Detailed information for compound 1107420

Basic information

Technical information
  • TDR Targets ID: 1107420
  • Name: 5-chloro-3-methyl-N-[3-[[(2S)-1-methylpyrroli din-2-yl]methyl]-1H-indol-5-yl]-1-benzothioph ene-2-sulfonamide
  • MW: 474.039 | Formula: C23H24ClN3O2S2
  • H donors: 2 H acceptors: 2 LogP: 5.77 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCC[C@H]1Cc1c[nH]c2c1cc(cc2)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl
  • InChi: 1S/C23H24ClN3O2S2/c1-14-19-11-16(24)5-8-22(19)30-23(14)31(28,29)26-17-6-7-21-20(12-17)15(13-25-21)10-18-4-3-9-27(18)2/h5-8,11-13,18,25-26H,3-4,9-10H2,1-2H3/t18-/m0/s1
  • InChiKey: KQRPYRJEZVKCOI-SFHVURJKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-chloro-3-methyl-N-[3-[[(2S)-1-methylpyrrolidin-2-yl]methyl]-1H-indol-5-yl]benzothiophene-2-sulfonamide
  • 5-chloro-3-methyl-N-[3-[[(2S)-1-methyl-2-pyrrolidinyl]methyl]-1H-indol-5-yl]-2-benzothiophenesulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_145685 All targets in OG5_145685
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_145685 All targets in OG5_145685
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0175 0.0536
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0381 0.0381
Entamoeba histolytica cysteine protease, putative 0.0061 0.0175 0.2985
Loa Loa (eye worm) hypothetical protein 0.0083 0.0253 0.0631
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.011 0.0274
Brugia malayi cathepsin Z-like cysteine proteinase 0.0061 0.0175 0.0436
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.011 0.011
Loa Loa (eye worm) fibroinase 0.0178 0.0585 0.1459
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0253 0.0253
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0045 0.0329
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0013 0.0008 0.0129
Echinococcus multilocularis cathepsin L 0.0061 0.0175 0.0175
Giardia lamblia Cathepsin B precursor 0.04 0.1361 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0061 0.0175 0.0436
Echinococcus granulosus cytochrome P450 2K1 0.0013 0.0008 0.0008
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0021 0.0035 0.0035
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0086 0.0086
Schistosoma mansoni cpg binding protein 0.0034 0.0083 0.0083
Toxoplasma gondii cytochrome p450 superfamily protein 0.0013 0.0008 0.006
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0086 0.115
Brugia malayi Cytochrome P450 family protein 0.0059 0.017 0.0424
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0013 0.0008 0.0109
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0032 0.0099
Echinococcus granulosus FTZ F1 alpha 0.0042 0.011 0.011
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0013 0.0008 0.0129
Echinococcus multilocularis leucyl tRNA synthetase 0.0021 0.0035 0.0035
Plasmodium vivax vivapain-1 0.0108 0.0341 0.5565
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.012 0.0381 0.0949
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0215
Plasmodium falciparum serine repeat antigen 5 0.0061 0.0175 0.2541
Entamoeba histolytica cysteine protease, putative 0.0108 0.0341 0.5829
Trypanosoma cruzi cysteine proteinase, putative 0.0108 0.0341 0.085
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0081
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0013 0.0008 0.0109
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0061 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0042 0.011 0.0274
Loa Loa (eye worm) hypothetical protein 0.0021 0.0035 0.0088
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0215
Entamoeba histolytica cysteine proteinase, putative 0.0108 0.0341 0.5829
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0013 0.0008 0.0129
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0031 0.0419
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0178 0.0585 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0013 0.0008 0.0109
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0178 0.0585 0.1459
Schistosoma mansoni methionine-tRNA synthetase 0.0054 0.0151 0.0151
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0192 0.0633 0.4648
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0061 0.0175 0.2541
Mycobacterium ulcerans aldehyde dehydrogenase 0.0192 0.0633 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0007 0.0007
Brugia malayi nuclear hormone receptor 0.002 0.0032 0.0081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.013 0.0419 0.1044
Loa Loa (eye worm) hypothetical protein 0.0042 0.011 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.011 0.0274
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0054 0.0151 0.2016
Plasmodium falciparum cysteine proteinase falcipain 3 0.0178 0.0585 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0081
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0101
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.006 0.0944
Brugia malayi hypothetical protein 0.0238 0.0794 0.198
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0086 0.5706
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0045 1
Entamoeba histolytica cysteine proteinase, putative 0.0108 0.0341 0.5829
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0054 0.0151 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0032 0.0032
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0013 0.0008 0.0129
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0054 0.0151 0.2386
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0061 0.0175 0.0536
Entamoeba histolytica cysteine protease, putative 0.0061 0.0175 0.2985
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0013 0.0008 0.0129
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0086 0.0086
Brugia malayi Papain family cysteine protease containing protein 0.0061 0.0175 0.0436
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0318 0.1076 0.7901
Onchocerca volvulus Cathepsin L homolog 0.0178 0.0585 0.1795
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.04 0.1361 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.012 0.0381 0.0381
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0013 0.0013
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0045 0.0333
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1159 0.4012 0.4012
