Detailed information for compound 1106136

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 726.76 | Formula: C31H38N10O9S
  • H donors: 6 H acceptors: 12 LogP: 1.44 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 4
  • SMILES: O[C@@H]1[C@H](O)[C@H](O[C@H]1n1cnc2c1nc(nc2N)n1nnc(c1)c1ccc(cc1)O)COS(=O)(=O)NC(=O)c1ccccc1O.CCN(CC)CC
  • InChi: 1S/C25H23N9O9S.C6H15N/c26-21-18-22(29-25(28-21)34-9-15(30-32-34)12-5-7-13(35)8-6-12)33(11-27-18)24-20(38)19(37)17(43-24)10-42-44(40,41)31-23(39)14-3-1-2-4-16(14)36;1-4-7(5-2)6-3/h1-9,11,17,19-20,24,35-38H,10H2,(H,31,39)(H2,26,28,29);4-6H2,1-3H3/t17-,19-,20-,24-;/m1./s1
  • InChiKey: MTNMWVMXDFNHJX-HPLROQDGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Get druggable targets OG5_146698 All targets in OG5_146698
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase Get druggable targets OG5_146698 All targets in OG5_146698
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 565 aa 475 aa 27.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0102 0.1488
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0055 0.0174 0.059
Echinococcus multilocularis thioredoxin glutathione reductase 0.0094 0.0332 0.0332
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0675 0.2701 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0055 0.0174 0.059
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1124 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0081 0.0278 0.0913
Loa Loa (eye worm) hypothetical protein 0.0058 0.0187 0.0614
Plasmodium falciparum glutathione reductase 0.0032 0.0081 0.1186
Treponema pallidum NADH oxidase 0.0032 0.0081 0.0565
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0123 0.0453 0.1388
Brugia malayi MH1 domain containing protein 0.0017 0.0018 0.0058
Loa Loa (eye worm) hypothetical protein 0.0058 0.0187 0.0614
Brugia malayi tailless protein 0.0058 0.0187 0.0614
Brugia malayi Smad1 0.0017 0.0018 0.0058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1124 1
Schistosoma mansoni apoferritin-2 0.0017 0.0019 0.0058
Schistosoma mansoni smad1 5 8 and 0.0017 0.0018 0.0054
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0123 0.0453 0.1488
Loa Loa (eye worm) hypothetical protein 0.0058 0.0187 0.0614
Mycobacterium ulcerans putative regulatory protein 0.0114 0.0413 0.1529
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0123 0.0453 0.1488
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0081 0.1186
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0081 0.1186
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0055 0.0174 0.0643
Brugia malayi photoreceptor-specific nuclear receptor 0.0123 0.0453 0.1488
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0018 0.0018
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0081 0.1186
Schistosoma mansoni lozenge 0.0056 0.0177 0.0543
Schistosoma mansoni lamin 0.0604 0.2413 0.7401
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0103 0.0316
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0102 0.0907
Brugia malayi hypothetical protein 0.002 0.003 0.0098
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1124 1
Trichomonas vaginalis guanylate cyclase, putative 0.0048 0.0147 0.1305
Schistosoma mansoni hypothetical protein 0.0036 0.0098 0.0301
Loa Loa (eye worm) DR-78 0.0058 0.0187 0.0614
Brugia malayi hypothetical protein 0.0445 0.1764 0.5797
Brugia malayi nuclear hormone receptor family member odr-7 0.0058 0.0187 0.0614
Schistosoma mansoni nuclear hormone receptor 0.0123 0.0453 0.1388
Trypanosoma brucei trypanothione reductase 0.0093 0.033 0.4813
Entamoeba histolytica hypothetical protein 0.0329 0.1291 1
Schistosoma mansoni ap endonuclease 0.0037 0.0102 0.0313
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0055 0.0174 0.0643
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0093 0.033 0.1121
Loa Loa (eye worm) hypothetical protein 0.0058 0.0187 0.0614
Schistosoma mansoni serine/threonine protein kinase 0.018 0.0685 0.2101
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0102 0.1488
Schistosoma mansoni cytochrome P450 0.0055 0.0174 0.0532
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0002 0.0019
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0102 0.0907
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0123 0.0453 0.0453
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0123 0.0453 0.1488
Loa Loa (eye worm) hypothetical protein 0.0053 0.0167 0.0548
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0147 0.1305
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0123 0.0453 0.1388
Plasmodium falciparum glutathione reductase 0.0093 0.033 0.4813
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0182 0.0598
Brugia malayi nuclear receptor NHR-88 0.0123 0.0453 0.1488
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0048 0.0147 0.1305
Loa Loa (eye worm) hypothetical protein 0.0048 0.0147 0.0482
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0292 0.1138 0.3491
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0278 0.2471
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0055 0.0174 0.059
Brugia malayi hypoxia-induced factor 1 0.0476 0.1888 0.6205
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0081 0.0723
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0007 0.0022
Schistosoma mansoni ferritin light chain 0.0017 0.0019 0.0058
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0081 0.0301
