Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.5814 | 0.5814 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.5814 | 0.5814 |
Onchocerca volvulus | Peroxidase homolog | 0.0032 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.5814 | 0.5814 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0032 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0065 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 1 | 1 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0922 | 0.0922 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0922 | 0.0922 |
Onchocerca volvulus | Peroxidase homolog | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0922 | 0.0922 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.5814 | 0.5814 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 1 | 1 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Onchocerca volvulus | Dual oxidase homolog | 0.0032 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.58 uM | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production by EIA | ChEMBL. | 20004572 |
IC50 (binding) | = 18.45 uM | Inhibition of COX2 assessed as PGF2alpha level by EIA | ChEMBL. | 20004572 |
IC50 (ADMET) | = 194.77 uM | Cytotoxicity against LPS-stimulated mouse RAW264.7 cells assessed as cell viability after 24 hrs by MTT assay | ChEMBL. | 20004572 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 20004572 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.