Detailed information for compound 1103569

Basic information

Technical information
  • TDR Targets ID: 1103569
  • Name: 2,3-dimethylfuro[3,2-g]chromen-7-one
  • MW: 214.217 | Formula: C13H10O3
  • H donors: 0 H acceptors: 1 LogP: 3.08 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1ccc2c(o1)cc1c(c2)c(c(o1)C)C
  • InChi: 1S/C13H10O3/c1-7-8(2)15-12-6-11-9(5-10(7)12)3-4-13(14)16-11/h3-6H,1-2H3
  • InChiKey: SXACOUILNSSCPR-UHFFFAOYSA-N  


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Synonyms

  • 2,3-dimethyl-7-furo[3,2-g]chromenone
  • Oprea1_133019
  • Oprea1_280627
  • STOCK1N-16637
  • ZINC00407796

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.003 0.019 0.0177
Loa Loa (eye worm) thioredoxin reductase 0.0328 0.3049 0.3468
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.1535 0.2355
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0287 0.0318
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0083 0.007
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.003 0.019 0.019
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0287 0.0278
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0073 0.02
Echinococcus granulosus snurportin 1 0.0684 0.6477 1
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0278 0.0874
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0287 0.0318
Echinococcus multilocularis heat shock protein 0.0039 0.0278 0.0285
Onchocerca volvulus 0.004 0.0287 0.0275
Echinococcus granulosus heat shock protein 90 0.0034 0.0223 0.0326
Brugia malayi Pre-SET motif family protein 0.0134 0.1183 0.1336
Echinococcus multilocularis importin subunit beta 1 0.0064 0.0516 0.0541
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0015 0.004 0.0042
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0265 0.0832
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0005
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0083 0.0108
Mycobacterium ulcerans hypothetical protein 0.0029 0.0175 0.1349
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0467 0.4386 0.4993
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0073 0.0061
Trypanosoma cruzi NADH dehydrogenase, putative 0.003 0.019 0.0582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Mycobacterium tuberculosis Conserved protein 0.004 0.0287 0.0348
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0105 0.0092
Schistosoma mansoni glutamate synthase 0.003 0.019 0.0178
Onchocerca volvulus 0.0019 0.0083 0.007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0084
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0084
Trypanosoma brucei Heat shock protein 83, putative 0.0039 0.0278 0.0885
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0083 0.0075
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0151 0.0495
Entamoeba histolytica hypothetical protein 0.0036 0.0245 0.2844
Loa Loa (eye worm) hypothetical protein 0.0029 0.0175 0.019
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0278 0.3248
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0073 0.0743
Trichomonas vaginalis heat shock protein, putative 0.0023 0.012 0.0111
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0138 0.0413
Schistosoma mansoni endoplasmin 0.0039 0.0278 0.0267
Schistosoma mansoni GTP-binding protein alpha subunit 0.0015 0.004 0.0027
Mycobacterium ulcerans hypothetical protein 0.004 0.0287 0.2282
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0025 0.0016
Schistosoma mansoni hypothetical protein 0.0166 0.1493 0.149
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0287 0.0318
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0013 0.0012
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0083 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0025 0.0016
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0036 0.025 0.0783
Echinococcus multilocularis glutamate synthase 0.003 0.019 0.019
Echinococcus multilocularis tumor protein p63 0.0301 0.279 0.2986
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0012 0.0016 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0004
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0114 0.0991 0.3231
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0175 0.1349
Brugia malayi Hsp90 protein 0.0026 0.0151 0.0158
Echinococcus multilocularis FTZ F1 alpha 0.0123 0.108 0.1148
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0015 0.004 0.0042
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0395 0.1295
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.003 0.019 0.0582
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0287 0.0318
Entamoeba histolytica hypothetical protein 0.0036 0.0245 0.2844
Toxoplasma gondii ABC1 family protein 0.004 0.0287 0.0915
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0175 0.1349
Trypanosoma brucei chrX additional, unordered contigs 0.0012 0.0013 0.0014
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0148 0.1319 0.1405
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0151 0.0455
Entamoeba histolytica HEAT repeat domain containing protein 0.0012 0.0016 0.0046
Brugia malayi hypothetical protein 0.0021 0.0105 0.0105
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0015 0.004 0.0029
Schistosoma mansoni hypothetical protein 0.0684 0.6477 0.6507
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0015 0.004 0.0027
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.003 0.019 0.0202
Mycobacterium ulcerans aldehyde dehydrogenase 0.0054 0.0419 0.3384
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0015 0.004 0.0031
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0015 0.004 0.0027
Trichomonas vaginalis disulfide oxidoreductase, putative 0.003 0.019 0.0181
Echinococcus granulosus geminin 0.0166 0.1493 0.229
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0013 0.0012
Treponema pallidum oxidoreductase 0.003 0.019 0.1808
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0013 0.0012
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0287 0.0425
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.003 0.019 0.0225
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0747 0.7083 0.8982
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0012 0.0013 0.0012
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.003 0.019 0.1469
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0628 0.0662
Toxoplasma gondii histone lysine methyltransferase SET1 0.0118 0.1033 0.337
Treponema pallidum NADH oxidase 0.0114 0.0991 1
Echinococcus multilocularis endoplasmin 0.0037 0.0255 0.026
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0015 0.004 0.0027
Brugia malayi RNA, U transporter 1 0.0182 0.1652 0.1871
Loa Loa (eye worm) hypothetical protein 0.004 0.0287 0.0318
Mycobacterium ulcerans aldehyde dehydrogenase 0.0054 0.0419 0.3384
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0265 0.0321
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0083 0.008
Echinococcus granulosus endoplasmin 0.0037 0.0255 0.0375
Mycobacterium tuberculosis Conserved hypothetical protein 0.0137 0.1213 0.1525
Schistosoma mansoni importin-beta 2 0.0012 0.0016 0.0004
Leishmania major DNA damage repair protein, putative 0.0012 0.0013 0.0002
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0287 0.0278
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0265 0.0843
Toxoplasma gondii heat shock protein 75, putative 0.0026 0.0151 0.0468
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0287 0.0295
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0152 0.047
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0287 0.0425
Loa Loa (eye worm) beta-lactamase 0.004 0.0287 0.0317
Trypanosoma brucei trypanothione reductase 0.0328 0.3049 1
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0287 0.0313
Brugia malayi G-protein alpha subunit 0.0015 0.004 0.0031
Schistosoma mansoni hypothetical protein 0.003 0.019 0.0178
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0073 0.0065
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0628 0.2027
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.003 0.019 0.1808
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0265 0.0292
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0083 0.007
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0287 0.0313
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0134 0.1183 0.1259
