Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.9243 | 0.5489 |
Onchocerca volvulus | 0.0065 | 1 | 0.5 | |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0064 | 0.9706 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 0.9243 | 0.9243 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0039 | 0.2852 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0065 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.9243 | 0.5489 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.9243 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0064 | 0.9706 | 0.9706 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.9243 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0065 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.9243 | 1 |
Giardia lamblia | Hypothetical protein | 0.0039 | 0.2852 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0065 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0065 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0064 | 0.9706 | 0.9706 |
Giardia lamblia | Hypothetical protein | 0.0039 | 0.2852 | 0.5 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0059 | 0.8321 | 0.8321 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0064 | 0.9706 | 0.9706 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0063 | 0.9243 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.9243 | 0.5489 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.9706 | 0.9604 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.9243 | 0.5489 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0059 | 0.8321 | 0.5 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0059 | 0.8321 | 0.8558 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0055 | 0.726 | 0.6319 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0065 | 1 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.9243 | 0.5 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0059 | 0.8321 | 0.8558 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 110.3 uM | Cytotoxicity against human U937 cells | ChEMBL. | 20035557 |
Inhibition (binding) | Inhibition of Mycobacterium tuberculosis mycothiol disulfide reductase assessed as NADPH oxidation at 800 uM by Ellmans reagent method | ChEMBL. | 20035557 | |
Inhibition (functional) | = 99.5 % | Antitubercular activity against Mycobacterium tuberculosis H37Rv infected in human U937 cells at MBC by radiometric method | ChEMBL. | 20035557 |
MBC (functional) | = 735.1 uM | Antitubercular activity against Mycobacterium tuberculosis H37Rv infected in human U937 cells by radiometric method | ChEMBL. | 20035557 |
MIC (functional) | = 367.6 uM | Antitubercular activity against Mycobacterium tuberculosis H37Rv by radiometric method | ChEMBL. | 20035557 |
MIC (functional) | = 367.6 uM | Antitubercular activity against Mycobacterium tuberculosis H37Rv infected in human U937 cells by radiometric method | ChEMBL. | 20035557 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.