Detailed information for compound 1107623

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 249.37 | Formula: C11H23NO3S
  • H donors: 4 H acceptors: 3 LogP: 0.86 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCSC[C@H]1NC([C@@H]([C@@H]1O)O)O
  • InChi: 1S/C11H23NO3S/c1-2-3-4-5-6-16-7-8-9(13)10(14)11(15)12-8/h8-15H,2-7H2,1H3/t8-,9-,10-,11?/m1/s1
  • InChiKey: UCMKAWHOZFFTMF-QHPFDFDXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tar DNA binding protein 0.0275 0.2907 0.8032
Echinococcus granulosus peregrin 0.0031 0.0214 0.0592
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.004
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0043 0.0347 0.0959
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0094 0.0904 0.2498
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0043 0.0347 0.6485
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.042 0.0419
Loa Loa (eye worm) hypothetical protein 0.0021 0.0101 0.0099
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0005 0.0003
Onchocerca volvulus 0.0021 0.0101 0.0644
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0101 0.0099
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0045 0.0124
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0101 0.0278
Loa Loa (eye worm) hypothetical protein 0.0035 0.0256 0.0255
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0304 0.03
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0003
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0419 0.1782
Plasmodium falciparum phd finger protein, putative 0.0031 0.0214 0.3004
Plasmodium falciparum DNase I-like protein, putative 0.0012 0.0005 0.003
Brugia malayi nuclear hormone receptor 0.0021 0.0101 0.0099
Loa Loa (eye worm) TAR-binding protein 0.0275 0.2907 0.2906
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0005 0.0003
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0101 0.0644
Trichomonas vaginalis glutaminase, putative 0.0917 1 1
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0043 0.0347 0.0346
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0101 0.0278
Echinococcus granulosus cpg binding protein 0.003 0.0206 0.0568
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.0995 0.2748
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0101 0.0099
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0214 0.0213
Mycobacterium tuberculosis Conserved protein 0.0035 0.0256 0.1081
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0101 0.0096
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0101 0.0278
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0005 0.0003
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0094 0.0904 0.2498
Loa Loa (eye worm) hypothetical protein 0.0035 0.0256 0.0255
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0043 0.0347 0.0346
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0256 0.0251
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0005 0.0003
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0101 0.0644
Loa Loa (eye worm) hypothetical protein 0.005 0.042 0.0419
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0707 0.7957
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0045 0.0044
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0707 1
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0304 0.0841
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0101 0.0096
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0579 0.0578
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0005 0.0003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.042 0.0419
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0101 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0101 0.0099
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0094 0.0904 0.09
Loa Loa (eye worm) apoptosis regulator protein 0.0094 0.0904 0.0903
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0043 0.0347 0.6485
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0043 0.0347 0.6485
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0349 0.0963
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0003
Echinococcus granulosus traf and tnf receptor associated protein 0.0012 0.0005 0.0013
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.0995 0.2748
Loa Loa (eye worm) hypothetical protein 0.0021 0.0101 0.0099
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0542 0.0538
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0081 0.0764 0.0762
Schistosoma mansoni ap endonuclease 0.006 0.0533 0.0528
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0043 0.0347 0.0342
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0101 0.0278
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0256 0.1081
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0256 0.0251
Brugia malayi beta-lactamase 0.0035 0.0256 0.0255
Loa Loa (eye worm) hypothetical protein 0.0031 0.0214 0.0213
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0256 0.0255
Schistosoma mansoni glutaminase 0.0917 1 1
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0043 0.0347 0.0959
Loa Loa (eye worm) hypothetical protein 0.0035 0.0256 0.0255
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0707 0.5
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0256 0.1081
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.006 0.0533 0.0284
Brugia malayi jmjC domain containing protein 0.0102 0.0995 0.0993
Brugia malayi TAR-binding protein 0.0275 0.2907 0.2906
Onchocerca volvulus 0.0035 0.0256 0.1687
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0707 1
Onchocerca volvulus Alhambra homolog 0.0031 0.0214 0.1407
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0101 0.0096
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.233 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0256 0.4761
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0867 0.2394
Echinococcus multilocularis cpg binding protein 0.003 0.0206 0.0568
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0707 0.0463
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0101 0.0096
