Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0153 | 0.1313 | 0.1313 |
Onchocerca volvulus | 0.0153 | 0.1313 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1313 | 0.0545 |
Loa Loa (eye worm) | hypothetical protein | 0.0907 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0141 | 0.1171 | 0.1171 |
Schistosoma mansoni | acetylcholinesterase | 0.0153 | 0.1313 | 0.1313 |
Loa Loa (eye worm) | carboxylesterase | 0.0907 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0907 | 1 | 1 |
Echinococcus multilocularis | dual specificity | 0.011 | 0.0812 | 0.0812 |
Echinococcus multilocularis | neuroligin | 0.0153 | 0.1313 | 0.1313 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0907 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0153 | 0.1313 | 0.5 |
Echinococcus granulosus | dual specificity | 0.011 | 0.0812 | 0.0812 |
Onchocerca volvulus | 0.0153 | 0.1313 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0153 | 0.1313 | 0.5 |
Loa Loa (eye worm) | haspin protein kinase | 0.0142 | 0.1182 | 0.0403 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0153 | 0.1313 | 0.1313 |
Brugia malayi | Carboxylesterase family protein | 0.0153 | 0.1313 | 0.1313 |
Echinococcus multilocularis | acetylcholinesterase | 0.0907 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0141 | 0.1171 | 0.1171 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0153 | 0.1313 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0153 | 0.1313 | 0.1313 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0153 | 0.1313 | 0.1313 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.011 | 0.0812 | 0.5 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.011 | 0.0812 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0907 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0153 | 0.1313 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0153 | 0.1313 | 0.1313 |
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.1171 | 0.1171 |
Echinococcus multilocularis | dual specificity | 0.011 | 0.0812 | 0.0812 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.011 | 0.0812 | 0.0812 |
Brugia malayi | hypothetical protein | 0.0153 | 0.1313 | 0.1313 |
Echinococcus granulosus | neuroligin | 0.0153 | 0.1313 | 0.1313 |
Schistosoma mansoni | gliotactin | 0.0153 | 0.1313 | 0.1313 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0907 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0153 | 0.1313 | 0.1313 |
Loa Loa (eye worm) | carboxylesterase | 0.0153 | 0.1313 | 0.0545 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0153 | 0.1313 | 0.1313 |
Loa Loa (eye worm) | haspin protein kinase | 0.0141 | 0.1171 | 0.0391 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1313 | 0.0545 |
Echinococcus granulosus | carboxylesterase 5A | 0.0907 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0907 | 1 | 1 |
Onchocerca volvulus | 0.0153 | 0.1313 | 0.5 | |
Onchocerca volvulus | 0.0153 | 0.1313 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0153 | 0.1313 | 1 |
Brugia malayi | hypothetical protein | 0.0141 | 0.1171 | 0.1171 |
Entamoeba histolytica | protein kinase domain containing protein | 0.011 | 0.0812 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0907 | 1 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.011 | 0.0812 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0153 | 0.1313 | 0.1313 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1313 | 0.0545 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1313 | 0.0545 |
Echinococcus multilocularis | dual specificity | 0.011 | 0.0812 | 0.0812 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1313 | 0.0545 |
Onchocerca volvulus | 0.0153 | 0.1313 | 0.5 | |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0141 | 0.1171 | 0.1171 |
Brugia malayi | GSG2 | 0.0141 | 0.1171 | 0.1171 |
Echinococcus granulosus | dual specificity | 0.011 | 0.0812 | 0.0812 |
Entamoeba histolytica | protein kinase, putative | 0.011 | 0.0812 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.011 | 0.0812 | 0.0812 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1313 | 0.0545 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0153 | 0.1313 | 0.1313 |
Loa Loa (eye worm) | carboxylesterase | 0.0153 | 0.1313 | 0.0545 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0141 | 0.1171 | 0.1171 |
Giardia lamblia | Kinase, CMGC DYRK | 0.011 | 0.0812 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0153 | 0.1313 | 0.1313 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0141 | 0.1171 | 0.1171 |
Echinococcus granulosus | acetylcholinesterase | 0.0907 | 1 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0141 | 0.1171 | 0.0391 |
Echinococcus granulosus | acetylcholinesterase | 0.0907 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0153 | 0.1313 | 0.1313 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1313 | 0.0545 |
Brugia malayi | Carboxylesterase family protein | 0.0153 | 0.1313 | 0.1313 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.011 | 0.0812 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0153 | 0.1313 | 0.1313 |
Echinococcus granulosus | dual specificity | 0.011 | 0.0812 | 0.0812 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0153 | 0.1313 | 0.1313 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0153 | 0.1313 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 10 uM | Cytotoxicity against human K562 cells after 48 hrs | ChEMBL. | 19697926 |
IC50 (functional) | > 10 uM | Cytotoxicity against human A549 cells after 48 hrs | ChEMBL. | 19697926 |
IC50 (functional) | > 10 uM | Cytotoxicity against human HepG2 cells after 48 hrs | ChEMBL. | 19697926 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 19697926 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.