TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 330.448 | Formula: C17H22N4OS
H donors: 3 H acceptors: 2 LogP: 1.94 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCSCC[C@@H](C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C#N)N
InChi: 1S/C17H22N4OS/c1-2-23-8-7-15(19)17(22)21-13(10-18)9-12-11-20-16-6-4-3-5-14(12)16/h3-6,11,13,15,20H,2,7-9,19H2,1H3,(H,21,22)/t13-,15-/m0/s1
InChiKey: IGUDMUOUKIZCPL-ZFWWWQNUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin C	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Babesia bovis	cathepsin C precursor, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Schistosoma japonicum	ko:K01275 cathepsin C [EC3.4.14.1], putative	Get druggable targets OG5_130494	All targets in OG5_130494
Plasmodium knowlesi	dipeptidyl aminopeptidase 2, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Plasmodium falciparum	dipeptidyl aminopeptidase 2	Get druggable targets OG5_130494	All targets in OG5_130494
Plasmodium falciparum	dipeptidyl aminopeptidase 1	Get druggable targets OG5_130494	All targets in OG5_130494
Schistosoma japonicum	Cathepsin C precursor, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	Get druggable targets OG5_130494	All targets in OG5_130494
Toxoplasma gondii	preprocathepsin c precursor, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Toxoplasma gondii	cathepsin CPC1	Get druggable targets OG5_130494	All targets in OG5_130494
Babesia bovis	preprocathepsin c precursor, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Neospora caninum	hypothetical protein	Get druggable targets OG5_130494	All targets in OG5_130494
Plasmodium knowlesi	dipeptidyl aminopeptidase 1, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Giardia lamblia	Dipeptidyl-peptidase I precursor	Get druggable targets OG5_130494	All targets in OG5_130494
Plasmodium yoelii	cathepsin c precursor	Get druggable targets OG5_130494	All targets in OG5_130494
Plasmodium yoelii	Homo sapiens P3ECSL-related	Get druggable targets OG5_130494	All targets in OG5_130494
Cryptosporidium parvum	preprocathepsin c precursor, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Plasmodium berghei	dipeptidyl aminopeptidase 2	Get druggable targets OG5_130494	All targets in OG5_130494
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_130494	All targets in OG5_130494
Plasmodium berghei	dipeptidyl aminopeptidase 1, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Theileria parva	cathepsin C, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Cryptosporidium hominis	preprocathepsin c precursor	Get druggable targets OG5_130494	All targets in OG5_130494
Theileria parva	cathepsin C, putative	Get druggable targets OG5_130494	All targets in OG5_130494

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	cathepsin C	141 aa	152 aa	22.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0344	0.005
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.012	0.0178
Onchocerca volvulus	Pyruvate kinase homolog	0.0038	0.0747	0.1476
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.012	0.0178
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0344	0.051
Loa Loa (eye worm)	MH1 domain-containing protein	0.0009	0.0086	0.0127
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.012	0.012
Schistosoma mansoni	hypothetical protein	0.0018	0.0288	0.0288
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0514	0.0761
Loa Loa (eye worm)	Smad1	0.0009	0.0086	0.0127
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0514	0.4223
Trichomonas vaginalis	glucosylceramidase, putative	0.0197	0.437	0.6479
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.009	0.009
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.012	0.012
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.012	0.012
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0002	0.0003
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0288	0.0288
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.0775	0.1151
Trichomonas vaginalis	glucosylceramidase, putative	0.0301	0.6729	1
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0136	0.2973	0.2973
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0288	0.0288
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0087	0.1862	0.3212
Onchocerca volvulus		0.0031	0.0581	0.1085
Onchocerca volvulus		0.0023	0.0388	0.0632
Trichomonas vaginalis	ran, putative	0.0021	0.0344	0.0468
Echinococcus multilocularis	musashi	0.0028	0.0514	0.0514
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0962	0.0962
Schistosoma mansoni	hypothetical protein	0.0018	0.0288	0.0288
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0392	0.054
Schistosoma mansoni	hypothetical protein	0.0444	1	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0087	0.1862	0.3212
Echinococcus granulosus	pyruvate kinase	0.002	0.032	0.032
Echinococcus multilocularis	Smad4	0.0009	0.0086	0.0086
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0514	0.0514
Brugia malayi	ecdysteroid receptor	0.0011	0.012	0.0178
