Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.0521 | 0.0358 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0067 | 0.0097 |
Brugia malayi | Ets-domain containing protein | 0.0071 | 0.1304 | 0.1893 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0139 | 0.3888 | 0.5644 |
Mycobacterium ulcerans | hypothetical protein | 0.0157 | 0.4586 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0104 | 0.255 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0104 | 0.255 | 0.2422 |
Loa Loa (eye worm) | fli-1 protein | 0.0217 | 0.6888 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0147 | 0.4219 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0139 | 0.3888 | 0.5644 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0067 | 0.0097 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0104 | 0.255 | 0.2422 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0104 | 0.255 | 0.3702 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0104 | 0.255 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.0666 | 0.0967 |
Echinococcus granulosus | tar DNA binding protein | 0.0139 | 0.3888 | 0.9203 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0071 | 0.1304 | 0.1893 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0298 | 1 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0104 | 0.255 | 0.2422 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0104 | 0.255 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0104 | 0.255 | 1 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0067 | 0.0097 |
Schistosoma mansoni | tar DNA-binding protein | 0.0139 | 0.3888 | 0.5644 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0104 | 0.255 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0104 | 0.255 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0104 | 0.255 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0141 | 0.3975 | 0.3871 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0141 | 0.3975 | 0.3871 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0104 | 0.255 | 0.5981 |
Schistosoma mansoni | gabp alpha | 0.0071 | 0.1304 | 0.1893 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0071 | 0.1304 | 0.2979 |
Brugia malayi | Fli-1 protein | 0.0217 | 0.6888 | 1 |
Brugia malayi | Ets-domain containing protein | 0.0071 | 0.1304 | 0.1893 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.0666 | 0.0967 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0298 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0147 | 0.4219 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0147 | 0.4219 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0139 | 0.3888 | 0.5644 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0157 | 0.4586 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0139 | 0.3888 | 0.5644 |
Schistosoma mansoni | tar DNA-binding protein | 0.0139 | 0.3888 | 0.5644 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0906 | 0.1315 |
Schistosoma mansoni | tar DNA-binding protein | 0.0139 | 0.3888 | 0.5644 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.4219 | 0.6125 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0298 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.0666 | 0.0967 |
Schistosoma mansoni | kinase | 0.0053 | 0.0588 | 0.0854 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0104 | 0.255 | 0.5981 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0141 | 0.3975 | 0.1912 |
Brugia malayi | Muscleblind-like protein | 0.0147 | 0.4219 | 0.6125 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0104 | 0.255 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0139 | 0.3888 | 0.5644 |
Brugia malayi | TAR-binding protein | 0.0139 | 0.3888 | 0.5644 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0104 | 0.255 | 0.3702 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.0406 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0666 | 0.0967 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0071 | 0.1304 | 0.2979 |
Schistosoma mansoni | tar DNA-binding protein | 0.0139 | 0.3888 | 0.5644 |
Brugia malayi | RNA binding protein | 0.0139 | 0.3888 | 0.5644 |
Giardia lamblia | Kinase, PLK | 0.0104 | 0.255 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.4219 | 0.6125 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0104 | 0.255 | 0.3702 |
Echinococcus multilocularis | tar DNA binding protein | 0.0139 | 0.3888 | 0.9203 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0104 | 0.255 | 1 |
Schistosoma mansoni | ets-related | 0.0217 | 0.6888 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of VEGFR2 assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATP | ChEMBL. | 20170163 |
IC50 (binding) | > 100 uM | Inhibition of PLK1 assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATP | ChEMBL. | 20170163 |
IC50 (binding) | > 100 uM | Inhibition of INSR assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATP | ChEMBL. | 20170163 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.