Detailed information for compound 1109127

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 394.507 | Formula: C24H30N2O3
  • H donors: 1 H acceptors: 0 LogP: 4.29 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO/N=C/1\C2CCCC1(C)C(NC2c1cccc(c1)OC)c1cccc(c1)OC
  • InChi: 1S/C24H30N2O3/c1-24-13-7-12-20(23(24)26-29-4)21(16-8-5-10-18(14-16)27-2)25-22(24)17-9-6-11-19(15-17)28-3/h5-6,8-11,14-15,20-22,25H,7,12-13H2,1-4H3/b26-23+
  • InChiKey: BKDUVIWIGOWQNK-WNAAXNPUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0141 0.1471 0.5065
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0029 0.0029
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0095 0.098 0.098
Brugia malayi Pyruvate kinase, M2 isozyme 0.0038 0.0366 0.1261
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0186 0.5078
Echinococcus multilocularis pyruvate kinase 0.002 0.0165 0.0165
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0022 0.0322
Brugia malayi Carboxylesterase family protein 0.0046 0.0452 0.1555
Brugia malayi MH2 domain containing protein 0.0017 0.014 0.0482
Schistosoma mansoni hypothetical protein 0.0018 0.0148 0.0385
Onchocerca volvulus 0.0028 0.0258 0.1754
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0685 0.1779
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0186 0.5078
Echinococcus multilocularis pyruvate kinase 0.0038 0.0366 0.0366
Brugia malayi Smad1 0.0017 0.014 0.0482
Brugia malayi MH2 domain containing protein 0.0255 0.27 0.9297
Brugia malayi Carboxylesterase family protein 0.0046 0.0452 0.1555
Loa Loa (eye worm) hypothetical protein 0.0046 0.0452 0.1555
Trypanosoma brucei pyruvate kinase 1, putative 0.0038 0.0366 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0037 0.0126
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0586 0.0586
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0186 0.2713
Schistosoma mansoni netrin receptor unc5 0.0016 0.0129 0.0334
Loa Loa (eye worm) hypothetical protein 0.0068 0.0685 0.236
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0022 0.0322
Brugia malayi MH1 domain containing protein 0.0017 0.014 0.0482
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0366 0.1261
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.0322
Loa Loa (eye worm) pyruvate kinase 0.0008 0.004 0.0138
Schistosoma mansoni hypothetical protein 0.0362 0.3852 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.0322
Schistosoma mansoni hypothetical protein 0.0016 0.0129 0.0334
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0443 0.1151
Schistosoma mansoni smad1 5 8 and 0.0017 0.014 0.0364
Loa Loa (eye worm) MH2 domain-containing protein 0.0255 0.27 0.9297
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0393 0.102
Plasmodium falciparum pyruvate kinase 2 0.002 0.0165 0.4508
Giardia lamblia Pyruvate kinase 0.002 0.0165 0.4508
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.0322
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0129 0.0334
Chlamydia trachomatis pyruvate kinase 0.0038 0.0366 0.5
Echinococcus multilocularis smad 0.0017 0.014 0.014
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0186 0.5
Mycobacterium leprae Probable pyruvate kinase PykA 0.0038 0.0366 0.5
Echinococcus granulosus BC026374 protein S09 family 0.0046 0.0452 0.1172
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0102 0.1051 0.2729
Echinococcus multilocularis mothers against decapentaplegic 2 0.0008 0.0037 0.0037
Brugia malayi mothers against decapentaplegic homolog 3 0.0008 0.0037 0.0126
Echinococcus multilocularis Smad4 0.0017 0.014 0.014
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0393 0.102
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0443 0.1527
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0274 0.2904 0.754
Brugia malayi Melibiase family protein 0.0068 0.0685 0.236
Brugia malayi Uncoordinated protein 44 0.0016 0.0129 0.0444
Schistosoma mansoni smad1 5 8 and 0.0017 0.014 0.0364
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.0322
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.014 0.0482
Schistosoma mansoni Smad4 0.0017 0.014 0.0364
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0186 0.4731
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0022 0.0322
Leishmania major pyruvate kinase 0.0038 0.0366 0.6255
