Detailed information for compound 1105475

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 520.044 | Formula: C24H30ClN5O4S
  • H donors: 4 H acceptors: 5 LogP: 3.22 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: CNS(=O)(=O)c1cc(cc2c1n(C[C@H]1CCCCC[C@H]1O)c(n2)NCc1ccccc1Cl)C(=O)N
  • InChi: 1S/C24H30ClN5O4S/c1-27-35(33,34)21-12-17(23(26)32)11-19-22(21)30(14-16-8-3-2-4-10-20(16)31)24(29-19)28-13-15-7-5-6-9-18(15)25/h5-7,9,11-12,16,20,27,31H,2-4,8,10,13-14H2,1H3,(H2,26,32)(H,28,29)/t16-,20-/m1/s1
  • InChiKey: JZHYBWZNIXVTHQ-OXQOHEQNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0221 0.1444 0.9079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0151 0.0952
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0093 0.0645
Loa Loa (eye worm) transcription factor SMAD2 0.0241 0.159 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0151 0.0952
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0151 0.0155
Loa Loa (eye worm) hypothetical protein 0.0041 0.0151 0.0952
Plasmodium vivax glutathione reductase, putative 0.0084 0.0462 0.2875
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0093 0.0645
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.076 0.5266
Loa Loa (eye worm) hypothetical protein 0.0041 0.0151 0.0952
Loa Loa (eye worm) hypothetical protein 0.0098 0.0561 0.3525
Leishmania major trypanothione reductase 0.0084 0.0462 0.3199
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0151 0.0155
Brugia malayi nuclear receptor NHR-88 0.0041 0.0151 0.0952
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0034 0.0103 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0222 0.1448 0.1478
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0173 0.1198
Schistosoma mansoni microtubule-associated protein tau 0.1384 0.9799 1
Trypanosoma cruzi cruzipain precursor, putative 0.0126 0.076 0.5266
Loa Loa (eye worm) RNA binding protein 0.0192 0.1237 0.778
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0093 0.0645
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0012 0.0012
Echinococcus multilocularis microtubule associated protein 2 0.1384 0.9799 1
Echinococcus multilocularis lamin dm0 0.0105 0.0609 0.0622
Loa Loa (eye worm) hypothetical protein 0.0041 0.0151 0.0952
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0192 0.1238 0.1238
Onchocerca volvulus 0.0105 0.0609 0.4163
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0066 0.0455
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0066 0.0455
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0173 0.1198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.076 0.5266
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.076 0.5266
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0092 0.0188
Trypanosoma brucei hypothetical protein, conserved 0.0221 0.1444 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0093 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0015 0.0101
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0006 0.004
Echinococcus granulosus lamin 0.0105 0.0609 0.0622
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0221 0.1444 1
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0093 0.0095
Echinococcus multilocularis tar DNA binding protein 0.0192 0.1237 0.1262
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0389 0.2653 0.2707
Entamoeba histolytica hypothetical protein 0.0222 0.1448 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0066 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0108 0.0749
Toxoplasma gondii cathepsin CPL 0.0033 0.0093 0.0199
Brugia malayi hypothetical protein 0.0034 0.0103 0.0651
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.001 0.0063
Brugia malayi cathepsin L-like precursor 0.0022 0.0015 0.0092
Loa Loa (eye worm) hypothetical protein 0.0221 0.1444 0.9079
Schistosoma mansoni tar DNA-binding protein 0.0192 0.1237 0.1262
Onchocerca volvulus 0.0033 0.0093 0.0549
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0151 0.0958
Onchocerca volvulus 0.0041 0.0151 0.0958
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0093 0.0645
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0093 0.0645
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0151 0.0952
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0115 0.0682 0.4722
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0202 0.1271
Echinococcus multilocularis tumor protein p63 0.067 0.4671 0.4767
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0173 0.1198
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0151 0.0155
Loa Loa (eye worm) hypothetical protein 0.0022 0.0015 0.0092
Loa Loa (eye worm) hypothetical protein 0.0041 0.0151 0.0952
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0066 0.0413
Echinococcus granulosus ferritin 0.0034 0.0103 0.0105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.076 0.5266
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.024 0.1261
Mycobacterium leprae Probable lipase LipE 0.0221 0.1444 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0045 0.0314
Leishmania major cathepsin L-like protease 0.0033 0.0093 0.0645
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0066 0.0455
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0151 0.0952
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0173 0.1088
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0108 0.075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0027 0.0187
Loa Loa (eye worm) ctsf protein 0.0033 0.0093 0.0585
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.024 0.1261
Echinococcus granulosus intermediate filament protein 0.0105 0.0609 0.0622
Plasmodium vivax vivapain-2 0.0033 0.0093 0.0199
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0066 0.0067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.076 0.5266
