Detailed information for compound 110517

Basic information

Technical information
  • TDR Targets ID: 110517
  • Name: 2-(3,4-dihydroxyphenyl)ethyl-dimethylsulfaniu m iodide
  • MW: 326.194 | Formula: C10H15IO2S
  • H donors: 2 H acceptors: 2 LogP: 3 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[S+](CCc1ccc(c(c1)O)O)C.[I-]
  • InChi: 1S/C10H14O2S.HI/c1-13(2)6-5-8-3-4-9(11)10(12)7-8;/h3-4,7H,5-6H2,1-2H3,(H-,11,12);1H
  • InChiKey: DQILVOWYCKLIMF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(3,4-dihydroxyphenyl)ethyl-dimethyl-sulfonium iodide
  • 2-(3,4-dihydroxyphenyl)ethyl-dimethylsulfonium iodide
  • 2-(3,4-dihydroxyphenyl)ethyl-dimethyl-sulfanium iodide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0407 0.223 0.2229
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0128 0.0127
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.1218 0.1217
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1526 0.5945
Echinococcus multilocularis neuropeptide receptor A26 0.045 0.2474 0.2473
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0136 0.178
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0067 0.0297 0.1074
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0036 0.001
Loa Loa (eye worm) hypothetical protein 0.0148 0.0757 0.0756
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0036 0.0035
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0076 0.0346 0.0345
Schistosoma mansoni DNA polymerase eta 0.005 0.0202 0.0201
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0036 0.0035
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0136 0.0956
Schistosoma mansoni cpg binding protein 0.0059 0.0251 0.025
Plasmodium vivax importin-beta 2, putative 0.0059 0.0253 0.3332
Leishmania major DNA polymerase kappa, putative 0.0022 0.0038 0.0354
Schistosoma mansoni hypothetical protein 0.0797 0.4451 0.4451
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0029 0.0078 0.103
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0038 0.0494
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.0757 0.2897
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0025 0.0024
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0036 0.0035
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.002 0.0027 0.0336
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0107 0.0106
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0396 0.0359
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0067 0.0297 0.1074
Echinococcus multilocularis dna polymerase eta 0.005 0.0202 0.0201
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0036 0.0035
Schistosoma mansoni hypothetical protein 0.0182 0.0949 0.0948
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0067 0.0297 0.8585
Schistosoma mansoni ran 0.0044 0.0164 0.0163
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0038 0.0037
Echinococcus multilocularis dnaJ subfamily B 0.0797 0.4451 0.4451
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0072 0.0325 0.4281
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0038 0.0508
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0164 0.2162
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0136 0.1792
Leishmania major geranylgeranyltransferase, putative 0.0029 0.0078 0.0729
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0035
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0036 0.0035
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0257 0.0256
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0006 0.0005
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0135 0.0134
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0189 0.0644
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0054 0.0694
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0253 0.0252
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0072 0.0325 0.0324
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0123 0.0122
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0036 0.0035
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0072 0.0325 0.0324
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0054 0.0694
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0109 0.0534 0.2012
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0201 0.1056 0.1021
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0164 0.215
Echinococcus granulosus muscleblind protein 0.0322 0.1747 0.1746
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.4386 0.4385
Leishmania major farnesyltransferase beta subunit 0.0067 0.0297 0.2809
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0036 0.0035
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0029 0.0078 0.2228
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1772 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.019 0.0997 0.0996
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.0997 0.0996
Loa Loa (eye worm) hypothetical protein 0.0229 0.1218 0.1217
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0123 0.0122
Plasmodium falciparum importin beta, putative 0.0059 0.0253 0.7299
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.0757 1
Onchocerca volvulus 0.0148 0.0757 0.0733
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.0997 0.0996
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.0757 0.2897
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.015 0.0149
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.002 0.0027 0.035
Brugia malayi Importin beta-1 subunit 0.0059 0.0253 0.0252
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1526 0.5945
