TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 436.489 | Formula: C24H30F2O5
H donors: 1 H acceptors: 4 LogP: 2.66 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCC(=O)O[C@@]1(CCC2C1(C)CC(O)[C@]1(C2C[C@@H](C2=CC(=O)C=CC12C)F)F)C(=O)C
InChi: 1S/C24H30F2O5/c1-5-20(30)31-23(13(2)27)9-7-15-16-11-18(25)17-10-14(28)6-8-21(17,3)24(16,26)19(29)12-22(15,23)4/h6,8,10,15-16,18-19,29H,5,7,9,11-12H2,1-4H3/t15?,16?,18-,19?,21?,22?,23-,24-/m0/s1
InChiKey: HNLYOLOBUQQTHZ-DKHXOQIWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	g-protein coupled receptor	0.045	0.457	0.457
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0259	0.0295
Echinococcus granulosus	fmrfamide receptor	0.045	0.457	0.457
Brugia malayi	ecdysteroid receptor	0.0838	0.8776	1
Echinococcus granulosus	neuropeptide s receptor	0.045	0.457	0.457
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Echinococcus granulosus	hypothetical protein	0.045	0.457	0.457
Brugia malayi	nuclear receptor NHR-88	0.0052	0.0259	0.0295
Onchocerca volvulus		0.045	0.457	0.5208
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.045	0.457	0.457
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.045	0.457	0.5208
Brugia malayi	hypothetical protein	0.045	0.457	0.5208
Echinococcus granulosus	neuropeptide FF receptor 2	0.045	0.457	0.457
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0052	0.0259	0.0259
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0052	0.0259	0.0295
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Loa Loa (eye worm)	neuropeptide F receptor	0.045	0.457	0.5208
Brugia malayi	Nuclear hormone receptor-like 1	0.0052	0.0259	0.0295
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.045	0.457	0.457
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0052	0.0259	0.0259
Schistosoma mansoni	adenoreceptor	0.045	0.457	0.457
Schistosoma mansoni	amine GPCR	0.045	0.457	0.457
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0052	0.0259	0.0295
Echinococcus granulosus	tm gpcr rhodopsin	0.045	0.457	0.457
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.045	0.457	0.457
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.045	0.457	0.457
Schistosoma mansoni	amine GPCR	0.045	0.457	0.457
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.045	0.457	0.457
Onchocerca volvulus		0.045	0.457	0.5208
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.045	0.457	0.457
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0052	0.0259	0.0295
Loa Loa (eye worm)	G-protein coupled receptor	0.045	0.457	0.5208
Echinococcus granulosus	g-protein coupled receptor	0.045	0.457	0.457
Loa Loa (eye worm)	neuropeptide F receptor	0.045	0.457	0.5208
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0052	0.0259	0.0295
Echinococcus multilocularis	neuropeptide receptor	0.045	0.457	0.457
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Brugia malayi	putative neuropeptide receptor	0.045	0.457	0.5208
Echinococcus multilocularis	g protein coupled receptor	0.045	0.457	0.457
Schistosoma mansoni	thyroid hormone receptor	0.0052	0.0259	0.0259
Schistosoma mansoni	hypothetical protein	0.045	0.457	0.457
Echinococcus multilocularis	dro:myosuppressin receptor	0.045	0.457	0.457
Echinococcus granulosus	neuropeptide receptor	0.045	0.457	0.457
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.045	0.457	0.457
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Echinococcus granulosus	neuropeptide Y receptor	0.045	0.457	0.457
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0052	0.0259	0.0295
Onchocerca volvulus	Protein ultraspiracle homolog	0.0052	0.0259	0.0295
Echinococcus multilocularis	neuropeptides capa receptor	0.045	0.457	0.457
Brugia malayi	Serotonin receptor	0.045	0.457	0.5208
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.045	0.457	0.457
Echinococcus multilocularis	neuropeptide s receptor	0.045	0.457	0.457
Brugia malayi	hypothetical protein	0.045	0.457	0.5208
Onchocerca volvulus		0.045	0.457	0.5208
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Echinococcus granulosus	rhodopsin orphan GPCR	0.045	0.457	0.457
Echinococcus multilocularis	neuropeptides capa receptor	0.045	0.457	0.457
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.045	0.457	0.457
