Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Lactobacillus casei | Dihydrofolate reductase | Starlite/ChEMBL | References |
Mus musculus | phosphoribosylglycinamide formyltransferase | Starlite/ChEMBL | References |
Mus musculus | dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Dihydrofolate reductase | 163 aa | 138 aa | 29.7 % |
Plasmodium yoelii | thymidylate synthase, putative | Dihydrofolate reductase | 163 aa | 139 aa | 21.6 % |
Onchocerca volvulus | Putative dihydrofolate reductase | Dihydrofolate reductase | 163 aa | 173 aa | 27.2 % |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | dihydrofolate reductase | 187 aa | 207 aa | 30.4 % |
Babesia bovis | dihydrofolate reductase/thymidilate synthase | Dihydrofolate reductase | 163 aa | 133 aa | 27.1 % |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.00000001 M | Inhibition of GAR transformylase from Lactobacillus casei | ChEMBL. | 3184124 |
IC50 (binding) | = 0.00000001 M | Inhibition of GAR transformylase from Lactobacillus casei | ChEMBL. | 3184124 |
IC50 (binding) | = 0.0000005 M | Inhibition of GAR transformylase from mammalian Manca | ChEMBL. | 3184124 |
IC50 (binding) | = 0.0000005 M | Inhibition of GAR transformylase from mammalian L1210 cells | ChEMBL. | 3184124 |
IC50 (binding) | = 0.0000005 M | Inhibition of GAR transformylase from mammalian Manca | ChEMBL. | 3184124 |
IC50 (binding) | = 0.0000005 M | Inhibition of GAR transformylase from mammalian L1210 cells | ChEMBL. | 3184124 |
IC50 (binding) | = 0.000019 M | Evaluated for inhibition of dihydrofolate reductase (DHFR) from Lactobacillus casei | ChEMBL. | 3184124 |
IC50 (binding) | = 0.000019 M | Evaluated for inhibition of dihydrofolate reductase (DHFR) from Lactobacillus casei | ChEMBL. | 3184124 |
IC50 (binding) | = 0.00002 M | Compound was tested for inhibition of AICAR formyltransferase | ChEMBL. | 3184124 |
IC50 (binding) | = 0.00002 M | Compound was tested for inhibition of AICAR formyltransferase | ChEMBL. | 3184124 |
IC50 (binding) | > 0.0001 M | Evaluated for inhibition of thymidylate synthase (TS) from Lactobacillus casei | ChEMBL. | 3184124 |
IC50 (binding) | > 0.0001 M | Evaluated for inhibition of thymidylate synthase (TS) from Lactobacillus casei | ChEMBL. | 3184124 |
IC50 (functional) | = 57.2 nM | Evaluated for cell growth inhibition of L1210 cells in cultures | ChEMBL. | 3184124 |
IC50 (functional) | = 57.2 nM | Evaluated for cell growth inhibition of L1210 cells in cultures | ChEMBL. | 3184124 |
Ki (binding) | > 1000 pM | Evaluated for inhibition of dihydrofolate reductase (DHFR) isolated from L1210 cells | ChEMBL. | 3184124 |
Ki (binding) | > 1000 pM | Evaluated for inhibition of dihydrofolate reductase (DHFR) isolated from L1210 cells | ChEMBL. | 3184124 |
Km (functional) | = 2.48 uM | Influx characteristics of the compound toward L1210 cells was evaluated | ChEMBL. | 3184124 |
Km (functional) | = 2.48 uM | Influx characteristics of the compound toward L1210 cells was evaluated | ChEMBL. | 3184124 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 3184124 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.