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0081 0.0249
Loa Loa (eye worm) hypothetical protein 0.0058 0.0187 0.0614
Brugia malayi hypothetical protein 0.0759 0.3043 1
Schistosoma mansoni hypothetical protein 0.0017 0.0018 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0123 0.0453 0.1488
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0123 0.0453 0.1388
Onchocerca volvulus Bile acid receptor homolog 0.0123 0.0453 0.1876
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0123 0.0453 0.0453
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0123 0.0453 0.1488
Loa Loa (eye worm) transcription factor SMAD2 0.0245 0.0949 0.312
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0058 0.0187 0.0573
Toxoplasma gondii cytochrome p450 superfamily protein 0.0055 0.0174 0.2534
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.005 0.0152 0.2223
Echinococcus granulosus ubiquitin specific protease 41 0.0081 0.0278 0.0852
Brugia malayi nuclear hormone receptor 0.0058 0.0187 0.0614
Loa Loa (eye worm) hypothetical protein 0.0058 0.0187 0.0614
Mycobacterium tuberculosis Probable reductase 0.0213 0.0817 0.2777
Schistosoma mansoni single-minded 0.0162 0.061 0.1872
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0115 0.0418 0.142
Echinococcus multilocularis tumor protein p63 0.0361 0.1422 0.1422
Loa Loa (eye worm) hypothetical protein 0.0445 0.1764 0.5797
Brugia malayi steroid hormone receptor 0.0123 0.0453 0.1488
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0123 0.0453 0.0453
Onchocerca volvulus 0.0123 0.0453 0.1876
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.0019 0.0205
Brugia malayi Nuclear hormone receptor E75 0.0058 0.0187 0.0614
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0215 0.3135
Loa Loa (eye worm) hypothetical protein 0.0544 0.2165 0.7116
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0081 0.0278 0.0852
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0081 0.0278 0.0278
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0055 0.0174 0.0643
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.005 0.0152 0.2223
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0018 0.0054
Schistosoma mansoni cpg binding protein 0.006 0.0195 0.0599
Schistosoma mansoni hypothetical protein 0.0155 0.058 0.178
Schistosoma mansoni serine/threonine protein kinase 0.018 0.0685 0.2101
Brugia malayi Steroid receptor seven-up type 2 0.0123 0.0453 0.1488
Leishmania major cytochrome p450-like protein 0.0092 0.0323 0.4711
Brugia malayi hypothetical protein 0.0544 0.2165 0.7116
Schistosoma mansoni hypothetical protein 0.0017 0.0018 0.0056
Echinococcus multilocularis ferritin 0.0017 0.0019 0.0019
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0115 0.0418 0.1373
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0055 0.0174 0.0643
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.0418 0.6099
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0055 0.0174 0.059
Loa Loa (eye worm) hypothetical protein 0.0115 0.0418 0.1373
Onchocerca volvulus 0.0115 0.0418 0.1731
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0123 0.0453 0.0453
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0055 0.0174 0.0643
Brugia malayi hypothetical protein 0.0065 0.0215 0.0708
Loa Loa (eye worm) hypothetical protein 0.0065 0.0215 0.0708
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0017 0.0019 0.1841
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0165 0.0506
Schistosoma mansoni ap endonuclease 0.0037 0.0102 0.0313
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.005 0.0152 0.2223
Loa Loa (eye worm) hypothetical protein 0.0123 0.0453 0.1488
Schistosoma mansoni aryl hydrocarbon receptor 0.0162 0.061 0.1872
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0018 0.0018
Loa Loa (eye worm) intermediate filament protein 0.0604 0.2413 0.793
Brugia malayi hypothetical protein 0.0058 0.0187 0.0614
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0098
Loa Loa (eye worm) glutathione reductase 0.0093 0.033 0.1084
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0018 0.0054
Schistosoma mansoni intermediate filament proteins 0.0604 0.2413 0.7401
Trichomonas vaginalis penicillin-binding protein, putative 0.0115 0.0418 0.3717
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0055 0.0174 0.0643
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0055 0.0174 0.0643
Schistosoma mansoni Smad4 0.0017 0.0018 0.0054
Loa Loa (eye worm) hypothetical protein 0.0053 0.0165 0.0542
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0147 0.1305
Loa Loa (eye worm) hypothetical protein 0.0123 0.0453 0.1488
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0098
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0081 0.1186
Loa Loa (eye worm) hypothetical protein 0.0037 0.0099 0.0324
Echinococcus multilocularis ubiquitin specific protease 41 0.0081 0.0278 0.0278
Echinococcus granulosus beta LACTamase domain containing family member 0.0115 0.0418 0.1281
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0081 0.0723
Echinococcus multilocularis ecdysone induced protein 78C 0.0123 0.0453 0.0453
Loa Loa (eye worm) hypothetical protein 0.0065 0.0215 0.0708
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0055 0.0174 0.0643
Brugia malayi Thioredoxin reductase 0.0093 0.033 0.1084
Brugia malayi Cytochrome P450 family protein 0.0055 0.0174 0.057
