Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0012 | 0.0069 | 0.0131 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0296 | 0.1059 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0276 | 0.0797 |
Trypanosoma cruzi | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0024 | 0.0223 | 0.0621 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0366 | 0.2771 |
Brugia malayi | Transient-receptor-potential like protein | 0.0036 | 0.0367 | 0.1095 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0223 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0342 | 0.101 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0115 | 0.0394 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0012 | 0.0069 | 0.0061 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0276 | 0.0985 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0042 | 0.0444 | 0.1602 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0115 | 0.0107 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.0036 | 0.0367 | 0.1319 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0257 | 0.3124 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0064 | 0.0716 | 0.2599 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0115 | 0.0107 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.0115 | 0.0394 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.1124 | 0.3536 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0488 | 0.048 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0177 | 0.2135 | 0.6835 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0012 | 0.0069 | 0.022 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0042 | 0.0444 | 0.0437 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0177 | 0.2135 | 0.6835 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0069 | 0.0126 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0367 | 0.1091 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0327 | 0.0961 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0064 | 0.0716 | 0.0709 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0115 | 0.0393 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0563 | 0.1722 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0012 | 0.0069 | 0.0223 |
Trichomonas vaginalis | Citrate lyase beta chain, putative | 0.0024 | 0.0223 | 0.0714 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0115 | 0.0393 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0115 | 0.0187 |
Trypanosoma cruzi | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0024 | 0.0223 | 0.0621 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0366 | 0.0359 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0098 | 0.1143 | 0.4166 |
Echinococcus granulosus | citrate lyase subunit beta protein | 0.0024 | 0.0223 | 0.079 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0257 | 0.3124 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0012 | 0.0069 | 0.0223 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0.0115 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0012 | 0.0069 | 0.0223 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0538 | 0.1646 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0096 | 0.1124 | 0.4096 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.003 | 0.0022 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0012 | 0.0069 | 0.022 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0115 | 0.0187 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0115 | 0.0393 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0012 | 0.0069 | 0.0061 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0115 | 0.0107 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0168 | 0.2022 | 0.6472 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0012 | 0.0069 | 0.0223 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0064 | 0.0716 | 0.0709 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0098 | 0.1143 | 0.1136 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0115 | 0.0107 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0115 | 0.0393 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.1143 | 0.3598 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0211 | 0.2559 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0366 | 0.1316 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0115 | 0.0281 |
Echinococcus multilocularis | citrate lyase subunit beta protein | 0.0024 | 0.0223 | 0.0216 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.0115 | 0.0885 |
Brugia malayi | TATA binding protein associated factor | 0.0012 | 0.0069 | 0.0131 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0115 | 0.0187 |
Echinococcus multilocularis | protein dispatched 1 | 0.0048 | 0.0519 | 0.0511 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0538 | 0.1642 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0676 | 0.2088 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0098 | 0.1143 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0342 | 0.1227 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0168 | 0.2022 | 0.6472 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0.0115 | 1 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0296 | 0.1059 |
Echinococcus granulosus | expressed conserved protein | 0.0092 | 0.1069 | 0.3894 |
Echinococcus multilocularis | expressed conserved protein | 0.0092 | 0.1069 | 0.1062 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0296 | 0.0289 |
Loa Loa (eye worm) | TATA binding protein associated factor | 0.0012 | 0.0069 | 0.0126 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0425 | 0.1533 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0042 | 0.0444 | 0.134 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0115 | 0.028 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0168 | 0.2022 | 1 |
Schistosoma mansoni | aminopeptidase A (M01 family) | 0.0012 | 0.0069 | 0.0223 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0012 | 0.0069 | 0.0126 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0069 | 0.0131 |
Schistosoma mansoni | Tata binding protein associated factor (M01 family) | 0.0012 | 0.0069 | 0.0223 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0257 | 0.3124 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0342 | 0.1014 |
Onchocerca volvulus | 0.0029 | 0.0276 | 0.1062 | |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0115 | 0.0281 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0488 | 0.1761 |
Schistosoma mansoni | transient receptor potential channel | 0.0064 | 0.0716 | 0.2599 |
Loa Loa (eye worm) | aminopeptidase N | 0.0012 | 0.0069 | 0.0126 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0488 | 0.1761 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.0036 | 0.0367 | 0.036 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0276 | 0.0801 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.003 | 0.008 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0425 | 0.1533 |