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0265 0.0254
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0134 0.1183 0.3863
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0015 0.004 0.0031
Leishmania major heat shock protein 83-1 0.0039 0.0278 0.0874
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0278 0.0885
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0073 0.02
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0025 0.0016
Echinococcus multilocularis cpg binding protein 0.0061 0.0483 0.0506
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0831 0.7885 1
Plasmodium vivax endoplasmin, putative 0.0039 0.0278 0.0912
Echinococcus granulosus translational activator gcn1 0.0012 0.0016 0.0006
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0083 0.0108
Giardia lamblia NADH oxidase lateral transfer candidate 0.0114 0.0991 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.083 0.0932
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.003 0.019 0.019
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0013 0.0014
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0114 0.0991 0.8152
Loa Loa (eye worm) latrophilin receptor protein 2 0.0148 0.1319 0.1495
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0287 0.0276
Brugia malayi Latrophilin receptor protein 2 0.0148 0.1319 0.1491
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0338 0.3153 0.3161
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0084
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0175 0.0185
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0015 0.004 0.0027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0025 0.0016
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0377 0.0293
Loa Loa (eye worm) glutathione reductase 0.0328 0.3049 0.3468
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0083 0.0108
Schistosoma mansoni cpg binding protein 0.0061 0.0483 0.0474
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0459 0.0509
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0035
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.003 0.019 0.005
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0278 0.0885
Entamoeba histolytica glutamate synthase beta subunit, putative 0.003 0.019 0.2165
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0114 0.0991 0.3231
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0084
Schistosoma mansoni endoplasmin 0.0039 0.0278 0.0267
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0134 0.1183 0.1178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Loa Loa (eye worm) hypothetical protein 0.004 0.0287 0.0317
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0158 0.0479
Loa Loa (eye worm) G protein alpha subunit 3 0.0015 0.004 0.0035
Leishmania major heat shock protein 83-1 0.0039 0.0278 0.0874
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0134 0.1183 0.1178
Mycobacterium tuberculosis Conserved protein 0.004 0.0287 0.0348
Trypanosoma brucei unspecified product 0.0038 0.0265 0.0843
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0037 0.0255 0.0308
Schistosoma mansoni ap endonuclease 0.0058 0.0459 0.0449
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0105 0.0109
Leishmania major heat shock protein 83-1 0.0039 0.0278 0.0874
Brugia malayi Importin beta-1 subunit 0.0064 0.0516 0.0574
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0148 0.1319 0.1405
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.003 0.019 0.0225
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0013 0.0012
Brugia malayi hypothetical protein 0.0015 0.004 0.0031
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.1582 0.158
Brugia malayi hypothetical protein 0.0017 0.0067 0.0062
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0015 0.004 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0152 0.047
Brugia malayi ecdysone receptor 0.0019 0.0083 0.008
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.003 0.019 0.1469
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0083 0.008
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0016 0.0005
Brugia malayi hypothetical protein 0.0021 0.0105 0.0105
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0013 0.0004
Trypanosoma brucei heat shock protein, putative 0.0039 0.0278 0.0885
Mycobacterium ulcerans dehydrogenase 0.003 0.019 0.1469
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0158 0.0479
Loa Loa (eye worm) hypothetical protein 0.0467 0.4386 0.4993
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0265 0.0843
Brugia malayi nuclear receptor NHR-67 0.0019 0.0083 0.008
Schistosoma mansoni nuclear receptor 0.0019 0.0083 0.007
Trypanosoma cruzi heat shock protein 90, putative 0.0034 0.0223 0.0694
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0013 0.0014
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0287 0.0348
Trichomonas vaginalis hypothetical protein 0.0012 0.0016 0.0008
Brugia malayi hypothetical protein 0.0019 0.0083 0.008
Schistosoma mansoni DNA polymerase eta 0.0038 0.0265 0.0254
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0025 0.0016
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0287 0.0276
Brugia malayi Pre-SET motif family protein 0.0923 0.8775 1
Giardia lamblia Thioredoxin reductase 0.003 0.019 0.1808
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0287 0.0275
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0134 0.1183 0.1178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.003 0.019 0.0594
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0073 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0035
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0148 0.1319 0.2021
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0047 0.0353 0.1122
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0015 0.004 0.0035
Echinococcus granulosus GPCR family 2 0.0148 0.1319 0.2021
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0123 0.108 0.1652
Schistosoma mansoni sulfide quinone reductase 0.003 0.019 0.0178
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0287 0.0318
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0395 0.0386
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0287 0.0295
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0459 0.069
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0015 0.004 0.0027
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.036 0.0352
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.083 0.0936
Brugia malayi MH2 domain containing protein 0.0118 0.1039 0.1171
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.011
Leishmania major importin beta-1 subunit, putative 0.0052 0.04 0.1274
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.011
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0628 0.2037
Onchocerca volvulus 0.0044 0.0323 0.0311
Schistosoma mansoni nuclear hormone receptor 0.004 0.0287 0.0276
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1039 0.1175
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0083 0.008
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0338 0.3153 0.3586
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0265 0.0843
Plasmodium vivax heat shock protein 86, putative 0.0039 0.0278 0.0912
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0084
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0084
Mycobacterium ulcerans glutamate synthase subunit beta 0.003 0.019 0.1469
Schistosoma mansoni aldehyde dehydrogenase 0.0054 0.0419 0.0409
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0073 0.02
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0013 0.0026 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0013 0.0002
Onchocerca volvulus 0.0015 0.004 0.0027
Leishmania major heat shock protein 83-1 0.0039 0.0278 0.0874
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0628 0.2061
Trypanosoma brucei importin beta-1 subunit, putative 0.0064 0.0516 0.1668
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0265 0.3092
Brugia malayi beta-lactamase family protein 0.004 0.0287 0.0313
Toxoplasma gondii aldehyde dehydrogenase 0.0054 0.0419 0.135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.011
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0013 0.0024 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0265 0.0843
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0287 0.0318
