H32O12/c1-28-13-19(31)18-12-30(28,29(18,27(37)42-28)15-39-25(36)17-10-6-3-7-11-17)41-26-23(34)22(33)21(32)20(40-26)14-38-24(35)16-8-4-2-5-9-16/h2-11,18-23,26,31-34H,12-15H2,1H3/t18-,19-,20-,21-,22+,23-,26+,28+,29+,30-/m1/s1
  • InChiKey: ZHQGREQIJCCKHT-AJJQULSGSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear receptor RXR 0.0049 0.0918 0.1394
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0884 0.0847
Loa Loa (eye worm) steroid hormone receptor 0.0093 0.2067 0.314
Echinococcus granulosus GPCR family 2 0.0082 0.1767 0.1733
Echinococcus granulosus geminin 0.0355 0.8916 0.8911
Loa Loa (eye worm) hypothetical protein 0.0049 0.0918 0.1394
Brugia malayi CXXC zinc finger family protein 0.0028 0.0359 0.0546
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0093 0.2067 0.314
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0884 0.0847
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0049 0.0918 0.088
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0686 0.1019
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0884 0.1344
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0868 0.7282
Loa Loa (eye worm) TAR-binding protein 0.0199 0.482 0.7324
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0622 0.9067
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0146 0.0106
Brugia malayi ecdysteroid receptor 0.0093 0.2067 0.314
Brugia malayi Latrophilin receptor protein 2 0.0082 0.1767 0.2684
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.1767 0.2684
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0686 0.1019
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0093 0.2067 0.2034
Echinococcus multilocularis ecdysone induced protein 78C 0.0093 0.2067 0.2034
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0686 0.1042
Loa Loa (eye worm) hypothetical protein 0.0093 0.2067 0.314
Schistosoma mansoni zinc finger protein 0.0027 0.0343 0.0303
Schistosoma mansoni thyroid hormone receptor 0.0093 0.2067 0.2034
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0131 0.009
Mycobacterium tuberculosis Conserved protein 0.004 0.0686 0.1019
Brugia malayi Bromodomain containing protein 0.0089 0.1966 0.2988
Brugia malayi RNA binding protein 0.0199 0.482 0.7324
Schistosoma mansoni hypothetical protein 0.0177 0.4245 0.4221
Brugia malayi Nuclear hormone receptor E75 0.0044 0.078 0.1185
Loa Loa (eye worm) hypothetical protein 0.0044 0.078 0.1185
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0093 0.2067 0.314
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0686 0.1019
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1173 0.0827
Brugia malayi hypothetical protein 0.0049 0.0918 0.1394
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0686 0.1019
Loa Loa (eye worm) hypothetical protein 0.0093 0.2067 0.314
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0093 0.2067 0.314
Brugia malayi Nuclear hormone receptor-like 1 0.0093 0.2067 0.314
Brugia malayi PHD-finger family protein 0.0033 0.0499 0.0759
Loa Loa (eye worm) hypothetical protein 0.0079 0.1702 0.2587
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0868 0.0831
Echinococcus multilocularis geminin 0.0355 0.8916 0.8911
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0093 0.2067 0.314
Brugia malayi Nuclear hormone receptor E75 0.0044 0.078 0.1185
Onchocerca volvulus 0.0044 0.078 0.3525
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2658 0.4038
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0258 0.638 0.9694
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0622 0.0944
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0622 0.0944
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0868 0.1319
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0044 0.078 0.0742
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0093 0.2067 0.2034
Loa Loa (eye worm) hypothetical protein 0.0049 0.0918 0.1394
Mycobacterium ulcerans glutaminase 0.0266 0.6581 1
Schistosoma mansoni tar DNA-binding protein 0.0199 0.482 0.4799
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0199 0.482 0.7324
Schistosoma mansoni nuclear receptor 0.0044 0.078 0.0742
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0049 0.0918 0.1394
Brugia malayi hypothetical protein 0.0232 0.5691 0.8647
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0622 0.511
Brugia malayi nuclear hormone receptor 0.0044 0.078 0.1185
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0093 0.2067 0.2034
Echinococcus multilocularis dnaJ subfamily B 0.0397 1 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0702 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.078 0.1185
Brugia malayi hypothetical protein 0.0044 0.078 0.1185
Onchocerca volvulus 0.0028 0.0359 0.1623
Loa Loa (eye worm) hypothetical protein 0.0082 0.1767 0.2684
Brugia malayi orphan nuclear receptor NR2E1 0.0044 0.078 0.1185
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0686 0.0647