Brugia malayi MH2 domain containing protein 0.0117 0.037 0.0923
Giardia lamblia Cathepsin B precursor 0.0061 0.0175 0.1283
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.011 0.011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.006 0.0798
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0178 0.0585 0.1459
Onchocerca volvulus 0.0178 0.0585 0.1795
Schistosoma mansoni cathepsin F (C01 family) 0.013 0.0419 0.0419
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0086 0.0264
Brugia malayi cathepsin L-like precursor 0.013 0.0419 0.1044
Schistosoma mansoni aldehyde dehydrogenase 0.0192 0.0633 0.0633
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0101
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.011 0.011
Schistosoma mansoni nuclear hormone receptor 0.002 0.0032 0.0032
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0032 0.0081
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0013 0.0008 0.0109
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0045 0.0707
Brugia malayi nuclear receptor RXR 0.002 0.0032 0.0081
Giardia lamblia Leucyl-tRNA synthetase 0.0021 0.0035 0.0256
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0086 0.0932
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0585 0.1795
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0086 0.115
Schistosoma mansoni coup transcription factor 0.0042 0.011 0.011
Plasmodium falciparum serine repeat antigen 3 0.0061 0.0175 0.2541
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0086 0.0264
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0076 0.019
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0013 0.0008 0.0129
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0061 0.0175 0.2541
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.011 0.011
Echinococcus granulosus cathepsin l1 0.013 0.0419 0.0419
Trypanosoma cruzi cruzipain precursor, putative 0.0318 0.1076 0.2681
Mycobacterium ulcerans aldehyde dehydrogenase 0.0192 0.0633 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.013 0.0419 0.1044
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0041 0.0041
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0013 0.0008 0.002
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0081
Brugia malayi protein ZK524.3 0.0021 0.0035 0.0087
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0032 0.0032
Brugia malayi nuclear receptor RXR 0.0022 0.0041 0.0101
Schistosoma mansoni nuclear hormone receptor 0.002 0.0032 0.0032
Trypanosoma cruzi cysteine peptidase, putative 0.0178 0.0585 0.1459
Brugia malayi Cathepsin L-like precursor 0.0178 0.0585 0.1459
Plasmodium vivax unspecified product 0.0061 0.0175 0.2541
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0318 0.1076 0.7901
Brugia malayi Cathepsin L-like precursor 0.0048 0.013 0.0323
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0275 0.0687
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0061 0.0175 0.2541
Trypanosoma cruzi cysteine proteinase, putative 0.0108 0.0341 0.085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0175 0.0536
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0192 0.0633 0.0633
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0585 0.1795
Brugia malayi Cathepsin L-like precursor 0.0178 0.0585 0.1459
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0086 0.0264
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.0585 0.1795
Mycobacterium ulcerans lipase LipD 0.0035 0.0086 0.1361
Schistosoma mansoni leucyl-tRNA synthetase 0.0021 0.0035 0.0035
Onchocerca volvulus 0.0035 0.0086 0.0264
Trypanosoma cruzi major cysteine proteinase, putative 0.0201 0.0665 0.1658
Brugia malayi Cathepsin L-like precursor 0.0178 0.0585 0.1459
Entamoeba histolytica cysteine protease, putative 0.0061 0.0175 0.2985
Trypanosoma cruzi cysteine protease, putative 0.0108 0.0341 0.085
Schistosoma mansoni cathepsin F (C01 family) 0.0178 0.0585 0.0585
Plasmodium falciparum serine repeat antigen 4 0.0061 0.0175 0.2541
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0061 0.0175 0.1283
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0061 0.0175 0.1283
Brugia malayi CXXC zinc finger family protein 0.0032 0.0076 0.019
Plasmodium falciparum serine repeat antigen 1 0.0061 0.0175 0.2541
Loa Loa (eye worm) beta-lactamase 0.0035 0.0086 0.0215
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0163 0.0163
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0045 0.0113
Brugia malayi TAR-binding protein 0.0062 0.018 0.0448
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0045 0.0113
Echinococcus multilocularis cathepsin b 0.1159 0.4012 0.4012
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0108 0.0341 0.0341
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0007 0.0007
Echinococcus multilocularis cysteine protease 0.0178 0.0585 0.0585
Loa Loa (eye worm) cysteine protease 0.0178 0.0585 0.1459
Giardia lamblia Cathepsin B precursor 0.04 0.1361 1
Toxoplasma gondii cathepsin CPL 0.0178 0.0585 0.4299
Plasmodium vivax unspecified product 0.0048 0.013 0.1721
Toxoplasma gondii cathepsin B 0.04 0.1361 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0012 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0108 0.0341 0.1046
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0175 0.0536
Brugia malayi hypothetical protein 0.002 0.0032 0.0081
Echinococcus granulosus cathepsin L cysteine protease 0.0108 0.0341 0.0341
Loa Loa (eye worm) hypothetical protein 0.0061 0.0175 0.0436
Echinococcus granulosus dnaJ subfamily B 0.0461 0.1575 0.1575
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0035 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0585 0.1795
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0175 0.0536
Onchocerca volvulus 0.0178 0.0585 0.1795
Loa Loa (eye worm) hypothetical protein 0.013 0.0419 0.1044
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0061 0.0175 0.2541
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0163 0.0163
Leishmania major cathepsin L-like protease 0.0318 0.1076 0.7901
Brugia malayi AMP-binding enzyme family protein 0.0028 0.006 0.0149
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0086 0.0215
Leishmania major cysteine peptidase A (CPA) 0.0178 0.0585 0.4299