Onchocerca volvulus 0.0068 0.0227 0.094
Loa Loa (eye worm) hypothetical protein 0.0281 0.1093 0.3593
Loa Loa (eye worm) hypothetical protein 0.0036 0.0098 0.0322
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0081 0.0723
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0123 0.0453 0.1488
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0167 0.0548
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0102 0.0752
Brugia malayi Nuclear hormone receptor-like 1 0.0065 0.0215 0.0708
Loa Loa (eye worm) hypothetical protein 0.0604 0.2413 0.793
Schistosoma mansoni hypothetical protein 0.0055 0.0174 0.0532
Echinococcus granulosus FTZ F1 alpha 0.0123 0.0453 0.1388
Echinococcus multilocularis 0.0179 0.0679 0.0679
Trichomonas vaginalis guanylate cyclase, putative 0.0048 0.0147 0.1305
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0167 0.0548
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0018 0.0054
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0068 0.0227 0.0746
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.002 0.0067
Echinococcus multilocularis smad 0.0017 0.0018 0.0018
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0215 0.3135
Schistosoma mansoni nuclear hormone receptor 0.0058 0.0187 0.0573
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0048 0.0147 0.1305
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0329 0.1291 0.396
Brugia malayi Intermediate filament tail domain containing protein 0.0604 0.2413 0.793
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0102 0.0313
Onchocerca volvulus 0.0115 0.0418 0.1731
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0058 0.0187 0.0774
Onchocerca volvulus 0.0057 0.0182 0.0754
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0115 0.0418 0.1547
Trypanosoma cruzi trypanothione reductase, putative 0.0093 0.033 0.4813
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0081 0.0278 0.2471
Loa Loa (eye worm) hypothetical protein 0.0123 0.0453 0.1488
Loa Loa (eye worm) hypothetical protein 0.0058 0.0187 0.0614
Brugia malayi aryl hydrocarbon receptor AHR-1 0.002 0.003 0.0098
Schistosoma mansoni thyroid hormone receptor 0.0123 0.0453 0.1388
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0102 0.0907
Loa Loa (eye worm) hypothetical protein 0.0115 0.0418 0.1373
Loa Loa (eye worm) hypothetical protein 0.0123 0.0453 0.1488
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0055 0.0174 0.059
Loa Loa (eye worm) hypothetical protein 0.0065 0.0215 0.0708
Mycobacterium tuberculosis Probable esterase LipL 0.0115 0.0418 0.142
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0058 0.0187 0.0573
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0048 0.0147 1
Echinococcus granulosus ferritin 0.0017 0.0019 0.0058
Brugia malayi beta-lactamase family protein 0.0115 0.0418 0.1373
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1124 1
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0055 0.0174 0.059
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1124 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0055 0.0174 0.2534
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0048 0.0147 0.1305
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0081 0.1186
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0081 0.1186
Echinococcus granulosus cpg binding protein 0.006 0.0195 0.0599
Plasmodium vivax serine/threonine kinase-1, putative 0.018 0.0685 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0002 0.0019
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0123 0.0453 0.1488
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0021 0.007
Loa Loa (eye worm) hypothetical protein 0.0058 0.0187 0.0614
Brugia malayi hypothetical protein 0.0058 0.0187 0.0614
Echinococcus granulosus expressed protein 0.0017 0.0019 0.0058
Brugia malayi glutathione reductase 0.0093 0.033 0.1084
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0055 0.0174 0.0643
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0065 0.0215 0.0708
Trichomonas vaginalis adenylate cyclase, putative 0.0048 0.0147 0.1305
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0081 0.1186
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0123 0.0453 0.1388
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0123 0.0453 0.1488
Echinococcus granulosus Nuclear hormone receptor HR96 0.0058 0.0187 0.0573
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0002 0.0019
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.018 0.0685 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0058 0.0187 0.0187
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0081 0.1186
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0734 0.2941 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0123 0.0453 0.1876
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0123 0.0453 0.1388
Loa Loa (eye worm) hypothetical protein 0.0065 0.0215 0.0708
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0055 0.0174 0.0643
Brugia malayi beta-lactamase family protein 0.0115 0.0418 0.1373
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.039 0.5692
Entamoeba histolytica hypothetical protein 0.0329 0.1291 1
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.0418 0.6099
Brugia malayi orphan nuclear receptor NR2E1 0.0058 0.0187 0.0614
Giardia lamblia Kinase, CMGC CLK 0.018 0.0685 0.6094