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0868 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0093 0.2067 0.2034
Schistosoma mansoni alpha glucosidase 0.0038 0.0622 0.0583
Echinococcus multilocularis GPCR, family 2 0.0082 0.1767 0.1733
Loa Loa (eye worm) hypothetical protein 0.004 0.0686 0.1042
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0222
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0686 0.1019
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0044 0.078 0.1185
Schistosoma mansoni nuclear receptor 0.0044 0.078 0.0742
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0686 0.1019
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.5691 0.5673
Loa Loa (eye worm) hypothetical protein 0.0044 0.078 0.1185
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0093 0.2067 0.314
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0093 0.2067 0.2034
Loa Loa (eye worm) RNA binding protein 0.0199 0.482 0.7324
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.1767 0.1733
Echinococcus granulosus ecdysone induced protein 78C 0.0093 0.2067 0.2034
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0686 0.0647
Loa Loa (eye worm) hypothetical protein 0.0093 0.2067 0.314
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.1767 0.1733
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0622 0.9067
Brugia malayi hypothetical protein 0.0049 0.0918 0.1394
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0093 0.2067 0.314
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0702 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0884 0.0847
Brugia malayi RNA recognition motif domain containing protein 0.0199 0.482 0.7324
Echinococcus multilocularis FTZ F1 alpha 0.0093 0.2067 0.2034
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0884 0.0847
Schistosoma mansoni tar DNA-binding protein 0.0199 0.482 0.4799
Schistosoma mansoni hypothetical protein 0.0047 0.0867 0.0829
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0686 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0622 0.0944
Brugia malayi beta-lactamase family protein 0.004 0.0686 0.1042
Brugia malayi nuclear receptor NHR-67 0.0044 0.078 0.1185
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0868 0.7282
Loa Loa (eye worm) glutaminase 2 0.0266 0.6581 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.2067 0.314
Loa Loa (eye worm) hypothetical protein 0.0093 0.2067 0.314
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0044 0.078 0.0742
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.1173 0.1137
Schistosoma mansoni retinoic acid receptor RXR 0.0093 0.2067 0.2034
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0044 0.078 0.1185
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0333 0.0293
Onchocerca volvulus Bile acid receptor homolog 0.0093 0.2067 0.9339
Brugia malayi acetyltransferase, GNAT family protein 0.0155 0.3672 0.5579
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0146 0.0106
Plasmodium vivax hypothetical protein, conserved 0.004 0.0686 0.7791
Loa Loa (eye worm) hypothetical protein 0.0044 0.078 0.1185
Loa Loa (eye worm) hypothetical protein 0.0044 0.078 0.1185
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2658 0.4038
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0041 0.06
Trypanosoma cruzi ISWI complex protein 0.0017 0.0079 0.1154
Toxoplasma gondii ABC1 family protein 0.004 0.0686 0.5673
Echinococcus multilocularis tar DNA binding protein 0.0199 0.482 0.4799
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0146 0.0106
Brugia malayi Nuclear hormone receptor-like 1 0.0049 0.0918 0.1394
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0686 1
Brugia malayi Steroid receptor seven-up type 2 0.0093 0.2067 0.314
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0049 0.0918 0.088
Loa Loa (eye worm) nuclear hormone receptor 0.0044 0.078 0.1185
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0258 0.6368 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0884 0.0847
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0093 0.2067 0.314
Schistosoma mansoni hypothetical protein 0.0082 0.1767 0.1733
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1173 0.0827
Brugia malayi ecdysone receptor 0.0044 0.078 0.1185
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1173 0.0827
Schistosoma mansoni alpha-glucosidase 0.0147 0.3473 0.3446
Onchocerca volvulus 0.004 0.0686 0.3098
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0049 0.0918 0.088
Echinococcus granulosus zinc finger protein 0.0027 0.0343 0.0303
Loa Loa (eye worm) hypothetical protein 0.0044 0.078 0.1185
Trichomonas vaginalis glutaminase, putative 0.0266 0.6581 1
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.5691 0.5673
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0686 0.0647
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0093 0.2067 0.2034