Brugia malayi Nuclear hormone receptor E75 0.002 0.0032 0.0081
Onchocerca volvulus 0.0178 0.0585 0.1795
Loa Loa (eye worm) hypothetical protein 0.0042 0.011 0.0274
Loa Loa (eye worm) hypothetical protein 0.0021 0.0035 0.0088
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0061 0.0175 0.2541
Echinococcus multilocularis dnaJ subfamily B 0.0461 0.1575 0.1575
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0013 0.0008 0.0129
Entamoeba histolytica hypothetical protein 0.0023 0.0045 0.0765
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.0045 0.0716
Onchocerca volvulus Huntingtin homolog 0.0122 0.0391 0.1198
Entamoeba histolytica cysteine protease, putative 0.0108 0.0341 0.5829
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0013 0.0008 0.0109
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0086 0.0215
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0086 0.0264
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.0585 0.1795
Onchocerca volvulus Cathepsin L homolog 0.0061 0.0175 0.0536
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0032 0.0081
Entamoeba histolytica cysteine proteinase, putative 0.013 0.0419 0.7156
Onchocerca volvulus 0.0061 0.0175 0.0536
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0163 0.2181
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0021 0.0035 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.012 0.0381 0.0381
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0061 0.0175 0.0536
Onchocerca volvulus 0.0033 0.0079 0.0243
Schistosoma mansoni tar DNA-binding protein 0.0062 0.018 0.018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0318 0.1076 0.7901
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0192 0.0633 0.0633
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0032 0.0032
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0061 0.0175 0.0175
Treponema pallidum leucyl-tRNA synthetase 0.0021 0.0035 0.7786
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0175 0.0536
Entamoeba histolytica cysteine proteinase 2 0.0108 0.0341 0.5829
Leishmania major cathepsin L-like protease 0.0318 0.1076 0.7901
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0021 0.0035 0.0595
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.0585 0.1795
Echinococcus granulosus cathepsin L 0.0108 0.0341 0.0341
Brugia malayi Cathepsin L-like precursor 0.0178 0.0585 0.1459
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0175 0.0536
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0081
Schistosoma mansoni cytochrome P450 0.0013 0.0008 0.0008
Plasmodium vivax unspecified product 0.0108 0.0341 0.5565
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.011 0.0274
Brugia malayi hypothetical protein 0.0122 0.0391 0.0974
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0035 0.0485
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0061 0.0175 0.0175
Echinococcus multilocularis cathepsin b 0.1159 0.4012 0.4012
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0013 0.0008 0.0129
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.011 0.0337
Echinococcus multilocularis methionine tRNA synthetase 0.0054 0.0151 0.0151
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.006 0.1021
Brugia malayi Pre-SET motif family protein 0.012 0.0381 0.0949
Schistosoma mansoni cpg binding protein 0.0034 0.0083 0.0083
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0192 0.0633 0.8449
Loa Loa (eye worm) hypothetical protein 0.0061 0.0175 0.0436
Brugia malayi RNA binding protein 0.0062 0.018 0.0448
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.011 0.011
Onchocerca volvulus 0.0032 0.0076 0.0234
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1159 0.4012 0.4012
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0045 0.2965
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.011 0.0274
Echinococcus granulosus cathepsin L 0.0061 0.0175 0.0175
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.0585 0.1795
Schistosoma mansoni cathepsin F (C01 family) 0.0178 0.0585 0.0585
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0061 0.0175 0.0436
Onchocerca volvulus 0.0178 0.0585 0.1795
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0585 0.1795
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0054 0.0151 0.0463
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0585 0.1795
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0061 0.0175 0.0536
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0013 0.0008 0.0109
Loa Loa (eye worm) hypothetical protein 0.0042 0.011 0.0274
Schistosoma mansoni hypothetical protein 0.0049 0.0133 0.0133
Schistosoma mansoni tar DNA-binding protein 0.0062 0.018 0.018
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0061 0.0175 0.0536
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0061 0.0175 0.0536
Giardia lamblia Methionyl-tRNA synthetase 0.0054 0.0151 0.1109
Plasmodium vivax methionine--tRNA ligase, putative 0.0054 0.0151 0.211
Plasmodium vivax vivapain-2 0.0178 0.0585 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.018 0.0448
Loa Loa (eye worm) hypothetical protein 0.0021 0.0035 0.0087
Echinococcus granulosus tar DNA binding protein 0.0062 0.018 0.018
Onchocerca volvulus 0.0035 0.0086 0.0264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0585 0.1795
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0013 0.0008 0.0129
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0061 0.0175 0.2541
Loa Loa (eye worm) hypothetical protein 0.0178 0.0585 0.1459
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.011 0.0274
Loa Loa (eye worm) ctsf protein 0.0178 0.0585 0.1459
Entamoeba histolytica cysteine protease, putative 0.0108 0.0341 0.5829
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0033 0.0079 0.0198
Entamoeba histolytica cysteine proteinase, putative 0.0178 0.0585 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1159 0.4012 1
Loa Loa (eye worm) histone methyltransferase 0.0014 0.0013 0.0034
Brugia malayi Papain family cysteine protease containing protein 0.0108 0.0341 0.085
Schistosoma mansoni cathepsin s 0.0048 0.013 0.013
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0045 0.0329
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.006 0.0944
