Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Blistered cuticle protein 3 | 0.0081 | 0.3713 | 0.4214 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0131 | 0.8036 | 1 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0131 | 0.8036 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.6134 | 0.7499 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0154 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0109 | 0.6152 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0044 | 0.0564 | 0.0177 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0109 | 0.6152 | 0.7479 |
Onchocerca volvulus | 0.0109 | 0.6152 | 1 | |
Brugia malayi | diacylglycerol acyltransferase | 0.0131 | 0.8036 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0109 | 0.6152 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0052 | 0.1205 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0081 | 0.3713 | 0.4317 |
Echinococcus granulosus | diacylglycerol O acyltransferase 1 | 0.0131 | 0.8036 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0044 | 0.0564 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0154 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0109 | 0.6152 | 0.7479 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0154 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0109 | 0.6152 | 0.7479 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0154 | 1 | 1 |
Echinococcus multilocularis | diacylglycerol O acyltransferase 1 | 0.0131 | 0.8036 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0109 | 0.6152 | 0.7523 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0154 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0052 | 0.1205 | 0.1148 |
Brugia malayi | hypothetical protein | 0.0052 | 0.1205 | 0.0858 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0109 | 0.6152 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0052 | 0.1205 | 0.1205 |
Echinococcus multilocularis | thymidylate synthase | 0.0109 | 0.6152 | 0.7479 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.