Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0317 | 0.0317 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0289 | 0.0794 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.002 | 0.0156 | 0.0428 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0026 | 0.025 | 0.025 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0089 | 0.0089 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.002 | 0.0156 | 0.0428 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0313 | 0.0313 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0402 | 0.1105 |
Echinococcus multilocularis | FTZ F1 alpha | 0.002 | 0.0156 | 0.0156 |
Brugia malayi | nuclear receptor RXR | 0.001 | 0.0017 | 0.0046 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0089 | 0.0089 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.0089 | 0.0089 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.2408 | 0.2408 |
Echinococcus granulosus | lamin dm0 | 0.0054 | 0.0668 | 0.0668 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.0572 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.1237 | 0.1237 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0089 | 0.0246 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0017 | 0.0046 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0583 | 0.1603 |
Onchocerca volvulus | 0.002 | 0.0156 | 0.0457 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.002 | 0.0156 | 0.0428 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0313 | 0.0313 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.0769 | 0.0769 |
Brugia malayi | hypothetical protein | 0.0072 | 0.0941 | 0.2587 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.012 | 0.1663 | 0.4845 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0402 | 0.4456 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0402 | 0.0892 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0108 | 0.1482 | 0.4282 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0156 | 0.0156 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0676 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.0769 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.025 | 0.0688 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0402 | 0.1105 |
Brugia malayi | glutathione reductase | 0.0047 | 0.0572 | 0.1571 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.002 | 0.0156 | 0.0156 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0402 | 0.1105 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0583 | 0.1603 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0156 | 0.0428 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0402 | 0.0402 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.002 | 0.0156 | 0.0156 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0313 | 0.0313 |
Schistosoma mansoni | ferritin light chain | 0.0017 | 0.011 | 0.011 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.002 | 0.0156 | 0.0457 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0017 | 0.0046 |
Onchocerca volvulus | 0.0029 | 0.0289 | 0.0846 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0072 | 0.0941 | 0.0941 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.0572 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0583 | 0.1603 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0156 | 0.0428 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0317 | 0.0317 |
Trichomonas vaginalis | set domain proteins, putative | 0.0237 | 0.3413 | 1 |
Brugia malayi | hypothetical protein | 0.001 | 0.0017 | 0.0046 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0402 | 0.4456 |
Echinococcus multilocularis | expressed protein | 0.0017 | 0.011 | 0.011 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0016 | 0.0107 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0156 | 0.0428 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.0572 | 0.1571 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0108 | 0.1482 | 0.4282 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0089 | 0.0089 |
Onchocerca volvulus | 0.0237 | 0.3413 | 1 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0583 | 0.1603 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.002 | 0.0156 | 0.0428 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.002 | 0.0156 | 0.0428 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.1237 | 0.1237 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0941 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.0941 | 0.0941 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0402 | 0.1105 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0402 | 0.0892 |
Brugia malayi | steroid hormone receptor | 0.002 | 0.0156 | 0.0428 |
Echinococcus multilocularis | lamin | 0.0054 | 0.0668 | 0.0668 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0402 | 0.1105 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0156 | 0.0428 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0156 | 0.0156 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0016 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0236 | 0.0648 |
Loa Loa (eye worm) | RNA binding protein | 0.0252 | 0.3639 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.012 | 0.1663 | 0.4845 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0402 | 0.0918 |
Echinococcus granulosus | FTZ F1 alpha | 0.002 | 0.0156 | 0.0156 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.002 | 0.0156 | 0.0428 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0092 | 0.1237 | 0.34 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.002 | 0.0156 | 0.0428 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0317 | 0.0317 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0245 | 0.3534 | 0.3534 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0017 | 0.0046 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0402 | 0.6349 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0012 | 0.0042 | 0.0115 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.002 | 0.0156 | 0.0428 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.002 | 0.0156 | 0.0428 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0402 | 0.0918 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.0572 | 1 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.0017 | 0.011 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0653 | 0.1796 |
Echinococcus granulosus | expressed protein | 0.0017 | 0.011 | 0.011 |
Brugia malayi | nuclear receptor NHR-88 | 0.002 | 0.0156 | 0.0428 |
Schistosoma mansoni | hypothetical protein | 0.0406 | 0.5955 | 0.5955 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0265 | 0.3829 | 0.3829 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.0402 | 0.0918 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0317 | 0.0317 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0072 | 0.0941 | 0.0941 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.001 | 0.0017 | 0.0017 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0156 | 0.0428 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0156 | 0.0428 |
Schistosoma mansoni | ferritin | 0.0017 | 0.011 | 0.011 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0061 | 0.0769 | 0.0769 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0089 | 0.0089 |
Schistosoma mansoni | nuclear hormone receptor | 0.002 | 0.0156 | 0.0156 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0941 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.0572 | 1 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.0017 | 0.011 | 0.0008 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0402 | 0.4456 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0402 | 0.1882 |