Loa Loa (eye worm) hypothetical protein 0.1159 0.4012 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0163 0.2581
Giardia lamblia Encystation-specific protease 0.0061 0.0175 0.1283
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0045 0.0113
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0032 0.0099
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0081
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0215
Loa Loa (eye worm) hypothetical protein 0.0177 0.0582 0.1451
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0035 0.0009
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0032 0.0032
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.011 0.011
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0178 0.0585 0.0585
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0045 0.0707
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.011 0.0274
Loa Loa (eye worm) hypothetical protein 0.0122 0.0391 0.0974
Onchocerca volvulus 0.0178 0.0585 0.1795
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.011 0.0274
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0318 0.1076 0.7901
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.0585 0.1795
Brugia malayi cathepsin F-like cysteine proteinase 0.0048 0.013 0.0323
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0032 0.0081
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.011 0.0274
Mycobacterium leprae Conserved hypothetical protein 0.0013 0.0008 0.0541
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0032 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0585 0.1795
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0585 0.1795
Onchocerca volvulus 0.0178 0.0585 0.1795
Echinococcus multilocularis cpg binding protein 0.0034 0.0083 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0585 0.1795
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0081
Plasmodium falciparum serine repeat antigen 7 0.0061 0.0175 0.2541
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0381 0.0381
Entamoeba histolytica cysteine proteinase, putative 0.0108 0.0341 0.5829
Loa Loa (eye worm) hypothetical protein 0.0061 0.0175 0.0436
Giardia lamblia Hypothetical protein 0.0061 0.0175 0.1283
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.037 0.0923
Echinococcus granulosus cathepsin b 0.1159 0.4012 0.4012
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0061 0.0175 0.2541
Loa Loa (eye worm) hypothetical protein 0.0021 0.0035 0.0088
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.006 0.1021
Giardia lamblia Cathepsin B precursor 0.0061 0.0175 0.1283
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0086 0.0264
Plasmodium falciparum serine repeat antigen 6 0.0061 0.0175 0.2541
Leishmania major leucyl-tRNA synthetase, putative 0.0021 0.0035 0.0256
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.011 0.0274
Trypanosoma cruzi cysteine peptidase, putative 0.0108 0.0341 0.085
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.011 0.011
Giardia lamblia Cathepsin L-like protease 0.0061 0.0175 0.1283
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0061 0.0175 0.0175
Trypanosoma cruzi cysteine peptidase, putative 0.0318 0.1076 0.2681
Loa Loa (eye worm) hypothetical protein 0.0048 0.013 0.0323
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0086 0.0633
Giardia lamblia Cathepsin L precursor 0.0061 0.0175 0.1283
Entamoeba histolytica cysteine protease, putative 0.0108 0.0341 0.5829
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0108 0.0341 0.2506
Entamoeba histolytica hypothetical protein 0.0061 0.0175 0.2985
Giardia lamblia Cathepsin L precursor 0.0061 0.0175 0.1283
Plasmodium falciparum serine repeat antigen 8 0.0061 0.0175 0.2541
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0013 0.0008 0.0129
Entamoeba histolytica cysteine protease, putative 0.0108 0.0341 0.5829
Brugia malayi tailless protein 0.002 0.0032 0.0081
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0035 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.011 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.011 0.0274
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0013 0.0008 0.0129
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0032 0.0032
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0086 0.115
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.015 0.0374
Echinococcus multilocularis tar DNA binding protein 0.0062 0.018 0.018
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0054 0.0151 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0013 0.0008 0.0109
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0215
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0013 0.0008 0.0109
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0163 0.2581
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.006 0.0439
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0013 0.0008 0.0129
Plasmodium falciparum serine repeat antigen 9 0.0061 0.0175 0.2541
Leishmania major cathepsin L-like protease 0.0178 0.0585 0.4299
Echinococcus granulosus cpg binding protein 0.0034 0.0083 0.0083
Mycobacterium leprae Probable lipase LipE 0.0035 0.0086 0.5706
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0271 0.0909 0.2266
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.006 0.0944
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0253 0.0631
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0041 0.0101
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0032 0.0032
Leishmania major cathepsin L-like protease 0.0178 0.0585 0.4299
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0013 0.0008 0.0109
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0031 0.0419
Schistosoma mansoni cathepsin C 0.0061 0.0175 0.0175
Brugia malayi hypothetical protein 0.0022 0.0041 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.013 0.0419 0.1284
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.011 0.0274
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0061 0.0175 0.0436
Loa Loa (eye worm) DR-78 0.002 0.0032 0.0081
Mycobacterium tuberculosis Conserved protein 0.0035 0.0086 0.115
Brugia malayi ecdysteroid receptor 0.0042 0.011 0.0274
Brugia malayi AMP-binding enzyme family protein 0.0028 0.006 0.0149