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0075
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0066 0.0455
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0151 0.0952
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0066 0.0455
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0093 0.0643
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0066 0.0455
Onchocerca volvulus 0.0033 0.0093 0.0549
Schistosoma mansoni ferritin 0.0034 0.0103 0.0105
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0056 0.0259 0.1632
Mycobacterium ulcerans lipase LipD 0.0221 0.1444 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.024 0.1659
Echinococcus granulosus cathepsin l cysteine peptidase 0.0033 0.0093 0.0095
Entamoeba histolytica hypothetical protein 0.0222 0.1448 1
Mycobacterium ulcerans hypothetical protein 0.0221 0.1444 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0151 0.0952
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0173 0.0177
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0066 0.0455
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0151 0.0155
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0151 0.0155
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0151 0.0952
Loa Loa (eye worm) hypothetical protein 0.0022 0.0015 0.0092
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0389 0.2653 0.2707
Brugia malayi Cathepsin L-like precursor 0.0033 0.0093 0.0585
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0093 0.0645
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0151 0.0155
Brugia malayi intermediate filament protein 0.0105 0.0609 0.3833
Leishmania major hypothetical protein, conserved 0.0053 0.024 0.1659
Leishmania major cathepsin L-like protease 0.0126 0.076 0.5266
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0051 0.0219 0.0224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0127 0.0877
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0093 0.0645
Brugia malayi Thioredoxin reductase 0.0084 0.0462 0.2904
Schistosoma mansoni lamin 0.0105 0.0609 0.0622
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0151 0.0155
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0066 0.0455
Brugia malayi RNA binding protein 0.0192 0.1237 0.778
Plasmodium falciparum glutathione reductase 0.0084 0.0462 1
Brugia malayi hypothetical protein 0.0222 0.1448 0.9107
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.076 0.5266
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0151 0.0155
Schistosoma mansoni coup transcription factor 0.0041 0.0151 0.0155
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0221 0.1444 0.9079
Echinococcus granulosus beta LACTamase domain containing family member 0.0221 0.1444 0.1473
Trichomonas vaginalis D-aminoacylase, putative 0.0221 0.1444 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0105 0.0609 0.3833
Mycobacterium tuberculosis Conserved protein 0.0221 0.1444 0.1444
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0202 0.1271
Onchocerca volvulus 0.0105 0.0609 0.4163
Mycobacterium tuberculosis Probable hydrolase 0.0221 0.1444 0.1444
Schistosoma mansoni tar DNA-binding protein 0.0192 0.1237 0.1262
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0151 0.0952
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0066 0.0455
Brugia malayi Cathepsin L-like precursor 0.0033 0.0093 0.0585
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0151 0.0952
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0151 0.0952
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0151 0.0952
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0192 0.1238 0.1238
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0151 0.0155
Loa Loa (eye worm) hypothetical protein 0.0049 0.0206 0.1293
Loa Loa (eye worm) hypothetical protein 0.0221 0.1444 0.9079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0027 0.0185
Giardia lamblia GTOR 0.0044 0.0173 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0093 0.0645
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.076 0.5266
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0066 0.0455
Trypanosoma cruzi major cysteine proteinase, putative 0.0099 0.0567 0.3925
Leishmania major cathepsin L-like protease 0.0126 0.076 0.5266
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0093 0.0645
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0221 0.1444 0.1473
Brugia malayi beta-lactamase 0.0221 0.1444 0.9079
Echinococcus multilocularis lamin 0.0105 0.0609 0.0622
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.076 0.5266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0027 0.0185
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0093 0.0645
Schistosoma mansoni intermediate filament proteins 0.0105 0.0609 0.0622
Trypanosoma cruzi hypothetical protein, conserved 0.0221 0.1444 1
Onchocerca volvulus 0.0221 0.1444 1
Loa Loa (eye worm) TAR-binding protein 0.0192 0.1237 0.778
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0151 0.0155
Schistosoma mansoni apoferritin-2 0.0034 0.0103 0.0105
Brugia malayi Cathepsin L-like precursor 0.0033 0.0093 0.0585
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0043 0.0301
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0066 0.0455
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0108 0.075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0045 0.0314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0092 0.0635
Toxoplasma gondii thioredoxin reductase 0.0084 0.0462 0.2875
Loa Loa (eye worm) hypothetical protein 0.0041 0.0151 0.0952
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0066 0.38
Schistosoma mansoni apoferritin-2 0.0034 0.0103 0.0105
