TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 471.572 | Formula: C23H29N5O4S
H donors: 4 H acceptors: 6 LogP: 2.91 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@H]1OC([C@@H]([C@@H]1O)O)n1c(NC2CCCCC2)nc2c1ncnc2SCc1ccccc1
InChi: 1S/C23H29N5O4S/c29-11-16-18(30)19(31)22(32-16)28-20-17(27-23(28)26-15-9-5-2-6-10-15)21(25-13-24-20)33-12-14-7-3-1-4-8-14/h1,3-4,7-8,13,15-16,18-19,22,29-31H,2,5-6,9-12H2,(H,26,27)/t16-,18-,19-,22?/m1/s1
InChiKey: GKDZQBOOQRTTOH-BEBASYGKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	solute carrier family 29 (equilibrative nucleoside transporter), member 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	equilibrative nucleoside transporter 3	Get druggable targets OG5_127378	All targets in OG5_127378
Brugia malayi	Nucleoside transporter family protein	Get druggable targets OG5_127378	All targets in OG5_127378
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	Get druggable targets OG5_127378	All targets in OG5_127378
Candida albicans	possible nucleoside transporter	Get druggable targets OG5_127378	All targets in OG5_127378
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	Get druggable targets OG5_127378	All targets in OG5_127378
Echinococcus granulosus	equilibrative nucleoside transporter	Get druggable targets OG5_127378	All targets in OG5_127378
Echinococcus granulosus	equilibrative nucleoside transporter 3	Get druggable targets OG5_127378	All targets in OG5_127378
Onchocerca volvulus	Equilibrative nucleoside transporter, putative homolog	Get druggable targets OG5_127378	All targets in OG5_127378
Candida albicans	possible nucleoside transporter	Get druggable targets OG5_127378	All targets in OG5_127378
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127378	All targets in OG5_127378
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127378	All targets in OG5_127378
Echinococcus multilocularis	equilibrative nucleoside transporter 3	Get druggable targets OG5_127378	All targets in OG5_127378
Onchocerca volvulus	Equilibrative nucleoside transporter, putative homolog	Get druggable targets OG5_127378	All targets in OG5_127378
Echinococcus multilocularis	equilibrative nucleoside transporter protein	Get druggable targets OG5_127378	All targets in OG5_127378
Giardia lamblia	Hypothetical protein	Get druggable targets OG5_127378	All targets in OG5_127378
Brugia malayi	hypothetical protein	Get druggable targets OG5_127378	All targets in OG5_127378
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	Get druggable targets OG5_127378	All targets in OG5_127378
Schistosoma japonicum	Equilibrative nucleoside transporter 3, putative	Get druggable targets OG5_127378	All targets in OG5_127378
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127378	All targets in OG5_127378
Entamoeba histolytica	nucleoside transporter, putative	Get druggable targets OG5_127378	All targets in OG5_127378
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	Get druggable targets OG5_127378	All targets in OG5_127378

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	purine nucleoside transporter	solute carrier family 29 (equilibrative nucleoside transporter), member 1	456 aa	396 aa	24.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	glutaminase DH11.1	0.028	0.1646	0.543
Onchocerca volvulus		0.0017	0.0035	0.0653
Onchocerca volvulus	Cathepsin F homolog	0.0017	0.0035	0.0653
Mycobacterium ulcerans	glutaminase	0.028	0.1646	0.5183
Loa Loa (eye worm)	hypothetical protein	0.0051	0.024	0.1459
Loa Loa (eye worm)	hypothetical protein	0.004	0.0172	0.1047
Echinococcus granulosus	equilibrative nucleoside transporter	0.0098	0.0532	0.1213
Schistosoma mansoni	sex comb on midleg homolog	0.005	0.0238	0.0542
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0197	0.1141	0.1125
Echinococcus multilocularis	Niemann Pick C1 protein	0.0148	0.0839	0.0822
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0156	0.0946
Echinococcus granulosus	sterol regulatory element binding protein	0.0044	0.0203	0.0462
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0035	0.0211
Trypanosoma brucei	adenosine transporter, putative	0.0017	0.0034	0.0045
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0174	0.0157
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.0269	0.0887
Echinococcus granulosus	dnaJ subfamily B	0.0397	0.2367	0.5394
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.006	0.0295	0.0912
Brugia malayi	Bromodomain containing protein	0.0074	0.0386	0.1274
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0225	0.0513
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0197	0.1141	0.693
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0174	0.0397
Trypanosoma cruzi	nucleobase transporter, putative	0.0017	0.0034	0.0045
Brugia malayi	beta-lactamase family protein	0.0037	0.0156	0.0514
Loa Loa (eye worm)	hypothetical protein	0.003	0.0113	0.0687