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0213 0.0817 0.2777
Entamoeba histolytica hypothetical protein 0.0329 0.1291 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0081 0.0278 0.4054
Loa Loa (eye worm) CYP4Cod1 0.0092 0.0323 0.1061
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0098
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0081 0.0278 0.2471
Schistosoma mansoni smad 0.0017 0.0018 0.0054
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0018 0.006
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0081 0.1186
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0081 0.0278 0.0852
Brugia malayi MH2 domain containing protein 0.0017 0.0018 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0002 0.0019
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0065 0.0215 0.066
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1124 1
Schistosoma mansoni nuclear receptor 0.0058 0.0187 0.0573
Echinococcus multilocularis Protein lozenge 0.0056 0.0177 0.0177
Mycobacterium leprae Probable lipase LipE 0.0115 0.0418 0.4573
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0215 0.3135
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.002 0.003 0.0098
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0081 0.0301
Loa Loa (eye worm) hypothetical protein 0.0759 0.3043 1
Echinococcus granulosus Smad4 0.0017 0.0018 0.0054
Mycobacterium ulcerans lipase LipD 0.0115 0.0418 0.1547
Schistosoma mansoni transcription factor LCR-F1 0.0329 0.1291 0.396
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0123 0.0453 0.1388
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0123 0.0453 0.1488
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0102 0.0377
Loa Loa (eye worm) hypothetical protein 0.0017 0.0018 0.006
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 0.1124 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0092 0.0323 0.1061
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0092 0.0323 0.1195
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0123 0.0453 0.1488
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0048 0.0147 0.0147
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0058 0.0187 0.0614
Loa Loa (eye worm) hypothetical protein 0.0445 0.1764 0.5797
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0018 0.0058
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.0443 0.1357
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0002 0.0019
Plasmodium vivax hypothetical protein, conserved 0.0115 0.0418 0.6099
Schistosoma mansoni nuclear hormone receptor 0.0058 0.0187 0.0573
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0046 0.0152
Loa Loa (eye worm) hypothetical protein 0.0179 0.0679 0.2233
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.0418 0.3717
Echinococcus multilocularis lamin 0.0604 0.2413 0.2413
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0055 0.0174 0.059
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.002 0.003 0.0098
Mycobacterium tuberculosis Probable hydrolase 0.0115 0.0418 0.142
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0081 0.1186
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1124 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0058 0.0187 0.0187
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0123 0.0453 0.1388
Schistosoma mansoni survival motor neuron protein 0.0155 0.058 0.178
Brugia malayi cytochrome P450 0.0055 0.0174 0.057
Schistosoma mansoni ferritin 0.0017 0.0019 0.0058
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0324 0.1269 0.4171
Mycobacterium tuberculosis Probable lipase LipE 0.0115 0.0418 0.142
Mycobacterium tuberculosis Conserved protein 0.0115 0.0418 0.142
Schistosoma mansoni RAR-like nuclear receptor 0.0123 0.0453 0.1388
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0019 0.0064
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0018 0.006
Schistosoma mansoni apoferritin-2 0.0017 0.0019 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0123 0.0453 0.1488
Loa Loa (eye worm) hypothetical protein 0.0065 0.0215 0.0708
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0081 0.1186
Trypanosoma cruzi cytochrome P450, putative 0.0092 0.0323 0.4711
Schistosoma mansoni nuclear receptor nhr-48 0.0058 0.0187 0.0573
Brugia malayi beta-lactamase 0.0115 0.0418 0.1373
Brugia malayi nuclear receptor NHR-67 0.0058 0.0187 0.0614
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0019 0.0069
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0215 0.0215
Schistosoma mansoni smad1 5 8 and 0.0017 0.0018 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0123 0.0453 0.1488
Mycobacterium leprae putative cytochrome p450 0.0055 0.0174 0.19
Loa Loa (eye worm) hypothetical protein 0.0123 0.0453 0.1488
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0081 0.0278 0.4054
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0002 0.0019
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.018 0.0685 1
Mycobacterium tuberculosis Conserved protein 0.0115 0.0418 0.142
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0215 0.0706
Loa Loa (eye worm) nuclear hormone receptor 0.0058 0.0187 0.0614
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0098
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0123 0.0453 0.1388
Loa Loa (eye worm) hypothetical protein 0.0058 0.0187 0.0614
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0007 0.0007
