Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 603 aa | 548 aa | 28.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 0.3026 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1481 | 0.4894 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0014 | 0 | 0.5 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.1481 | 0.1481 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.3026 | 1 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.3026 | 0.3026 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.3026 | 0.3026 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1481 | 0.4894 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 0.3026 | 0.3026 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0014 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.1481 | 0.1481 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.3026 | 0.3026 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0014 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0239 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.3026 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.3026 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1481 | 0.4894 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.3026 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 0.3026 | 0.3026 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1481 | 0.4894 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0014 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.3026 | 0.3026 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1481 | 0.4894 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 0.3026 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1481 | 0.4894 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1481 | 0.4894 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 0.3026 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 980 nM | Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric method | ChEMBL. | 20137941 |
IC50 (binding) | = 48000 nM | Inhibition of mouse brain AChE after 1 hr by modified Ellman's colorimetric method | ChEMBL. | 20137941 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.