Schistosoma mansoni | hypothetical protein | 0.0245 | 0.3534 | 0.3534 |
Schistosoma mansoni | apoferritin-2 | 0.0017 | 0.011 | 0.011 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0156 | 0.0428 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0402 | 0.0892 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.0402 | 0.0918 |
Schistosoma mansoni | ferritin | 0.0017 | 0.011 | 0.011 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.002 | 0.0156 | 0.0156 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.002 | 0.0156 | 0.0457 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0156 | 0.0156 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0012 | 0.0042 | 0.0115 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.002 | 0.0156 | 0.0428 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0317 | 0.0317 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0156 | 0.0156 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0289 | 0.0794 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.0017 | 0.011 | 0.004 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.0402 | 0.0918 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.1237 | 0.1237 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.001 | 0.0017 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0156 | 0.0428 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.1237 | 0.1237 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.1612 | 0.4431 |
Schistosoma mansoni | apoferritin-2 | 0.0017 | 0.011 | 0.011 |
Echinococcus multilocularis | ferritin | 0.0017 | 0.011 | 0.011 |
Onchocerca volvulus | 0.0036 | 0.0402 | 0.1178 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0402 | 0.0892 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0402 | 0.6349 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.002 | 0.0156 | 0.0156 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0156 | 0.0156 |
Echinococcus granulosus | geminin | 0.017 | 0.2408 | 0.2408 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0941 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0402 | 0.0402 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0289 | 0.0289 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.0769 | 0.2061 |
Echinococcus multilocularis | tar DNA binding protein | 0.0252 | 0.3639 | 0.3639 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0072 | 0.0941 | 0.0941 |
Echinococcus granulosus | lamin | 0.0054 | 0.0668 | 0.0668 |
Onchocerca volvulus | 0.003 | 0.0317 | 0.0928 | |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0231 | 0.3319 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0317 | 0.3165 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0156 | 0.0156 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0402 | 0.4456 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0156 | 0.0428 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0402 | 0.1882 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0402 | 0.6349 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0054 | 0.0668 | 0.1836 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0402 | 0.1105 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0092 | 0.1237 | 0.34 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0317 | 0.451 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0026 | 0.025 | 0.025 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.002 | 0.0156 | 0.0156 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0156 | 0.0156 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0402 | 0.1105 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0017 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0156 | 0.0428 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.012 | 0.1663 | 1 |
Schistosoma mansoni | ferritin | 0.0017 | 0.011 | 0.011 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0156 | 0.0156 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0089 | 0.0246 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0017 | 0.011 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.1237 | 0.1237 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0317 | 0.087 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0402 | 0.4456 |
Schistosoma mansoni | thyroid hormone receptor | 0.0265 | 0.3829 | 0.3829 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.002 | 0.0156 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0402 | 0.1105 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0016 | 0.0107 | 0.0107 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0402 | 0.4456 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.0572 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.0317 | 0.0317 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0156 | 0.0156 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0402 | 0.0402 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0016 | 0.0107 | 0.0107 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0108 | 0.1482 | 0.4282 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.002 | 0.0156 | 0.0428 |
Echinococcus multilocularis | lamin dm0 | 0.0054 | 0.0668 | 0.0668 |
Schistosoma mansoni | tar DNA-binding protein | 0.0252 | 0.3639 | 0.3639 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0355 | 0.0355 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0017 | 0.011 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0252 | 0.3639 | 1 |
Schistosoma mansoni | ferritin | 0.0017 | 0.011 | 0.011 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.002 | 0.0156 | 0.0428 |
Trichomonas vaginalis | ferritin, putative | 0.0017 | 0.011 | 0.0008 |
Schistosoma mansoni | intermediate filament proteins | 0.0054 | 0.0668 | 0.0668 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0402 | 0.0918 |
Echinococcus granulosus | ferritin | 0.0017 | 0.011 | 0.011 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.0572 | 0.7019 |
Onchocerca volvulus | 0.0054 | 0.0668 | 0.1958 | |
Echinococcus granulosus | intermediate filament protein | 0.0054 | 0.0668 | 0.0668 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0089 | 0.0089 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.0572 | 0.1571 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.0572 | 0.0572 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0089 | 0.0246 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.0572 | 0.0572 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0016 | 0.0107 | 0.0295 |
Loa Loa (eye worm) | intermediate filament protein | 0.0054 | 0.0668 | 0.1836 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0062 | 0.0785 | 0.0785 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0108 | 0.1482 | 0.4282 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.002 | 0.0156 | 0.0428 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0402 | 0.1105 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0676 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0029 | 0.0293 | 0.0806 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0291 | 0.0291 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0317 | 0.087 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.001 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0017 | 0.0046 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 0.0769 | 0.0769 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0668 | 0.1836 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.001 | 0.001 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0313 | 0.0313 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0108 | 0.1482 | 0.4282 |