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.045	0.457	0.457
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.045	0.457	0.457
Brugia malayi	hypothetical protein	0.045	0.457	0.5208
Brugia malayi	G-protein coupled receptor	0.045	0.457	0.5208
Echinococcus granulosus	rhodopsin orphan GPCR	0.045	0.457	0.457
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0052	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.045	0.457	0.457
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Echinococcus granulosus	alpha 1A adrenergic receptor	0.045	0.457	0.457
Brugia malayi	hypothetical protein	0.045	0.457	0.5208
Brugia malayi	Serotonin receptor	0.045	0.457	0.5208
Echinococcus granulosus	neuropeptide receptor A26	0.045	0.457	0.457
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.045	0.457	0.457
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.045	0.457	0.457
Echinococcus multilocularis	orexin receptor type 2	0.045	0.457	0.457
Brugia malayi	hypothetical protein	0.045	0.457	0.5208
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Echinococcus multilocularis	g protein coupled receptor	0.045	0.457	0.457
Loa Loa (eye worm)	TYRA-2 protein	0.045	0.457	0.5208
Brugia malayi	neuropeptide F receptor	0.045	0.457	0.5208
Schistosoma mansoni	histamine h1 receptor	0.045	0.457	0.457
Schistosoma mansoni	neuropeptide receptor	0.045	0.457	0.457
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0052	0.0259	0.0295
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.045	0.457	0.5208
Schistosoma mansoni	nuclear hormone receptor	0.0052	0.0259	0.0259
Echinococcus granulosus	rhodopsin orphan GPCR	0.045	0.457	0.457
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0052	0.0259	0.0295
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.045	0.457	0.457
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0052	0.0259	0.0259
Brugia malayi	RE15519p	0.045	0.457	0.5208
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.045	0.457	0.457
Onchocerca volvulus		0.045	0.457	0.5208
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0052	0.0259	0.0295
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.045	0.457	0.457
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.045	0.457	0.457
Brugia malayi	Dopamine receptor	0.045	0.457	0.5208
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0052	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Onchocerca volvulus		0.045	0.457	0.5208
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.045	0.457	0.457
Schistosoma mansoni	opsin-like receptor	0.045	0.457	0.457
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0052	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Schistosoma mansoni	tyrosine kinase	0.0951	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.045	0.457	0.457
Echinococcus multilocularis	fmrfamide receptor	0.045	0.457	0.457
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.045	0.457	0.457
Schistosoma mansoni	hypothetical protein	0.045	0.457	0.457
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0052	0.0259	0.0259
Brugia malayi	neuropeptide F receptor	0.045	0.457	0.5208
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0052	0.0259	0.0295
Echinococcus multilocularis	G protein coupled receptor 139	0.045	0.457	0.457
Schistosoma mansoni	retinoic acid receptor RXR	0.0052	0.0259	0.0259
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.045	0.457	0.457
Brugia malayi	Melatonin receptor type 1A	0.045	0.457	0.5208
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.045	0.457	0.5208
Brugia malayi	Steroid receptor seven-up type 2	0.0052	0.0259	0.0295
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.045	0.457	0.457
Echinococcus granulosus	somatostatin receptor	0.045	0.457	0.457
Brugia malayi	GnHR receptor homolog	0.045	0.457	0.5208
Echinococcus multilocularis	rhodopsin orphan GPCR	0.045	0.457	0.457
Echinococcus granulosus	G protein coupled receptor 139	0.045	0.457	0.457
Onchocerca volvulus	Bile acid receptor homolog	0.0838	0.8776	1
Brugia malayi	hypothetical protein	0.045	0.457	0.5208
Echinococcus multilocularis	ecdysone induced protein 78C	0.0052	0.0259	0.0259
Brugia malayi	G protein-coupled receptor	0.045	0.457	0.5208