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0015 0.004 0.0031
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0083 0.0075
Toxoplasma gondii selenide, water dikinase 0.003 0.019 0.0594
Schistosoma mansoni ap endonuclease 0.0058 0.0459 0.0449
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0257 0.2373 0.2998
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0073 0.02
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0013 0.0014
Leishmania major heat shock protein 83-1 0.0039 0.0278 0.0874
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0114 0.0991 0.3223
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0004
Brugia malayi kap beta 3 protein 0.0012 0.0016 0.0004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0265 0.0832
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.003 0.019 0.2165
Brugia malayi glutamate synthase 0.003 0.019 0.0202
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0123 0.108 0.3514
Schistosoma mansoni glutamate synthase 0.003 0.019 0.0178
Loa Loa (eye worm) hypothetical protein 0.0021 0.0105 0.0109
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0287 0.0903
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0265 0.0843
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0175 0.1349
Brugia malayi CXXC zinc finger family protein 0.0057 0.0452 0.0501
Schistosoma mansoni thyroid hormone receptor 0.004 0.0287 0.0276
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0084
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0073 0.0094
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0287 0.0276
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0287 0.0313
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0265 0.0843
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.003 0.019 0.019
Echinococcus multilocularis heat shock protein 90 0.0034 0.0223 0.0227
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0831 0.7885 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0114 0.0991 0.8152
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0025 0.0016
Brugia malayi nuclear hormone receptor 0.004 0.0287 0.0313
Brugia malayi Probable ClpP-like protease 0.0076 0.0628 0.0702
Leishmania major heat shock protein 83-1 0.0039 0.0278 0.0874
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0015 0.004 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Schistosoma mansoni hypothetical protein 0.0148 0.1319 0.1315
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0459 0.5458
Plasmodium vivax thioredoxin reductase, putative 0.0328 0.3049 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0083 0.0075
Echinococcus granulosus thioredoxin glutathione reductase 0.0328 0.3053 0.4704
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0074 0.0201
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0013 0.0042
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0013 0.0012
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0047 0.0353 0.1133
Giardia lamblia GTOR 0.0018 0.0073 0.062
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0013 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0025 0.0016
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0015 0.004 0.0031
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0013 0.0004
Trichomonas vaginalis heat shock protein, putative 0.0037 0.0255 0.0246
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0114 0.0991 1
Onchocerca volvulus 0.0134 0.1183 0.1172
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0015 0.004 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0013 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0025 0.0016
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0013 0.0042
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0278 0.0874
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0012 0.0013 0.0004
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0287 0.0425
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0083 0.0075
Schistosoma mansoni zinc finger protein 0.0019 0.0083 0.007
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0083 0.007
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0287 0.0278
Trypanosoma brucei hypothetical protein, conserved 0.003 0.019 0.0594
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Plasmodium falciparum importin beta, putative 0.0064 0.0516 0.1658
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0338 0.3153 0.3583
Toxoplasma gondii heat shock protein HSP90 0.0039 0.0278 0.0885
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.003 0.019 0.0582
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0459 0.1469
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0015 0.004 0.0027
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0175 0.1349
Plasmodium falciparum thioredoxin reductase 0.0114 0.0991 0.3223
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.003 0.019 0.019
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.003 0.019 0.0582
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0013 0.0001
Echinococcus granulosus GTP binding nuclear protein Ran 0.0047 0.0353 0.0527
Entamoeba histolytica glutamate synthase beta subunit, putative 0.003 0.019 0.2165
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.003 0.019 0.0202
Leishmania major hypothetical protein, conserved 0.0027 0.0158 0.0479
Mycobacterium ulcerans ferredoxin reductase 0.003 0.019 0.1469
Loa Loa (eye worm) hypothetical protein 0.004 0.0287 0.0318
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0259 0.2392 0.7838
Brugia malayi beta-lactamase 0.004 0.0287 0.0313
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0016 0.0003
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.003 0.019 0.0582
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0073 0.0094
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0287 0.0295
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0459 0.3356
Mycobacterium tuberculosis Probable oxidoreductase 0.0831 0.7885 1
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.003 0.019 0.0181
Toxoplasma gondii thioredoxin reductase 0.0328 0.3049 1
Schistosoma mansoni glutamate synthase 0.003 0.019 0.0178
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0265 0.0257
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0084
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.036 0.0352
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0152 0.047
Leishmania major DNA polymerase kappa, putative 0.0012 0.0013 0.0002
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0073 0.02
Schistosoma mansoni nuclear receptor 0.0019 0.0083 0.007
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.003 0.019 0.0594
Trichomonas vaginalis Phospholipase C precursor, putative 0.0012 0.0013 0.0004
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0015 0.004 0.0031
Plasmodium vivax transportin, putative 0.0012 0.0016 0.0054
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0114 0.0991 0.3223
Schistosoma mansoni heat shock protein 0.0039 0.0278 0.0267
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0452 0.0505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Toxoplasma gondii hypothetical protein 0.0042 0.0302 0.0964
Mycobacterium ulcerans monoxygenase 0.003 0.019 0.1469
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Leishmania major heat shock protein 83-1 0.0039 0.0278 0.0874
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0459 0.3712
Treponema pallidum thioredoxin reductase (trxB) 0.003 0.019 0.1808
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0459 0.0479
Brugia malayi hypothetical protein 0.0019 0.0083 0.008
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0083 0.008
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0105 0.0303
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0013 0.0004
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0047 0.0353 0.1133
Entamoeba histolytica disulphide oxidoreductase, putative 0.003 0.019 0.2165
Loa Loa (eye worm) hypothetical protein 0.0021 0.0105 0.0109
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0628 0.5473
Loa Loa (eye worm) importin-beta domain-containing protein 0.0012 0.0016 0.0009
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0015 0.004 0.0031
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0083 0.0075
