Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | butyrylcholinesterase | Starlite/ChEMBL | References |
Mus musculus | acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 603 aa | 548 aa | 28.6 % |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase | 614 aa | 507 aa | 26.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lamin | 0.0029 | 0.0808 | 0.0072 |
Brugia malayi | RNA binding protein | 0.0068 | 0.3155 | 0.3518 |
Schistosoma mansoni | lamin | 0.0029 | 0.0808 | 0.0072 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.8968 | 0.8885 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0776 | 0.0865 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.3155 | 0.3518 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.8968 | 0.8885 |
Onchocerca volvulus | 0.0029 | 0.0808 | 1 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3155 | 0.2607 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.8968 | 0.8885 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0028 | 0.0741 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0028 | 0.0741 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0741 | 0.0826 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0741 | 0.0826 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0808 | 0.0901 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0808 | 0.0901 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.8968 | 0.8885 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0028 | 0.0741 | 0.5 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0741 | 0.0826 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0741 | 0.0826 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.3155 | 0.2607 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.8968 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.0741 | 0.0826 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3155 | 0.2607 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0741 | 0.0826 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.0741 | 0.0826 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.0808 | 0.0901 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.8968 | 1 |
Echinococcus multilocularis | musashi | 0.0029 | 0.0808 | 0.0072 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.8968 | 0.8885 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.0808 | 0.0072 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0028 | 0.0741 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0028 | 0.0741 | 0.5 |
Echinococcus multilocularis | geminin | 0.0181 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0028 | 0.0741 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.8968 | 0.8885 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.3155 | 0.2607 |
Loa Loa (eye worm) | carboxylesterase | 0.0028 | 0.0741 | 0.0826 |
Schistosoma mansoni | lamin | 0.0029 | 0.0808 | 0.0072 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.0808 | 0.0072 |
Loa Loa (eye worm) | carboxylesterase | 0.0028 | 0.0741 | 0.0826 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.8968 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.8968 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.0808 | 0.0901 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.0808 | 0.0072 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.8968 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0808 | 0.0901 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3155 | 0.2607 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.3155 | 0.3518 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.8968 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.0808 | 0.0072 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.0741 | 0.0826 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3155 | 0.2607 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0741 | 0.0826 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0741 | 0.0826 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.3155 | 0.3518 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.3155 | 0.3518 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.0741 | 0.0826 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3155 | 0.2607 |
Echinococcus granulosus | lamin | 0.0029 | 0.0808 | 0.0072 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.8968 | 0.8885 |
Onchocerca volvulus | 0.0029 | 0.0808 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0741 | 0.0826 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.3155 | 0.3518 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.8 nM | Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric method | ChEMBL. | 20137941 |
IC50 (binding) | = 2500 nM | Inhibition of mouse brain AChE after 1 hr by modified Ellman's colorimetric method | ChEMBL. | 20137941 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.