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0702 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0044 0.078 0.3525
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.1173 0.179
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0093 0.2067 0.2034
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0093 0.2067 0.314
Echinococcus multilocularis zinc finger protein 0.0027 0.0343 0.0303
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0093 0.2067 0.2034
Loa Loa (eye worm) hypothetical protein 0.004 0.0686 0.1042
Echinococcus granulosus Nuclear hormone receptor HR96 0.0044 0.078 0.0742
Brugia malayi latrophilin 2 splice variant baaae 0.0177 0.4245 0.645
Echinococcus granulosus Nuclear hormone receptor HR96 0.0044 0.078 0.0742
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.4095 0.6222
Schistosoma mansoni bromodomain containing protein 0.0076 0.1623 0.1589
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0093 0.2067 0.314
Echinococcus multilocularis cpg binding protein 0.0032 0.0457 0.0417
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0049 0.0918 0.088
Brugia malayi Nuclear hormone receptor-like 1 0.0049 0.0918 0.1394
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0686 0.1042
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0683 0.0645
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1175 0.1139
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0093 0.2067 0.2034
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0884 0.0847
Loa Loa (eye worm) hypothetical protein 0.004 0.0686 0.1042
Onchocerca volvulus 0.004 0.0686 0.3098
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0622 0.0944
Brugia malayi MH2 domain containing protein 0.0116 0.2658 0.4038
Schistosoma mansoni cpg binding protein 0.0028 0.0359 0.0319
Brugia malayi TAR-binding protein 0.0199 0.482 0.7324
Echinococcus multilocularis thyroid hormone receptor alpha 0.0093 0.2067 0.2034
Schistosoma mansoni hypothetical protein 0.0355 0.8916 0.8911
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0044 0.078 0.0742
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0093 0.2067 0.2034
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0622 0.886
Schistosoma mansoni zinc finger protein 0.0044 0.078 0.0742
Mycobacterium tuberculosis Conserved protein 0.004 0.0686 0.1019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0093 0.2067 0.2034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0093 0.2067 0.314
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0155 0.3672 0.3645
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0093 0.2067 0.314
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0686 0.1042
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0686 0.1019
Brugia malayi tailless protein 0.0044 0.078 0.1185
Loa Loa (eye worm) hypothetical protein 0.0053 0.1019 0.1548
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0093 0.2067 0.2034
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0041 0.0351
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0093 0.2067 0.314
Brugia malayi nuclear receptor NHR-88 0.0093 0.2067 0.314
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0686 0.1042
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0686 0.1042
Loa Loa (eye worm) hypothetical protein 0.0049 0.0918 0.1394
Loa Loa (eye worm) hypothetical protein 0.0258 0.638 0.9694
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.4095 0.4071
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1173 0.1137
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.1767 0.1733
Schistosoma mansoni nuclear hormone receptor 0.0093 0.2067 0.2034
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0686 0.0647
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0131 0.009
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0622 0.0944
Loa Loa (eye worm) hypothetical protein 0.0044 0.078 0.1185
Echinococcus multilocularis nuclear receptor nhr 48 0.0044 0.078 0.0742
Loa Loa (eye worm) hypothetical protein 0.0049 0.0918 0.1394
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.4095 0.4071
Brugia malayi glutaminase DH11.1 0.0266 0.6581 1
Schistosoma mansoni hypothetical protein 0.0355 0.8916 0.8911
Loa Loa (eye worm) hypothetical protein 0.0232 0.5691 0.8647
Loa Loa (eye worm) hypothetical protein 0.0044 0.078 0.1185
Schistosoma mansoni tar DNA-binding protein 0.0199 0.482 0.4799
Schistosoma mansoni survival motor neuron protein 0.0047 0.0867 0.0829
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0041 0.06
Brugia malayi Bromodomain containing protein 0.0047 0.085 0.1292
Loa Loa (eye worm) hypothetical protein 0.0049 0.0921 0.14
Brugia malayi beta-lactamase family protein 0.004 0.0686 0.1042
Mycobacterium leprae Probable lipase LipE 0.004 0.0686 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0146 0.0106
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0686 0.1042