Loa Loa (eye worm) hypothetical protein 0.004 0.0287 0.0317
Schistosoma mansoni aldehyde dehydrogenase 0.0054 0.0419 0.0409
Plasmodium falciparum ferrodoxin reductase-like protein 0.003 0.019 0.0582
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0015 0.004 0.0035
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0287 0.0295
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0015 0.004 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0025 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.019 0.0582
Leishmania major mitochondrial DNA polymerase beta 0.0259 0.2392 0.7838
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0037 0.0255 0.0814
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0015 0.004 0.0035
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0287 0.0275
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0265 0.0257
Toxoplasma gondii hypothetical protein 0.0026 0.0151 0.0467
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0015 0.004 0.0031
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0047 0.0353 0.0389
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0025 0.0016
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0245 0.0234
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.083 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0287 0.0425
Schistosoma mansoni disulfide oxidoreductase 0.003 0.019 0.0178
Schistosoma mansoni hypothetical protein 0.0012 0.0016 0.0003
Schistosoma mansoni hypothetical protein 0.0319 0.2967 0.2974
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0105 0.0092
Trypanosoma cruzi heat shock protein 90, putative 0.0016 0.0058 0.015
Schistosoma mansoni hypothetical protein 0.0036 0.0245 0.0234
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0174 0.0166
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0012 0.002 0.0035
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0012 0.0013 0.0004
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0013 0.0012
Echinococcus granulosus transportin 1 0.0012 0.0016 0.0006
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0923 0.8775 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0245 0.025
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0287 0.0317
Trypanosoma brucei unspecified product 0.0026 0.0152 0.047
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0114 0.0991 0.3231
Brugia malayi glutathione reductase 0.0328 0.3049 0.3465
Entamoeba histolytica hypothetical protein 0.0052 0.04 0.4734
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0073 0.0061
Brugia malayi Endoplasmin precursor 0.0039 0.0278 0.0303
Leishmania major heat shock protein 83-1 0.0039 0.0278 0.0874
Echinococcus granulosus expressed protein 0.0015 0.004 0.0042
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0175 0.1988
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0265 0.0272
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0114 0.0991 0.3251
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0265 0.2101
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.083 0.0878
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0278 0.2712
Mycobacterium ulcerans beta-lactamase 0.004 0.0287 0.2282
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0175 0.1988
Loa Loa (eye worm) hypothetical protein 0.0029 0.0175 0.019
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0047 0.0353 0.0366
Loa Loa (eye worm) hypothetical protein 0.0123 0.108 0.1222
Plasmodium vivax SET domain protein, putative 0.0134 0.1183 0.3881
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0094 0.0104
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0287 0.0313
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0084 0.011
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0015 0.004 0.0027
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0015 0.004 0.0031
Plasmodium falciparum glutathione reductase 0.0114 0.0991 0.3223
Loa Loa (eye worm) kap beta 3 protein 0.0012 0.0016 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0338 0.3153 0.3161
Trichomonas vaginalis apoptosis inducing factor, putative 0.003 0.019 0.0181
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0015 0.004 0.0042
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0083 0.0075
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0114 0.0991 0.1117
Plasmodium vivax importin-beta 2, putative 0.0064 0.0516 0.1693
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0287 0.0313
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.083 0.1264
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0083 0.0702 0.0786
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0628 0.062
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0138 0.0194
Trypanosoma brucei heat shock protein 84, putative 0.0026 0.0151 0.0468
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0035
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0025 0.0016
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0148 0.1319 0.2021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0287 0.0276
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0287 0.0425
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0328 0.3049 0.3857
Brugia malayi ecdysteroid receptor 0.004 0.0287 0.0313
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0114 0.0991 0.3231
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0004
Trypanosoma brucei heat shock protein, putative 0.0039 0.0278 0.0885
Echinococcus granulosus mixed lineage leukemia protein mll 0.0019 0.0084 0.011
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.083 0.0821
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0395 0.1269
Plasmodium falciparum DNA repair protein REV1, putative 0.0012 0.0013 0.0002
Mycobacterium tuberculosis Conserved protein 0.004 0.0287 0.0348
Loa Loa (eye worm) hypothetical protein 0.0021 0.0105 0.0109
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0013 0.0002
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0175 0.1349
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0037 0.0255 0.0797
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0034 0.0223 0.0326
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0013 0.0042
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0628 0.2037
Plasmodium vivax exodeoxyribonuclease III, putative 0.0012 0.0013 0.0042
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0083 0.008
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0073 0.02
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0123 0.108 0.1218
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0114 0.0991 0.3223
Echinococcus multilocularis heat shock protein 90 0.0039 0.0278 0.0285
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0158 0.0519
Leishmania major DNA polymerase eta, putative 0.0012 0.0013 0.0002
Trichomonas vaginalis disulfide oxidoreductase, putative 0.003 0.019 0.0181
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0052 0.04 0.0391
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.003 0.019 0.0582
Brugia malayi nuclear receptor NHR-88 0.0019 0.0083 0.008
Loa Loa (eye worm) hypothetical protein 0.004 0.0287 0.0318
Trypanosoma brucei heat shock protein, putative 0.0039 0.0278 0.0885
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0265 0.0843
Echinococcus granulosus sulfide:quinone oxidoreductase 0.003 0.019 0.0274
Leishmania major heat shock protein 83-1 0.0039 0.0278 0.0874
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0628 0.5126
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.003 0.019 0.0225
Echinococcus granulosus importin 5 0.0012 0.0016 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0265 0.0843
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0106 0.0306
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0459 0.1469
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.003 0.019 0.005
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0073 0.0212
Schistosoma mansoni hypothetical protein 0.0148 0.1319 0.1315
Echinococcus multilocularis expressed protein 0.0015 0.004 0.0029
Loa Loa (eye worm) hypothetical protein 0.004 0.0287 0.0317
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0278 0.0874
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0138 0.0126
Entamoeba histolytica hypothetical protein 0.0036 0.0245 0.2844
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.003 0.019 0.0274
