Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 2, subfamily D, polypeptide 6 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 2, subfamily D, polypeptide 6 | 497 aa | 425 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0353 | 0.1353 | 0.1353 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2091 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0353 | 0.1353 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0353 | 0.1353 | 0.1353 |
Loa Loa (eye worm) | hypothetical protein | 0.0353 | 0.1353 | 0.1353 |
Loa Loa (eye worm) | carboxylesterase | 0.0353 | 0.1353 | 0.1353 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0353 | 0.1353 | 0.1353 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0353 | 0.1353 | 0.1353 |
Brugia malayi | MH2 domain containing protein | 0.0128 | 0.023 | 0.023 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0353 | 0.1353 | 0.5 |
Onchocerca volvulus | 0.0353 | 0.1353 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2091 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0353 | 0.1353 | 0.1353 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0353 | 0.1353 | 0.1353 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0353 | 0.1353 | 0.1353 |
Echinococcus granulosus | acetylcholinesterase | 0.2091 | 1 | 1 |
Onchocerca volvulus | 0.0353 | 0.1353 | 1 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.2091 | 1 | 1 |
Onchocerca volvulus | 0.0353 | 0.1353 | 1 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0128 | 0.023 | 0.023 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0353 | 0.1353 | 0.1353 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0353 | 0.1353 | 0.1353 |
Loa Loa (eye worm) | hypothetical protein | 0.0353 | 0.1353 | 0.1353 |
Loa Loa (eye worm) | hypothetical protein | 0.2091 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2091 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0353 | 0.1353 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.2091 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0353 | 0.1353 | 0.1353 |
Loa Loa (eye worm) | hypothetical protein | 0.0353 | 0.1353 | 0.1353 |
Brugia malayi | Carboxylesterase family protein | 0.0353 | 0.1353 | 0.1353 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0353 | 0.1353 | 0.5 |
Onchocerca volvulus | 0.0353 | 0.1353 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0353 | 0.1353 | 0.1353 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0868 | 0.3913 | 0.3913 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0128 | 0.023 | 0.023 |
Brugia malayi | Carboxylesterase family protein | 0.2091 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0353 | 0.1353 | 0.1353 |
Echinococcus multilocularis | acetylcholinesterase | 0.2091 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.2091 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0353 | 0.1353 | 0.5 |
Onchocerca volvulus | 0.0353 | 0.1353 | 1 | |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0353 | 0.1353 | 0.1353 |
Brugia malayi | Carboxylesterase family protein | 0.0353 | 0.1353 | 0.1353 |
Loa Loa (eye worm) | hypothetical protein | 0.0353 | 0.1353 | 0.1353 |
Loa Loa (eye worm) | hypothetical protein | 0.2091 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0353 | 0.1353 | 0.1353 |
Schistosoma mansoni | gliotactin | 0.0353 | 0.1353 | 0.1353 |
Echinococcus granulosus | acetylcholinesterase | 0.2091 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0353 | 0.1353 | 0.1353 |
Brugia malayi | Carboxylesterase family protein | 0.0353 | 0.1353 | 0.1353 |
Loa Loa (eye worm) | hypothetical protein | 0.0353 | 0.1353 | 0.1353 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0353 | 0.1353 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0353 | 0.1353 | 0.1353 |
Echinococcus granulosus | neuroligin | 0.0353 | 0.1353 | 0.1353 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0353 | 0.1353 | 0.1353 |
Loa Loa (eye worm) | carboxylesterase | 0.0353 | 0.1353 | 0.1353 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.