Echinococcus multilocularis geminin 0.0339 0.3619 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0214 0.2373
Trichomonas vaginalis esterase, putative 0.0035 0.0256 0.0251
Schistosoma mansoni hypothetical protein 0.0031 0.0214 0.021
Echinococcus multilocularis deoxyribonuclease 1 2 0.0012 0.0005 0.0013
Echinococcus granulosus synaptojanin 1 0.0012 0.0005 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0275 0.2907 0.2903
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.008 0.0079
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0005 0.003
Brugia malayi exodeoxyribonuclease III family protein 0.006 0.0533 0.0531
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0419 0.1158
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.006 0.0533 1
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0256 0.1081
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0256 0.4761
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0101 0.0096
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0707 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0256 0.0707
Loa Loa (eye worm) hypothetical protein 0.0035 0.0256 0.0255
Onchocerca volvulus 0.0035 0.0256 0.1687
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0005 0.003
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0081 0.0764 0.0762
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0101 0.0278
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0256 0.1081
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0101 0.0096
Schistosoma mansoni hypothetical protein 0.0094 0.0904 0.09
Loa Loa (eye worm) hypothetical protein 0.0021 0.0101 0.0099
Entamoeba histolytica exodeoxyribonuclease III, putative 0.006 0.0533 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0045 0.0124
Onchocerca volvulus 0.0035 0.0256 0.1687
Schistosoma mansoni hypothetical protein 0.0094 0.0904 0.09
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0101 0.0278
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0214 0.2373
Brugia malayi nuclear receptor NHR-88 0.0021 0.0101 0.0099
Echinococcus multilocularis traf and tnf receptor associated protein 0.0012 0.0005 0.0013
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0471 0.5277
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0533 0.7524
Mycobacterium leprae Probable lipase LipE 0.0035 0.0256 0.1768
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0092 0.0887 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0707 1
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0533 0.0528
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0101 0.0096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0101 0.0099
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0533 0.7524
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0101 0.0099
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0533 0.0528
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0012 0.0005 0.003
Brugia malayi steroid hormone receptor 0.0021 0.0101 0.0099
Mycobacterium ulcerans glutaminase 0.0917 1 1
Plasmodium vivax exodeoxyribonuclease III, putative 0.0012 0.0005 0.003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0867 0.2394
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0101 0.0099
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0349 0.0963
Schistosoma mansoni hypothetical protein 0.0094 0.0904 0.09
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0003
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0101 0.0278
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0101 0.0099
Onchocerca volvulus 0.0147 0.1494 1
Brugia malayi beta-lactamase family protein 0.0035 0.0256 0.0255
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0005 0.0003
Brugia malayi CXXC zinc finger family protein 0.0029 0.0188 0.0186
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0101 0.0278
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0043 0.0347 0.0346
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0092 0.0887 0.2452
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0101 0.0278
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0867 0.2394
Mycobacterium tuberculosis Conserved protein 0.0035 0.0256 0.1081
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0012 0.0005 0.003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0101 0.0099
Schistosoma mansoni ap endonuclease 0.006 0.0533 0.0528
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0707 0.0463
Schistosoma mansoni hypothetical protein 0.0339 0.3619 0.3616
Loa Loa (eye worm) hypothetical protein 0.0034 0.0247 0.0245
Toxoplasma gondii hypothetical protein 0.0026 0.0159 0.175
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0081 0.0764 0.211
Echinococcus multilocularis tar DNA binding protein 0.0275 0.2907 0.8032
Schistosoma mansoni hypothetical protein 0.0339 0.3619 0.3616
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0867 0.0865
Loa Loa (eye worm) hypothetical protein 0.0021 0.0101 0.0099
Mycobacterium tuberculosis Conserved protein 0.0035 0.0256 0.1081
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0062 0.0057
Loa Loa (eye worm) hypothetical protein 0.0092 0.0887 0.0886
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0256 0.4761
Schistosoma mansoni cpg binding protein 0.0029 0.0188 0.0183
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0012 0.0005 0.0013
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0286 0.0791
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0247 0.0245
Loa Loa (eye worm) RNA binding protein 0.0275 0.2907 0.2906
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.006 0.0533 0.227
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0101 0.0644
Loa Loa (eye worm) beta-lactamase 0.0035 0.0256 0.0255
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.006 0.0533 0.5981
Loa Loa (eye worm) hypothetical protein 0.0021 0.0101 0.0099
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0159 0.2199
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0256 0.1081
Leishmania major hypothetical protein, conserved 0.0035 0.0256 0.4761
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0256 0.1081