Brugia malayi N-terminal motif family protein 0.0204 0.0781 0.2566
Brugia malayi follicle stimulating hormone receptor 0.0236 0.0911 0.2993
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0081 0.1186
Schistosoma mansoni coup transcription factor 0.0123 0.0453 0.1388
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0081 0.1186
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0115 0.0418 0.1281
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0055 0.0174 0.059
Schistosoma mansoni ferritin 0.0017 0.0019 0.0058
Onchocerca volvulus 0.0604 0.2413 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0058 0.0187 0.0614
Mycobacterium ulcerans beta-lactamase 0.0115 0.0418 0.1547
Mycobacterium leprae Possible regulatory protein 0.0048 0.0147 0.1606
Leishmania major trypanothione reductase 0.0093 0.033 0.4813
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0329 0.1291 0.1291
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0523 0.1779
Mycobacterium tuberculosis Probable lipase LipD 0.0115 0.0418 0.142
Schistosoma mansoni ferritin 0.0017 0.0019 0.0058
Trichomonas vaginalis helicase, putative 0.0013 0.0002 0.0019
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0123 0.0453 0.1488
Leishmania major protein kinase, putative 0.018 0.0685 1
Echinococcus multilocularis lamin dm0 0.0604 0.2413 0.2413
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0048 0.0147 0.045
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0102 0.1488
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0058 0.0187 0.0187
Brugia malayi Protein kinase domain containing protein 0.018 0.0685 0.2251
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0055 0.0174 0.0643
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0055 0.0174 0.2534
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0081 0.0278 0.0852
Trichomonas vaginalis penicillin-binding protein, putative 0.0115 0.0418 0.3717
Echinococcus granulosus survival motor neuron protein 1 0.0759 0.3043 0.9333
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0055 0.0174 0.059
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0018 0.0018
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0007 0.0022
Trypanosoma brucei cytochrome P450, putative 0.0092 0.0323 0.4711
Brugia malayi ecdysteroid receptor 0.0123 0.0453 0.1488
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0081 0.0278 0.0852
Loa Loa (eye worm) hypothetical protein 0.0292 0.1138 0.3741
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0123 0.0453 0.1488
Trichomonas vaginalis esterase, putative 0.0115 0.0418 0.3717
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0002 0.0019
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0098 0.0322
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0055 0.0174 0.0643
Trypanosoma brucei hypothetical protein, conserved 0.0115 0.0418 0.6099
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0215 0.0706
Plasmodium falciparum protein serine/threonine kinase-1 0.018 0.0685 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0102 0.0335
Echinococcus multilocularis expressed protein 0.0017 0.0019 0.0019
Loa Loa (eye worm) beta-lactamase 0.0115 0.0418 0.1373
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.018 0.0685 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0123 0.0453 0.1388
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0213 0.0817 0.8941
Brugia malayi nuclear receptor NHR-88 0.0058 0.0187 0.0614
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0081 0.1186
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0102 0.1488
Echinococcus multilocularis cpg binding protein 0.006 0.0195 0.0195
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.1124 0.8707
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0081 0.0278 0.2151
Schistosoma mansoni cpg binding protein 0.006 0.0195 0.0599
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0055 0.0174 0.059
Schistosoma mansoni thyroid hormone receptor 0.0123 0.0453 0.1388
Schistosoma mansoni ferritin light chain 0.0017 0.0019 0.0058
Schistosoma mansoni hypothetical protein 0.0017 0.0018 0.0056
Schistosoma mansoni nuclear receptor 0.0058 0.0187 0.0573
Onchocerca volvulus 0.0058 0.0187 0.0774
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0055 0.0174 0.0643
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0019 0.0064
Plasmodium vivax thioredoxin reductase, putative 0.0093 0.033 0.4813
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0081 0.7972
Brugia malayi Nuclear hormone receptor E75 0.0058 0.0187 0.0614
Brugia malayi hypothetical protein 0.0329 0.1291 0.4243
Loa Loa (eye worm) hypothetical protein 0.0281 0.1093 0.3593
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.018 0.0685 1
Trypanosoma cruzi cytochrome P450, putative 0.0092 0.0323 0.4711
Plasmodium vivax glutathione reductase, putative 0.0093 0.033 0.4813
Loa Loa (eye worm) hypothetical protein 0.0204 0.0781 0.2566
Echinococcus multilocularis GPCR, family 2 0.0017 0.0018 0.0018
Toxoplasma gondii ABC1 family protein 0.0115 0.0418 0.6099
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.018 0.0685 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0065 0.0215 0.066
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0115 0.0418 0.142
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0055 0.0174 0.0643
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0055 0.0174 0.0643