Schistosoma mansoni	coup transcription factor	0.0011	0.012	0.012
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.012	0.012
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0514	0.0763
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.012	0.0178
Trichomonas vaginalis	glucosylceramidase, putative	0.0208	0.4613	0.684
Brugia malayi	intermediate filament protein	0.0028	0.0514	0.0763
Onchocerca volvulus	Pyruvate kinase homolog	0.0038	0.0747	0.1476
Loa Loa (eye worm)	hypothetical protein	0.0011	0.012	0.0177
Trichomonas vaginalis	pyruvate kinase, putative	0.0038	0.0747	0.107
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.012	0.0178
Onchocerca volvulus		0.0023	0.0388	0.0632
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0047	0.0949	0.0949
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.023	0.512	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0301	0.6729	1
Giardia lamblia	Histone acetyltransferase GCN5	0.0043	0.0859	0.1123
Echinococcus granulosus	pyruvate kinase	0.0038	0.0747	0.0747
Schistosoma mansoni	pyruvate kinase	0.002	0.032	0.032
Echinococcus multilocularis	pyruvate kinase	0.0038	0.0747	0.0747
Echinococcus multilocularis	RUN	0.0023	0.0388	0.0388
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0002	0.0003
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0514	0.0405
Loa Loa (eye worm)	pyruvate kinase	0.0038	0.0747	0.1106
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.023	0.512	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0143	0.3128	0.4624
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0392	0.054
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.012	0.012
Brugia malayi	pyruvate kinase, muscle isozyme	0.0008	0.0054	0.0081
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.012	0.012
Schistosoma mansoni	hypothetical protein	0.0018	0.0288	0.0288
Loa Loa (eye worm)	MH2 domain-containing protein	0.0139	0.3041	0.4502
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.012	0.012
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0392	0.0454
Echinococcus granulosus	Polycystic kidney disease protein	0.0023	0.0388	0.0388
Schistosoma mansoni	cpg binding protein	0.0033	0.0621	0.0621
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.012	0.012
Plasmodium falciparum	LCCL domain-containing protein	0.0023	0.0388	0.0142
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0038	0.0747	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0388	0.0575
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.012	0.012
Schistosoma mansoni	polycystin 1-related	0.0023	0.0388	0.0388
Schistosoma mansoni	ran	0.0021	0.0344	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0011	0.012	0.0177
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0288	0.0429
Plasmodium vivax	multidomain scavenger receptor, putative	0.0023	0.0388	0.0142
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0066	0.1378	0.1378
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.023	0.512	0.512
Schistosoma mansoni	pyruvate kinase	0.0038	0.0747	0.0747
Schistosoma mansoni	Smad4	0.0009	0.0086	0.0086
Onchocerca volvulus		0.0028	0.0514	0.0927
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0288	0.0288
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.012	0.012
Loa Loa (eye worm)	hypothetical protein	0.0011	0.012	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0002	0.0003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.012	0.0177
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0962	0.0962
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0962	0.0962
Brugia malayi	MH2 domain containing protein	0.0139	0.3041	0.4518
Echinococcus granulosus	lamin	0.0028	0.0514	0.0514
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0514	0.0514
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.023	0.512	1
Brugia malayi	MH2 domain containing protein	0.0009	0.0086	0.0127
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0038	0.0747	0.5
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0087	0.1862	0.3212
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.012	0.012
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0747	0.1106
Toxoplasma gondii	cathepsin CPC1	0.023	0.512	1
Trichomonas vaginalis	pyruvate kinase, putative	0.0038	0.0747	0.107
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0344	0.0344
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.1408	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.1408	0.1408
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.012	0.012
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0067	0.1408	1
Echinococcus multilocularis	Polycystic kidney disease protein	0.0023	0.0388	0.0388
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0046	0.0046
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.012	0.0177
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0002	0.0003
Schistosoma mansoni	cpg binding protein	0.0033	0.0621	0.0621
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0502	0.0743
