Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TEK tyrosine kinase, endothelial | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA binding protein | 0.0068 | 0.5122 | 0.5122 |
Schistosoma mansoni | Smad4 | 0.0009 | 0.0316 | 0.0495 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0316 | 0.0316 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.5122 | 0.5122 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0009 | 0.0316 | 0.0495 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0009 | 0.0316 | 0.0495 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.5122 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0127 | 1 | 1 |
Echinococcus granulosus | smad | 0.0009 | 0.0316 | 0.0495 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0316 | 0.0495 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0009 | 0.0316 | 0.0316 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.5122 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.5122 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0316 | 0.0495 |
Echinococcus multilocularis | smad | 0.0009 | 0.0316 | 0.0495 |
Loa Loa (eye worm) | Smad1 | 0.0009 | 0.0316 | 0.0316 |
Echinococcus granulosus | Smad4 | 0.0009 | 0.0316 | 0.0495 |
Schistosoma mansoni | smad | 0.0009 | 0.0316 | 0.0495 |
Echinococcus multilocularis | Smad4 | 0.0009 | 0.0316 | 0.0495 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0316 | 0.0316 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.5122 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.5122 | 0.5122 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0009 | 0.0316 | 0.0495 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.5122 | 0.5122 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.5122 | 0.5122 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0127 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.5122 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0009 | 0.0316 | 0.0495 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0316 | 0.0316 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0316 | 0.0316 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0009 | 0.0316 | 0.0495 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.5122 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0316 | 0.0495 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.5122 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.5122 | 0.5122 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0009 | 0.0316 | 0.0316 |
Brugia malayi | Smad1 | 0.0009 | 0.0316 | 0.0316 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.49 uM | Inhibition of Tie-2 phosphorylation by cell based assay | ChEMBL. | 19854647 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.