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.9313 1
Toxoplasma gondii HEAT repeat-containing protein 0.0064 0.0516 0.1668
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0084
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0114 0.0991 0.1243
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0158 0.0479
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0012 0.0013 0.0012
Entamoeba histolytica hypothetical protein 0.0036 0.0245 0.2844
Leishmania major heat shock protein 83-1 0.0039 0.0278 0.0874
Leishmania major hypothetical protein, conserved 0.004 0.0287 0.0903
Echinococcus multilocularis geminin 0.0166 0.1493 0.1591
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0013 0.0014
Entamoeba histolytica hypothetical protein 0.0025 0.0138 0.1536
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0287 0.0278
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0013 0.0002
Brugia malayi hypothetical protein 0.0036 0.0245 0.0265
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.003 0.019 0.0594
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0105 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0287 0.0313
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0459 0.045
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0287 0.0275
Echinococcus granulosus importin subunit beta 1 0.0064 0.0516 0.0779
Mycobacterium ulcerans NADH dehydrogenase 0.003 0.019 0.1469
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0047 0.0353 0.3482
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0628 0.6291
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0175 0.1988
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0287 0.0348
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0015 0.004 0.0027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0083 0.0108
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0083 0.008
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.003 0.019 0.0582
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0073 0.0212
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.003 0.019 0.0594
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0747 0.7083 0.8982
Leishmania major heat shock protein 83-1 0.0039 0.0278 0.0874
Brugia malayi nuclear hormone receptor 0.0019 0.0083 0.008
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0114 0.0991 0.3223
Schistosoma mansoni cellular tumor antigen P53 0.0044 0.0323 0.0312
Giardia lamblia Grp94/Hsp90 0.0037 0.0255 0.2475
Schistosoma mansoni hypothetical protein 0.0148 0.1319 0.1315
Trypanosoma brucei heat shock protein, putative 0.0039 0.0278 0.0885
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.083 0.0821
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.003 0.019 0.0622
Entamoeba histolytica G protein alpha subunit, putative 0.0015 0.004 0.033
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0015 0.004 0.0031
Toxoplasma gondii exonuclease III APE 0.0058 0.0459 0.1479
Giardia lamblia Glutamate synthase 0.003 0.019 0.1808
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0459 0.1479
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.003 0.019 0.0582
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0127 0.1124 0.172
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0278 0.0874
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0354 0.4171
Echinococcus multilocularis GPCR, family 2 0.0148 0.1319 0.1405
Brugia malayi nuclear receptor RXR 0.0021 0.0105 0.0105
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0015 0.004 0.0031
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0377 0.0463
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.003 0.019 0.0582
Schistosoma mansoni heat shock protein 0.0026 0.0151 0.0139
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0054 0.0419 0.0516
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0084 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.003 0.019 0.019
Onchocerca volvulus 0.004 0.0287 0.0275
Trichomonas vaginalis importin beta-1, putative 0.0052 0.04 0.0391
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0073 0.0069
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.003 0.019 0.1469
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0287 0.0425
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0287 0.0313
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0106 0.0346
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.003 0.019 0.1469
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.083 0.0821
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0013 0.0012
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0117 0.0113
Onchocerca volvulus 0.004 0.0287 0.0275
Brugia malayi Thioredoxin reductase 0.0328 0.3049 0.3465
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0013 0.0004
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0114 0.0991 0.8152
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0019 0.0084 0.0076
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0265 0.0321
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0175 0.0185
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0123 0.108 0.3522
Echinococcus multilocularis transportin 1 0.0012 0.0016 0.0004
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0015 0.004 0.0031
Leishmania major heat shock protein 83-1 0.0039 0.0278 0.0874
Schistosoma mansoni heat shock protein 0.0039 0.0278 0.0267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0684 0.6477 0.7378
Loa Loa (eye worm) hypothetical protein 0.0064 0.0516 0.0578
Trypanosoma brucei heat shock protein, putative 0.0039 0.0278 0.0885
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0114 0.0991 0.0985
Trypanosoma cruzi DNA polymerase eta, putative 0.0012 0.0013 0.0002
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0035
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0117 0.0162
Loa Loa (eye worm) hypothetical protein 0.0021 0.0105 0.0109
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.003 0.019 0.005
Echinococcus granulosus cpg binding protein 0.0061 0.0483 0.0728
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0074 0.0201
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0175 0.0031
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.003 0.019 0.0225
Onchocerca volvulus 0.0015 0.004 0.0027
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0287 0.0276
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0036 0.025 0.0783
Echinococcus multilocularis translational activator gcn1 0.0012 0.0016 0.0004
Plasmodium falciparum heat shock protein 90, putative 0.0149 0.1333 0.4349
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0015 0.004 0.0029
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0287 0.0903
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0025 0.0016
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0287 0.0276
Brugia malayi nuclear receptor RXR 0.0019 0.0083 0.008
Leishmania major hypothetical protein, conserved 0.003 0.019 0.0582
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0114 0.0991 0.3223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Loa Loa (eye worm) hypothetical protein 0.0038 0.0265 0.0292
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0459 0.045
Trypanosoma cruzi trypanothione reductase, putative 0.0328 0.3049 1
Leishmania major DNA polymerase kappa, putative 0.0038 0.0265 0.0832
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0083 0.007
Mycobacterium tuberculosis Probable dehydrogenase 0.0747 0.7083 0.8982
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0265 0.0843
Chlamydia trachomatis thioredoxin reductase 0.003 0.019 0.0949
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.003 0.019 0.1469
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0114 0.0991 0.3223
Loa Loa (eye worm) hypothetical protein 0.004 0.0287 0.0317
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0013 0.0014
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0047 0.0353 0.1159
Leishmania major GTP-binding protein, putative 0.0047 0.0353 0.1122
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0013 0.0014
Trichomonas vaginalis glutamate synthase, putative 0.003 0.019 0.0181
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.003 0.019 0.0181
Brugia malayi latrophilin 2 splice variant baaae 0.0319 0.2967 0.3371