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0052	0.0259	0.0259
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.045	0.457	0.5208
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Brugia malayi	hypothetical protein	0.045	0.457	0.5208
Echinococcus granulosus	rhodopsin orphan GPCR	0.045	0.457	0.457
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.045	0.457	0.5208
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.045	0.457	0.457
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Schistosoma mansoni	myosin xvIII	0.045	0.457	0.457
Echinococcus granulosus	sex peptide receptor	0.045	0.457	0.457
Echinococcus multilocularis	neuropeptide Y receptor	0.045	0.457	0.457
Schistosoma mansoni	alpha-1 adrenergic receptor	0.045	0.457	0.457
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0052	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0259	0.0295
Echinococcus multilocularis	rhodopsin orphan GPCR	0.045	0.457	0.457
Onchocerca volvulus		0.045	0.457	0.5208
Onchocerca volvulus		0.045	0.457	0.5208
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.045	0.457	0.457
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Echinococcus granulosus	FTZ F1 alpha	0.0052	0.0259	0.0259
Echinococcus multilocularis	neuropeptide Y receptor	0.045	0.457	0.457
Echinococcus multilocularis	rhodopsin orphan GPCR	0.045	0.457	0.457
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0052	0.0259	0.0295
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Brugia malayi	photoreceptor-specific nuclear receptor	0.0052	0.0259	0.0295
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0052	0.0259	0.0259
Echinococcus multilocularis	neuropeptide FF receptor 2	0.045	0.457	0.457
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.045	0.457	0.5208
Onchocerca volvulus		0.045	0.457	0.5208
Echinococcus granulosus	7tm_1 domain containing protein	0.045	0.457	0.457
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.045	0.457	0.5208
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.045	0.457	0.457
Schistosoma mansoni	tyrosine kinase	0.0929	0.9764	0.9764
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0052	0.0259	0.0259
Schistosoma mansoni	amine GPCR	0.045	0.457	0.457
Schistosoma mansoni	biogenic amine receptor	0.045	0.457	0.457
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.045	0.457	0.457
Brugia malayi	follicle stimulating hormone receptor	0.045	0.457	0.5208
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.045	0.457	0.457
Schistosoma mansoni	neuropeptide receptor	0.045	0.457	0.457
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0052	0.0259	0.0259
Brugia malayi	hypothetical protein	0.045	0.457	0.5208
Echinococcus granulosus	g protein coupled receptor	0.045	0.457	0.457
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0052	0.0259	0.0295
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0052	0.0259	0.0295
Echinococcus granulosus	rhodopsin orphan GPCR	0.045	0.457	0.457
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.045	0.457	0.457
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Echinococcus granulosus	neuropeptides capa receptor	0.045	0.457	0.457
Echinococcus granulosus	rhodopsin orphan GPCR	0.045	0.457	0.457
Echinococcus granulosus	neuropeptide Y receptor	0.045	0.457	0.457
Onchocerca volvulus		0.045	0.457	0.5208
Brugia malayi	Dopamine receptor protein 1	0.045	0.457	0.5208
Brugia malayi	nuclear hormone receptor	0.0052	0.0259	0.0295
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.045	0.457	0.457
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0052	0.0259	0.0259
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0052	0.0259	0.0295
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.045	0.457	0.457
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0052	0.0259	0.0295
Schistosoma mansoni	growth hormone secretagogue receptor	0.045	0.457	0.457
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0052	0.0259	0.0295
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.045	0.457	0.457
Schistosoma mansoni	biogenic amine receptor	0.045	0.457	0.457
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Echinococcus multilocularis	serotonin receptor	0.045	0.457	0.457