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0029 0.0078 0.1017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0036 0.0035
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0072 0.0325 0.0324
Loa Loa (eye worm) excitatory amino acid transporter 0.1772 1 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0164 0.0163
Loa Loa (eye worm) beta-lactamase 0.0148 0.0757 0.0756
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.002 0.0027 0.035
Leishmania major DNA polymerase eta, putative 0.0035 0.0116 0.1094
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0135 0.1777
Entamoeba histolytica hypothetical protein 0.0037 0.0123 0.0641
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0054 0.1521
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0054 0.1521
Mycobacterium ulcerans esterase/lipase LipP 0.0148 0.0757 0.7063
Schistosoma mansoni hypothetical protein 0.0047 0.0181 0.0179
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0189 0.2486
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0107 0.0106
Echinococcus granulosus geminin 0.0182 0.0949 0.0948
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0107 0.0106
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0036 0.0035
Echinococcus multilocularis beta LACTamase domain containing family member 0.0148 0.0757 0.0756
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0107 0.0106
Giardia lamblia Rab geranylgeranyltransferase 0.0076 0.0346 0.2132
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.053 0.5017
Trichomonas vaginalis penicillin-binding protein, putative 0.0148 0.0757 0.2897
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0148 0.0757 0.0722
Trypanosoma cruzi lanosterol synthase, putative 0.0029 0.0078 0.1017
Leishmania major hypothetical protein, conserved 0.0148 0.0757 0.7167
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0038 0.0508
Brugia malayi beta-lactamase family protein 0.0148 0.0757 0.0756
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0067 0.0297 0.1806
Loa Loa (eye worm) hypothetical protein 0.0072 0.0325 0.0324
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0116 0.1526
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0396 0.0359
Loa Loa (eye worm) hypothetical protein 0.005 0.0202 0.0201
Onchocerca volvulus 0.0148 0.0757 0.0733
Schistosoma mansoni hypothetical protein 0.0034 0.0107 0.0106
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0148 0.0757 0.7063
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0135 0.0134
Echinococcus granulosus neutral amino acid transporter 0.1772 1 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0072 0.0325 0.0324
Brugia malayi hypothetical protein 0.0037 0.0123 0.0122
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0233 0.0232
Echinococcus granulosus excitatory amino acid transporter 2 0.1772 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0036 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0036 0.0035
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0036 0.0035
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.019 0.0997 0.0996
Brugia malayi CXXC zinc finger family protein 0.0056 0.0233 0.0232
Loa Loa (eye worm) hypothetical protein 0.0148 0.0757 0.0756
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0025 0.0024
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0067 0.0297 0.3928
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1526 0.5945
Schistosoma mansoni ap endonuclease 0.0039 0.0136 0.0135
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0067 0.0297 0.1074
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0067 0.0297 0.0296
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0135 0.0726
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.045 0.0413
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0109 0.0534 0.0533
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.0644 0.0643
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0076 0.0346 0.1268
Schistosoma mansoni microtubule-associated protein tau 0.074 0.4127 0.4126
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0136 0.0728
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0067 0.0297 0.1074
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0078 0.1017
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0136 0.0135
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0036 0.0035
Chlamydia trachomatis glutamate symporter 0.1772 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0201 0.1056 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0164 0.1541
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0251 0.1342 0.1342
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0253 0.3342
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0786 0.4385 0.4384
Trypanosoma cruzi DNA polymerase eta, putative 0.005 0.0202 0.2655
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0038 0.0508
Echinococcus granulosus lysosomal alpha glucosidase 0.0175 0.091 0.0909
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0036 0.0035
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0038 0.0494
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0201 0.1056 0.1055
Brugia malayi glutathione reductase 0.0037 0.0126 0.0125
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0038 0.0508
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0164 0.0163
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0035
Entamoeba histolytica hypothetical protein 0.0037 0.0123 0.0641
Brugia malayi ecdysteroid receptor 0.0021 0.0036 0.0035
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0076 0.0346 0.4565
