Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0304 | 0.0469 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0143 | 0.294 | 0.4993 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0537 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0055 | 0.0969 | 0.1609 |
Brugia malayi | RNA binding protein | 0.0143 | 0.294 | 0.4993 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0304 | 0.0469 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0537 | 0.0918 |
Echinococcus multilocularis | lamin | 0.0026 | 0.0304 | 0.0304 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0455 | 1 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.0537 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0537 | 1 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0537 | 0.0869 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0537 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.5857 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0143 | 0.294 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0537 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0096 | 0.1873 | 0.3162 |
Schistosoma mansoni | lamin | 0.0026 | 0.0304 | 0.0633 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0537 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0031 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0294 | 0.0501 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0537 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0126 | 0.0163 |
Schistosoma mansoni | lamin | 0.0026 | 0.0304 | 0.0633 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0126 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0304 | 0.052 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.0537 | 0.0537 |
Schistosoma mansoni | tar DNA-binding protein | 0.0143 | 0.294 | 1 |
Onchocerca volvulus | 0.0055 | 0.0969 | 1 | |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0537 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.1873 | 0.6209 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0033 | 0.0451 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.0304 | 0.0304 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0304 | 0.052 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.1873 | 0.6209 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.1873 | 0.6209 |
Schistosoma mansoni | survival motor neuron protein | 0.0055 | 0.0969 | 0.2993 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0537 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0143 | 0.294 | 1 |
Brugia malayi | TAR-binding protein | 0.0143 | 0.294 | 0.4993 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.0537 | 0.0537 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0272 | 0.5857 | 0.5857 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0126 | 0.0216 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0455 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0143 | 0.294 | 0.5019 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0126 | 0.0126 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0126 | 0.5 |
Echinococcus granulosus | lamin | 0.0026 | 0.0304 | 0.0304 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.0537 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.0304 | 0.0304 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0126 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0143 | 0.294 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0143 | 0.294 | 0.5019 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0096 | 0.1873 | 0.1873 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0537 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0126 | 0.5 |
Brugia malayi | hypothetical protein | 0.0272 | 0.5857 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0537 | 0.1461 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.0304 | 0.0304 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0033 | 0.0451 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0455 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0026 | 0.0304 | 0.0304 |
Echinococcus granulosus | tar DNA binding protein | 0.0143 | 0.294 | 0.294 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0126 | 0.0126 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0272 | 0.5857 | 0.5857 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0096 | 0.1873 | 0.3198 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0143 | 0.294 | 0.5019 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0096 | 0.1873 | 0.1873 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0096 | 0.1873 | 0.1873 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.0304 | 0.0633 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0096 | 0.1873 | 0.1873 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.0969 | 0.2993 |
Echinococcus multilocularis | tar DNA binding protein | 0.0143 | 0.294 | 0.294 |
Schistosoma mansoni | tar DNA-binding protein | 0.0143 | 0.294 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0304 | 0.052 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0537 | 0.1461 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.