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0113	0.0687
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.033	0.1028
Loa Loa (eye worm)	MBCTL1	0.0057	0.028	0.1704
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0035	0.0211
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0057	0.028	0.0263
Schistosoma mansoni	protein kinase	0.0017	0.0034	0.0078
Loa Loa (eye worm)	mbt repeat family protein	0.005	0.0238	0.1445
Leishmania major	cathepsin L-like protease	0.0065	0.033	0.1028
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0017	0.0035	0.0079
Onchocerca volvulus		0.003	0.0113	0.2125
Schistosoma mansoni	lamin	0.003	0.0113	0.0258
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0035	0.0115
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0035	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0035	0.0212
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0037	0.0019
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0031	0.0071
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0017	0.0034	0.0208
Trypanosoma cruzi	nucleoside transporter 1, putative	0.0017	0.0034	0.0045
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0225	0.0743
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0156	0.0355
Loa Loa (eye worm)	cysteine protease	0.0017	0.0035	0.0211
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1, putative	0.0017	0.0034	0.0045
Schistosoma mansoni	hypothetical protein	0.0305	0.1803	0.4109
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0105	0.0576	0.1312
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0035	0.0211
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0017	0.0035	0.0079
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0197	0.1141	0.693
Schistosoma mansoni	hypothetical protein	0.0178	0.1024	0.2335
Trypanosoma cruzi	cysteine peptidase, putative	0.0065	0.033	0.1028
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.005	0.0238	0.4467
Brugia malayi	mbt repeat family protein	0.005	0.0238	0.0784
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0057	0.028	0.0639
Echinococcus multilocularis	geminin	0.0178	0.1024	0.1008
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0035	0.0211
Leishmania major	cathepsin L-like protease	0.0017	0.0035	0.0046
Entamoeba histolytica	hypothetical protein	0.004	0.0174	0.1529
Giardia lamblia	Hypothetical protein	0.0098	0.0532	0.5
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0156	0.0946
Leishmania major	dihydroorotate dehydrogenase	0.0506	0.3031	1
Onchocerca volvulus		0.0037	0.0156	0.2925
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0044	0.0203	0.1231
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0197	0.1141	0.1125
Echinococcus multilocularis	polycomb protein SCMH1	0.005	0.0238	0.022
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0098	0.0532	0.3234
Trypanosoma brucei	unspecified product	0.0017	0.0034	0.0045
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0035	0.0211
Schistosoma mansoni	hypothetical protein	0.0017	0.0037	0.0084
Echinococcus granulosus	Protein patched homolog 1	0.0044	0.0203	0.0462
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0197	0.1141	0.693
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0035	0.0115
Schistosoma mansoni	sex comb on midleg homolog	0.005	0.0238	0.0542
Echinococcus multilocularis	cysteine protease	0.0017	0.0035	0.0017
Schistosoma mansoni	hypothetical protein	0.0043	0.0193	0.0439
Echinococcus granulosus	equilibrative nucleoside transporter 3	0.0098	0.0532	0.1213
Plasmodium falciparum	dihydroorotate dehydrogenase	0.0506	0.3031	1
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0017	0.0034	0.0208
Schistosoma mansoni	cpg binding protein	0.0028	0.0101	0.023
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0193	0.1175
Brugia malayi	Bromodomain containing protein	0.0037	0.0158	0.0521
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0156	0.0448
Echinococcus granulosus	SAM and MBT domain containing protein	0.005	0.0238	0.0542
Echinococcus granulosus	cpg binding protein	0.0031	0.0122	0.0278
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0225	0.0513
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0113	0.0687
Schistosoma mansoni	intermediate filament proteins	0.003	0.0113	0.0258
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.033	0.1028
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0057	0.028	0.0925
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.033	0.1028
Echinococcus multilocularis	microtubule associated protein 2	0.0727	0.4388	0.4378
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1, putative	0.0017	0.0034	0.0045
Toxoplasma gondii	ABC1 family protein	0.0037	0.0156	0.0405
Echinococcus multilocularis	tumor protein p63	0.0346	0.2051	0.2037
Leishmania major	cathepsin L-like protease	0.0017	0.0035	0.0046