Leishmania major | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0024 | 0.0223 | 0.0621 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0012 | 0.0069 | 0.0061 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0012 | 0.0069 | 0.022 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0488 | 0.048 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.01 | 0.1162 | 0.4236 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0115 | 0.0276 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0168 | 0.2022 | 0.6472 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0012 | 0.0069 | 0.0223 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0115 | 0.0393 |
Schistosoma mansoni | transient receptor potential channel | 0.0096 | 0.1124 | 0.4096 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0168 | 0.2022 | 0.6472 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0115 | 0.0107 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0168 | 0.2022 | 0.6472 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0115 | 0.0107 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0.0115 | 0.0187 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0223 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0488 | 0.1481 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0296 | 0.1059 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.0444 | 0.1422 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0042 | 0.0444 | 0.1602 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0225 | 0.2733 | 0.2727 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0115 | 0.0107 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0488 | 0.1761 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0069 | 0.0126 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0366 | 0.2771 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0425 | 0.1533 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0012 | 0.0069 | 0.0223 |
Echinococcus multilocularis | aminopeptidase N | 0.0012 | 0.0069 | 0.0061 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0257 | 0.3124 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0257 | 0.3124 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0257 | 0.3124 | 1 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0225 | 0.2733 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0366 | 0.2771 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0444 | 0.134 |
Mycobacterium ulcerans | citrate (pro-3S)-lyase subunit beta | 0.0024 | 0.0223 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0168 | 0.2022 | 0.6472 |
Mycobacterium ulcerans | citrate lyase beta subunit, CitE_2 | 0.0024 | 0.0223 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0115 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0115 | 0.0276 |
Brugia malayi | Peptidase family M1 containing protein | 0.0012 | 0.0069 | 0.0131 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0012 | 0.0069 | 0.0223 |
Schistosoma mansoni | transient receptor potential channel | 0.0064 | 0.0716 | 0.2599 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.0115 | 0.0885 |
Schistosoma mansoni | patched 1 | 0.0042 | 0.0444 | 0.1602 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0366 | 0.1316 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0012 | 0.0069 | 0.0223 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0093 | 0.1084 | 0.1077 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0115 | 0.0393 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0012 | 0.0069 | 0.0061 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0012 | 0.0069 | 0.0061 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0211 | 0.2559 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.0012 | 0.0069 | 0.0131 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0488 | 0.1761 |
Echinococcus granulosus | aminopeptidase N | 0.0012 | 0.0069 | 0.0223 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0096 | 0.1124 | 0.4096 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.014 | 0.1668 | 0.6094 |
Brugia malayi | hypothetical protein | 0.0104 | 0.1213 | 0.3826 |
Mycobacterium ulcerans | citrate (pro-3S)-lyase subunit beta | 0.0024 | 0.0223 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0425 | 0.1533 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0168 | 0.2022 | 0.6472 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0538 | 0.1646 |
Brugia malayi | Peptidase family M1 containing protein | 0.0012 | 0.0069 | 0.0131 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0064 | 0.0716 | 0.2599 |
Brugia malayi | CHE-14 protein | 0.0042 | 0.0444 | 0.1344 |
Echinococcus multilocularis | protein patched | 0.0042 | 0.0444 | 0.0437 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0069 | 0.0126 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0366 | 0.1316 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0225 | 0.2733 | 0.8734 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.014 | 0.1668 | 0.1662 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0366 | 0.2771 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0257 | 0.3124 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0115 | 0.0393 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0366 | 0.1092 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0488 | 0.1761 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0098 | 0.1143 | 0.3601 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0488 | 0.1484 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0115 | 0.0107 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0211 | 0.2559 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0.0115 | 0.0187 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0225 | 0.2733 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0115 | 0.0277 |
Mycobacterium tuberculosis | Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) | 0.0024 | 0.0223 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0211 | 0.2559 | 1 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0096 | 0.1124 | 0.1117 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0538 | 0.1642 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0012 | 0.0069 | 0.0061 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0054 | 0.0596 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0257 | 0.3124 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0061 | 0.0676 | 0.2454 |
Mycobacterium tuberculosis | Conserved protein | 0.0024 | 0.0223 | 1 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0093 | 0.1084 | 0.3948 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
k cat (binding) | = 7.4 s-1 | The turnover kinetic parameter (kcat) evaluated for Class A TEM-1 beta-lactamase | ChEMBL. | 10633044 |
k cat/Km (binding) | = 93000 M-1 s-1 | The turnover kinetic parameter (kcat/Km) evaluated for class A TEM-1 Beta-latctamase | ChEMBL. | 10633044 |
Km (binding) | = 80 uM | The turnover kinetic parameter (Km) evaluated for Class A TEM-1 beta-lactamase | ChEMBL. | 10633044 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.