Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | intermediate filament protein | 0.0028 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0028 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0028 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.4151 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.4151 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.4151 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.4151 | 0.5 |
Onchocerca volvulus | 0.0028 | 1 | 0.5 | |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.4151 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.4151 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.4151 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.4151 | 0.4151 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.4151 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.4151 | 0.3482 |
Echinococcus multilocularis | musashi | 0.0028 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.4151 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.1026 | 0.1026 |
Schistosoma mansoni | lamin | 0.0028 | 1 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.4151 | 0.4151 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.4151 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.4151 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.4151 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.4151 | 0.5 |
Onchocerca volvulus | 0.0028 | 1 | 0.5 | |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.4151 | 0.4151 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.4151 | 0.5 |
Echinococcus multilocularis | lamin | 0.0028 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.4151 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.9646 | 0.9646 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 128 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 18 to 24 hrs by NCCLS M100-S11 two fold serial dilution method | ChEMBL. | 21764484 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against Escherichia coli 08-21 after 18 to 24 hrs by NCCLS M100-S11 two fold serial dilution method | ChEMBL. | 21764484 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against Escherichia coli 08-22 after 18 to 24 hrs by NCCLS M100-S11 two fold serial dilution method | ChEMBL. | 21764484 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.