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0506	0.3031	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0035	0.0211
Brugia malayi	beta-lactamase family protein	0.0037	0.0156	0.0514
Loa Loa (eye worm)	glutaminase	0.028	0.1646	1
Schistosoma mansoni	patched 1	0.0044	0.0203	0.0462
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0035	0.0211
Trichomonas vaginalis	esterase, putative	0.0037	0.0156	0.0946
Brugia malayi	intermediate filament protein	0.003	0.0113	0.0373
Schistosoma mansoni	cpg binding protein	0.0031	0.0122	0.0278
Trypanosoma brucei	adenosine transporter 2	0.0017	0.0034	0.0045
Brugia malayi	Niemann-Pick C1 protein precursor	0.0104	0.0566	0.1866
Echinococcus granulosus	GPCR family 2	0.0017	0.0037	0.0084
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0057	0.028	0.0263
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.033	0.1028
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0031	0.0071
Onchocerca volvulus		0.0017	0.0035	0.0653
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	0.0506	0.3031	1
Toxoplasma gondii	dihydroorotate dehydrogenase reveal, putative	0.0506	0.3031	1
Echinococcus multilocularis	SAM and MBT domain containing protein	0.005	0.0238	0.022
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0037	0.0084
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0098	0.0532	0.3234
Loa Loa (eye worm)	hypothetical protein	0.005	0.0238	0.1445
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0018	0.0041
Schistosoma mansoni	microtubule-associated protein tau	0.0727	0.4388	1
Echinococcus multilocularis	protein dispatched 1	0.0051	0.0241	0.0223
Onchocerca volvulus		0.0037	0.0156	0.2925
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.033	0.1028
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.033	0.1028
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0156	0.0946
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0037	0.0122
Trypanosoma cruzi	cysteine peptidase, putative	0.0065	0.033	0.1028
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0235	0.1374	0.4237
Schistosoma mansoni	hypothetical protein	0.0043	0.0193	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0037	0.0224
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0035	0.0211
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0037	0.0019
Onchocerca volvulus		0.0037	0.0156	0.2925
Onchocerca volvulus		0.0017	0.0035	0.0653
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0156	0.0946
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0035	0.0211
Schistosoma mansoni	hypothetical protein	0.0043	0.0193	0.0439
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0053	0.0319
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1, putative	0.0017	0.0034	0.0045
Schistosoma mansoni	zinc finger protein	0.0015	0.0021	0.0047
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0101	0.0332
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.033	0.1028
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0035	0.0305
Schistosoma mansoni	hypothetical protein	0.0017	0.0037	0.0084
Onchocerca volvulus		0.0028	0.0101	0.1892
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0035	0.008
Echinococcus multilocularis	cysteine protease	0.0017	0.0035	0.0017
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0197	0.1141	0.372
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0156	0.0404
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0506	0.3031	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0144	0.0328
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0161	0.0533
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0264	0.1604
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0113	0.0373
Echinococcus multilocularis	musashi	0.003	0.0113	0.0095
Trypanosoma cruzi	nucleoside transporter-like, putative	0.0017	0.0034	0.0045
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0035	0.0211
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0035	0.0211
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0506	0.3031	1
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0506	0.3031	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0037	0.0084
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0156	0.0448
Echinococcus multilocularis	equilibrative nucleoside transporter 3	0.0098	0.0532	0.0515
Schistosoma mansoni	cpg binding protein	0.0031	0.0122	0.0278
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.0269	0.0887
Entamoeba histolytica	hypothetical protein	0.004	0.0174	0.1529
Brugia malayi	beta-lactamase	0.0037	0.0156	0.0514
Echinococcus granulosus	polycomb protein SCMH1	0.005	0.0238	0.0542
Echinococcus granulosus	histone acetyltransferase MYST2	0.0057	0.028	0.0639
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.0269	0.1633
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0035	0.0115