Plasmodium falciparum	pyruvate kinase	0.0038	0.0747	0.089
Echinococcus multilocularis	pyruvate kinase	0.002	0.032	0.032
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0344	0.005
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0962	0.0962
Echinococcus multilocularis	dnaJ subfamily B	0.0444	1	1
Toxoplasma gondii	cathepsin CPC2	0.0087	0.1862	0.3212
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.012	0.0178
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.012	0.012
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0962	0.0962
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.012	0.012
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0087	0.0129
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0301	0.6729	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.012	0.0178
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0023	0.0388	0.0388
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.012	0.0178
Brugia malayi	hypothetical protein	0.0023	0.0388	0.0577
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0215	0.0319
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0046	0.0046
Trichomonas vaginalis	glucosylceramidase, putative	0.0301	0.6729	1
Echinococcus granulosus	pyruvate kinase	0.0038	0.0747	0.0747
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.012	0.0178
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0288	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1194	0.1767
Brugia malayi	pyruvate kinase	0.0008	0.0054	0.0081
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0046	0.0046
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0136	0.2973	0.2973
Onchocerca volvulus	Glucosylceramidase homolog	0.0197	0.437	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0301	0.6729	1
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0038	0.0747	0.1111
Trypanosoma brucei	pyruvate kinase 1	0.0038	0.0747	1
Schistosoma mansoni	hypothetical protein	0.004	0.0775	0.0775
Plasmodium falciparum	importin beta, putative	0.0028	0.0514	0.0405
Schistosoma mansoni	cpg binding protein	0.0031	0.0581	0.0581
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0006	0.0002	0.0003
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0063	0.1307	0.2056
Echinococcus multilocularis	pyruvate kinase	0.002	0.032	0.032
Plasmodium vivax	pyruvate kinase, putative	0.0038	0.0747	0.089
Echinococcus granulosus	pyruvate kinase	0.002	0.032	0.032
Brugia malayi	Smad1	0.0009	0.0086	0.0127
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0215	0.0318
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.012	0.0177
Giardia lamblia	Pyruvate kinase	0.0038	0.0747	0.089
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.018	0.018
Schistosoma mansoni	pyruvate kinase	0.0038	0.0747	0.0747
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.0002	0.0002
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0161	0.3541	0.3541
Echinococcus granulosus	pyruvate kinase	0.002	0.032	0.032
Schistosoma mansoni	hypothetical protein	0.0302	0.6754	0.6754
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.012	0.012
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.012	0.0177
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.012	0.012
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.1408	1
Giardia lamblia	Encystation-specific protease	0.0087	0.1862	0.3212
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.012	0.012
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0161	0.3541	0.3541
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.012	0.012
Loa Loa (eye worm)	MH2 domain-containing protein	0.0009	0.0086	0.0127
Brugia malayi	Pyruvate kinase, alpha/beta domain containing protein	0.0012	0.0135	0.0201
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0023	0.0388	0.0388
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0514	0.0761
Trichomonas vaginalis	glucosylceramidase, putative	0.0197	0.437	0.6479
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0288	0.0429
Loa Loa (eye worm)	pyruvate kinase	0.0038	0.0747	0.1106
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.023	0.512	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.012	0.012
Toxoplasma gondii	pyruvate kinase PyK1	0.0038	0.0747	0.089
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0288	0.0427
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.1194	0.1774
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.012	0.0177
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.023	0.512	1
Leishmania major	pyruvate kinase	0.0038	0.0747	0.3791
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0067	0.1408	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.012	0.0178
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0086	0.0086
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0009	0.0086	0.0086
Loa Loa (eye worm)	transcription factor SMAD2	0.0139	0.3041	0.4502
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0006	0.0002	0.0002