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.001 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0093 0.0645
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0066 0.0455
Echinococcus multilocularis cysteine protease 0.0033 0.0093 0.0095
Echinococcus granulosus lamin dm0 0.0105 0.0609 0.0622
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0012 0.0075
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0012 0.0075
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0066 0.0455
Loa Loa (eye worm) hypothetical protein 0.0033 0.0092 0.0581
Mycobacterium tuberculosis Probable esterase LipL 0.0221 0.1444 0.1444
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0151 0.0952
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0151 0.0958
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.024 0.1659
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0173 0.0177
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0214 0.1393 0.1393
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.024 0.4388
Echinococcus granulosus tumor protein p63 0.067 0.4671 0.4767
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0066 0.0066
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0151 0.0155
Mycobacterium ulcerans esterase/lipase LipP 0.0221 0.1444 1
Mycobacterium ulcerans bacterioferritin BfrB 0.0034 0.0103 0.0714
Loa Loa (eye worm) hypothetical protein 0.0051 0.0219 0.138
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0066 0.0455
Loa Loa (eye worm) beta-lactamase 0.0221 0.1444 0.9079
Schistosoma mansoni hypothetical protein 0.0033 0.0092 0.0094
Leishmania major hypothetical protein, conserved 0.0221 0.1444 1
Leishmania major cysteine peptidase A (CPA) 0.0033 0.0093 0.0645
Plasmodium vivax thioredoxin reductase, putative 0.0084 0.0462 0.2875
Entamoeba histolytica cysteine protease, putative 0.0033 0.0093 0.0643
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0029 0.0066 0.5
Mycobacterium tuberculosis Conserved protein 0.0221 0.1444 0.1444
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0389 0.2653 0.2707
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0151 0.0155
Trypanosoma brucei trypanothione reductase 0.0084 0.0462 0.3199
Loa Loa (eye worm) hypothetical protein 0.0103 0.0596 0.3746
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0093 0.0095
Loa Loa (eye worm) hypothetical protein 0.0221 0.1444 0.9079
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0066 0.0455
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0093 0.0549
Loa Loa (eye worm) hypothetical protein 0.0221 0.1444 0.9079
Loa Loa (eye worm) glutathione reductase 0.0084 0.0462 0.2904
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0173 0.1198
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0151 0.0952
Loa Loa (eye worm) cysteine protease 0.0033 0.0093 0.0585
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.076 0.5266
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0028 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0093 0.0645
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0151 0.0958
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0093 0.0645
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0221 0.1444 0.1444
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0202 0.1271
Brugia malayi steroid hormone receptor 0.0041 0.0151 0.0952
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0173 0.1198
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0151 0.0155
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.024 0.1659
Entamoeba histolytica hypothetical protein 0.0222 0.1448 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0092 0.0635
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.076 0.5266
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0012 0.0075
Loa Loa (eye worm) thioredoxin reductase 0.0084 0.0462 0.2904
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0075
Brugia malayi TAR-binding protein 0.0192 0.1237 0.778
Mycobacterium ulcerans bacterioferritin BfrA 0.0034 0.0103 0.0714
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0027 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0043 0.0301
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0221 0.1444 0.1444
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0151 0.0155
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0151 0.0155
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0015 0.0101
Mycobacterium tuberculosis Probable lipase LipE 0.0221 0.1444 0.1444
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0093 0.0585
Onchocerca volvulus 0.0033 0.0093 0.0549
Brugia malayi nuclear hormone receptor 0.0041 0.0151 0.0952
Brugia malayi Cathepsin L-like cysteine proteinase 0.0022 0.0015 0.0092
Echinococcus granulosus thioredoxin glutathione reductase 0.0085 0.0465 0.0475
Plasmodium vivax vivapain-2 0.0033 0.0093 0.0199
Onchocerca volvulus 0.0033 0.0093 0.0549
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0034 0.0103 0.0103
Echinococcus granulosus microtubule associated protein 2 0.1384 0.9799 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0093 0.0095
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0151 0.0155
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0015 0.0101
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0012 0.0012
Schistosoma mansoni lamin 0.0105 0.0609 0.0622
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0151 0.0952
Schistosoma mansoni transcription factor LCR-F1 0.0222 0.1448 0.1478
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0092 0.0581
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0027 0.0187
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0093 0.0643
Brugia malayi Cathepsin L-like precursor 0.0033 0.0093 0.0585
