Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.024 | 0.0245 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0074 | 0.0845 | 0.0845 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0074 | 0.0845 | 0.1645 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.024 | 0.0245 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0667 | 0.9802 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0667 | 0.9802 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.05 | 0.0651 |
Loa Loa (eye worm) | inositol-1 | 0.0074 | 0.0845 | 0.0862 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0298 | 0.4224 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0141 | 0.1857 | 0.4057 |
Loa Loa (eye worm) | hypothetical protein | 0.0667 | 0.9802 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0034 | 0.024 | 0.024 |
Brugia malayi | Animal haem peroxidase family protein | 0.0667 | 0.9802 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0042 | 0.0362 | 0.0304 |
Schistosoma mansoni | peroxidasin | 0.0667 | 0.9802 | 0.9802 |
Loa Loa (eye worm) | hypothetical protein | 0.0667 | 0.9802 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0362 | 0.0304 |
Loa Loa (eye worm) | hypothetical protein | 0.0667 | 0.9802 | 1 |
Brugia malayi | hypothetical protein | 0.0667 | 0.9802 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0667 | 0.9802 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0074 | 0.0845 | 0.0845 |
Loa Loa (eye worm) | glutaminase | 0.0277 | 0.3915 | 0.3994 |
Mycobacterium ulcerans | hypothetical protein | 0.0157 | 0.2097 | 0.5053 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.024 | 0.0245 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0298 | 0.4224 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0667 | 0.9802 | 1 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0034 | 0.024 | 0.0245 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.024 | 0.0245 |
Brugia malayi | Animal haem peroxidase family protein | 0.0667 | 0.9802 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0298 | 0.4224 | 1 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0034 | 0.024 | 0.0245 |
Plasmodium vivax | pyruvate kinase, putative | 0.0034 | 0.024 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0074 | 0.0845 | 0.1517 |
Onchocerca volvulus | Peroxidase homolog | 0.0667 | 0.9802 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0667 | 0.9802 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0667 | 0.9802 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0667 | 0.9802 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0066 | 0.0728 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.068 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0667 | 0.9802 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0667 | 0.9802 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0667 | 0.9802 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0074 | 0.0845 | 0.1517 |
Giardia lamblia | Pyruvate kinase | 0.0034 | 0.024 | 0.5 |
Trichomonas vaginalis | glutaminase, putative | 0.0277 | 0.3915 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0074 | 0.0845 | 0.0845 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0667 | 0.9802 | 1 |
Onchocerca volvulus | 0.0667 | 0.9802 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0667 | 0.9802 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0362 | 0.0304 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0074 | 0.0845 | 0.1645 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.0455 | 0.3544 |
Echinococcus multilocularis | pyruvate kinase | 0.0027 | 0.0133 | 0.0133 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0141 | 0.1857 | 0.4057 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0042 | 0.0362 | 0.0304 |
Schistosoma mansoni | glutaminase | 0.0277 | 0.3915 | 0.3915 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0667 | 0.9802 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0074 | 0.0845 | 0.1645 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0066 | 0.0728 | 0.2626 |
Loa Loa (eye worm) | hypothetical protein | 0.0667 | 0.9802 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.024 | 0.0245 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.024 | 0.024 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0141 | 0.1857 | 0.4057 |
Loa Loa (eye worm) | hypothetical protein | 0.0667 | 0.9802 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.068 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0157 | 0.2097 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0667 | 0.9802 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.024 | 0.024 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0074 | 0.0845 | 0.1517 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.024 | 0.0245 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0074 | 0.0845 | 1 |
Echinococcus granulosus | peroxidasin | 0.0667 | 0.9802 | 0.9802 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0074 | 0.0845 | 1 |
Onchocerca volvulus | 0.0667 | 0.9802 | 1 | |
Brugia malayi | Peroxidasin | 0.0667 | 0.9802 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0074 | 0.0845 | 0.0845 |
Echinococcus granulosus | pyruvate kinase | 0.0034 | 0.024 | 0.024 |
Onchocerca volvulus | Dual oxidase homolog | 0.0667 | 0.9802 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0074 | 0.0845 | 0.1645 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0086 | 0.0088 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0024 | 0.0086 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0667 | 0.9802 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.024 | 0.0245 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0074 | 0.0845 | 0.5 |
Chlamydia trachomatis | pyruvate kinase | 0.0034 | 0.024 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0667 | 0.9802 | 1 |
Schistosoma mansoni | peroxidasin | 0.0667 | 0.9802 | 0.9802 |
Schistosoma mansoni | pyruvate kinase | 0.0034 | 0.024 | 0.024 |
Brugia malayi | Inositol-1 | 0.0074 | 0.0845 | 0.0862 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0298 | 0.4224 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0034 | 0.024 | 0.024 |
Echinococcus multilocularis | peroxidasin | 0.0667 | 0.9802 | 0.9802 |
Loa Loa (eye worm) | glutaminase 2 | 0.0277 | 0.3915 | 0.3994 |
Onchocerca volvulus | 0.0667 | 0.9802 | 1 | |
Plasmodium falciparum | pyruvate kinase | 0.0034 | 0.024 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0667 | 0.9802 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.0277 | 0.3915 | 0.3994 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0074 | 0.0845 | 0.1517 |
Mycobacterium ulcerans | glutaminase | 0.0277 | 0.3915 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0667 | 0.9802 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0667 | 0.9802 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0667 | 0.9802 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0667 | 0.9802 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0667 | 0.9802 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.