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0009	0.0086	0.0086
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.012	0.0178
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0002	0.0003
Entamoeba histolytica	pyruvate kinase, putative	0.0027	0.0482	0.2671
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0392	0.1198
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.018	0.018
Echinococcus granulosus	snurportin 1	0.0302	0.6754	0.6754
Schistosoma mansoni	smad	0.0009	0.0086	0.0086
Echinococcus multilocularis	snurportin 1	0.0302	0.6754	0.6754
Loa Loa (eye worm)	hypothetical protein	0.0014	0.018	0.0267
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0301	0.6729	0.9963
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0514	0.0762
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.0002	0.0002
Echinococcus multilocularis	lamin	0.0028	0.0514	0.0514
Onchocerca volvulus		0.0028	0.0514	0.0927
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.012	0.0177
Trypanosoma brucei	pyruvate kinase 1, putative	0.0038	0.0747	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0046	0.0046
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.1408	1
Brugia malayi	acetyltransferase, GNAT family protein	0.0161	0.3541	0.5262
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0067	0.1408	0.1408
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.012	0.012
Schistosoma mansoni	lamin	0.0028	0.0514	0.0514
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0087	0.1862	0.3212
Schistosoma mansoni	lamin	0.0028	0.0514	0.0514
Trichomonas vaginalis	glucosylceramidase, putative	0.0197	0.437	0.6479
Schistosoma mansoni	lipoxygenase	0.0095	0.2039	0.2039
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.012	0.012
Brugia malayi	MH1 domain containing protein	0.0009	0.0086	0.0127
Schistosoma mansoni	hypothetical protein	0.0018	0.0288	0.0288
Schistosoma mansoni	loxhd1	0.0023	0.0388	0.0388
Loa Loa (eye worm)	hypothetical protein	0.004	0.0775	0.1147
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0514	0.0761
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.012	0.0178
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0514	0.0514
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0169	0.025
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.012	0.012
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0344	0.005
Echinococcus granulosus	GPCR family 2	0.0018	0.0288	0.0288
Brugia malayi	hypothetical protein	0.0006	0.0002	0.0003
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.1194	0.1767
Loa Loa (eye worm)	pyruvate kinase-PB	0.0027	0.0482	0.0713
Toxoplasma gondii	preprocathepsin c precursor, putative	0.023	0.512	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0288	0.0427
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.012	0.012
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0047	0.0949	0.1311
Schistosoma mansoni	importin beta-1	0.0028	0.0514	0.0514
Brugia malayi	Importin beta-1 subunit	0.0028	0.0514	0.0764
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.1194	0.1774
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.012	0.0177
Trichomonas vaginalis	glucosylceramidase, putative	0.0197	0.437	0.6479
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.012	0.0178
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.012	0.012
Brugia malayi	nuclear hormone receptor	0.0011	0.012	0.0178
Trichomonas vaginalis	glucosylceramidase, putative	0.0197	0.437	0.6479
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0962	0.0962
Loa Loa (eye worm)	histone methyltransferase	0.001	0.009	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0011	0.012	0.0177
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.012	0.0178
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.009	0.009
Schistosoma mansoni	rab6-interacting	0.0023	0.0388	0.0388
Echinococcus granulosus	RUN	0.0023	0.0388	0.0388
Brugia malayi	hypothetical protein	0.0023	0.0388	0.0577
Brugia malayi	nuclear receptor NHR-88	0.0011	0.012	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0002	0.0003
Loa Loa (eye worm)	doublecortin family protein	0.0023	0.0388	0.0575
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0047	0.0949	0.1371
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0344	0.005
Onchocerca volvulus	Pyruvate kinase homolog	0.0038	0.0747	0.1476
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.012	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0011	0.012	0.0177
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0046	0.0046
Echinococcus granulosus	lipoxygenase domain containing protein	0.0023	0.0388	0.0388
Echinococcus multilocularis	pyruvate kinase	0.002	0.032	0.032
Echinococcus granulosus	lamin dm0	0.0028	0.0514	0.0514
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0009	0.0086	0.0086
Brugia malayi	steroid hormone receptor	0.0011	0.012	0.0178
Brugia malayi	MH2 domain containing protein	0.0009	0.0086	0.0127
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0038	0.0747	0.1111