Echinococcus granulosus sodium:dicarboxylate symporter 0.1772 1 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0239 0.0238
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.0644 0.0643
Mycobacterium leprae conserved hypothetical protein 0.0148 0.0757 1
Mycobacterium ulcerans hypothetical protein 0.0148 0.0757 0.7063
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0148 0.0757 0.0722
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.0602 0.0601
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0164 0.471
Trypanosoma cruzi protein farnesyltransferase, putative 0.0067 0.0297 0.3919
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0029 0.0078 0.0729
Loa Loa (eye worm) hypothetical protein 0.0034 0.0107 0.0106
Schistosoma mansoni coup transcription factor 0.0021 0.0036 0.0035
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0109 0.0534 0.0533
Brugia malayi hypothetical protein 0.0024 0.0054 0.0053
Leishmania major protein farnesyltransferase alpha subunit, putative 0.002 0.0027 0.0241
Loa Loa (eye worm) hypothetical protein 0.0059 0.0253 0.0252
Trichomonas vaginalis set domain proteins, putative 0.0463 0.2549 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0175 0.091 0.0909
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0253 0.2388
Giardia lamblia DINP protein human, muc B family 0.0022 0.0038 0.0079
Echinococcus granulosus importin subunit beta 1 0.0059 0.0253 0.0252
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0006 0.0005
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0164 0.0915
Loa Loa (eye worm) hypothetical protein 0.0148 0.0757 0.0756
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0109 0.0534 0.3384
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0076 0.0346 0.0345
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.002 0.0027 0.0025
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0107 0.0106
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.1526 0.3272
Mycobacterium tuberculosis Probable esterase LipL 0.0148 0.0757 0.0722
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0036 0.001
Echinococcus granulosus snurportin 1 0.0635 0.3527 0.3527
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0019 0.0018
Brugia malayi beta-lactamase family protein 0.0148 0.0757 0.0756
Echinococcus granulosus GPCR family 2 0.0034 0.0107 0.0106
Loa Loa (eye worm) glutathione reductase 0.0037 0.0126 0.0125
Schistosoma mansoni ap endonuclease 0.0039 0.0136 0.0135
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.002 0.0027 0.0025
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0148 0.0757 0.0756
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0067 0.0297 0.1074
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0038 0.0508
Leishmania major trypanothione reductase 0.0037 0.0126 0.1181
Echinococcus granulosus Excitatory amino acid transporter 0.1772 1 1
Echinococcus granulosus neutral amino acid transporter A 0.1772 1 1
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0109 0.0534 0.0533
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0067 0.0297 0.0296
Loa Loa (eye worm) hypothetical protein 0.0322 0.1747 0.1746
Schistosoma mansoni alpha-glucosidase 0.0151 0.0771 0.077
Toxoplasma gondii hypothetical protein 0.0056 0.0234 0.2211
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0036 0.001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0036 0.0035
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0039 0.0134 0.1759
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0036 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0325 0.1182
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0029 0.0078 0.0343
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0253 0.0252
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0006 0.0005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0201 0.1056 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0523 0.0522
Schistosoma mansoni hypothetical protein 0.0073 0.0331 0.033
Schistosoma mansoni hypothetical protein 0.0182 0.0949 0.0948
Schistosoma mansoni hypothetical protein 0.0034 0.0107 0.0106
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.0997 0.0996
Trichomonas vaginalis esterase, putative 0.0148 0.0757 0.2897
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.0997 0.0996
Schistosoma mansoni survival motor neuron protein 0.0047 0.0181 0.0179
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0257 0.0256
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0257 0.0256
Echinococcus multilocularis geminin 0.0182 0.0949 0.0948
Loa Loa (eye worm) hypothetical protein 0.0148 0.0757 0.0756
Schistosoma mansoni hypothetical protein 0.0034 0.0107 0.0106
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0148 0.0757 0.0756
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0038 0.0047
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0054 0.0708
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0036 0.0035
Leishmania major importin beta-1 subunit, putative 0.0048 0.0189 0.1782
Schistosoma mansoni cpg binding protein 0.0059 0.0251 0.025
Loa Loa (eye worm) hypothetical protein 0.0148 0.0757 0.0756
Mycobacterium leprae Probable lipase LipE 0.0148 0.0757 1
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0029 0.0078 0.0204
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0136 0.0433
Entamoeba histolytica hypothetical protein 0.0048 0.0189 0.1084
Schistosoma mansoni hypothetical protein 0.0635 0.3527 0.3527
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0253 0.0252
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0038 0.0494
Brugia malayi beta-lactamase 0.0148 0.0757 0.0756