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0203	0.1231
Trypanosoma brucei	nucleoside transporter 1, putative	0.0017	0.0034	0.0045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0035	0.0211
Brugia malayi	hypothetical protein	0.004	0.0174	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0532	0.3234
Schistosoma mansoni	hypothetical protein	0.0015	0.0021	0.0047
Echinococcus granulosus	zinc finger protein	0.0021	0.0056	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0015	0.009
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0035	0.008
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0057	0.028	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0532	0.3234
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.011
Echinococcus multilocularis	lamin dm0	0.003	0.0113	0.0095
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0035	0.0115
Trichomonas vaginalis	glutaminase, putative	0.028	0.1646	1
Schistosoma mansoni	zinc finger protein	0.0021	0.0056	0.0128
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.033	0.1028
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	0.0506	0.3031	1
Brugia malayi	Zinc finger, C2H2 type family protein	0.0197	0.1141	0.3763
Trypanosoma brucei	dihydroorotate dehydrogenase (fumarate)	0.0506	0.3031	1
Echinococcus granulosus	fetal alzheimer antigen falz	0.0023	0.0074	0.0168
Trypanosoma brucei	nucleoside transporter 1, putative	0.0017	0.0034	0.0045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0035	0.0211
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0156	0.0946
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0566	0.3437
Trypanosoma brucei	purine nucleoside transporter	0.0017	0.0034	0.0045
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0035	0.0115
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0035	0.0211
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.033	0.1028
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0035	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0161	0.0981
Leishmania major	cathepsin L-like protease	0.0017	0.0035	0.0046
Entamoeba histolytica	nucleoside transporter, putative	0.0017	0.0034	0.0301
Onchocerca volvulus		0.0051	0.024	0.4512
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.0197	0.1141	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0144	0.0126
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0197	0.1141	0.26
Trypanosoma cruzi	nucleoside transporter 1, putative	0.0017	0.0034	0.0045
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0225	0.0207
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.033	0.1028
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0034	0.0208
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0037	0.0019
Leishmania major	nucleobase transporter	0.0017	0.0034	0.0045
Onchocerca volvulus		0.0017	0.0035	0.0653
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1, putative	0.0017	0.0034	0.0045
Schistosoma mansoni	hypothetical protein	0.0043	0.0193	0.0439
Trypanosoma cruzi	dihydroorotate dehydrogenase (fumarate), putative	0.0506	0.3031	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.0035	0.0046
Echinococcus multilocularis	cpg binding protein	0.0031	0.0122	0.0104
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0035	0.0211
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0035	0.0653
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0225	0.1368
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	0.0506	0.3031	0.5
Trypanosoma brucei	adenosine transporter 2, putative	0.0017	0.0034	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0203	0.1231
Schistosoma mansoni	hypothetical protein	0.0178	0.1024	0.2335
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0268	0.078
Trypanosoma brucei	purine nucleoside transporter	0.0017	0.0034	0.0045
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0028	0.017
Echinococcus granulosus	intermediate filament protein	0.003	0.0113	0.0258
Leishmania major	cathepsin L-like protease	0.0017	0.0035	0.0046
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0035	0.0305
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0035	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0156	0.0946
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.006	0.0295	0.0277
Trypanosoma brucei	adenosine transporter 2	0.0017	0.0034	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0532	0.3234
Schistosoma mansoni	bromodomain containing protein	0.0063	0.0316	0.0721
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0156	0.0946
Onchocerca volvulus		0.005	0.0238	0.4467
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0035	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0035	0.0211
Echinococcus granulosus	lamin dm0	0.003	0.0113	0.0258
Trypanosoma cruzi	cysteine peptidase, putative	0.0065	0.033	0.1028
Trypanosoma brucei	adenosine transporter 2, putative	0.0017	0.0034	0.0045