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0086	0.0086
Chlamydia trachomatis	pyruvate kinase	0.0038	0.0747	0.5
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0169	0.025
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0156	0.3438	0.3438
Leishmania major	pyruvate kinase	0.0038	0.0747	0.3791
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0962	0.1425
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0047	0.0949	0.1371
Echinococcus multilocularis	pyruvate kinase	0.003	0.0562	0.0562
Trichomonas vaginalis	glucosylceramidase, putative	0.0208	0.4613	0.684
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.1408	0.1408
Brugia malayi	hypothetical protein	0.0006	0.0002	0.0003
Trichomonas vaginalis	glucosylceramidase, putative	0.0301	0.6729	1
Loa Loa (eye worm)	acetyltransferase	0.0161	0.3541	0.5243
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.012	0.012
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0581	0.086
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.012	0.012
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0962	0.143
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0962	0.0962
Echinococcus granulosus	Smad4	0.0009	0.0086	0.0086
Brugia malayi	RNA, U transporter 1	0.008	0.1703	0.2531
Echinococcus granulosus	cpg binding protein	0.0033	0.0621	0.0621
Echinococcus granulosus	smad	0.0009	0.0086	0.0086
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.012	0.012
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0388	0.0575
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.012	0.012
Plasmodium falciparum	histone acetyltransferase GCN5	0.0043	0.0859	0.1123
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0514	0.4223
Loa Loa (eye worm)	hypothetical protein	0.0011	0.012	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0011	0.012	0.0177
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.012	0.0177
Entamoeba histolytica	acetyltransferase, GNAT family	0.0043	0.0859	1
Echinococcus granulosus	mothers against decapentaplegic 5	0.0009	0.0086	0.0086
Schistosoma mansoni	lipoxygenase	0.0136	0.2973	0.2973
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0047	0.0949	0.1311
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0344	0.0344
Echinococcus multilocularis	smad	0.0009	0.0086	0.0086
Echinococcus multilocularis	cpg binding protein	0.0033	0.0621	0.0621
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0067	0.1408	0.1408
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0038	0.0747	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0514	0.0405
Toxoplasma gondii	aldehyde dehydrogenase	0.0067	0.1408	0.2266
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0086	0.0086
Entamoeba histolytica	hypothetical protein	0.0023	0.0392	0.0938
Trichomonas vaginalis	glucosylceramidase, putative	0.0197	0.437	0.6479
Loa Loa (eye worm)	hypothetical protein	0.0011	0.012	0.0177
Echinococcus multilocularis	lamin dm0	0.0028	0.0514	0.0514
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0392	0.054
Schistosoma mansoni	hypothetical protein	0.0023	0.0388	0.0388
Brugia malayi	nuclear receptor RXR	0.0006	0.0002	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0482	0.0713
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0581	0.0863
Brugia malayi	MH1 domain containing protein	0.0009	0.0086	0.0127
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0344	0.0511
Echinococcus multilocularis	pyruvate kinase	0.0038	0.0747	0.0747
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.012	0.0178
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.012	0.0178
Loa Loa (eye worm)	pyruvate kinase	0.0038	0.0747	0.1106
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0006	0.0002	0.0002
Echinococcus granulosus	lipoxygenase domain containing protein	0.0023	0.0388	0.0388
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0047	0.0949	0.1311
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0002	0.0003
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0302	0.6754	1
Schistosoma mansoni	ran	0.0021	0.0344	0.0344
Schistosoma mansoni	rab6-interacting	0.0023	0.0388	0.0388
Brugia malayi	Doublecortin family protein	0.0023	0.0388	0.0577
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.012	0.012
Trichomonas vaginalis	glucosylceramidase, putative	0.0197	0.437	0.6479
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0009	0.0086	0.0086
Trichomonas vaginalis	glucosylceramidase, putative	0.0301	0.6729	1
Echinococcus granulosus	intermediate filament protein	0.0028	0.0514	0.0514
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.012	0.012
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0288	0.0288
Loa Loa (eye worm)	pyruvate kinase	0.0008	0.0054	0.0081

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1580 nM	Inhibition of human recombinant cathepsin C	ChEMBL.	19665376

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1079350

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1105999