Echinococcus multilocularis	rhodopsin orphan GPCR	0.045	0.457	0.457
Echinococcus multilocularis	FTZ F1 alpha	0.0052	0.0259	0.0259
Echinococcus granulosus	peptide allatostatin:somatostatin	0.045	0.457	0.457
Onchocerca volvulus		0.045	0.457	0.5208
Onchocerca volvulus		0.045	0.457	0.5208
Schistosoma mansoni	neuropeptide f receptor 76f	0.045	0.457	0.457
Schistosoma mansoni	thyroid hormone receptor	0.0052	0.0259	0.0259
Echinococcus multilocularis	rhodopsin orphan GPCR	0.045	0.457	0.457
Onchocerca volvulus		0.045	0.457	0.5208
Schistosoma mansoni	hypothetical protein	0.045	0.457	0.457
Echinococcus multilocularis	rhodopsin orphan GPCR	0.045	0.457	0.457
Schistosoma mansoni	biogenic amine (5HT) receptor	0.045	0.457	0.457
Echinococcus granulosus	biogenic amine 5HT receptor	0.045	0.457	0.457
Echinococcus granulosus	allatostatin A receptor	0.045	0.457	0.457
Onchocerca volvulus	Neuropeptide F receptor homolog	0.045	0.457	0.5208
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0259	0.0295
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.045	0.457	0.5208
Schistosoma mansoni	opsin-like receptor	0.045	0.457	0.457
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.045	0.457	0.457
Echinococcus granulosus	orexin receptor type 2	0.045	0.457	0.457
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.045	0.457	0.457
Echinococcus multilocularis	tyrosine protein kinase shark	0.0951	1	1
Echinococcus multilocularis	neuropeptide receptor A26	0.045	0.457	0.457
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0052	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Echinococcus granulosus	rhodopsin orphan GPCR	0.045	0.457	0.457
Brugia malayi	hypothetical protein	0.045	0.457	0.5208
Echinococcus multilocularis	rhodopsin orphan GPCR	0.045	0.457	0.457
Brugia malayi	AKH receptor	0.045	0.457	0.5208
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.045	0.457	0.5208
Echinococcus granulosus	tm gpcr rhodopsin	0.045	0.457	0.457
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0259	0.0295
Brugia malayi	Tachykinin-like peptides receptor 99D	0.045	0.457	0.5208
Echinococcus granulosus	neuropeptide receptor	0.045	0.457	0.457
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0028	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0052	0.0259	0.0295
Schistosoma mansoni	hypothetical protein	0.045	0.457	0.457
Schistosoma mansoni	opsin-like receptor	0.045	0.457	0.457
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Brugia malayi	G-protein coupled receptor	0.045	0.457	0.5208
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0052	0.0259	0.0259
Echinococcus granulosus	ecdysone induced protein 78C	0.0052	0.0259	0.0259
Schistosoma mansoni	RAR-like nuclear receptor	0.0052	0.0259	0.0259
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.045	0.457	0.5208
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Echinococcus multilocularis	G-protein coupled receptor, putative	0.045	0.457	0.457
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Schistosoma mansoni	neuropeptide receptor	0.045	0.457	0.457
Onchocerca volvulus		0.045	0.457	0.5208
Echinococcus multilocularis	allatostatin A receptor	0.045	0.457	0.457
Loa Loa (eye worm)	steroid hormone receptor	0.0052	0.0259	0.0295
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0052	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0259	0.0295
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.045	0.457	0.457
Onchocerca volvulus		0.045	0.457	0.5208
Echinococcus multilocularis	rhodopsin orphan GPCR	0.045	0.457	0.457
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0052	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Loa Loa (eye worm)	melatonin receptor type 1A	0.045	0.457	0.5208
Schistosoma mansoni	amine GPCR	0.045	0.457	0.457
Schistosoma mansoni	biogenic amine (5HT) receptor	0.045	0.457	0.457
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.045	0.457	0.457
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.045	0.457	0.457
Echinococcus multilocularis	neuropeptide receptor	0.045	0.457	0.457
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.045	0.457	0.457
Schistosoma mansoni	neuropeptide F-like receptor	0.045	0.457	0.457
Echinococcus granulosus	tachykinin peptides receptor 99D	0.045	0.457	0.457