Schistosoma mansoni apoptosis regulator bax 0.0094 0.0904 0.09
Loa Loa (eye worm) hypothetical protein 0.0021 0.0101 0.0099
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0005 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0101 0.0099
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0012 0.0005 0.0013
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.042 0.0419
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0005 0.0003
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0043 0.0347 0.0342
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0092 0.0887 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0101 0.0099
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0094 0.0904 0.2498
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0101 0.0099
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0012 0.0005 0.003
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0043 0.0347 0.0346
Echinococcus multilocularis GPCR, family 2 0.0016 0.0045 0.0124
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.006 0.0533 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0101 0.0099
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0707 0.1954
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0005 0.0003
Toxoplasma gondii exonuclease III APE 0.006 0.0533 0.5981
Echinococcus multilocularis neutral sphingomyelinase 0.0012 0.0005 0.0013
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0005 0.0013
Echinococcus granulosus GPCR family 2 0.0016 0.0045 0.0124
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0043 0.0347 0.6485
Loa Loa (eye worm) hypothetical protein 0.0035 0.0256 0.0255
Giardia lamblia PHD finger protein 15 0.0031 0.0214 0.2373
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0101 0.0099
Brugia malayi CCR4 0.0012 0.0005 0.0003
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0764 0.0759
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0159 0.2223
Brugia malayi jmjC domain containing protein 0.0039 0.0304 0.0303
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0304 0.0303
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0101 0.0099
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0101 0.0278
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0012 0.0005 0.003
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0188 0.0186
Loa Loa (eye worm) glutaminase 2 0.0917 1 1
Schistosoma mansoni tar DNA-binding protein 0.0275 0.2907 0.2903
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0256 0.0707
Schistosoma mansoni tar DNA-binding protein 0.0275 0.2907 0.2903
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0092 0.0887 0.0883
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0214 0.0592
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0256 0.0251
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0043 0.0347 0.4889
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0101 0.0096
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0081 0.0764 0.211
Schistosoma mansoni tar DNA-binding protein 0.0275 0.2907 0.2903
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0256 0.1081
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0101 0.0096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0101 0.0099
Loa Loa (eye worm) hypothetical protein 0.0094 0.0904 0.0903
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0707 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0256 0.3598
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0101 0.0278
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0045 0.0044
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0419 0.1158
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0867 0.0865
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0419 0.4744
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0101 0.0099
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0005 0.0003
Brugia malayi PHD-finger family protein 0.0031 0.0214 0.0213
Brugia malayi hypothetical protein 0.0147 0.1494 0.1493
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0101 0.0099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0867 0.0862
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.006 0.0533 0.0531
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0101 0.0099
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0005 0.0003
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0256 0.1768
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0101 0.0099
Schistosoma mansoni coup transcription factor 0.0021 0.0101 0.0096
Brugia malayi beta-lactamase family protein 0.0035 0.0256 0.0255
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0101 0.0096
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0005 0.003
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0094 0.0904 0.0903
Brugia malayi Bromodomain containing protein 0.0031 0.0214 0.0213
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0214 0.3004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0003
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.006 0.0533 0.1472
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0101 0.0278
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0256 0.0251
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0101 0.0099
Loa Loa (eye worm) hypothetical protein 0.0053 0.0459 0.0458
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0043 0.0347 0.6485
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.006 0.0533 0.1472
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0101 0.0278
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0101 0.0278
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0043 0.0347 0.4889
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0707 0.1954
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.004
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0043 0.0347 0.0342
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0867 0.0862
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0256 0.0251
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0867 0.2394