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0013 0.0008 0.0109
Leishmania major cathepsin L-like protease 0.0178 0.0585 0.4299
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.017 0.0424
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0133 0.0331
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0215
Loa Loa (eye worm) hypothetical protein 0.0021 0.0035 0.0088
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0086 0.1361
Schistosoma mansoni methionine-tRNA synthetase 0.0021 0.0035 0.0035
Brugia malayi hypothetical protein 0.002 0.0032 0.0081
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0013 0.0008 0.0129
Loa Loa (eye worm) hypothetical protein 0.0028 0.006 0.0149
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0045 0.0598
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0013 0.0008 0.006
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0061 0.0175 0.0536
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0086 0.1361
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.011 0.0274
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0032 0.0032
Entamoeba histolytica cysteine proteinase, putative 0.0108 0.0341 0.5829
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0013 0.0008 0.0109
Schistosoma mansoni tar DNA-binding protein 0.0062 0.018 0.018
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0013 0.0008 0.0109
Loa Loa (eye worm) hypothetical protein 0.0028 0.006 0.0149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.011 0.0274
Giardia lamblia Cathepsin B precursor 0.0061 0.0175 0.1283
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0012 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0101
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0013 0.0008 0.0129
Schistosoma mansoni cpg binding protein 0.0032 0.0076 0.0076
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0013 0.0008 0.0129
Giardia lamblia Hypothetical protein 0.0061 0.0175 0.1283
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0215
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.011 0.0337
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0318 0.1076 0.7901
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0021 0.0035 0.0551
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.011 0.0274
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0115 0.0363 0.0363
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.011 0.011
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0163 0.12
Giardia lamblia Cysteine protease 0.0061 0.0175 0.1283
Giardia lamblia Cathepsin L precursor 0.0061 0.0175 0.1283
Onchocerca volvulus Huntingtin homolog 0.0122 0.0391 0.1198
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0381 0.0381
Entamoeba histolytica cysteine protease, putative 0.0108 0.0341 0.5829
Onchocerca volvulus 0.0178 0.0585 0.1795
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.011 0.011
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.0794 0.0794
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0086 0.115
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0108 0.0341 0.085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0175 0.0536
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.006 0.0798
Toxoplasma gondii ABC1 family protein 0.0035 0.0086 0.0633
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0048 0.013 0.0323
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.011 0.0274
Schistosoma mansoni survival motor neuron protein 0.0049 0.0133 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.013 0.0419 0.1284
Echinococcus granulosus cathepsin b 0.1159 0.4012 0.4012
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0013 0.0008 0.002
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.011 0.011
Brugia malayi Cathepsin L-like precursor 0.0178 0.0585 0.1459
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.083 0.2861 0.7131
Trypanosoma cruzi cysteine peptidase, putative 0.0318 0.1076 0.2681
Schistosoma mansoni cathepsin S (C01 family) 0.0061 0.0175 0.0175
Entamoeba histolytica cysteine protease, putative 0.0061 0.0175 0.2985
Echinococcus multilocularis microtubule associated protein 2 0.2873 1 1
Schistosoma mansoni cathepsin B (C01 family) 0.0061 0.0175 0.0175
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0013 0.0008 0.0129
Brugia malayi nuclear receptor NHR-88 0.0042 0.011 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.011 0.0274
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0086 0.0215
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0108 0.0341 0.0341
Echinococcus multilocularis cathepsin L cysteine protease 0.0178 0.0585 0.0585
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0013 0.0008 0.0109
Brugia malayi beta-lactamase family protein 0.0035 0.0086 0.0215
Entamoeba histolytica cysteine protease, putative 0.0108 0.0341 0.5829
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0163 0.0407
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0013 0.0008 0.0109
Mycobacterium tuberculosis Conserved protein 0.0035 0.0086 0.115
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0177 0.0582 0.1451
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0041 0.0101
Entamoeba histolytica cysteine protease, putative 0.0108 0.0341 0.5829
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.037 0.0923
Trypanosoma cruzi cysteine peptidase, putative 0.0318 0.1076 0.2681
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0193 0.1416
Mycobacterium ulcerans beta-lactamase 0.0035 0.0086 0.1361
Brugia malayi Papain family cysteine protease containing protein 0.0061 0.0175 0.0436
Leishmania major methionyl-tRNA synthetase, putative 0.0054 0.0151 0.1109
Brugia malayi nuclear hormone receptor 0.0042 0.011 0.0274
Schistosoma mansoni tar DNA-binding protein 0.0062 0.018 0.018
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0061 0.0175 0.0175
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0013 0.0008 0.0109
Brugia malayi cathepsin B-like cysteine proteinase 0.1159 0.4012 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.011 0.0337
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0032 0.0032
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0013 0.0008 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0318 0.1076 0.7901
