TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 353.309 | Formula: C17H18Cl2N2S
H donors: 1 H acceptors: 1 LogP: 4.61 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cc1csc(n1)C[C@]12CNCC[C@@]2(C1)c1ccc(c(c1)Cl)Cl
InChi: 1S/C17H18Cl2N2S/c1-11-8-22-15(21-11)7-16-9-17(16,4-5-20-10-16)12-2-3-13(18)14(19)6-12/h2-3,6,8,20H,4-5,7,9-10H2,1H3/t16-,17-/m1/s1
InChiKey: KMNJYBBPXRFSBY-IAGOWNOFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 2	Starlite/ChEMBL	References
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 3	Starlite/ChEMBL	References
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	sodium/chloride dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent noradrenaline transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Onchocerca volvulus		Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	IPR000175,Sodium:neurotransmitter symporter,domain-containing	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	norepinephrine/norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus granulosus	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Treponema pallidum	sodium- and chloride- dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus multilocularis	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	solute carrier family 6 member 4	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	serotonin transporter b	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Brugia malayi	Sodium:neurotransmitter symporter family protein	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 3	620 aa	579 aa	33.2 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 4	630 aa	574 aa	31.5 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 2	617 aa	638 aa	32.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.005	0.1232	0.1232
Onchocerca volvulus		0.0047	0.1133	0.0991
Echinococcus multilocularis	sodium and chloride dependent glycine	0.005	0.1232	0.1232
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0047	0.1133	1
Echinococcus granulosus	sodium and chloride dependent glycine	0.005	0.1232	0.1232
Loa Loa (eye worm)	hypothetical protein	0.005	0.1232	0.1232
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0158	0.0158
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.002	0.0158	0.0158
Echinococcus multilocularis	geminin	0.0166	0.5458	0.5458
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.065	0.065
Entamoeba histolytica	acyl-coA synthetase, putative	0.0047	0.1133	0.3418
Loa Loa (eye worm)	hypothetical protein	0.002	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0292	1	1
Brugia malayi	nuclear hormone receptor	0.002	0.0158	0.0158
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.005	0.1232	0.1232
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0158	0.0158
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0158	0.0158
Echinococcus granulosus	geminin	0.0166	0.5458	0.5458
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.2795	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.1232	0.1232
Loa Loa (eye worm)	hypothetical protein	0.005	0.1232	0.1232
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0047	0.1133	1
Onchocerca volvulus		0.005	0.1232	0.1092
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0093	0.2795	0.2795
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0047	0.1133	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.002	0.0158	0.0158
Schistosoma mansoni	retinoic acid receptor RXR	0.002	0.0158	0.0158
Echinococcus multilocularis	survival motor neuron protein 1	0.0232	0.7838	0.7838
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.1232	0.1232
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0082	0.2393	0.2393
Trypanosoma cruzi	polo-like protein kinase, putative	0.0093	0.2795	0.5
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0047	0.1133	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.1133	1
Echinococcus granulosus	serotonin transporter	0.0292	1	1
Schistosoma mansoni	coup transcription factor	0.002	0.0158	0.0158
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0047	0.1133	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.002	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.002	0.0158	0.0158
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.2795	1
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0023	0.027	0.5
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.1232	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.002	0.0158	0.0158
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0158	0.0158
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0636	0.4238
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0158	0.0158
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0093	0.2795	1
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.005	0.1232	0.1232
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.1133	0.1133
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.002	0.0158	0.0158
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.005	0.1232	0.1232
Schistosoma mansoni	kinase	0.0047	0.1145	0.1145
Mycobacterium ulcerans	hypothetical protein	0.0047	0.1133	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.002	0.0158	0.0158
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.1232	1
Echinococcus multilocularis	serotonin transporter	0.0292	1	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.1133	0.3418
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0082	0.2393	0.2393