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0036 0.0035
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0036 0.0035
Brugia malayi jmjC domain containing protein 0.0057 0.0239 0.0238
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0239 0.0238
Plasmodium vivax SET domain protein, putative 0.0059 0.0253 0.3328
Mycobacterium tuberculosis Conserved protein 0.0148 0.0757 0.0722
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0038 0.0494
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.091 0.0909
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0036 0.0035
Plasmodium vivax geranylgeranyltransferase, putative 0.0029 0.0078 0.1017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1526 0.5945
Echinococcus granulosus ubiquitin specific protease 41 0.0072 0.0325 0.0324
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0076 0.0346 0.0345
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0029 0.0078 0.0077
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1772 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1526 0.5945
Onchocerca volvulus 0.0463 0.2549 0.2529
Loa Loa (eye worm) hypothetical protein 0.0029 0.0078 0.0077
Echinococcus granulosus dna polymerase eta 0.005 0.0202 0.0201
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.002 0.0027 0.0025
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0148 0.0757 0.0756
Entamoeba histolytica hypothetical protein 0.0037 0.0123 0.0641
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0029 0.0078 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0036 0.0035
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0027 0.035
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0024 0.0023
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0036 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0036 0.0035
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0036 0.0035
Mycobacterium ulcerans beta-lactamase 0.0148 0.0757 0.7063
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0076 0.0346 0.0345
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0072 0.0325 0.1989
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.0702 0.8468
Echinococcus granulosus excitatory amino acid transporter 3 0.1772 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0054 0.0694
Schistosoma mansoni importin beta-1 0.0059 0.0253 0.0252
Loa Loa (eye worm) hypothetical protein 0.0073 0.0331 0.033
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0076 0.0346 1
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0786 0.4385 0.4384
Echinococcus granulosus neuropeptide s receptor 0.045 0.2474 0.2473
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.0997 0.0996
Plasmodium falciparum glutathione reductase 0.0037 0.0126 0.3608
Brugia malayi Thioredoxin reductase 0.0037 0.0126 0.0125
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0036 0.0035
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0253 0.2385
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0035
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0036 0.0035
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0136 0.1276
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1526 0.5945
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0135 0.0134
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0036 0.0035
Brugia malayi Muscleblind-like protein 0.0322 0.1747 0.1746
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0135 0.0432
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0128 0.0127
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.0702 0.6519
Schistosoma mansoni aldehyde dehydrogenase 0.0201 0.1056 0.1055
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1772 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0036 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0253 0.0252
Echinococcus multilocularis neutral amino acid transporter A 0.1772 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0036 0.0035
Brugia malayi hypothetical protein 0.0016 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0035
Plasmodium falciparum thioredoxin reductase 0.0037 0.0126 0.3608
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1772 1 1
Brugia malayi nuclear receptor NHR-88 0.0021 0.0036 0.0035
Brugia malayi RNA, U transporter 1 0.0169 0.0877 0.0876
Loa Loa (eye worm) hypothetical protein 0.0107 0.0523 0.0522
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0038 0.0037
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0135 0.1274
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0136 0.0135
Brugia malayi nuclear hormone receptor 0.0021 0.0036 0.0035
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0036 0.0035
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0036 0.0035
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0136 0.0098
Echinococcus granulosus microtubule associated protein 2 0.074 0.4127 0.4126
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0038 0.0508
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0038 0.0037
Echinococcus granulosus protein prenyltransferase alpha subunit 0.002 0.0027 0.0025
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0234 0.0232
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1772 1 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0038 0.0079
Treponema pallidum glutamate/aspartate transporter 0.0786 0.4385 1
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0135 0.1274
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.0757 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0201 0.1056 1
