Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 3-hydroxy-3-methylglutaryl-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0065 | 0.1101 | 0.195 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0068 | 0.1233 | 0.2183 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.1663 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.1663 | 1 |
Brugia malayi | CHE-14 protein | 0.0068 | 0.1233 | 0.2183 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.5646 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0065 | 0.1101 | 0.195 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.5646 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0078 | 0.1663 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0502 | 0.0889 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0502 | 0.0889 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0502 | 0.0889 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0065 | 0.1101 | 0.195 |
Toxoplasma gondii | ABC1 family protein | 0.0041 | 0 | 0.5 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.5646 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0068 | 0.1233 | 0.2183 |
Mycobacterium leprae | conserved hypothetical protein | 0.0041 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.0714 | 0.1264 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.0502 | 0.0889 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.5646 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.5646 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.5646 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0165 | 0.5646 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0714 | 0.1264 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0165 | 0.5646 | 1 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0165 | 0.5646 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0502 | 0.0889 |
Onchocerca volvulus | 0.0041 | 0 | 0.5 | |
Onchocerca volvulus | 0.0041 | 0 | 0.5 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0502 | 0.0889 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0065 | 0.1101 | 0.195 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0065 | 0.1101 | 0.195 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.1663 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0068 | 0.1233 | 0.2183 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0065 | 0.1101 | 0.195 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.0502 | 0.0889 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0068 | 0.1233 | 0.2183 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0065 | 0.1101 | 0.195 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0068 | 0.1233 | 0.2183 |
Onchocerca volvulus | 0.0041 | 0 | 0.5 | |
Schistosoma mansoni | patched 1 | 0.0068 | 0.1233 | 0.2183 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0068 | 0.1233 | 0.2183 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0065 | 0.1101 | 0.1101 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0502 | 0.0889 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0068 | 0.1233 | 0.2183 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0068 | 0.1233 | 0.2183 |
Echinococcus multilocularis | protein patched | 0.0068 | 0.1233 | 0.2183 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.5646 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0068 | 0.1233 | 0.741 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0502 | 0.0889 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.0714 | 0.1264 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0061 | 0.0902 | 0.1598 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.0714 | 0.1264 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1233 | 0.2183 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.1 uM | Inhibition of HMG CoA reductase by spectrophotometry | ChEMBL. | 19879766 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.