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0055 0.0174 0.059
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0123 0.0453 0.1488
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0081 0.0278 0.0278
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0081 0.1186
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0102 0.0335
Loa Loa (eye worm) hypothetical protein 0.0058 0.0187 0.0614
Echinococcus multilocularis dnaJ subfamily B 0.0812 0.326 0.326
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0123 0.0453 0.1488
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0102 0.1488
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0102 0.0102
Echinococcus granulosus ecdysone induced protein 78C 0.0123 0.0453 0.1388
Loa Loa (eye worm) CMGC/CLK protein kinase 0.018 0.0685 0.2251
Schistosoma mansoni ferritin 0.0017 0.0019 0.0058
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0055 0.0174 0.059
Echinococcus multilocularis Smad4 0.0017 0.0018 0.0018
Onchocerca volvulus 0.0115 0.0418 0.1731
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0055 0.0174 0.059
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0046 0.0152
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.1124 0.8707
Brugia malayi Cytochrome P450 family protein 0.0092 0.0323 0.1061
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0213 0.0817 0.2777
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0204 0.0781 0.3236
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0123 0.0453 0.1488
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0055 0.0174 0.0643
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0002 0.0019
Echinococcus multilocularis dual specificity protein kinase clk2 0.018 0.0685 0.0685
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0002 0.0019
Leishmania major protein kinase, putative 0.0054 0.017 0.2485
Brugia malayi nuclear hormone receptor 0.0123 0.0453 0.1488
Onchocerca volvulus 0.0053 0.0165 0.0684
Echinococcus granulosus lamin dm0 0.0604 0.2413 0.7401
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0123 0.0453 0.1388
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0213 0.0817 0.2777
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0103 0.0103
Echinococcus multilocularis musashi 0.0604 0.2413 0.2413
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0123 0.0453 0.1488
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0102 0.0789
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0292 0.1138 0.1138
Echinococcus multilocularis survival motor neuron protein 1 0.0759 0.3043 0.3043
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.0911 0.2993
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.0418 0.3717
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0123 0.0453 0.1488
Brugia malayi intermediate filament protein 0.0604 0.2413 0.793
Echinococcus granulosus aryl hydrocarbon receptor 0.0068 0.0227 0.0696
Echinococcus granulosus thioredoxin glutathione reductase 0.0094 0.0332 0.1018
Echinococcus multilocularis FTZ F1 alpha 0.0123 0.0453 0.0453
Loa Loa (eye worm) hypothetical protein 0.0081 0.0278 0.0913
Brugia malayi nuclear receptor RXR 0.0065 0.0215 0.0708
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0123 0.0453 0.1388
Echinococcus granulosus single minded 2 0.0114 0.0413 0.1267
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0215 0.3135
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0018 0.0056
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0055 0.0174 0.2534
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0058 0.0187 0.0774
Onchocerca volvulus 0.0114 0.0413 0.1712
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.002 0.003 0.0091
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0523 0.5727
Echinococcus granulosus dnaJ subfamily B 0.0812 0.326 1
Mycobacterium ulcerans hypothetical protein 0.0115 0.0418 0.1547
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0002 0.0019
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0065 0.0215 0.066
Loa Loa (eye worm) hypoxia-induced factor 1 0.0476 0.1888 0.6205
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0147 0.1305
Mycobacterium leprae Conserved hypothetical protein 0.0055 0.0174 0.19
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0123 0.0453 0.0453
Brugia malayi PAS domain containing protein 0.0162 0.061 0.2006
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0007 0.0022
Echinococcus granulosus thyroid hormone receptor alpha 0.0058 0.0187 0.0573
Mycobacterium tuberculosis Conserved protein 0.0115 0.0418 0.142
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0002 0.0019
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0055 0.0174 0.0643
Trichomonas vaginalis ferritin, putative 0.0017 0.0019 0.0167
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0155 0.058 0.1908
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0055 0.0174 0.059
Mycobacterium tuberculosis Probable oxidoreductase 0.0237 0.0914 0.3106
Loa Loa (eye worm) hypothetical protein 0.0058 0.0187 0.0614
Loa Loa (eye worm) hypothetical protein 0.0123 0.0453 0.1488
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0048 0.0147 0.1305
Toxoplasma gondii exonuclease III APE 0.0037 0.0102 0.1488
Toxoplasma gondii thioredoxin reductase 0.0093 0.033 0.4813
Loa Loa (eye worm) hypothetical protein 0.0593 0.2368 0.7781