Loa Loa (eye worm) hypothetical protein 0.0041 0.0151 0.0952
Echinococcus multilocularis musashi 0.0105 0.0609 0.0622
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0151 0.0952
Brugia malayi Cathepsin L-like precursor 0.0022 0.0015 0.0092
Trypanosoma cruzi trypanothione reductase, putative 0.0084 0.0462 0.3199
Loa Loa (eye worm) fibroinase 0.0033 0.0093 0.0585
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0151 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0092 0.0635
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0151 0.0952
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0151 0.0952
Brugia malayi hypothetical protein 0.0053 0.024 0.1506
Schistosoma mansoni tar DNA-binding protein 0.0192 0.1237 0.1262
Mycobacterium tuberculosis Probable lipase LipD 0.0221 0.1444 0.1444
Schistosoma mansoni ferritin 0.0034 0.0103 0.0105
Schistosoma mansoni ferritin 0.0034 0.0103 0.0105
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0093 0.0645
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0151 0.0155
Loa Loa (eye worm) intermediate filament protein 0.0105 0.0609 0.3833
Loa Loa (eye worm) hypothetical protein 0.0105 0.0609 0.3833
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0033 0.0093 0.0691
Brugia malayi MH2 domain containing protein 0.0241 0.159 1
Mycobacterium tuberculosis Conserved protein 0.0221 0.1444 0.1444
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0033 0.0093 0.0691
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0093 0.0645
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0151 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0151 0.0952
Loa Loa (eye worm) hypothetical protein 0.0022 0.0015 0.0092
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0093 0.0585
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0151 0.0155
Brugia malayi Cathepsin L-like precursor 0.0033 0.0093 0.0585
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0066 0.0455
Brugia malayi ecdysteroid receptor 0.0041 0.0151 0.0952
Brugia malayi Cathepsin L-like precursor 0.0033 0.0093 0.0585
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0066 0.0455
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0173 0.1198
Onchocerca volvulus 0.0033 0.0093 0.0549
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0093 0.0645
Brugia malayi Cathepsin L-like precursor 0.0022 0.0015 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0092 0.0635
Echinococcus multilocularis thioredoxin glutathione reductase 0.0085 0.0465 0.0475
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0192 0.1237 0.778
Loa Loa (eye worm) hypothetical protein 0.0049 0.0206 0.1293
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0093 0.0095
Trichomonas vaginalis D-aminoacylase, putative 0.0221 0.1444 1
Onchocerca volvulus 0.0221 0.1444 1
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0093 0.0549
Schistosoma mansoni tar DNA-binding protein 0.0192 0.1237 0.1262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0027 0.0185
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0093 0.0645
Echinococcus granulosus tar DNA binding protein 0.0192 0.1237 0.1262
Echinococcus multilocularis ferritin 0.0034 0.0103 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0151 0.0952
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0093 0.0645
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0066 0.0455
Echinococcus granulosus cathepsin l1 0.0033 0.0093 0.0095
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.0561 0.0572
Schistosoma mansoni tar DNA-binding protein 0.0192 0.1237 0.1262
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0173 0.1198
Entamoeba histolytica hypothetical protein 0.0222 0.1448 1
Onchocerca volvulus 0.0033 0.0093 0.0549
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0151 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0092 0.0635
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0034 0.0103 0.0103
Mycobacterium ulcerans beta-lactamase 0.0221 0.1444 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0221 0.1444 0.1473
Brugia malayi hypothetical protein 0.0022 0.0012 0.0075
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0192 0.1238 0.8469
Leishmania major cathepsin L-like protease 0.0033 0.0093 0.0645
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0221 0.1444 0.1473
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0221 0.1444 0.9079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0093 0.0645
Brugia malayi beta-lactamase family protein 0.0221 0.1444 0.9079
Schistosoma mansoni hypothetical protein 0.0222 0.1448 0.1478
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0093 0.0645
Trichomonas vaginalis esterase, putative 0.0221 0.1444 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0173 0.1088
Echinococcus granulosus expressed protein 0.0034 0.0103 0.0105
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0151 0.0155
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0033 0.0093 0.0585
Schistosoma mansoni ferritin 0.0034 0.0103 0.0105
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0192 0.1238 0.1238
Leishmania major cathepsin L-like protease 0.0033 0.0093 0.0645
Loa Loa (eye worm) hypothetical protein 0.0048 0.0202 0.1271
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0069 0.0475
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0151 0.0155
Plasmodium vivax hypothetical protein, conserved 0.0221 0.1444 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.076 0.5266
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0151 0.0952
Echinococcus granulosus cathepsin l1 0.0022 0.0015 0.0015
Brugia malayi RNA recognition motif domain containing protein 0.0192 0.1237 0.778
Schistosoma mansoni thyroid hormone receptor 0.0431 0.2949 0.3009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0151 0.0952