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.1133	1
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.005	0.1232	0.1232
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.002	0.0158	0.0158
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0292	1	1
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.005	0.1232	0.1232
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0035	0.0705	0.5039
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.002	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1133	0.1133
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.002	0.0158	0.0158
Schistosoma mansoni	hypothetical protein	0.0166	0.5458	0.5458
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.121	0.121
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0292	1	1
Brugia malayi	hypothetical protein	0.0232	0.7838	0.7838
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.005	0.1232	0.1232
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.2795	1
Schistosoma mansoni	RAR-like nuclear receptor	0.002	0.0158	0.0158
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.1232	0.1232
Toxoplasma gondii	hypothetical protein	0.005	0.1232	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0158	0.0158
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.1133	0.1133
Loa Loa (eye worm)	hypothetical protein	0.002	0.0158	0.0158
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.121	0.121
Onchocerca volvulus		0.0292	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0033	0.065	0.065
Trypanosoma cruzi	polo-like protein kinase, putative	0.0093	0.2795	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3255	0.3255
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0115	0.3588	0.3588
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.002	0.0158	0.0158
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.002	0.0158	0.0158
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.1232	0.1232
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0705	0.0705
Schistosoma mansoni	steroid hormone receptor ad4bp	0.002	0.0158	0.0158
Brugia malayi	photoreceptor-specific nuclear receptor	0.002	0.0158	0.0158
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.002	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0705	0.0705
Schistosoma mansoni	nuclear hormone receptor	0.002	0.0158	0.0158
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.1232	0.1232
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0125	0.3968	0.3968
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.002	0.0158	0.0158
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.1133	0.3418
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.002	0.0158	0.0158
Plasmodium falciparum	amino acid transporter, putative	0.005	0.1232	1
Schistosoma mansoni	thyroid hormone receptor	0.002	0.0158	0.0158
Treponema pallidum	sodium- and chloride- dependent transporter	0.0292	1	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.005	0.1243	0.1243
Loa Loa (eye worm)	hypothetical protein	0.002	0.0158	0.0158
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.1232	0.1232
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.121	0.121
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0125	0.3968	0.3968
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.002	0.0158	0.0158
Schistosoma mansoni	sodium/chloride dependent transporter	0.005	0.1232	0.1232
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0705	0.0705
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.2795	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.1232	0.1232
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.002	0.0158	0.0158
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.005	0.1232	1
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.2795	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.002	0.0158	0.0158
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0125	0.3968	0.3968
Onchocerca volvulus		0.0047	0.1153	0.1011
Schistosoma mansoni	sodium/chloride dependent transporter	0.0292	1	1
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.005	0.1232	0.1232
Loa Loa (eye worm)	hypothetical protein	0.005	0.1232	0.1232
Schistosoma mansoni	thyroid hormone receptor	0.002	0.0158	0.0158
Brugia malayi	steroid hormone receptor	0.002	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0292	1	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.002	0.0158	0.0158
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0636	0.4238
Brugia malayi	nuclear receptor NHR-88	0.002	0.0158	0.0158
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0636	0.4238
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0093	0.2795	0.2679
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.002	0.0158	0.0158
Echinococcus multilocularis	sodium and chloride dependent glycine	0.005	0.1232	0.1232
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.002	0.0158	0.0158
Brugia malayi	serine/threonine-protein kinase plk-2	0.0093	0.2795	0.2795
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.1133	1
Plasmodium falciparum	transporter, putative	0.005	0.1232	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0158	0.0158
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.2795	1
Loa Loa (eye worm)	norepinephrine transporter	0.0292	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.002	0.0158	0.0158
Schistosoma mansoni	hypothetical protein	0.0033	0.065	0.065
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0035	0.0705	0.5039
