Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0262 | 1 | 0.5 |
Onchocerca volvulus | 0.013 | 0.4008 | 0.5 | |
Loa Loa (eye worm) | acetyltransferase | 0.014 | 0.4487 | 0.4338 |
Echinococcus multilocularis | geminin | 0.0164 | 0.5562 | 0.2624 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.5562 | 0.2624 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.014 | 0.4487 | 0.0808 |
Echinococcus granulosus | geminin | 0.0164 | 0.5562 | 0.5601 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.4008 | 0.384 |
Chlamydia trachomatis | dihydrofolate reductase | 0.026 | 0.993 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.026 | 0.993 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.026 | 0.993 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.026 | 0.993 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0262 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0262 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.026 | 0.993 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.014 | 0.4487 | 0.0808 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0262 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.4008 | 0.4037 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.5562 | 0.2624 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0.0927 | 1 |
Brugia malayi | hypothetical protein | 0.0062 | 0.0927 | 0.0634 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.026 | 0.993 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.026 | 0.993 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0136 | 0.4309 | 0.4339 |
Brugia malayi | thymidylate synthase | 0.013 | 0.4008 | 0.384 |
Brugia malayi | dihydrofolate reductase family protein | 0.026 | 0.993 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.026 | 0.993 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.4008 | 0.3423 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0262 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.026 | 0.993 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.014 | 0.4487 | 0.4338 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.34 | Inhibition of rat liver DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 6.8 | Inhibition of Toxoplasma gondii DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 0.16 uM | Inhibition of Toxoplasma gondii DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 4.57 uM | Inhibition of rat liver DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.