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0066 0.0455
Mycobacterium leprae conserved hypothetical protein 0.0221 0.1444 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0093 0.0645
Loa Loa (eye worm) hypothetical protein 0.0053 0.024 0.1506
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0092 0.0635
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0151 0.0155
Schistosoma mansoni hypothetical protein 0.0024 0.0028 0.0028
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0151 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0108 0.0749
Onchocerca volvulus Cathepsin F homolog 0.0033 0.0093 0.0549
Echinococcus granulosus cathepsin L cysteine proteinase 0.0033 0.0093 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0151 0.0952
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0151 0.0155
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0084 0.0462 0.0462
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0108 0.075
Schistosoma mansoni thyroid hormone receptor 0.0431 0.2949 0.3009
Loa Loa (eye worm) hypothetical protein 0.0041 0.0151 0.0952
Loa Loa (eye worm) hypothetical protein 0.0221 0.1444 0.9079
Brugia malayi Intermediate filament tail domain containing protein 0.0105 0.0609 0.3833
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0093 0.0095
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0066 0.0455
Onchocerca volvulus 0.0033 0.0093 0.0549
Trypanosoma cruzi hypothetical protein, conserved 0.0221 0.1444 1
Mycobacterium tuberculosis Probable reductase 0.0192 0.1238 0.1238
Plasmodium falciparum thioredoxin reductase 0.0084 0.0462 1
Toxoplasma gondii ABC1 family protein 0.0221 0.1444 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0066 0.0455
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0173 0.0177
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.076 0.5266
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0173 0.1194
Treponema pallidum bacterioferrin (TpF1) 0.0034 0.0103 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.076 0.5266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0108 0.0749
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0045 0.0314
Brugia malayi beta-lactamase family protein 0.0221 0.1444 0.9079
Mycobacterium tuberculosis Probable dehydrogenase 0.0192 0.1238 0.1238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0108 0.0749
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.024 0.4388
Trichomonas vaginalis D-aminoacylase, putative 0.0221 0.1444 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0192 0.1238 0.1238
Trichomonas vaginalis ferritin, putative 0.0034 0.0103 0.0714
Onchocerca volvulus 0.0098 0.0561 0.3821
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0093 0.0645
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0151 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0092 0.0635
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0015 0.0015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0093 0.0645
Loa Loa (eye worm) MH2 domain-containing protein 0.0241 0.159 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0151 0.0952
Schistosoma mansoni ferritin light chain 0.0034 0.0103 0.0105
Echinococcus multilocularis cysteine protease 0.0033 0.0093 0.0095
Brugia malayi glutathione reductase 0.0084 0.0462 0.2904
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.076 0.5266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0108 0.0749
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0066 0.0455
Brugia malayi nuclear receptor RXR 0.0022 0.0012 0.0075
Onchocerca volvulus 0.0221 0.1444 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0033 0.0093 0.0691
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0222 0.1448 0.1478
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0027 0.0187
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0214 0.1393 0.1393
Trichomonas vaginalis penicillin-binding protein, putative 0.0221 0.1444 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0173 0.1198
Mycobacterium tuberculosis Probable oxidoreductase 0.0214 0.1393 0.1393
Leishmania major cathepsin L-like protease 0.0033 0.0093 0.0645
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0173 0.1198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0093 0.0645
Brugia malayi cytoplasmic intermediate filament protein 0.0056 0.0259 0.1632
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0173 0.1194
Leishmania major cathepsin L-like protease 0.0033 0.0093 0.0645
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0093 0.0645
Echinococcus multilocularis thyroid hormone receptor alpha 0.0431 0.2949 0.3009
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0214 0.1393 0.962
Brugia malayi hypothetical protein 0.0022 0.0012 0.0075
Echinococcus multilocularis expressed protein 0.0034 0.0103 0.0105
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0066 0.0067
Trichomonas vaginalis penicillin-binding protein, putative 0.0221 0.1444 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0151 0.0952
Loa Loa (eye worm) hypothetical protein 0.0033 0.0093 0.0585
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0093 0.0645
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0028 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0151 0.0952
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0221 0.1444 0.1444
Schistosoma mansoni ferritin light chain 0.0034 0.0103 0.0105
Leishmania major cathepsin L-like protease 0.0126 0.076 0.5266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0062 0.0427
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0051 0.0219 0.0224

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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