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0327 0.1035
Schistosoma mansoni cpg binding protein 0.0061 0.0483 0.0474
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.003 0.019 0.0582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0073 0.0743
Loa Loa (eye worm) programmed cell death 8 0.003 0.019 0.0206
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0628 0.0617
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.003 0.019 0.0594
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0223 0.0694
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.003 0.019 0.0274
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0287 0.0295
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0083 0.0084
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0459 0.1469
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0158 0.0491
Schistosoma mansoni coup transcription factor 0.004 0.0287 0.0276
Brugia malayi hypothetical protein 0.0027 0.0158 0.0166
Onchocerca volvulus 0.0012 0.0019 0.0006
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0015 0.004 0.0029
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1039 0.1175
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0265 0.0843
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0025 0.0016
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0013 0.0012
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0287 0.0313
Loa Loa (eye worm) hypothetical protein 0.004 0.0287 0.0317
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0004
Plasmodium vivax hypothetical protein, conserved 0.004 0.0287 0.0941
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.003 0.019 0.0181
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0036 0.025 0.0794
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0377 0.0564
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.003 0.019 0.0594
Schistosoma mansoni kinase 0.0049 0.0372 0.0362
Plasmodium vivax glutathione reductase, putative 0.0328 0.3049 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0084
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.1582 0.1688
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0377 0.0392
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0073 0.0069
Loa Loa (eye worm) hypothetical protein 0.0021 0.0105 0.0109
Loa Loa (eye worm) hypothetical protein 0.0148 0.1319 0.1495
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0015 0.004 0.0027
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0459 0.1469
Brugia malayi tailless protein 0.0019 0.0083 0.008
Trichomonas vaginalis disulfide oxidoreductase, putative 0.003 0.019 0.0181
Onchocerca volvulus 0.0057 0.0452 0.044
Mycobacterium ulcerans hypothetical protein 0.0137 0.1213 1
Brugia malayi nuclear receptor NHR-88 0.004 0.0287 0.0313
Leishmania major heat shock protein 83-1 0.0039 0.0278 0.0874
Trypanosoma brucei RNA editing exonuclease 2 0.0012 0.0013 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.003 0.019 0.0181
Trichomonas vaginalis glutathione reductase, putative 0.0114 0.0991 0.0983
Mycobacterium ulcerans lipase LipD 0.004 0.0287 0.2282
Trichomonas vaginalis endoplasmin, putative 0.0029 0.0174 0.0166
Schistosoma mansoni hypothetical protein 0.0148 0.1319 0.1315
Mycobacterium leprae conserved hypothetical protein 0.004 0.0287 0.0176
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0265 0.0272
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0354 0.3483
Brugia malayi heat shock protein 90 0.0039 0.0278 0.0303
Echinococcus granulosus histone lysine methyltransferase setb 0.0134 0.1183 0.1811
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0015 0.004 0.0031
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.083 0.2691
Plasmodium falciparum heat shock protein 90, putative 0.0023 0.012 0.0353
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.083 0.2691
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0148 0.1319 0.1491
Onchocerca volvulus 0.0019 0.0083 0.007
Echinococcus granulosus heat shock protein 90 0.0039 0.0278 0.0411
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0015 0.004 0.0031
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0747 0.7083 0.8982
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0083 0.0084
Trypanosoma brucei polo-like protein kinase 0.0097 0.083 0.27
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0265 0.0832
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0831 0.7885 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0083 0.0084
Plasmodium vivax heat shock protein, putative 0.0149 0.1333 0.4373
Loa Loa (eye worm) hypothetical protein 0.0076 0.0628 0.0706
Loa Loa (eye worm) hypothetical protein 0.0319 0.2967 0.3374
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0138 0.0135
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0747 0.7083 0.8964
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0628 0.0952
Loa Loa (eye worm) hypothetical protein 0.0044 0.0323 0.0358
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0083 0.0702 0.0786
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0012 0.0013 0.0004
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0025 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.083 0.0821
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0265 0.0391
Giardia lamblia DINP protein human, muc B family 0.0038 0.0265 0.2581
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.083 0.0821
Echinococcus granulosus glutamate synthase 0.003 0.019 0.0274
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0459 0.1504
Leishmania major heat shock protein 83-1 0.0039 0.0278 0.0874
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Leishmania major heat shock protein, putative 0.0026 0.0151 0.0456
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0114 0.0991 0.3223
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.1582 0.1791
Trypanosoma brucei heat shock protein, putative 0.0039 0.0278 0.0885
Leishmania major hypothetical protein, conserved 0.0012 0.0016 0.0012
Toxoplasma gondii HEAT repeat-containing protein 0.0012 0.0016 0.0025
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0287 0.0295
Toxoplasma gondii Hsp90 domain-containing protein 0.0149 0.1333 0.4356
Trypanosoma cruzi trypanothione reductase, putative 0.0114 0.0991 0.3223
Plasmodium falciparum endoplasmin, putative 0.0029 0.0174 0.0532
Schistosoma mansoni hypothetical protein 0.0083 0.0693 0.0685
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0265 0.0832
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0265 0.0288
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0338 0.3153 0.3161
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0012 0.0013 0.0004
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.0265 0.0843
Plasmodium falciparum glutathione reductase 0.0328 0.3049 1
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.003 0.019 0.0225
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0175 0.0535
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0114 0.0991 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0287 0.0348
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0026 0.0151 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0287 0.0313
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0138 0.0425
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.003 0.019 0.0594
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0025 0.0016
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0013 0.0012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0094 0.0104
Mycobacterium ulcerans aldehyde dehydrogenase 0.0054 0.0419 0.3384
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0287 0.0313
Trypanosoma brucei NADH dehydrogenase 0.003 0.019 0.0594
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0054 0.0419 0.0629
Schistosoma mansoni importin beta-1 0.0064 0.0516 0.0507
Trichomonas vaginalis set domain proteins, putative 0.1051 1 1
Plasmodium falciparum heat shock protein 90 0.0039 0.0278 0.0874
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0287 0.0348
Mycobacterium ulcerans hypothetical protein 0.003 0.019 0.1469
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0114 0.0991 0.3223
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0123 0.108 0.1218
Loa Loa (eye worm) hypothetical protein 0.003 0.019 0.0206