Echinococcus multilocularis Excitatory amino acid transporter 0.1772 1 1
Echinococcus multilocularis excitatory amino acid transporter 2 0.1772 1 1
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.002 0.0027 0.035
Schistosoma mansoni alpha glucosidase 0.0039 0.0135 0.0134
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0136 0.0433
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0107 0.0106
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.1218 0.1217
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0019 0.0018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0035
Leishmania major GTP-binding protein, putative 0.0044 0.0164 0.1541
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0036 0.0035
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0056 0.0234 0.0824
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0036 0.0035
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0109 0.0534 0.0533
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0038 0.0508
Mycobacterium ulcerans lipase LipD 0.0148 0.0757 0.7063
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0076 0.0346 0.1268
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0029 0.0078 0.0204
Echinococcus multilocularis Excitatory amino acid transporter 0.1772 1 1
Schistosoma mansoni alpha-glucosidase 0.0151 0.0771 0.077
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0109 0.0534 0.0533
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0038 0.0508
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0253 0.0252
Echinococcus granulosus Excitatory amino acid transporter 0.1772 1 1
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0036 0.0035
Trypanosoma brucei trypanothione reductase 0.0037 0.0126 0.1659
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0036 0.0035
Onchocerca volvulus 0.0148 0.0757 0.0733
Loa Loa (eye worm) hypothetical protein 0.0029 0.0078 0.0077
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0164 0.0163
Loa Loa (eye worm) hypothetical protein 0.0148 0.0757 0.0756
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0067 0.0297 0.2809
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0135 0.0432
Echinococcus granulosus cpg binding protein 0.0059 0.0251 0.025
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0036 0.0035
Echinococcus multilocularis ubiquitin specific protease 41 0.0072 0.0325 0.0324
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1526 0.5945
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0036 0.0035
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0038 0.0508
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0078 0.1017
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0072 0.0325 0.0324
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1772 1 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0072 0.0325 0.429
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0135 0.0432
Echinococcus granulosus dnaJ subfamily B 0.0797 0.4451 0.4451
Echinococcus multilocularis cpg binding protein 0.0059 0.0251 0.025
Echinococcus multilocularis excitatory amino acid transporter 2 0.1772 1 1
Brugia malayi follicle stimulating hormone receptor 0.0251 0.1342 0.1342
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0036 0.0035
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0331 0.033
Echinococcus multilocularis excitatory amino acid transporter 3 0.1772 1 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0126 0.0088
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0136 0.0728
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0072 0.0325 0.1182
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0038 0.0508
Trypanosoma brucei DNA polymerase eta, putative 0.005 0.0202 0.2666
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.0997 0.0996
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0036 0.0035
Trypanosoma brucei unspecified product 0.0022 0.0038 0.0508
Plasmodium vivax hypothetical protein, conserved 0.0148 0.0757 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0135 0.0432
Trypanosoma brucei lanosterol synthase 0.0029 0.0078 0.103
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0136 0.178
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0006 0.0005
Onchocerca volvulus 0.0021 0.0036 0.001
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0164 0.0163
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.0997 0.0996
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.045 0.0413
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0239 0.0238
Echinococcus granulosus excitatory amino acid transporter 2 0.1772 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1526 0.5945
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0635 0.3527 0.3527
Toxoplasma gondii thioredoxin reductase 0.0037 0.0126 0.1181
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0001 0.0014
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0025 0.0024
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0148 0.0757 0.0756
Toxoplasma gondii hypothetical protein 0.002 0.0027 0.0241
Echinococcus multilocularis muscleblind protein 0.0322 0.1747 0.1746
Echinococcus multilocularis neutral amino acid transporter A 0.1772 1 1
Brugia malayi hypothetical protein 0.0229 0.1218 0.1217
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0164 0.215
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0036 0.0035
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.045 0.0413
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.1526 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0136 0.178
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0038 0.0047