Brugia malayi hypothetical protein 0.0022 0.0041 0.0101
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0275 0.0275
Leishmania major cytochrome p450-like protein 0.0013 0.0008 0.006
Plasmodium falciparum cysteine proteinase falcipain 1 0.0108 0.0341 0.5565
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0086 0.115
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.011 0.011
Brugia malayi cathepsin Z-like cysteine proteinase 0.0061 0.0175 0.0436
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.011 0.011
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0007 0.0007
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0013 0.0008 0.0129
Leishmania major cathepsin L-like protease 0.0178 0.0585 0.4299
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.011 0.011
Brugia malayi conserved hypotetical protein 0.002 0.0032 0.0081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0275 0.0275
Leishmania major hypothetical protein, conserved 0.0035 0.0086 0.0633
Plasmodium vivax vivapain-3 0.0108 0.0341 0.5565
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0041 0.0041
Onchocerca volvulus 0.0012 0.0005 0.0015
Schistosoma mansoni nuclear hormone receptor 0.0042 0.011 0.011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0175 0.0536
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0032 0.0032
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0032 0.0032
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.011 0.0274
Schistosoma mansoni nuclear receptor 0.002 0.0032 0.0032
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0178 0.0585 0.0585
Brugia malayi nuclear receptor NHR-88 0.002 0.0032 0.0081
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.011 0.0274
Loa Loa (eye worm) hypothetical protein 0.0061 0.0175 0.0436
Mycobacterium leprae putative cytochrome p450 0.0013 0.0008 0.0541
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0318 0.1076 0.7901
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1159 0.4012 0.4012
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.006 0.0944
Brugia malayi Cathepsin L-like precursor 0.0178 0.0585 0.1459
Loa Loa (eye worm) hypothetical protein 0.0021 0.0035 0.0087
Entamoeba histolytica cysteine protease, putative 0.0178 0.0585 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1159 0.4012 0.4012
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0013 0.0008 0.0129
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0035 0.0472
Plasmodium vivax serine-repeat antigen (SERA) 0.0061 0.0175 0.2541
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0086 0.0215
Echinococcus multilocularis cathepsin L cysteine protease 0.0178 0.0585 0.0585
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0045 0.0329
Giardia lamblia Cathepsin B precursor 0.0061 0.0175 0.1283
Echinococcus granulosus cathepsin L cysteine proteinase 0.0178 0.0585 0.0585
Plasmodium vivax serine-repeat antigen (SERA) 0.0061 0.0175 0.2541
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.0565 0.1733
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0163 0.0163
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.011 0.011
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.006 0.0439
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.006 0.1021
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0032 0.0032
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0054 0.0151 0.0376
Echinococcus granulosus tm gpcr rhodopsin 0.1003 0.3466 0.3466
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.011 0.011
Leishmania major cytochrome p450-like protein 0.0013 0.0008 0.006
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0032 0.0032
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.006 0.0944
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0045 0.0329
Giardia lamblia Cathepsin B precursor 0.04 0.1361 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0032 0.0081
Loa Loa (eye worm) hypothetical protein 0.013 0.0419 0.1044
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.011 0.011
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0061 0.0175 0.0175
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0032 0.0032
Brugia malayi cathepsin F-like cysteine proteinase 0.0061 0.0175 0.0436
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0086 0.115
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0013 0.0008 0.0109
Onchocerca volvulus 0.002 0.0032 0.0099
Mycobacterium ulcerans hypothetical protein 0.0028 0.006 0.0944
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0086 0.0086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0585 0.1795
Brugia malayi fibroinase precursor 0.0061 0.0175 0.0436
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0086 0.0086
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0061 0.0175 0.0175
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.04 0.1361 0.4175
Brugia malayi Cytochrome P450 family protein 0.0024 0.0045 0.0113
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0045 0.0113
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0061 0.0175 0.2541
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0175 0.0536
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0013 0.0008 0.002
Loa Loa (eye worm) hypothetical protein 0.0048 0.013 0.0323
Treponema pallidum methionyl-tRNA synthetase 0.0021 0.0035 0.7786
Echinococcus granulosus cathepsin l1 0.0178 0.0585 0.0585
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0585 0.1795
Giardia lamblia Cathepsin L precursor 0.0061 0.0175 0.1283
Echinococcus granulosus cysteine protease 0.0108 0.0341 0.0341
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0013 0.0008 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0318 0.1076 0.7901
Brugia malayi methionyl-tRNA synthetase 0.0021 0.0035 0.0087
Schistosoma mansoni thyroid hormone receptor 0.0042 0.011 0.011
Echinococcus granulosus histone lysine methyltransferase setb 0.012 0.0381 0.0381
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0013 0.0013
Toxoplasma gondii cathepsin CPC2 0.0061 0.0175 0.1283
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.018 0.0448
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0061 0.0175 0.2541
