Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0686 | 0.0593 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0337 | 1 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0034 | 0.056 | 0.0467 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.2438 | 0.2438 |
Echinococcus granulosus | aldo keto reductase | 0.0337 | 1 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 0.0686 | 0.0686 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0022 | 0.0177 | 0.0079 |
Entamoeba histolytica | aldose reductase, putative | 0.0337 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0038 | 0.0686 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0423 | 0.0423 |
Echinococcus multilocularis | aldo keto reductase | 0.0337 | 1 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 0.0686 | 0.0686 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0095 | 0.2438 | 0.2438 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.006 | 0.1348 | 0.1262 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.006 | 0.1348 | 0.1348 |
Echinococcus granulosus | aldehyde reductase | 0.0239 | 0.6955 | 0.6955 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0098 | 0.0098 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1104 | 0.1104 |
Onchocerca volvulus | 0.0337 | 1 | 1 | |
Leishmania major | GTP-binding protein, putative | 0.0022 | 0.0177 | 0.0079 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0337 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0337 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.2438 | 0.2438 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0098 | 0.0098 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0098 | 0.2533 | 0.2459 |
Onchocerca volvulus | 0.0337 | 1 | 1 | |
Echinococcus multilocularis | aldo keto reductase | 0.0337 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0337 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0337 | 1 | 1 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0098 | 0.2533 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0337 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0098 | 0.2533 | 0.2459 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0337 | 1 | 1 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.006 | 0.1348 | 0.1262 |
Loa Loa (eye worm) | hypothetical protein | 0.0337 | 1 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0337 | 1 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0247 | 0.015 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0098 | 0.2533 | 0.2459 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0022 | 0.0177 | 0.0177 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0337 | 1 | 1 |
Onchocerca volvulus | 0.0337 | 1 | 1 | |
Onchocerca volvulus | 0.0337 | 1 | 1 | |
Brugia malayi | RNA, U transporter 1 | 0.0085 | 0.2146 | 0.2146 |
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.0098 | 0.2533 | 0.2533 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0247 | 0.015 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0177 | 0.0321 |
Schistosoma mansoni | ran | 0.0022 | 0.0177 | 0.0177 |
Schistosoma mansoni | potassium channel beta | 0.0098 | 0.2533 | 0.2533 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.032 | 0.9464 | 0.9464 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0337 | 1 | 1 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0177 | 0.0079 |
Toxoplasma gondii | aldo-keto reductase | 0.0098 | 0.2533 | 0.2459 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0098 | 0.2533 | 0.2459 |
Mycobacterium ulcerans | hypothetical protein | 0.0098 | 0.2533 | 0.2459 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0239 | 0.6955 | 0.6775 |
Brugia malayi | NADH-dependent xylose reductase | 0.0098 | 0.2533 | 0.2533 |
Leishmania major | importin beta-1 subunit, putative | 0.0024 | 0.0247 | 0.015 |
Echinococcus multilocularis | voltage gated potassium channel subunit | 0.0098 | 0.2533 | 0.2533 |
Trypanosoma brucei | aldo/keto reductase, putative | 0.0098 | 0.2533 | 0.2459 |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0098 | 0.2533 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.0686 | 0.0686 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 0.0686 | 0.0686 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.006 | 0.1348 | 0.1348 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0337 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0337 | 1 | 1 |
Brugia malayi | Inositol-1 | 0.0038 | 0.0686 | 0.0686 |
Echinococcus granulosus | snurportin 1 | 0.032 | 0.9464 | 0.9464 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0177 | 0.0177 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0337 | 1 | 1 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.006 | 0.1348 | 0.1348 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0337 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0337 | 1 | 1 |
Plasmodium falciparum | importin beta, putative | 0.003 | 0.0423 | 0.1334 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0247 | 0.015 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0337 | 1 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.0337 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0337 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0337 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0337 | 1 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0038 | 0.0686 | 0.0593 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0098 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0241 | 0.6994 | 0.6994 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0098 | 0.2533 | 0.2459 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.1104 | 0.1104 |
Mycobacterium tuberculosis | Conserved protein | 0.0098 | 0.2533 | 0.2459 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.003 | 0.0423 | 0.0328 |
Echinococcus granulosus | aldo keto reductase | 0.0337 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.1104 | 0.1104 |
Echinococcus multilocularis | aldehyde reductase | 0.0239 | 0.6955 | 0.6955 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.0098 | 0.2533 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.003 | 0.0423 | 0.1334 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0337 | 1 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.006 | 0.1348 | 0.1262 |
Echinococcus multilocularis | importin subunit beta 1 | 0.003 | 0.0423 | 0.0423 |
Toxoplasma gondii | aldo/keto reductase family oxidoreductase | 0.0098 | 0.2533 | 0.2459 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0337 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0337 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0098 | 0.0098 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.003 | 0.0423 | 0.0328 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0038 | 0.0686 | 0.0593 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0022 | 0.0177 | 0.0079 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0022 | 0.0177 | 0.0321 |