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0067 0.0297 0.0296
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0067 0.0297 0.1074
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0036 0.0035
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0135 0.0432
Plasmodium vivax glutathione reductase, putative 0.0037 0.0126 0.1647
Trypanosoma cruzi protein farnesyltransferase, putative 0.0067 0.0297 0.3919
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0036 0.0035
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0072 0.0325 0.3069
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0201 0.1056 1
Schistosoma mansoni cpg binding protein 0.0056 0.0233 0.0232
Plasmodium falciparum geranylgeranyltransferase, putative 0.0029 0.0078 0.2228
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0038 0.0037
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0253 0.0252
Echinococcus granulosus neutral amino acid transporter A 0.1772 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0396 0.0359
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0038 0.0508
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0029 0.0078 0.0729
Onchocerca volvulus 0.0056 0.0233 0.0207
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0029 0.0078 0.004
Echinococcus granulosus neuropeptide receptor A26 0.045 0.2474 0.2473
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0072 0.0325 0.1989
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0027 0.0336
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0257 0.0256
Mycobacterium tuberculosis Probable lipase LipE 0.0148 0.0757 0.0722
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0136 0.39
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0036 0.0035
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0029 0.0078 0.1017
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0038 0.0508
Onchocerca volvulus 0.0059 0.0253 0.0227
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.002 0.0027 0.0737
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.002 0.0027 0.0336
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0239 0.0238
Trypanosoma brucei hypothetical protein, conserved 0.0148 0.0757 1
Trichomonas vaginalis ran, putative 0.0044 0.0164 0.0544
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0136 0.0135
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0036 0.0035
Mycobacterium tuberculosis Probable hydrolase 0.0148 0.0757 0.0722
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0072 0.0325 0.1182
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0189 0.0644
Brugia malayi jmjC domain containing protein 0.006 0.0257 0.0256
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0036 0.0035
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0036 0.0035
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0135 0.0432
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0036 0.0035
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0036 0.0035
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0786 0.4385 0.4384
Leishmania major DNA polymerase eta, putative 0.005 0.0202 0.1903
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0038 0.0354
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.002 0.0027 0.0025
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0038 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0036 0.0035
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0523 0.0522
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0072 0.0325 0.0324
Toxoplasma gondii exonuclease III APE 0.0039 0.0136 0.1276
Giardia lamblia Prenyltransferase 0.0067 0.0297 0.1806
Mycobacterium tuberculosis Probable reductase 0.0085 0.0396 0.0359
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0054 0.0498
Echinococcus multilocularis microtubule associated protein 2 0.074 0.4127 0.4126
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0109 0.0534 0.0533
Onchocerca volvulus 0.0047 0.0181 0.0154
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0076 0.0346 0.2132
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0036 0.0035
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.045 0.1487
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.091 0.0909
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.1526 1
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.002 0.0027 0.0336
Echinococcus granulosus dna polymerase kappa 0.0022 0.0038 0.0037
Trypanosoma cruzi lanosterol synthase, putative 0.0029 0.0078 0.1017
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0135 0.0432
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0038 0.0508
Loa Loa (eye worm) hypothetical protein 0.0059 0.0253 0.0252
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0135 0.0134
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0123 0.0122
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0035
Mycobacterium tuberculosis Conserved protein 0.0148 0.0757 0.0722
Brugia malayi steroid hormone receptor 0.0021 0.0036 0.0035
Brugia malayi Pre-SET motif family protein 0.0059 0.0253 0.0252
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0036 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0135 0.1777
Loa Loa (eye worm) hypothetical protein 0.0322 0.1747 0.1746
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0181 0.0179
Echinococcus multilocularis neuropeptide s receptor 0.045 0.2474 0.2473
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0107 0.0106
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0067 0.0297 0.0296
Echinococcus multilocularis snurportin 1 0.0635 0.3527 0.3527