Loa Loa (eye worm)	hypothetical protein	0.005	0.1232	0.1232
Echinococcus granulosus	sodium and chloride dependent glycine	0.005	0.1232	0.1232
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.005	0.1232	0.1232
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.002	0.0158	0.0158
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0125	0.3968	0.3968
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.002	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0082	0.2393	0.2393
Schistosoma mansoni	sodium-dependent amino acid transporter	0.005	0.1232	0.1232
Onchocerca volvulus		0.005	0.1232	0.1092
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0047	0.1133	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.1232	0.1232
Giardia lamblia	Kinase, PLK	0.0093	0.2795	0.5
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0093	0.2795	0.2795
Schistosoma mansoni	survival motor neuron protein	0.0047	0.1153	0.1153
Plasmodium vivax	amine transporter, putative	0.005	0.1232	1
Plasmodium vivax	hypothetical protein, conserved	0.005	0.1232	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1133	0.1133
Echinococcus granulosus	transcription factor eb	0.0106	0.3273	0.3273
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.005	0.1232	0.1232
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0636	0.4238
Onchocerca volvulus		0.005	0.1232	0.1092
Echinococcus granulosus	survival motor neuron protein 1	0.0232	0.7838	0.7838
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.1133	0.1133
Echinococcus granulosus	L aminoadipate semialdehyde	0.0082	0.2393	0.2393
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0035	0.0705	0.4519
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.002	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.002	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0705	0.0705
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.002	0.0158	0.0158
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.1232	0.1232
Brugia malayi	Steroid receptor seven-up type 2	0.002	0.0158	0.0158
Loa Loa (eye worm)	serotonin transporter b	0.0292	1	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.0035	0.0705	0.4519
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.002	0.0158	0.0158
Echinococcus granulosus	ecdysone induced protein 78C	0.002	0.0158	0.0158
Echinococcus granulosus	FTZ F1 alpha	0.002	0.0158	0.0158
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.1133	1
Schistosoma mansoni	serine/threonine protein kinase	0.0093	0.2795	0.2795
Trypanosoma brucei	polo-like protein kinase	0.0093	0.2795	1
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.1232	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0158	0.0158
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.002	0.0158	0.0158
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0705	0.0705
Brugia malayi	hypothetical protein	0.005	0.1232	0.1232
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.1153	0.1153
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0093	0.2795	1
Schistosoma mansoni	hypothetical protein	0.0047	0.1153	0.1153
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1133	0.1133
Loa Loa (eye worm)	steroid hormone receptor	0.002	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0232	0.7838	0.7838
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.1133	0.3418
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.2795	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.002	0.0158	0.0158
Plasmodium falciparum	acyl-CoA synthetase	0.0035	0.0705	0.4519
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.1232	0.1232
Schistosoma mansoni	hypothetical protein	0.0166	0.5458	0.5458
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.1133	0.3418
Loa Loa (eye worm)	hypothetical protein	0.005	0.1232	0.1232
Echinococcus multilocularis	FTZ F1 alpha	0.002	0.0158	0.0158
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0158	0.0158
Onchocerca volvulus		0.0082	0.2393	0.2271
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.005	0.1232	0.1232
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.0106	0.3273	0.3273
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.005	0.1232	0.1232
Loa Loa (eye worm)	hypothetical protein	0.0049	0.121	0.121
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0105	0.3255	0.3255
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.1133	0.3418
Brugia malayi	ecdysteroid receptor	0.002	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.005	0.1232	0.1232
Loa Loa (eye worm)	hypothetical protein	0.002	0.0158	0.0158
Echinococcus multilocularis	transcription factor eb	0.0106	0.3273	0.3273
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0082	0.2393	0.2393
Loa Loa (eye worm)	hypothetical protein	0.0292	1	1
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0093	0.2795	0.2795
Toxoplasma gondii	hypothetical protein	0.005	0.1232	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.1133	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 8.2	Displacement of [3H]WIN-35428 from human recombinant DAT by scintillation proximity assay	ChEMBL.	21550808
Ki (binding)	= 9.2	Displacement of [3H]nisoxetine from human recombinant NET by scintillation proximity assay	ChEMBL.	21550808
Ki (binding)	= 10	Displacement of [3H]citalopram from human recombinant SERT scintillation proximity assay	ChEMBL.	21550808

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1818448

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1104562