Schistosoma mansoni | importin beta-1 | 0.003 | 0.0423 | 0.0423 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0022 | 0.0177 | 0.0177 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0337 | 1 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0038 | 0.0686 | 0.0593 |
Onchocerca volvulus | 0.0337 | 1 | 1 | |
Loa Loa (eye worm) | oxidoreductase | 0.0337 | 1 | 1 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.006 | 0.1348 | 0.1262 |
Giardia lamblia | Aldose reductase | 0.0337 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0593 | 0.0593 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0686 | 0.0593 |
Brugia malayi | Importin beta-1 subunit | 0.003 | 0.0423 | 0.0423 |
Entamoeba histolytica | alcohol dehydrogenase, putative | 0.0098 | 0.2533 | 0.2459 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0337 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0337 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0337 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0098 | 0.0098 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0686 | 0.0593 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0024 | 0.0247 | 0.015 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0337 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0337 | 1 | 1 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0022 | 0.0177 | 0.0079 |
Schistosoma mansoni | hypothetical protein | 0.032 | 0.9464 | 0.9464 |
Mycobacterium ulcerans | oxidoreductase | 0.0337 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0337 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel subunit | 0.0098 | 0.2533 | 0.2533 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0337 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0337 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0337 | 1 | 1 |
Trichomonas vaginalis | ran, putative | 0.0022 | 0.0177 | 0.0079 |
Echinococcus multilocularis | snurportin 1 | 0.032 | 0.9464 | 0.9464 |
Entamoeba histolytica | aldose reductase, putative | 0.0337 | 1 | 1 |
Onchocerca volvulus | 0.0337 | 1 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0337 | 1 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 0.0686 | 0.0593 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0337 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0337 | 1 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0241 | 0.6994 | 0.6994 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0337 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0337 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.2438 | 0.2438 |
Mycobacterium leprae | Possible oxidoreductase | 0.0098 | 0.2533 | 0.209 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.2438 | 0.2438 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0337 | 1 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0686 | 0.0593 |
Loa Loa (eye worm) | oxidoreductase | 0.0337 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0593 | 0.0593 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0337 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0337 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0337 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.2438 | 0.2438 |
Trypanosoma cruzi | aldo-keto reductase | 0.0337 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0337 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0337 | 1 | 1 |
Leishmania major | aldo/keto reductase, putative,aldo/keto reductase family-like protein | 0.0098 | 0.2533 | 0.2459 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.0686 | 0.0593 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0177 | 0.0177 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0337 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0337 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0337 | 1 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0056 | 0.1223 | 0.1223 |
Echinococcus granulosus | importin subunit beta 1 | 0.003 | 0.0423 | 0.0423 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.003 | 0.0423 | 0.0328 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0337 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.2438 | 0.2438 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0337 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0337 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0095 | 0.2438 | 0.2438 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.1104 | 0.1104 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.0686 | 0.0593 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0337 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0098 | 0.2533 | 0.2459 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0337 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0337 | 1 | 1 |
Entamoeba histolytica | Ran family GTPase | 0.0022 | 0.0177 | 0.0079 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0337 | 1 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.0686 | 0.0686 |
Toxoplasma gondii | oxidoreductase, aldo/keto reductase family protein | 0.0098 | 0.2533 | 0.2459 |
Loa Loa (eye worm) | oxidoreductase | 0.0337 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0337 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0593 | 0.0593 |
Echinococcus multilocularis | aldo keto reductase | 0.0337 | 1 | 1 |
Trichomonas vaginalis | importin beta-1, putative | 0.0024 | 0.0247 | 0.015 |
Loa Loa (eye worm) | glutamate-cysteine ligase modifier subunit | 0.0098 | 0.2533 | 0.2533 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0022 | 0.0177 | 0.0079 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0098 | 0.0098 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0337 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.0337 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0337 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0337 | 1 | 1 |
Schistosoma mansoni | ran | 0.0022 | 0.0177 | 0.0177 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.2438 | 0.2438 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.006 | 0.1348 | 0.1348 |
Toxoplasma gondii | aldose reductase, putative | 0.0337 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1, member B4 | 0.0098 | 0.2533 | 0.2533 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0098 | 0.0098 |
Entamoeba histolytica | alcohol dehydrogenase, putative | 0.0098 | 0.2533 | 0.2459 |
Plasmodium vivax | aldehyde reductase, putative | 0.0098 | 0.2533 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0337 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.