Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | acetylcholinesterase | Starlite/ChEMBL | References |
Mus musculus | butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase | 614 aa | 507 aa | 26.0 % |
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 603 aa | 548 aa | 28.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0093 | 0.0211 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.441 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0028 | 0.0093 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0028 | 0.0093 | 0.0211 |
Loa Loa (eye worm) | carboxylesterase | 0.0028 | 0.0093 | 0.0211 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.441 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0093 | 0.0211 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.034 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.441 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.441 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0048 | 0.0732 | 0.0732 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.441 | 1 |
Onchocerca volvulus | 0.0028 | 0.0093 | 0.5 | |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.034 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0093 | 0.0211 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.441 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.441 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.441 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0179 | 0.4896 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0093 | 0.0211 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.441 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0161 | 0.4319 | 0.4319 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0093 | 0.0211 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.0093 | 0.0211 |
Mycobacterium ulcerans | hypothetical protein | 0.0179 | 0.4896 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0055 | 0.0955 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0093 | 0.0211 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0093 | 0.0211 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.441 | 1 |
Onchocerca volvulus | 0.0028 | 0.0093 | 0.5 | |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0048 | 0.0732 | 0.0732 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0028 | 0.0093 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.0093 | 0.0211 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0093 | 0.0211 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0161 | 0.4319 | 0.4319 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.0093 | 0.0211 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0048 | 0.0732 | 0.0732 |
Onchocerca volvulus | 0.0028 | 0.0093 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.441 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.034 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.0093 | 0.0211 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.441 | 1 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0048 | 0.0732 | 0.0732 |
Onchocerca volvulus | 0.0028 | 0.0093 | 0.5 | |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0161 | 0.4319 | 0.4319 |
Onchocerca volvulus | 0.0028 | 0.0093 | 0.5 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0058 | 0.1063 | 0.1063 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.441 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 160 nM | Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric method | ChEMBL. | 20137934 |
IC50 (binding) | = 4200 nM | Inhibition of mouse brain AChE after 1 hr by modified Ellman's colorimetric method | ChEMBL. | 20137934 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.