Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0028 | 0.3537 | 0.5 | |
Brugia malayi | intermediate filament protein | 0.0028 | 0.3537 | 0.3537 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.3537 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0375 | 0.0375 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0375 | 0.0375 |
Onchocerca volvulus | 0.0028 | 0.3537 | 0.5 | |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.3537 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.3537 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.3039 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.3397 | 0.3397 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.3039 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0375 | 0.0375 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0028 | 0.3537 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.5545 | 0.5545 |
Schistosoma mansoni | lamin | 0.0028 | 0.3537 | 0.6116 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.5545 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.3537 | 0.3537 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.3039 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.3537 | 0.3537 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.3039 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0375 | 0.0375 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.3537 | 0.6116 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.3537 | 0.3537 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.3039 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.3039 | 0.5 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0516 | 0.0516 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.3039 | 0.3039 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.3039 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.3537 | 0.3537 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.3039 | 0.5 |
Echinococcus multilocularis | lamin | 0.0028 | 0.3537 | 1 |
Echinococcus multilocularis | musashi | 0.0028 | 0.3537 | 1 |
Brugia malayi | hypothetical protein | 0.0026 | 0.3039 | 0.3039 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.5545 | 0.5545 |
Schistosoma mansoni | lamin | 0.0028 | 0.3537 | 0.6116 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.