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0045 0.0113
Loa Loa (eye worm) hypothetical protein 0.0028 0.006 0.0149
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0175 0.0536
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.0585 0.1795
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0175 0.0436
Giardia lamblia Cysteine protease 0.0061 0.0175 0.1283
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0031 0.0419
Trypanosoma brucei cysteine peptidase C (CPC) 0.04 0.1361 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0041 0.0041
Brugia malayi Papain family cysteine protease containing protein 0.0178 0.0585 0.1459
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0032 0.0081
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0253 0.0253
Brugia malayi Cytochrome P450 family protein 0.0013 0.0008 0.002
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0048 0.013 0.0323
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.0585 0.1795
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0013 0.0032
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.012 0.0381 0.2798
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0061 0.0175 0.1283
Entamoeba histolytica cysteine protease, putative 0.0108 0.0341 0.5829
Onchocerca volvulus 0.0035 0.0086 0.0264
Loa Loa (eye worm) hypothetical protein 0.0061 0.0175 0.0436
Echinococcus granulosus methionine tRNA synthetase 0.0054 0.0151 0.0151
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0275 0.0275
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0048 0.013 0.0323
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0032 0.0081
Entamoeba histolytica cysteine protease, putative 0.0108 0.0341 0.5829
Brugia malayi AMP-binding enzyme family protein 0.0028 0.006 0.0149
Onchocerca volvulus 0.0049 0.0133 0.0407
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.006 0.0944
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0013 0.0008 0.0109
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0013 0.0008 0.006
Giardia lamblia Cathepsin L-like protease 0.0061 0.0175 0.1283
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.011 0.011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0585 0.1795
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0061 0.0175 0.0536
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.011 0.011
Echinococcus granulosus cathepsin l cysteine peptidase 0.0178 0.0585 0.0585
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0061 0.0175 0.2541
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0253 0.0253
Brugia malayi ecdysone receptor 0.002 0.0032 0.0081
Plasmodium falciparum serine repeat antigen 2 0.0061 0.0175 0.2541
Onchocerca volvulus 0.013 0.0419 0.1284
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0086 0.115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0585 0.1795
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0061 0.0175 0.2985
Schistosoma mansoni thyroid hormone receptor 0.0042 0.011 0.011
Onchocerca volvulus Cathepsin L homolog 0.0178 0.0585 0.1795
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.0749 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0061 0.0175 0.0436
Schistosoma mansoni zinc finger protein 0.002 0.0032 0.0032
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0041 0.0101
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.0218 0.0218
Echinococcus multilocularis cathepsin L 0.0108 0.0341 0.0341
Toxoplasma gondii preprocathepsin c precursor, putative 0.0061 0.0175 0.1283
Trypanosoma cruzi cysteine peptidase, putative 0.0048 0.013 0.0323
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.011 0.0274
Giardia lamblia Cysteine protease 0.0061 0.0175 0.1283
Schistosoma mansoni nuclear receptor 0.002 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0013 0.0008 0.0008
Trichomonas vaginalis esterase, putative 0.0035 0.0086 0.0264
Mycobacterium tuberculosis Conserved protein 0.0035 0.0086 0.115
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0054 0.0151 0.0376
Onchocerca volvulus 0.0944 0.3261 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0175 0.0436
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0178 0.0585 0.1795
Brugia malayi Papain family cysteine protease containing protein 0.0061 0.0175 0.0436
Brugia malayi Cytochrome P450 family protein 0.0024 0.0045 0.0113
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0108 0.0341 0.0341
Brugia malayi Nuclear hormone receptor E75 0.002 0.0032 0.0081
Onchocerca volvulus 0.0042 0.011 0.0337
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0061 0.0175 0.2541
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0061 0.0175 0.1283
Giardia lamblia Cathepsin B precursor 0.0061 0.0175 0.1283
Toxoplasma gondii aldehyde dehydrogenase 0.0192 0.0633 0.4648
Entamoeba histolytica cysteine protease, putative 0.0061 0.0175 0.2985
Schistosoma mansoni hypothetical protein 0.0461 0.1575 0.1575
Loa Loa (eye worm) RNA binding protein 0.0062 0.018 0.0448
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0108 0.0341 0.2506
Leishmania major cathepsin L-like protease 0.0318 0.1076 0.7901
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1003 0.3466 0.3466
Echinococcus multilocularis 0.0013 0.0008 0.0008
Entamoeba histolytica cysteine proteinase, putative 0.0178 0.0585 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0061 0.0175 0.2985
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.011 0.0274
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.0794 0.0794
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0585 0.1795
Brugia malayi Cathepsin L-like precursor 0.013 0.0419 0.1044
Onchocerca volvulus 0.002 0.0032 0.0099
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0061 0.0175 0.2541
Brugia malayi cathepsin L-like cysteine proteinase 0.0061 0.0175 0.0436
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.04 0.1361 0.1361
Giardia lamblia Cysteine protease 0.0061 0.0175 0.1283
Plasmodium vivax vivapain-2 0.0178 0.0585 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0081
Schistosoma mansoni tar DNA-binding protein 0.0062 0.018 0.018
Entamoeba histolytica cysteine proteinase 1, putative 0.0108 0.0341 0.5829
Leishmania major cytochrome p450-like protein 0.0024 0.0045 0.0333