Schistosoma mansoni | ferritin light chain | 0.0017 | 0.011 | 0.011 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0047 | 0.0572 | 0.1446 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0402 | 0.0402 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.012 | 0.1663 | 0.4845 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0017 | 0.0046 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0402 | 0.4456 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0402 | 0.1105 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.002 | 0.0156 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0236 | 0.0648 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0017 | 0.0046 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0017 | 0.0017 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.0402 | 0.0918 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.2408 | 0.2408 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.001 | 0.0017 | 0.0017 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0089 | 0.0246 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.0402 | 0.0918 |
Onchocerca volvulus | 0.0036 | 0.0402 | 0.1178 | |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0317 | 0.0317 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0402 | 0.1105 |
Schistosoma mansoni | tar DNA-binding protein | 0.0252 | 0.3639 | 0.3639 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.0572 | 0.1571 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.002 | 0.0156 | 0.0156 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.0769 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0156 | 0.0428 |
Onchocerca volvulus | Bile acid receptor homolog | 0.002 | 0.0156 | 0.0457 |
Brugia malayi | RNA binding protein | 0.0252 | 0.3639 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.002 | 0.0156 | 0.0428 |
Schistosoma mansoni | thyroid hormone receptor | 0.0265 | 0.3829 | 0.3829 |
Schistosoma mansoni | lamin | 0.0054 | 0.0668 | 0.0668 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0054 | 0.0668 | 0.1836 |
Loa Loa (eye worm) | steroid hormone receptor | 0.002 | 0.0156 | 0.0428 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0029 | 0.0293 | 0.0806 |
Schistosoma mansoni | coup transcription factor | 0.002 | 0.0156 | 0.0156 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.0089 | 0.0089 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0402 | 0.6349 |
Brugia malayi | TAR-binding protein | 0.0252 | 0.3639 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.002 | 0.0156 | 0.0156 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0055 | 0.0688 | 0.8777 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.0572 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0156 | 0.0428 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.0017 | 0.011 | 0.004 |
Schistosoma mansoni | tar DNA-binding protein | 0.0252 | 0.3639 | 0.3639 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.1612 | 0.4431 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0156 | 0.0428 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0245 | 0.3534 | 0.3534 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0402 | 0.0892 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0355 | 0.0975 |
Echinococcus multilocularis | geminin | 0.017 | 0.2408 | 0.2408 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.0769 | 0.0769 |
Brugia malayi | ecdysteroid receptor | 0.002 | 0.0156 | 0.0428 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.0402 | 0.0918 |
Leishmania major | trypanothione reductase | 0.0047 | 0.0572 | 0.7019 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.002 | 0.0156 | 0.0428 |
Schistosoma mansoni | lamin | 0.0054 | 0.0668 | 0.0668 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.002 | 0.0156 | 0.0428 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0108 | 0.1482 | 0.8835 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0402 | 0.0892 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.1237 | 0.1237 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0406 | 0.5955 | 0.5955 |
Brugia malayi | nuclear hormone receptor | 0.002 | 0.0156 | 0.0428 |
Schistosoma mansoni | tar DNA-binding protein | 0.0252 | 0.3639 | 0.3639 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0016 | 0.0107 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0252 | 0.3639 | 0.3639 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0089 | 0.0089 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0252 | 0.3639 | 1 |
Onchocerca volvulus | 0.0036 | 0.0402 | 0.1178 | |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0.0769 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.002 | 0.0156 | 0.0156 |
Echinococcus multilocularis | musashi | 0.0054 | 0.0668 | 0.0668 |
Echinococcus granulosus | dnaJ subfamily B | 0.0406 | 0.5955 | 0.5955 |
Brugia malayi | intermediate filament protein | 0.0054 | 0.0668 | 0.1836 |
Brugia malayi | Pre-SET motif family protein | 0.0208 | 0.2983 | 0.8198 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0252 | 0.3639 | 1 |
Onchocerca volvulus | 0.0054 | 0.0668 | 0.1958 | |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.0769 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.002 | 0.0156 | 0.0156 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.1237 | 0.1237 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.0402 | 0.0918 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0208 | 0.2983 | 0.8198 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.1612 | 0.4431 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.002 | 0.0156 | 0.0156 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.0008 | 0.0022 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0089 | 0.0089 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.002 | 0.0156 | 0.0428 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0941 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.001 | 0.0017 | 0.0046 |
Schistosoma mansoni | tar DNA-binding protein | 0.0252 | 0.3639 | 0.3639 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.002 | 0.0156 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0156 | 0.0428 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0156 | 0.0156 |
Mycobacterium tuberculosis | Probable reductase | 0.0108 | 0.1482 | 0.4282 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0402 | 0.1105 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0355 | 0.0975 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.0769 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.002 | 0.0156 | 0.0156 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0089 | 0.0089 |
Brugia malayi | hypothetical protein | 0.001 | 0.0017 | 0.0046 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.001 | 0.0027 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 50 ug ml-1 | Antifungal activity against Candida albicans after 48 hrs by broth microdilution technique | ChEMBL. | 19906466 |
MIC (functional) | > 50 ug ml-1 | Antifungal activity against Cryptococcus neoformans after 48 hrs by broth microdilution technique | ChEMBL. | 19906466 |
MIC (functional) | = 9.25 uM | Antitrichomonal activity against Trichomonas vaginalis after 48 hrs by trypan blue exclusion assay | ChEMBL. | 19906466 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.