Brugia malayi	CHE-14 protein	0.0044	0.0203	0.0668
Brugia malayi	hypothetical protein	0.0098	0.0532	0.1756
Schistosoma mansoni	glutaminase	0.028	0.1646	0.3751
Onchocerca volvulus		0.0017	0.0035	0.0653
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.033	0.1028
Trypanosoma cruzi	nucleoside transporter-like, putative	0.0017	0.0034	0.0045
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0035	0.0017
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0197	0.1141	0.693
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0017	0.0034	0.0208
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0035	0.0211
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0037	0.0224
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0174	0.0397
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.006	0.0295	0.0672
Echinococcus multilocularis	Niemann Pick C1 protein	0.0104	0.0566	0.0549
Onchocerca volvulus		0.003	0.0113	0.2125
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0156	0.0514
Brugia malayi	Nucleoside transporter family protein	0.0098	0.0532	0.1756
Trypanosoma brucei	adenosine transporter 2, putative	0.0017	0.0034	0.0045
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0035	0.0115
Trypanosoma brucei	adenosine transporter 2, putative	0.0017	0.0034	0.0045
Echinococcus granulosus	tumor protein p63	0.0346	0.2051	0.4675
Leishmania major	hypothetical protein, conserved	0.0037	0.0156	0.0448
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0198	0.1144	0.2607
Onchocerca volvulus	Equilibrative nucleoside transporter, putative homolog	0.0098	0.0532	1
Entamoeba histolytica	nucleoside transporter, putative	0.0098	0.0532	0.4666
Echinococcus multilocularis	protein patched	0.0044	0.0203	0.0185
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	0.0506	0.3031	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0035	0.0211
Trypanosoma brucei	adenosine transporter, putative	0.0017	0.0034	0.0045
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0156	0.0448
Schistosoma mansoni	hypothetical protein	0.0397	0.2367	0.5394
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.0293	0.0667
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0017	0.0034	0.0208
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0156	0.0138
Echinococcus multilocularis	zinc finger protein	0.0021	0.0056	0.0038
Entamoeba histolytica	hypothetical protein	0.004	0.0174	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0156	0.0946
Onchocerca volvulus	Equilibrative nucleoside transporter, putative homolog	0.0098	0.0532	1
Trypanosoma brucei	adenosine transporter 2, putative	0.0017	0.0034	0.0045
Leishmania major	nucleoside transporter 1, putative	0.0017	0.0034	0.0045
Leishmania major	cathepsin L-like protease	0.0065	0.033	0.1028
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0225	0.0513
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0156	0.0355
Echinococcus multilocularis	sterol regulatory element binding protein	0.0044	0.0203	0.0185
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0197	0.1141	0.693
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0035	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0057	0.028	0.1704
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0156	0.0946
Loa Loa (eye worm)	glutaminase 2	0.028	0.1646	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0017	0.0035	0.008
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0015	0.009
Trypanosoma cruzi	nucleobase transporter, putative	0.0017	0.0034	0.0045
Trypanosoma brucei	unspecified product	0.0017	0.0034	0.0045
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0101	0.0612
Echinococcus multilocularis	lamin	0.003	0.0113	0.0095
Schistosoma mansoni	hypothetical protein	0.0038	0.0161	0.0368
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0104	0.0566	0.4959
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0035	0.0211
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0156	0.0946
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0037	0.0122
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0156	0.0355
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.005	0.0238	0.0542
Loa Loa (eye worm)	fibroinase	0.0017	0.0035	0.0211
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0035	0.0017
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0225	0.0513
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0017	0.0034	0.0208
Echinococcus multilocularis	dnaJ subfamily B	0.0397	0.2367	0.2353
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0035	0.0079
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0197	0.1141	0.693
Leishmania major	inosine-guanosine transporter;with=GeneDB:LinJ36_V3.2040	0.0017	0.0034	0.0045
Trypanosoma cruzi	nucleobase transporter, putative	0.0017	0.0034	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0156	0.0946