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0073 0.02
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0287 0.0276
Trichomonas vaginalis helicase, putative 0.0013 0.0025 0.0016
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0073 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0158 0.0491
Leishmania major hypothetical protein, conserved 0.003 0.019 0.0582
Toxoplasma gondii NADPH-glutathione reductase 0.0114 0.0991 0.3231
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0106 0.0769
Giardia lamblia DNA damage repair protein 0.0012 0.0013 0.0006
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0013 0.0004
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0013 0.0002
Mycobacterium tuberculosis Probable reductase 0.0747 0.7083 0.8982
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0175 0.0185
Echinococcus granulosus heat shock protein 0.0039 0.0278 0.0411
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0287 0.0348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Leishmania major trypanothione reductase 0.0328 0.3049 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0175 0.0031
Mycobacterium leprae Probable lipase LipE 0.004 0.0287 0.0176
Echinococcus granulosus FTZ F1 alpha 0.0429 0.4022 0.6202
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0265 0.2101
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0287 0.2282
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0459 0.0566
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0114 0.0991 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0047 0.0353 0.1122
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0395 0.0386
Trichomonas vaginalis heat shock protein, putative 0.0037 0.0255 0.0246
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0084 0.0072
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0134 0.1183 0.1178
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0287 0.0424
Trichomonas vaginalis mercuric reductase, putative 0.0114 0.0991 0.0983
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0287 0.0276
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0083 0.0108
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0114 0.0991 0.3251
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0094 0.0104
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0054 0.0419 0.0437
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0459 0.0513
Loa Loa (eye worm) hypothetical protein 0.0134 0.1183 0.134
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0013 0.0014
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.004 0.0287 0.0318
Leishmania major pantothenate kinase subunit, putative 0.0013 0.0024 0.0037
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0175 0.0535
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0047 0.0353 0.1122
Schistosoma mansoni GTP-binding protein alpha subunit 0.0015 0.004 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Onchocerca volvulus 0.0029 0.0175 0.0163
Leishmania major heat shock protein 83-1 0.0039 0.0278 0.0874
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0025 0.0016
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0259 0.2392 0.7838
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.0278 0.0874
Giardia lamblia Heat shock protein HSP 90-alpha 0.0034 0.0223 0.2154
Loa Loa (eye worm) DR-78 0.0019 0.0083 0.0084
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0265 0.0832
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.003 0.019 0.1469
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0084
Brugia malayi beta-lactamase family protein 0.004 0.0287 0.0313
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.019 0.0582
Loa Loa (eye worm) hypothetical protein 0.004 0.0287 0.0318
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0083 0.007
Loa Loa (eye worm) hypothetical protein 0.004 0.0287 0.0318
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.003 0.019 0.0274
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0052 0.04 0.0391
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0265 0.0843
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.083 0.0821
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0354 0.1122
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.003 0.019 0.2165
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0073 0.02
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0338 0.3153 0.3376
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.003 0.019 0.1469
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0628 0.5902
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0015 0.004 0.0031
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0628 0.5902
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0123 0.108 0.3514
Plasmodium vivax DNA repair protein REV1, putative 0.0012 0.0013 0.0044
Trichomonas vaginalis esterase, putative 0.004 0.0287 0.0278
Leishmania major hypothetical protein, conserved 0.003 0.019 0.0582
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0259 0.2392 0.7841
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.003 0.019 0.0594
Entamoeba histolytica Ran family GTPase 0.0047 0.0353 0.417
Leishmania major NADH dehydrogenase, putative 0.003 0.019 0.0582
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0287 0.0915
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.011
Plasmodium vivax heat shock protein 90, putative 0.0026 0.0151 0.0496
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0138 0.0143
Trypanosoma brucei importin beta-1 subunit, putative 0.0064 0.0516 0.1668
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.083 0.2691
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0037 0.0255 0.0134
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0073 0.0065
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0114 0.0991 0.3223
Plasmodium falciparum transportin 0.0012 0.0016 0.0012
Brugia malayi follicle stimulating hormone receptor 0.0206 0.1881 0.2132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0175 0.0206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0287 0.0313
Loa Loa (eye worm) hypothetical protein 0.004 0.0287 0.0318
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0287 0.2282
Schistosoma mansoni cpg binding protein 0.0057 0.0452 0.0442
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0114 0.0991 0.3223
Trichomonas vaginalis disulfide oxidoreductase, putative 0.003 0.019 0.0181
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0134 0.1183 0.1259
Trypanosoma brucei unspecified product 0.0026 0.0152 0.047
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0013 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0287 0.0313
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0012 0.0013 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0287 0.0276
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0123 0.108 0.1148
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0015 0.004 0.0027
Echinococcus multilocularis thioredoxin glutathione reductase 0.0328 0.3053 0.3269
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0073 0.02
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0084
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0114 0.0991 0.3231
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.003 0.019 0.0622
Plasmodium vivax ferrodoxin reductase, putative 0.003 0.019 0.0622
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0287 0.0313
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0012 0.0013 0.0004
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.003 0.019 0.2165
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0114 0.0991 0.1052
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0026 0.0151 0.0214
Loa Loa (eye worm) heat shock protein 75 0.0026 0.0151 0.0162
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0073 0.02
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.003 0.019 0.0225
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0084
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0175 0.1349
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0175 0.0206
Trichomonas vaginalis glutamate synthase, putative 0.003 0.019 0.0181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0114 0.0991 0.1514
Mycobacterium ulcerans heat shock protein 90 0.0037 0.0255 0.2014
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.003 0.019 0.0202