Loa Loa (eye worm) runx1 0.0056 0.0177 0.0582
Loa Loa (eye worm) steroid hormone receptor 0.0123 0.0453 0.1488
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0115 0.0418 0.1373
Loa Loa (eye worm) cytochrome P450 family protein 0.0092 0.0323 0.1061
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0048 0.0147 0.1305
Onchocerca volvulus 0.0445 0.1764 0.7311
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0123 0.0453 0.0453
Brugia malayi Cytochrome P450 family protein 0.0154 0.0578 0.1898
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0081 0.1186
Mycobacterium ulcerans esterase/lipase LipP 0.0115 0.0418 0.1547
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0081 0.0249
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0604 0.2413 0.793
Brugia malayi Nuclear hormone receptor-like 1 0.0123 0.0453 0.1488
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0055 0.0174 0.2534
Brugia malayi hypothetical protein 0.0065 0.0215 0.0708
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0237 0.0914 0.3106
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.002 0.003 0.0098
Leishmania major cytochrome p450-like protein 0.0055 0.0174 0.2534
Plasmodium falciparum thioredoxin reductase 0.0032 0.0081 0.1186
Brugia malayi conserved hypotetical protein 0.0058 0.0187 0.0614
Onchocerca volvulus 0.0021 0.0034 0.0142
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0215 0.1664
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0019 0.0069
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0081 0.1186
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0055 0.0174 0.059
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0055 0.0174 0.059
Leishmania major hypothetical protein, conserved 0.0115 0.0418 0.6099
Brugia malayi MH2 domain containing protein 0.0017 0.0018 0.0058
Brugia malayi cytoplasmic intermediate filament protein 0.0324 0.1269 0.4171
Loa Loa (eye worm) MH2 domain-containing protein 0.0245 0.0949 0.312
Echinococcus granulosus nuclear receptor nhr 48 0.0058 0.0187 0.0573
Schistosoma mansoni zinc finger protein 0.0058 0.0187 0.0573
Mycobacterium tuberculosis Probable dehydrogenase 0.0213 0.0817 0.2777
Onchocerca volvulus 0.0604 0.2413 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0058 0.0187 0.0573
Echinococcus granulosus cytochrome P450 2K1 0.0055 0.0174 0.0532
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0055 0.0174 0.0643
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0055 0.0174 0.059
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0081 0.1186
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0018 0.0056
Leishmania major protein kinase, putative 0.005 0.0152 0.2223
Brugia malayi ecdysone receptor 0.0058 0.0187 0.0614
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0081 0.1186
Loa Loa (eye worm) hypothetical protein 0.0115 0.0418 0.1373
Echinococcus granulosus dual specificity protein kinase clk2 0.018 0.0685 0.2101
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0048 0.0147 0.2141
Schistosoma mansoni hypothetical protein 0.0812 0.326 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0081 0.0278 0.4054
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0213 0.0817 0.2777
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0081 0.0081
Leishmania major cytochrome p450-like protein 0.0055 0.0174 0.2534
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0081 0.0267
Onchocerca volvulus Protein ultraspiracle homolog 0.0123 0.0453 0.1876
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0123 0.0453 0.1488
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0002 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1124 1
Mycobacterium leprae conserved hypothetical protein 0.0115 0.0418 0.4573
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0018 0.0058
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.0418 0.3717
Trichomonas vaginalis CMGC family protein kinase 0.018 0.0685 0.6094
Echinococcus granulosus GPCR family 2 0.0017 0.0018 0.0056
Loa Loa (eye worm) hypothetical protein 0.0123 0.0453 0.1488
Echinococcus granulosus smad 0.0017 0.0018 0.0054
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.018 0.0685 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0055 0.0174 0.059
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0081 0.0278 0.4054
Onchocerca volvulus 0.0155 0.058 0.2406
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0167 0.0548
Loa Loa (eye worm) hypothetical protein 0.0115 0.0418 0.1373
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0002 0.0019
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0081 0.0278 0.2471
Loa Loa (eye worm) hypothetical protein 0.0123 0.0453 0.1488
Echinococcus multilocularis aryl hydrocarbon receptor 0.0068 0.0227 0.0227
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0055 0.0174 0.0643
Brugia malayi CXXC zinc finger family protein 0.0057 0.0182 0.0598
Brugia malayi MH2 domain containing protein 0.0245 0.0949 0.312
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0058 0.0187 0.0187
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0021 0.0021
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0675 0.2701 0.9183
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0081 0.1186
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0055 0.0174 0.059
Echinococcus granulosus intermediate filament protein 0.0604 0.2413 0.7401