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.078 0.0742
Brugia malayi isocitrate dehydrogenase 0.0016 0.0041 0.0063
Schistosoma mansoni thyroid hormone receptor 0.0093 0.2067 0.2034
Loa Loa (eye worm) hypothetical protein 0.0093 0.2067 0.314
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.078 0.0742
Trypanosoma brucei ISWI complex protein 0.0017 0.0079 0.1154
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1173 0.1137
Trypanosoma brucei glucosidase, putative 0.0038 0.0622 0.9067
Schistosoma mansoni cpg binding protein 0.0032 0.0457 0.0417
Schistosoma mansoni nuclear receptor nhr-48 0.0044 0.078 0.0742
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0093 0.2067 0.314
Schistosoma mansoni zinc finger protein 0.0017 0.0079 0.0038
Loa Loa (eye worm) nuclear receptor NHR-67 0.0044 0.078 0.1185
Schistosoma mansoni tar DNA-binding protein 0.0199 0.482 0.4799
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0131 0.009
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0041 0.06
Brugia malayi hypothetical protein 0.0044 0.078 0.1185
Loa Loa (eye worm) hypothetical protein 0.0177 0.4245 0.645
Brugia malayi nuclear hormone receptor 0.0093 0.2067 0.314
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0622 0.886
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0333 0.0293
Onchocerca volvulus Protein ultraspiracle homolog 0.0093 0.2067 0.9339
Brugia malayi nuclear receptor NHR-88 0.0044 0.078 0.1185
Schistosoma mansoni alpha-glucosidase 0.0147 0.3473 0.3446
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0093 0.2067 0.2034
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0622 0.0944
Loa Loa (eye worm) hypothetical protein 0.004 0.0686 0.1042
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0622 0.0944
Schistosoma mansoni nuclear hormone receptor 0.0044 0.078 0.0742
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.4095 0.6222
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0884 0.1344
Loa Loa (eye worm) hypothetical protein 0.0049 0.0918 0.1394
Loa Loa (eye worm) hypothetical protein 0.0044 0.078 0.1185
Schistosoma mansoni steroid hormone receptor ad4bp 0.0093 0.2067 0.2034
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.1767 0.1733
Brugia malayi nuclear receptor RXR 0.0044 0.078 0.1185
Schistosoma mansoni hypothetical protein 0.0082 0.1767 0.1733
Loa Loa (eye worm) hypothetical protein 0.0044 0.078 0.1185
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.1173 0.1137
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0093 0.2067 0.9339
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0622 0.0944
Brugia malayi nuclear hormone receptor family member nhr-6 0.0044 0.078 0.1185
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0041 0.0063
Loa Loa (eye worm) hypothetical protein 0.004 0.0686 0.1042
Leishmania major hypothetical protein, conserved 0.0017 0.0079 0.0674
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0246 0.0373
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0044 0.078 0.0742
Brugia malayi photoreceptor-specific nuclear receptor 0.0093 0.2067 0.314
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0686 1
Schistosoma mansoni hypothetical protein 0.0023 0.0235 0.0195
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0093 0.2067 0.2034
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0622 0.0944
Loa Loa (eye worm) hypothetical protein 0.0093 0.2067 0.314
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0683 0.0645
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0622 0.0583
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.4095 0.4071
Schistosoma mansoni cpg binding protein 0.0032 0.0457 0.0417
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0093 0.2067 0.2034
Schistosoma mansoni hypothetical protein 0.0082 0.1767 0.1733
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0258 0.638 0.9694
Onchocerca volvulus 0.0044 0.078 0.3525
Schistosoma mansoni coup transcription factor 0.0093 0.2067 0.2034
Leishmania major hypothetical protein, conserved 0.004 0.0686 0.5843
Echinococcus granulosus tar DNA binding protein 0.0199 0.482 0.4799
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0093 0.2067 0.314
Loa Loa (eye worm) hypothetical protein 0.0044 0.078 0.1185
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0622 0.0583
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0044 0.078 0.0742
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0333 0.0293
Loa Loa (eye worm) beta-lactamase 0.004 0.0686 0.1042
Mycobacterium leprae conserved hypothetical protein 0.004 0.0686 0.5
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.1173 1
Schistosoma mansoni nuclear hormone receptor 0.0044 0.078 0.0742
Trypanosoma cruzi ISWI complex protein 0.0017 0.0079 0.1154
Schistosoma mansoni tar DNA-binding protein 0.0199 0.482 0.4799
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0235 0.0358