Giardia lamblia Kinase, PLK 0.0097 0.083 0.835
Brugia malayi Calcitonin receptor-like protein seb-1 0.0467 0.4386 0.4991
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0265 0.0288
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0287 0.0295
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0223 0.0215
Echinococcus granulosus dna polymerase kappa 0.0038 0.0265 0.0391
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0265 0.0832
Toxoplasma gondii HEAT repeat-containing protein 0.0012 0.0016 0.0025
Schistosoma mansoni thyroid hormone receptor 0.004 0.0287 0.0276
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0105 0.0105
Trypanosoma cruzi importin beta-1 subunit, putative 0.0052 0.04 0.1274
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.017
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0747 0.7083 0.8982
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0206 0.1881 0.2135
Leishmania major heat shock protein 83-1 0.0039 0.0278 0.0874
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0287 0.0278
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0175 0.1349
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0245 0.0359
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.003 0.019 0.0594
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0073 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0151 0.1412
Echinococcus granulosus tumor protein p63 0.0301 0.279 0.4296
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0287 0.0318
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0115 0.0117
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0026 0.0151 0.0139
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0047 0.0353 0.0393
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0265 0.0843
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0158 0.0479
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0015 0.004 0.0029
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0287 0.0295
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0338 0.3153 0.4857
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0012 0.0013 0.0004
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.003 0.019 0.0206
Treponema pallidum heat shock protein 90 0.0037 0.0255 0.2475
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.003 0.019 0.0274
Trichomonas vaginalis disulfide oxidoreductase, putative 0.003 0.019 0.0181
Plasmodium falciparum thioredoxin reductase 0.0328 0.3049 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0287 0.0318
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0395 0.1269
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0094 0.0104
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0265 0.0254
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0287 0.0276
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.1117 0.1112
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.003 0.019 0.019
Loa Loa (eye worm) histone methyltransferase 0.0023 0.0117 0.0124
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0015 0.004 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0265 0.0843
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0138 0.0425
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.083 0.0821
Leishmania major DNA polymerase eta, putative 0.0038 0.0265 0.0832
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.083 0.0822
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0395 0.0591
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0073 0.0212
Entamoeba histolytica thioredoxin reductase, putative 0.003 0.019 0.2165
Loa Loa (eye worm) heat shock protein 90 0.0039 0.0278 0.0307
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0035
Echinococcus multilocularis importin 5 0.0012 0.0016 0.0004
Toxoplasma gondii heat shock protein 90, putative 0.0039 0.0278 0.0885
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0377 0.0463
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0105 0.0142
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0013 0.0004
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0628 0.5126
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.003 0.019 0.0274
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0459 0.4557
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0015 0.004 0.0042
Brugia malayi conserved hypotetical protein 0.0019 0.0083 0.008
Leishmania major heat shock protein 83-1 0.0039 0.0278 0.0874
Onchocerca volvulus 0.004 0.0287 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0138 0.0129
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0459 0.4557
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0025 0.0016
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.011
Schistosoma mansoni sulfide quinone reductase 0.003 0.019 0.0178
Brugia malayi steroid hormone receptor 0.004 0.0287 0.0313
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0013 0.0014
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0287 0.0348
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0015 0.004 0.0042
Schistosoma mansoni hypothetical protein 0.0166 0.1493 0.149
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.083 0.0818
Loa Loa (eye worm) hypothetical protein 0.004 0.0287 0.0317
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0114 0.0991 0.3223
Loa Loa (eye worm) endoplasmin 0.0039 0.0278 0.0307
Trypanosoma brucei heat shock protein, putative 0.0039 0.0278 0.0885
Schistosoma mansoni ran 0.0047 0.0353 0.0343
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0114 0.0991 0.3223
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0338 0.3153 0.3376
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0123 0.108 0.1075
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0054 0.0419 0.1339
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0287 0.0425
Brugia malayi polk-prov protein 0.0012 0.0013 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0338 0.3153 0.4857
Loa Loa (eye worm) hypothetical protein 0.0021 0.0105 0.0109
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0015 0.004 0.0031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0114 0.0991 0.3223
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0175 0.0535
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.003 0.019 0.005
Schistosoma mansoni ran 0.0047 0.0353 0.0343
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0036 0.025 0.0783
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0287 0.0313
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0105 0.0105
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0073 0.0212
Trypanosoma brucei heat shock protein, putative 0.0039 0.0278 0.0885
Loa Loa (eye worm) acetyltransferase 0.0175 0.1582 0.1795
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0065
Trypanosoma cruzi heat shock protein, putative 0.0026 0.0151 0.0456
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0278 0.0269
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0287 0.0313
Echinococcus multilocularis dna polymerase eta 0.0038 0.0265 0.0272
Onchocerca volvulus 0.0015 0.004 0.0027
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0073 0.0212
Echinococcus granulosus dna polymerase eta 0.0038 0.0265 0.0391
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0278 0.3248
Echinococcus multilocularis snurportin 1 0.0684 0.6477 0.6951
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0083 0.007
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0287 0.0348
Loa Loa (eye worm) hypothetical protein 0.0029 0.0175 0.019
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0012 0.0013 0.0012
Trichomonas vaginalis disulfide oxidoreductase, putative 0.003 0.019 0.0181
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0467 0.4386 0.4991
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0106 0.0118
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0026 0.0151 0.1694
Trypanosoma cruzi NADH dehydrogenase, putative 0.003 0.019 0.0582
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0114 0.0991 0.3223
Trichomonas vaginalis ran, putative 0.0047 0.0353 0.0345
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0083 0.0108

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.99 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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