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.006 0.0439
Brugia malayi cathepsin L precursor 0.0061 0.0175 0.0436
Loa Loa (eye worm) hypothetical protein 0.0122 0.0391 0.0974
Toxoplasma gondii cathepsin CPC1 0.0061 0.0175 0.1283
Entamoeba histolytica cysteine protease, putative 0.0108 0.0341 0.5829
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0061 0.0175 0.0175
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0108 0.0341 0.1046
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.012 0.0381 0.0381
Brugia malayi beta-lactamase 0.0035 0.0086 0.0215
Giardia lamblia Cathepsin L precursor 0.0061 0.0175 0.1283
Loa Loa (eye worm) hypothetical protein 0.0238 0.0794 0.198
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0081
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0045 0.018
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0275 0.0687
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.011 0.0274
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.04 0.1361 0.3394
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0318 0.1076 0.7901
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0178 0.0585 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.011 0.0274
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.011 0.011
Entamoeba histolytica cysteine protease, putative 0.0061 0.0175 0.2985
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.011 0.0274
Loa Loa (eye worm) cytochrome P450 0.0013 0.0008 0.002
Loa Loa (eye worm) hypothetical protein 0.0042 0.011 0.0274
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.006 0.3958
Schistosoma mansoni aldehyde dehydrogenase 0.0192 0.0633 0.0633
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0032 0.0032
Onchocerca volvulus 0.0028 0.006 0.0183
Onchocerca volvulus 0.0083 0.0253 0.0777
Brugia malayi beta-lactamase family protein 0.0035 0.0086 0.0215
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0061 0.0175 0.0175
Onchocerca volvulus Cathepsin F homolog 0.0178 0.0585 0.1795
Echinococcus multilocularis cysteine protease 0.0178 0.0585 0.0585
Trichomonas vaginalis set domain proteins, putative 0.0944 0.3261 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0013 0.0008 0.0109
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.011 0.011
Entamoeba histolytica cysteine protease, putative 0.0108 0.0341 0.5829
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.011 0.011
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0054 0.0151 0.1109
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0021 0.0035 0.2308
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.006 0.3958
Loa Loa (eye worm) hypothetical protein 0.0042 0.011 0.0274
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0061 0.0175 0.2541
Brugia malayi Pre-SET motif family protein 0.083 0.2861 0.7131
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0013 0.0008 0.0129
Brugia malayi steroid hormone receptor 0.0042 0.011 0.0274
Plasmodium vivax SET domain protein, putative 0.012 0.0381 0.6287
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0275 0.0275
Loa Loa (eye worm) cathepsin B 0.04 0.1361 0.3394
Loa Loa (eye worm) hypothetical protein 0.0021 0.0035 0.0087
Toxoplasma gondii tRNA ligases class I (M) protein 0.0021 0.0035 0.0256
Giardia lamblia Cathepsin L precursor 0.0061 0.0175 0.1283
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0035 0.0558
Schistosoma mansoni microtubule-associated protein tau 0.2873 1 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0045 0.018
Mycobacterium ulcerans hypothetical protein 0.0035 0.0086 0.1361
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0178 0.0585 0.1795
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.0585 0.1795
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0081
Leishmania major cathepsin L-like protease 0.0178 0.0585 0.4299
Entamoeba histolytica cysteine protease, putative 0.0108 0.0341 0.5829
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.011 0.011
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.011 0.011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0175 0.0536
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0275 0.0275
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0013 0.0008 0.0129
Trypanosoma cruzi cruzipain precursor, putative 0.0048 0.013 0.0323
Loa Loa (eye worm) hypothetical protein 0.0042 0.011 0.0274
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0101
Loa Loa (eye worm) hypothetical protein 0.0042 0.011 0.0274
Brugia malayi cytochrome P450 0.0013 0.0008 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0318 0.1076 0.7901
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0045 1
Brugia malayi Cathepsin L-like precursor 0.013 0.0419 0.1044
Onchocerca volvulus 0.012 0.0381 0.1168
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.0585 0.1795
Mycobacterium ulcerans aldehyde dehydrogenase 0.0192 0.0633 1
Brugia malayi Papain family cysteine protease containing protein 0.0108 0.0341 0.085
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0031 0.0419
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.006 0.0944
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.018 0.0448
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0061 0.0175 0.0536
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0045 0.2965
Brugia malayi nuclear receptor NHR-67 0.002 0.0032 0.0081
Brugia malayi methionyl-tRNA synthetase 0.0054 0.0151 0.0376
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0318 0.1076 0.7901
Toxoplasma gondii methionyl-tRNA synthetase 0.0054 0.0151 0.1109
Plasmodium falciparum methionine--tRNA ligase 0.0054 0.0151 0.211

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1.1 nM Inhibition of 5-HT stimulated cAMP production in HeLa cells expressing human 5-hydroxytryptamine 6 receptor ChEMBL. 15658848
Imax (functional) = 91 % Maximum percentage inhibition of 5-HT stimulated cAMP production in HeLa cells expressing 5-hydroxytryptamine 6 receptor ChEMBL. 15658848
Ki (binding) = 2 nM Inhibition of [3H]-LSD binding to human 5-hydroxytryptamine 6 receptor expressed in HeLa cells ChEMBL. 15658848

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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