Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cytochrome p450-like protein | 0.0127 | 0.1732 | 0.4632 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0162 | 0.2448 | 0.6547 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0162 | 0.2448 | 0.6547 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0051 | 0.0201 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0226 | 0.3739 | 0.3739 |
Trypanosoma brucei | cytochrome P450, putative | 0.0127 | 0.1732 | 0.4632 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0162 | 0.2448 | 0.6547 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0127 | 0.1732 | 0.4632 |
Leishmania major | cytochrome p450-like protein | 0.0078 | 0.0751 | 0.2008 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0051 | 0.0201 | 1 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0182 | 0.2848 | 0.2848 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0226 | 0.3739 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0127 | 0.1732 | 0.1732 |
Entamoeba histolytica | hypothetical protein | 0.0051 | 0.0201 | 0.0821 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0078 | 0.0751 | 0.4334 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0078 | 0.0751 | 1 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0182 | 0.2848 | 0.7617 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0078 | 0.0751 | 1 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0078 | 0.0751 | 0.2008 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0078 | 0.0751 | 1 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0162 | 0.2448 | 1 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0162 | 0.2448 | 0.6547 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0078 | 0.0751 | 0.4334 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0078 | 0.0751 | 1 |
Brugia malayi | cytochrome P450 | 0.0078 | 0.0751 | 0.0751 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0078 | 0.0751 | 0.4334 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0162 | 0.2448 | 0.2448 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0051 | 0.0201 | 0.0538 |
Brugia malayi | Cytochrome P450 family protein | 0.0078 | 0.0751 | 0.0751 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0078 | 0.0751 | 0.2008 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0269 | 0.46 | 0.46 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0078 | 0.0751 | 0.2008 |
Mycobacterium leprae | putative cytochrome p450 | 0.0078 | 0.0751 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0751 | 0.2008 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0078 | 0.0751 | 0.2008 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0078 | 0.0751 | 1 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0078 | 0.0751 | 0.4334 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0078 | 0.0751 | 1 |
Loa Loa (eye worm) | cytochrome P450 | 0.0078 | 0.0751 | 0.0751 |
Brugia malayi | MAP kinase sur-1 | 0.0226 | 0.3739 | 0.3739 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0078 | 0.0751 | 0.4334 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0226 | 0.3739 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0078 | 0.0751 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0536 | 1 | 1 |
Echinococcus multilocularis | 0.0078 | 0.0751 | 0.2008 | |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0078 | 0.0751 | 0.4334 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0051 | 0.0201 | 0.1161 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0162 | 0.2448 | 0.6547 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0162 | 0.2448 | 0.6547 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0162 | 0.2448 | 0.6547 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0078 | 0.0751 | 0.4334 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0078 | 0.0751 | 0.2008 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0078 | 0.0751 | 0.2008 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0078 | 0.0751 | 0.4334 |
Schistosoma mansoni | cytochrome P450 | 0.0078 | 0.0751 | 0.2008 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0127 | 0.1732 | 0.4632 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0162 | 0.2448 | 0.6547 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.2448 | 0.2448 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0051 | 0.0201 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0078 | 0.0751 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0226 | 0.3739 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0127 | 0.1732 | 0.1732 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0162 | 0.2448 | 0.6547 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0078 | 0.0751 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0078 | 0.0751 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0147 | 0.0147 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0226 | 0.3739 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0162 | 0.2448 | 0.6547 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0078 | 0.0751 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0226 | 0.3739 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0078 | 0.0751 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0127 | 0.1732 | 0.1732 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0182 | 0.2848 | 0.7617 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0078 | 0.0751 | 1 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0078 | 0.0751 | 0.4334 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0078 | 0.0751 | 0.4334 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0162 | 0.2448 | 0.6547 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0078 | 0.0751 | 0.4334 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.2848 | 0.2848 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0162 | 0.2448 | 0.6547 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0226 | 0.3739 | 1 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0051 | 0.0201 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0078 | 0.0751 | 0.4334 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0226 | 0.3739 | 1 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0051 | 0.0201 | 1 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0051 | 0.0201 | 0.2678 |
Trypanosoma brucei | protein kinase, putative | 0.0226 | 0.3739 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0269 | 0.46 | 0.46 |
Onchocerca volvulus | 0.0182 | 0.2848 | 0.5 | |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0078 | 0.0751 | 0.4334 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0226 | 0.3739 | 1 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0162 | 0.2448 | 0.6547 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0078 | 0.0751 | 0.4334 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0078 | 0.0751 | 0.4334 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0226 | 0.3739 | 1 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0162 | 0.2448 | 0.6547 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0051 | 0.0201 | 0.1161 |
Brugia malayi | Cytochrome P450 family protein | 0.0127 | 0.1732 | 0.1732 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0127 | 0.1732 | 0.1732 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0162 | 0.2448 | 0.6547 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0127 | 0.1732 | 1 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0078 | 0.0751 | 0.4334 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0226 | 0.3739 | 1 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0182 | 0.2848 | 0.7617 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0078 | 0.0751 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0078 | 0.0751 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0226 | 0.3739 | 1 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0078 | 0.0751 | 0.4334 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0078 | 0.0751 | 1 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0051 | 0.0201 | 0.0538 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0051 | 0.0201 | 0.0538 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0226 | 0.3739 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0162 | 0.2448 | 0.6547 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0078 | 0.0751 | 0.4334 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0078 | 0.0751 | 1 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0078 | 0.0751 | 0.4334 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0078 | 0.0751 | 1 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0078 | 0.0751 | 0.2008 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0078 | 0.0751 | 0.4334 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0226 | 0.3739 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0078 | 0.0751 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0078 | 0.0751 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0078 | 0.0751 | 0.2008 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0051 | 0.0201 | 0.0538 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0078 | 0.0751 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0226 | 0.3739 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0226 | 0.3739 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0226 | 0.3739 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0226 | 0.3739 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0226 | 0.3739 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta blood pressure (functional) | < 20 mmHg | Change in systolic blood pressure at intervals of 1 hr after oral administration of 1 mg/kg of compound in spontaneously hypertensive rats (in vitro); Not significant | ChEMBL. | 8340916 |
IC50 (functional) | > 10 uM | In vitro inhibition of spontaneous tone of guinea pig tracheal spirals | ChEMBL. | 8340916 |
Inhibition (functional) | = 0 % | Percentage of inhibition of noradrenaline-induced contractions in rat portal vein at 10 microM (in vitro) | ChEMBL. | 8340916 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.