Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0257 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0257 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0082 | 0.0137 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0551 | 0.1313 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0035 | 0.049 | 0.049 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0145 | 0.3412 | 0.5692 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0551 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0082 | 0.5 |
Echinococcus multilocularis | chromobox protein 1 | 0.0078 | 0.1644 | 0.1644 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0082 | 0.1675 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0082 | 0.0082 |
Echinococcus granulosus | geminin | 0.0174 | 0.4195 | 0.4195 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.4195 | 1 |
Echinococcus multilocularis | geminin | 0.0174 | 0.4195 | 0.4195 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.4195 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0242 | 0.5994 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0035 | 0.049 | 0.049 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0257 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0082 | 0.1675 |
Echinococcus multilocularis | tar DNA binding protein | 0.0145 | 0.3412 | 0.3412 |
Onchocerca volvulus | 0.0048 | 0.083 | 0.0545 | |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0082 | 0.0196 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0082 | 0.0196 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0082 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0082 | 0.3197 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0031 | 0.0393 | 0.0457 |
Echinococcus granulosus | chromobox protein 1 | 0.0078 | 0.1644 | 0.1644 |
Echinococcus multilocularis | chromobox protein 1 | 0.0078 | 0.1644 | 0.1644 |
Echinococcus multilocularis | tumor protein p63 | 0.0393 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0257 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0082 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0048 | 0.083 | 0.1979 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.0821 | 0.1086 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0551 | 0.0551 |
Schistosoma mansoni | tar DNA-binding protein | 0.0145 | 0.3412 | 0.8133 |
Loa Loa (eye worm) | RNA binding protein | 0.0145 | 0.3412 | 0.5692 |
Schistosoma mansoni | tar DNA-binding protein | 0.0145 | 0.3412 | 0.8133 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0481 | 0.0802 |
Brugia malayi | RNA binding protein | 0.0145 | 0.3412 | 0.5692 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0035 | 0.049 | 0.049 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0257 | 0.0428 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0082 | 0.3197 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0078 | 0.1644 | 0.2744 |
Onchocerca volvulus | 0.0276 | 0.6881 | 1 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0145 | 0.3412 | 0.8133 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0732 | 0.0956 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.049 | 0.1169 |
Onchocerca volvulus | 0.0058 | 0.1095 | 0.096 | |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0082 | 1 |
Brugia malayi | chromobox protein homolog 3 | 0.0044 | 0.0732 | 0.1222 |
Brugia malayi | TAR-binding protein | 0.0145 | 0.3412 | 0.5692 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0031 | 0.0393 | 0.0457 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0082 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0257 | 0.5239 |
Trichomonas vaginalis | chromobox protein, putative | 0.0078 | 0.1644 | 0.2298 |
Loa Loa (eye worm) | TAR-binding protein | 0.0145 | 0.3412 | 0.5692 |
Schistosoma mansoni | tar DNA-binding protein | 0.0145 | 0.3412 | 0.8133 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.049 | 0.1169 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.0821 | 0.1086 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0551 | 0.0919 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.049 | 0.0818 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0732 | 0.0956 |
Trichomonas vaginalis | set domain proteins, putative | 0.0276 | 0.6881 | 1 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0013 | 0.0022 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0082 | 0.0082 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0033 | 0.0456 | 0.0456 |
Brugia malayi | Pre-SET motif family protein | 0.0242 | 0.5994 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0732 | 0.1222 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0551 | 0.0551 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0551 | 1 |
Schistosoma mansoni | chromobox protein | 0.0078 | 0.1644 | 0.392 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0551 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0082 | 0.3197 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0044 | 0.0732 | 0.0393 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0257 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0145 | 0.3412 | 0.8133 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1095 | 0.1828 |
Brugia malayi | Heterochromatin protein 1 | 0.0078 | 0.1644 | 0.2744 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0145 | 0.3412 | 0.5692 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0035 | 0.049 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0035 | 0.049 | 0.0818 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.0821 | 0.0531 |
Schistosoma mansoni | chromobox protein | 0.0078 | 0.1644 | 0.392 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0082 | 0.0137 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0058 | 0.1095 | 0.2612 |
Echinococcus granulosus | tar DNA binding protein | 0.0145 | 0.3412 | 0.3412 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0551 | 0.1313 |
Plasmodium vivax | SET domain protein, putative | 0.0035 | 0.049 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0257 | 0.5239 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.049 | 0.1169 |
Trichomonas vaginalis | chromobox protein, putative | 0.0078 | 0.1644 | 0.2298 |
Echinococcus granulosus | chromobox protein 1 | 0.0078 | 0.1644 | 0.1644 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0082 | 0.3197 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0257 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0082 | 0.3197 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0551 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0257 | 0.0428 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine uptake by microculture radioisotope technique | ChEMBL. | 19627125 | |
MIC (functional) | Antimycobacterial activity against Mycobacterium tuberculosis H37Ra by microplate Alamar blue assay | ChEMBL. | 19627125 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.