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0101 0.0278
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0101 0.0099
Loa Loa (eye worm) hypothetical protein 0.0076 0.0707 0.0706
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0101 0.0096
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0092 0.0887 0.2452
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.006 0.0533 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0707 0.0703
Brugia malayi RNA recognition motif domain containing protein 0.0275 0.2907 0.2906
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0092 0.0887 0.2452
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0101 0.0278
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0101 0.0278
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0005 0.0003
Schistosoma mansoni cpg binding protein 0.003 0.0206 0.0201
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0256 0.0255
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0256 0.0255
Echinococcus multilocularis synaptojanin 1 0.0012 0.0005 0.0013
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.006 0.0533 1
Echinococcus granulosus geminin 0.0339 0.3619 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0256 0.0251
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0214 0.021
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0101 0.0096
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.004
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0012 0.0005 0.0013
Schistosoma mansoni hypothetical protein 0.0034 0.0247 0.0242
Loa Loa (eye worm) hypothetical protein 0.0147 0.1494 0.1493
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0101 0.0099
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0005 0.0003
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0012 0.0005 0.0013
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0159 0.2223
Toxoplasma gondii ABC1 family protein 0.0035 0.0256 0.2847
Loa Loa (eye worm) hypothetical protein 0.0021 0.0101 0.0099
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0101 0.0278
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0005 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0101 0.0099
Echinococcus multilocularis peregrin 0.0031 0.0214 0.0592
Schistosoma mansoni tar DNA-binding protein 0.0275 0.2907 0.2903
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0304 0.03
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0419 0.1782
Brugia malayi RNA binding protein 0.0275 0.2907 0.2906
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0045 0.0124
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0043 0.0347 0.3878
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.0044
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0045 0.0124
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0707 0.7957
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0012 0.0005 0.0003
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0094 0.0904 0.2498
Onchocerca volvulus 0.0029 0.0188 0.1228
Treponema pallidum exodeoxyribonuclease (exoA) 0.006 0.0533 0.7516
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0101 0.0099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0867 0.0862
Loa Loa (eye worm) glutaminase 0.0917 1 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0214 0.0592
Schistosoma mansoni cpg binding protein 0.003 0.0206 0.0201
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0256 0.0251
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0092 0.0887 0.2452
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0707 0.5
Brugia malayi Probable ClpP-like protease 0.0076 0.0707 0.0706
Echinococcus granulosus neutral sphingomyelinase 0.0012 0.0005 0.0013
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0275 0.2907 0.2906
Brugia malayi ecdysteroid receptor 0.0021 0.0101 0.0099

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 42 % Modulation of Pseudomonas aeruginosa lacZ-fused lasI expressed in Escherichia coli DH5alpha co-expressing pBAD-lasR assessed as 3-oxo-C12-AHL-induced effect at 0.80 mM after 3 hrs by beta-galactosidase assay relative to control ChEMBL. 21855349
Activity (binding) = 51 % Modulation of Pseudomonas aeruginosa lacZ-fused lasI expressed in Escherichia coli DH5alpha co-expressing pBAD-lasR assessed as 3-oxo-C12-AHL-induced effect at 0.60 mM after 3 hrs by beta-galactosidase assay relative to control ChEMBL. 21855349
Activity (binding) = 68 % Modulation of Pseudomonas aeruginosa lacZ-fused lasI expressed in Escherichia coli DH5alpha co-expressing pBAD-lasR assessed as 3-oxo-C12-AHL-induced effect at 0.40 mM after 3 hrs by beta-galactosidase assay relative to control ChEMBL. 21855349
Activity (binding) = 84 % Modulation of Pseudomonas aeruginosa lacZ-fused lasI expressed in Escherichia coli DH5alpha co-expressing pBAD-lasR assessed as 3-oxo-C12-AHL-induced effect at 0.20 mM after 3 hrs by beta-galactosidase assay relative to control ChEMBL. 21855349
Activity (binding) = 94 % Modulation of Pseudomonas aeruginosa lacZ-fused rhlA expressed in Escherichia coli DH5alpha co-expressing Ptac-rhlR assessed as C4-AHL-induced effect at 0.20 mM after 4 hrs by beta-galactosidase assay relative to control ChEMBL. 21855349
Activity (binding) = 105 % Modulation of Pseudomonas aeruginosa lacZ-fused rhlA expressed in Escherichia coli DH5alpha co-expressing Ptac-rhlR assessed as C4-AHL-induced effect at 0.40 mM after 4 hrs by beta-galactosidase assay relative to control ChEMBL. 21855349
Activity (binding) = 109 % Modulation of Pseudomonas aeruginosa lacZ-fused rhlA expressed in Escherichia coli DH5alpha co-expressing Ptac-rhlR assessed as C4-AHL-induced effect at 0.60 mM after 4 hrs by beta-galactosidase assay relative to control ChEMBL. 21855349
Activity (binding) = 116 % Modulation of Pseudomonas aeruginosa lacZ-fused rhlA expressed in Escherichia coli DH5alpha co-expressing Ptac-rhlR assessed as C4-AHL-induced effect at 0.80 mM after 4 hrs by beta-galactosidase assay relative to control ChEMBL. 21855349

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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