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0622 0.5298
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0093 0.2067 0.2034
Schistosoma mansoni hypothetical protein 0.0017 0.0079 0.0038
Brugia malayi nuclear hormone receptor family member odr-7 0.0044 0.078 0.1185
Brugia malayi Calcitonin receptor-like protein seb-1 0.0258 0.638 0.9694
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0093 0.2067 0.2034
Echinococcus granulosus histone acetyltransferase KAT2B 0.0148 0.3491 0.3464
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0044 0.078 0.3525
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.1518 0.1483
Onchocerca volvulus 0.0047 0.0867 0.3918
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0093 0.2067 0.314
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0044 0.078 0.0742
Schistosoma mansoni hypothetical protein 0.0397 1 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0044 0.078 0.0742
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0093 0.2067 0.2034
Onchocerca volvulus 0.0099 0.2213 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0884 0.0847
Loa Loa (eye worm) hypothetical protein 0.0093 0.2067 0.314
Schistosoma mansoni hypothetical protein 0.0082 0.1767 0.1733
Schistosoma mansoni RAR-like nuclear receptor 0.0093 0.2067 0.2034
Loa Loa (eye worm) hypothetical protein 0.004 0.0686 0.1042
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0686 0.1042
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0041 0.0063
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0093 0.2067 0.2034
Onchocerca volvulus 0.0093 0.2067 0.9339
Loa Loa (eye worm) hypothetical protein 0.0043 0.0755 0.1147
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.1767 0.2684
Loa Loa (eye worm) DR-78 0.0044 0.078 0.1185
Brugia malayi steroid hormone receptor 0.0093 0.2067 0.314
Echinococcus granulosus cpg binding protein 0.0032 0.0457 0.0417
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0093 0.2067 0.314
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0093 0.2067 0.314
Loa Loa (eye worm) hypothetical protein 0.0044 0.078 0.1185
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0868 0.1319
Trichomonas vaginalis esterase, putative 0.004 0.0686 0.1042
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.1518 0.1483
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0622 0.0944
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0867 0.1318
Mycobacterium tuberculosis Conserved protein 0.004 0.0686 0.1019
Loa Loa (eye worm) hypothetical protein 0.0044 0.078 0.1185
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0622 0.0944
Loa Loa (eye worm) glutaminase 0.0266 0.6581 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0131 0.009
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0093 0.2067 0.314
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0359 0.0546
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.1173 0.9968
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.1177 1
Loa Loa (eye worm) acetyltransferase 0.0155 0.3672 0.5579
Schistosoma mansoni glutaminase 0.0266 0.6581 0.6567
Brugia malayi beta-lactamase 0.004 0.0686 0.1042
Onchocerca volvulus 0.004 0.0686 0.3098
Brugia malayi conserved hypotetical protein 0.0044 0.078 0.1185
Echinococcus granulosus thyroid hormone receptor alpha 0.0044 0.078 0.0742
Echinococcus granulosus FTZ F1 alpha 0.0093 0.2067 0.2034
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0093 0.2067 0.314
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0041 0.06
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0093 0.2067 0.314
Echinococcus granulosus nuclear receptor nhr 48 0.0044 0.078 0.0742
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0155 0.3672 0.3645

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 100 uM Antiinflammatory activity against mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production after 48 hrs by Griess reaction relative to control ChEMBL. 19691309
Inhibition (functional) = 82 % Antiinflammatory activity against mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production at 10 uM after 48 hrs by Griess reaction relative to control ChEMBL. 19691309
Inhibition (functional) = 82.6 % Antiinflammatory activity against mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production at 30 uM after 48 hrs by Griess reaction relative to control ChEMBL. 19691309
Inhibition (functional) = 86.7 % Antiinflammatory activity against mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production at 1 uM after 48 hrs by Griess reaction relative to control ChEMBL. 19691309
Inhibition (functional) = 88.3 % Antiinflammatory activity against mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production at 3 uM after 48 hrs by Griess reaction relative to control ChEMBL. 19691309

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.