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0052	0.0259	0.0295
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0052	0.0259	0.0259
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0052	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Brugia malayi	G protein-coupled receptor F59B2.13	0.045	0.457	0.5208
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.045	0.457	0.457
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0259	0.0295
Echinococcus granulosus	7TM GPCR rhodopsin	0.045	0.457	0.457
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Echinococcus granulosus	tm gpcr rhodopsin	0.045	0.457	0.457
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0052	0.0259	0.0295
Echinococcus multilocularis	fmrfamide receptor	0.045	0.457	0.457
Onchocerca volvulus		0.045	0.457	0.5208
Echinococcus multilocularis	serotonin receptor	0.045	0.457	0.457
Echinococcus granulosus	serotonin receptor	0.045	0.457	0.457
Echinococcus granulosus	neuropeptides capa receptor	0.045	0.457	0.457
Echinococcus granulosus	biogenic amine 5HT receptor	0.045	0.457	0.457
Brugia malayi	ORL1-like opioid receptor	0.045	0.457	0.5208
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.045	0.457	0.5208
Echinococcus multilocularis	sex peptide receptor	0.045	0.457	0.457
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0052	0.0259	0.0295
Echinococcus multilocularis	somatostatin receptor	0.045	0.457	0.457
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0259	0.0295
Onchocerca volvulus		0.045	0.457	0.5208
Echinococcus granulosus	g protein coupled receptor	0.045	0.457	0.457
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Brugia malayi	putative neuropeptide receptor NPR1	0.045	0.457	0.5208
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Brugia malayi	Dopamine receptor protein 2	0.045	0.457	0.5208
Brugia malayi	hypothetical protein	0.045	0.457	0.5208
Onchocerca volvulus		0.0052	0.0259	0.0295
Brugia malayi	steroid hormone receptor	0.0052	0.0259	0.0295
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.045	0.457	0.457
Schistosoma mansoni	neuropeptide receptor	0.045	0.457	0.457
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Echinococcus multilocularis	g protein coupled receptor	0.045	0.457	0.457
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0052	0.0259	0.0295
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.045	0.457	0.457
Echinococcus granulosus	g protein coupled receptor	0.045	0.457	0.457
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0052	0.0259	0.0259
Schistosoma mansoni	neuropeptide F-like receptor	0.045	0.457	0.457
Brugia malayi	sulfakinin receptor protein	0.045	0.457	0.5208
Brugia malayi	larval opioid receptor	0.045	0.457	0.5208
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Loa Loa (eye worm)	G-protein coupled receptor	0.045	0.457	0.5208
Loa Loa (eye worm)	hypothetical protein	0.0838	0.8776	1
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Schistosoma mansoni	amine GPCR	0.045	0.457	0.457
Schistosoma mansoni	coup transcription factor	0.0052	0.0259	0.0259
Schistosoma mansoni	biogenic amine receptor	0.045	0.457	0.457
Echinococcus granulosus	dro:myosuppressin receptor	0.045	0.457	0.457
Onchocerca volvulus		0.045	0.457	0.5208
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.045	0.457	0.457
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0052	0.0259	0.0295
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0052	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.045	0.457	0.5208

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)		Antiinflammatory activity measured by using McKenzie-Stoughton human vasoconstrictor assay; Potent	ChEMBL.	3783574
Activity (functional)	P 0	Antiinflammatory activity measured by using McKenzie-Stoughton human vasoconstrictor assay; Potent	ChEMBL.	3783574
Potency (functional)	= 900	Potency relative to fluocinolone 16,17-acetonide in the human vasoconstictor test	ChEMBL.	6827553
Potency (functional)	= 900	Potency relative to fluocinolone 16,17-acetonide in the human vasoconstictor test	ChEMBL.	6827553

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL69922

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 110683