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0123 0.0453 0.1388
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0002 0.0019
Schistosoma mansoni hypothetical protein 0.0329 0.1291 0.396
Loa Loa (eye worm) cytochrome P450 0.0055 0.0174 0.057
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0018 0.006
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0237 0.0914 0.3106
Schistosoma mansoni retinoic acid receptor RXR 0.0123 0.0453 0.1388
Echinococcus multilocularis transfer RNA-Lys 0.0114 0.0413 0.0413
Schistosoma mansoni smad1 5 8 and 0.0017 0.0018 0.0054
Echinococcus granulosus hypothetical protein 0.0179 0.0679 0.2084
Echinococcus multilocularis 0.0055 0.0174 0.0174
Schistosoma mansoni hypothetical protein 0.0017 0.0018 0.0056
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0102 0.0346
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0055 0.0174 0.2534
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0058 0.0187 0.0573
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0115 0.0418 0.1281
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0081 0.0276
Schistosoma mansoni lamin 0.0604 0.2413 0.7401
Echinococcus granulosus lamin 0.0604 0.2413 0.7401
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0002 0.0019
Echinococcus multilocularis thyroid hormone receptor alpha 0.0123 0.0453 0.0453
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0055 0.0174 0.0643
Brugia malayi Cytochrome P450 family protein 0.0092 0.0323 0.1061
Brugia malayi hypothetical protein 0.002 0.003 0.0098
Plasmodium falciparum thioredoxin reductase 0.0093 0.033 0.4813
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0081 0.1186
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0021 0.0066
Onchocerca volvulus 0.0058 0.0187 0.0774
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0115 0.0418 0.142
Loa Loa (eye worm) hypothetical protein 0.0058 0.0187 0.0614
Leishmania major protein kinase, putative 0.018 0.0685 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0002 0.0019
Loa Loa (eye worm) thioredoxin reductase 0.0093 0.033 0.1084
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0055 0.0174 0.059
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0002 0.0019
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0215 0.0659
Brugia malayi nuclear receptor RXR 0.0058 0.0187 0.0614
Schistosoma mansoni cpg binding protein 0.0057 0.0182 0.0558
Loa Loa (eye worm) hypothetical protein 0.0058 0.0187 0.0614
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0523 0.1937
Onchocerca volvulus Protein cycle homolog 0.002 0.003 0.0123
Echinococcus granulosus tumor protein p63 0.0361 0.1422 0.4361
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0102 0.1488
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0058 0.0187 0.0187
Brugia malayi nuclear hormone receptor family member nhr-6 0.0058 0.0187 0.0614
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0065 0.0215 0.0215
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0123 0.0453 0.1388
Entamoeba histolytica hypothetical protein 0.0329 0.1291 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0115 0.0418 0.0418
Loa Loa (eye worm) Smad1 0.0017 0.0018 0.0058
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0018 0.0018
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0102 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0048 0.0147 0.2141
Brugia malayi Nuclear hormone receptor-like 1 0.0065 0.0215 0.0708
Loa Loa (eye worm) cytochrome P450 family protein 0.0154 0.0578 0.1898
Schistosoma mansoni steroid hormone receptor ad4bp 0.0123 0.0453 0.1388
Loa Loa (eye worm) hypothetical protein 0.0115 0.0418 0.1373
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0081 0.7972
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0081 0.1186
Treponema pallidum fructose-bisphosphate aldolase 0.0288 0.1124 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.0418 0.1373
Brugia malayi MH1 domain containing protein 0.0017 0.0018 0.0058
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.005 0.0152 0.2223
Brugia malayi bHLH-PAS transcription factor 0.0114 0.0413 0.1357
Echinococcus multilocularis nuclear receptor nhr 48 0.0058 0.0187 0.0187
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0081 0.0301
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0237 0.0914 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0081 0.1186
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.018 0.0685 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0058 0.0187 0.0614
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0048 0.0147 0.2141
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0058 0.0187 0.0573
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0215 0.0659

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.61 nM Inhibition of Mycobacterium tuberculosis MbtA expressed in Escherichia coli assessed as ATP-[32P]Ppi exchange ChEMBL. 19053762
MIC99 (functional) = 1.56 uM Antimicrobial activity against Mycobacterium tuberculosis H37Rv in Fe-deficient medium by broth microdilution method ChEMBL. 19053762
MIC99 (functional) = 6.25 uM Antimicrobial activity against Mycobacterium tuberculosis H37Rv in Fe-rich medium by broth microdilution method ChEMBL. 19053762

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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