Schistosoma mansoni	lamin	0.003	0.0113	0.0258
Brugia malayi	hypothetical protein	0.0017	0.0034	0.0113
Leishmania major	cathepsin L-like protease	0.0065	0.033	0.1028
Entamoeba histolytica	hypothetical protein	0.004	0.0174	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0029	0.011	0.0667
Leishmania major	nucleoside transporter 1, putative	0.0017	0.0034	0.0045
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0225	0.0207
Schistosoma mansoni	hypothetical protein	0.0017	0.0037	0.0084
Schistosoma mansoni	hypothetical protein	0.0017	0.0037	0.0084
Echinococcus granulosus	Niemann Pick C1 protein	0.0104	0.0566	0.1289
Entamoeba histolytica	nucleoside transporter, putative	0.0017	0.0034	0.0301
Onchocerca volvulus		0.0017	0.0035	0.0653
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0035	0.0211
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0023	0.0074	0.0056
Trypanosoma cruzi	major cysteine proteinase, putative	0.0051	0.0244	0.0743
Echinococcus granulosus	microtubule associated protein 2	0.0727	0.4388	1
Leishmania major	cysteine peptidase A (CPA)	0.0017	0.0035	0.0046
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1	0.0017	0.0034	0.0045
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0156	0.0946
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0017	0.0035	0.0211
Brugia malayi	cytoplasmic intermediate filament protein	0.0016	0.0028	0.0092
Brugia malayi	PHD-finger family protein	0.0026	0.0088	0.029
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0035	0.0211
Onchocerca volvulus		0.0017	0.0035	0.0653
Schistosoma mansoni	hypothetical protein	0.004	0.0174	0.0397
Echinococcus multilocularis	equilibrative nucleoside transporter 3	0.0081	0.0428	0.041
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0035	0.0211
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0225	0.0513
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0098	0.0532	0.3234
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0197	0.1141	0.26
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0035	0.0017
Echinococcus granulosus	Niemann Pick C1 protein	0.0148	0.0839	0.1911
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0506	0.3031	1
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0031	0.0071
Loa Loa (eye worm)	bromodomain containing protein	0.0017	0.0035	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0269	0.1633
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0035	0.0211
Schistosoma mansoni	cellular tumor antigen P53	0.0051	0.024	0.0547
Echinococcus granulosus	lamin	0.003	0.0113	0.0258
Leishmania major	nucleobase transporter	0.0017	0.0034	0.0045
Schistosoma mansoni	hypothetical protein	0.002	0.0053	0.012
Echinococcus granulosus	cathepsin l1	0.0017	0.0035	0.0079
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1	0.0017	0.0034	0.0045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0035	0.0211
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0023	0.0074	0.0168
Leishmania major	cathepsin L-like protease	0.0017	0.0035	0.0046
Loa Loa (eye worm)	ctsf protein	0.0017	0.0035	0.0211
Toxoplasma gondii	cathepsin CPL	0.0017	0.0035	0.0002
Trypanosoma cruzi	nucleoside transporter 1, putative	0.0017	0.0034	0.0045
Echinococcus multilocularis	equilibrative nucleoside transporter protein	0.0098	0.0532	0.0515
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.0035	0.0211
Trypanosoma cruzi	cruzipain precursor, putative	0.0065	0.033	0.1028
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0035	0.0115
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0198	0.1144	0.1128
Echinococcus granulosus	geminin	0.0178	0.1024	0.2335
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0098	0.0532	0.3234
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1, putative	0.0017	0.0034	0.0045
Echinococcus multilocularis	expressed conserved protein	0.0097	0.0527	0.051
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0031	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0351	0.2132
Brugia malayi	mbt repeat family protein	0.005	0.0238	0.0784
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0035	0.0211
Schistosoma mansoni	equilibrative nucleoside transporter	0.0017	0.0034	0.0078
Schistosoma mansoni	dihydroorotate dehydrogenase	0.0506	0.3031	0.6908
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0156	0.0946
Echinococcus granulosus	expressed conserved protein	0.0097	0.0527	0.1201
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0158	0.0961
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0017	0.0035	0.0017

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.94 nM	Inhibition of [3H]-NBTI binding to equilibrative nucleoside transport protein 1 (ENT1) in human erythrocyte membranes	ChEMBL.	15634027

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL608795

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1107709