Schistosoma mansoni aldehyde dehydrogenase 0.0201 0.1056 0.1055
Echinococcus multilocularis neutral amino acid transporter A 0.1772 1 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0164 0.215
Treponema pallidum glutamate transporter 0.0786 0.4385 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0253 0.3342
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0135 0.0432
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0189 0.0644
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0148 0.0757 0.0722
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0135 0.0432
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0029 0.0078 0.0077
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0027 0.0336
Leishmania major hypothetical protein, conserved 0.0024 0.0054 0.0498
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0253 0.0252
Giardia lamblia Rab geranylgeranyltransferase 0.0029 0.0078 0.0343
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0038 0.0037
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0076 0.0346 0.0345
Loa Loa (eye worm) hypothetical protein 0.0076 0.0346 0.0345
Brugia malayi Glycosyl hydrolases family 31 protein 0.0175 0.091 0.0909
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.002 0.0027 0.0336
Brugia malayi Pre-SET motif family protein 0.0407 0.223 0.2229
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0786 0.4385 0.4384
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0036 0.0035
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.0702 0.0666
Toxoplasma gondii aldehyde dehydrogenase 0.0201 0.1056 1
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0067 0.0297 0.3919
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.1526 1
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0067 0.0297 0.0296
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0076 0.0346 0.1268
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0006 0.0005
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0201 0.1056 0.1055
Schistosoma mansoni hypothetical protein 0.0034 0.0107 0.0106
Onchocerca volvulus 0.0101 0.049 0.0465
Schistosoma mansoni hypothetical protein 0.0037 0.0123 0.0122
Schistosoma mansoni ran 0.0044 0.0164 0.0163
Mycobacterium tuberculosis Conserved protein 0.0148 0.0757 0.0722
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0126 0.0125
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0396 0.0359
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0072 0.0325 0.4281
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0036 0.0035
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0396 0.0359
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.0757 0.2897
Entamoeba histolytica hypothetical protein 0.0037 0.0123 0.0641
Echinococcus multilocularis muscleblind protein 1 0.0322 0.1747 0.1746
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0126 0.1647
Echinococcus multilocularis GPCR, family 2 0.0034 0.0107 0.0106
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0253 0.0252
Echinococcus granulosus beta LACTamase domain containing family member 0.0148 0.0757 0.0756
Brugia malayi ImpB/MucB/SamB family protein 0.005 0.0202 0.0201
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0946 0.5298 0.5279
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0135 0.0726
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0136 0.0135
Toxoplasma gondii ABC1 family protein 0.0148 0.0757 0.7167
Mycobacterium tuberculosis Probable lipase LipD 0.0148 0.0757 0.0722
Entamoeba histolytica Ran family GTPase 0.0044 0.0164 0.0915
Trichomonas vaginalis penicillin-binding protein, putative 0.0148 0.0757 0.2897
Brugia malayi MH2 domain containing protein 0.0128 0.0644 0.0643
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0523 0.0522
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0036 0.0035
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0035 0.0116 0.1094
Trypanosoma brucei glucosidase, putative 0.0039 0.0135 0.1789
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0072 0.0325 0.0324
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0126 0.1647
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.002 0.0027 0.0025

Activities

Activity type Activity value Assay description Source Reference
Control (functional) = 50 % Ability to inhibit the K+-induced release of [3H]-Acetylcholine in normal striatal slices at 30 microM ChEMBL. 3806598
Control (functional) = 61 % Ability to inhibit the K+-induced release of [3H]-Acetylcholine in dopamine depleted striatal slices at 30 microM ChEMBL. 3806598
IC50 (functional) = 4.4 M Compound concentration required to reduce specific binding of tritiated dopamine to rat brain striatal membrane ChEMBL. 7252978
Inhibition (functional) = 19 % Maximal degree of inhibition was determined from displacement of [3H]-dopamine binding to rat brain striatal membrane ChEMBL. 7252978
Rate of rotation (functional) = 11.25 Contralateral rotation produced by intrastriatal injection in rats with unilateral 6-hydroxydopamine-induced lesions of the substantia nigra at 10 nmol; turns/5 min ChEMBL. 7252978
Rate of rotation (functional) = 20.75 Contralateral rotation produced by intrastriatal injection in rats with unilateral 6-hydroxydopamine-induced lesions of the substantia nigra at 30 nmol; turns/5 min ChEMBL. 7252978
Rate of rotation (functional) = 31.5 Contralateral rotation produced by intrastriatal injection in rats with unilateral 6-hydroxydopamine-induced lesions of the substantia nigra at 90 nmol; turns/5 min ChEMBL. 7252978

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.