Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A2b receptor | References | |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A2a receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Dihydrofolate reductase | 0.4379 | 1 | 1 |
Onchocerca volvulus | 0.0889 | 0.1501 | 0.5 | |
Brugia malayi | thymidylate synthase | 0.0889 | 0.1501 | 0.1501 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.2953 | 0.6529 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2953 | 0.6529 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.4379 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0423 | 0.0367 | 0.0367 |
Loa Loa (eye worm) | thymidylate synthase | 0.0889 | 0.1501 | 0.1501 |
Echinococcus granulosus | dihydrofolate reductase | 0.4379 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.4379 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2953 | 0.6529 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.4379 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2953 | 0.6529 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2953 | 0.6529 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2953 | 0.6529 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0889 | 0.1501 | 0.1501 |
Echinococcus multilocularis | dihydrofolate reductase | 0.4379 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0423 | 0.0367 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0889 | 0.1501 | 0.1501 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.4379 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.4379 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.4379 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0889 | 0.1501 | 0.1178 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 4.4 | Tested for adenosine A1 receptor agonistic activity by determining concentration needed to prolong the stimulus-QRS interval by 50% of the maximum response | ChEMBL. | 1469688 |
EC50 (functional) | = 8.49 | Tested for adenosine A2 receptor agonistic activity by determining coronary vasodilation | ChEMBL. | 1469688 |
EC50 (functional) | = 747 nM | Functional activity at Adenosine A2A receptor as vasorelaation of rat aorta | ChEMBL. | 7658444 |
EC50 (functional) | > 10 uM | Activitty at Adenosine A1 receptor of rat atria | ChEMBL. | 7658444 |
Ki (binding) | = 29 nM | Displacement of [3H]-CGS- 21680 from Adenosine A2A receptor of rat striatum | ChEMBL. | 7658444 |
Ki (binding) | = 1770 nM | Displacement of [3H]-CHA from Adenosine A1 receptor of rat brain | ChEMBL. | 7658444 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.