Loa Loa (eye worm) hypothetical protein 0.0046 0.0452 0.1555
Schistosoma mansoni cpg binding protein 0.003 0.0275 0.0715
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.1051 0.2729
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.0322
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0586 0.152
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0022 0.0322
Loa Loa (eye worm) hypothetical protein 0.0046 0.0452 0.1555
Echinococcus granulosus para nitrobenzyl esterase 0.0046 0.0452 0.1172
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0047 0.0047
Echinococcus granulosus pyruvate kinase 0.002 0.0165 0.0429
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0029 0.0029
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0366 0.249
Loa Loa (eye worm) hypothetical protein 0.0046 0.0452 0.1555
Brugia malayi follicle stimulating hormone receptor 0.0266 0.2823 0.9719
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0186 0.064
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0022 0.0322
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0129 0.0129
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0047 0.0163
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0586 0.5569
Echinococcus granulosus nuclear factor of activated T cells 5 0.0084 0.0854 0.2217
Onchocerca volvulus 0.0046 0.0452 0.307
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0571 0.1965
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.1051 0.2729
Toxoplasma gondii melibiase subfamily protein 0.0102 0.1051 1
Brugia malayi Carboxylesterase family protein 0.0274 0.2904 1
Brugia malayi pyruvate kinase, muscle isozyme 0.0008 0.004 0.0138
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0186 0.0186
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0068 0.0685 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0022 0.0322
Echinococcus granulosus death domain containing protein 0.0016 0.0129 0.0334
Brugia malayi MH2 domain containing protein 0.0008 0.0037 0.0126
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0046 0.0452 0.1172
Schistosoma mansoni cpg binding protein 0.0028 0.0258 0.067
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.014 0.014
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0586 1
Onchocerca volvulus 0.0046 0.0452 0.307
Loa Loa (eye worm) Smad1 0.0017 0.014 0.0482
Loa Loa (eye worm) hypothetical protein 0.0046 0.0452 0.1555
Loa Loa (eye worm) acetylcholinesterase 1 0.0274 0.2904 1
Schistosoma mansoni hypothetical protein 0.0018 0.0148 0.0385
Onchocerca volvulus Huntingtin homolog 0.0141 0.1471 1
Toxoplasma gondii pyruvate kinase PyK1 0.0038 0.0366 0.3484
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0129 0.0334
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.001 0.0056 0.0194
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0029 0.0075
Loa Loa (eye worm) hypothetical protein 0.0038 0.0366 0.1261
Brugia malayi Death domain containing protein 0.0016 0.0129 0.0444
Echinococcus granulosus GPCR family 2 0.0018 0.0148 0.0385
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0129 0.0444
Loa Loa (eye worm) carboxylesterase 0.0274 0.2904 1
Echinococcus multilocularis GPCR, family 2 0.0018 0.0148 0.0148
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0102 0.1051 0.1051
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0022 0.0322
Entamoeba histolytica hypothetical protein 0.0041 0.0393 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0029 0.0075
Echinococcus granulosus jun protein 0.0095 0.098 0.2545
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0046 0.0452 0.6589
Giardia lamblia Pyruvate kinase 0.0038 0.0366 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0586 1
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0186 0.2713
Onchocerca volvulus 0.0046 0.0452 0.307
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0186 0.064
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0126
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0014 0.0108 0.0281
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0452 0.1172
Loa Loa (eye worm) hypothetical protein 0.0141 0.1471 0.5065
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0586 0.152
Loa Loa (eye worm) carboxylesterase 0.0046 0.0452 0.1555
Brugia malayi MH1 domain containing protein 0.001 0.0056 0.0194
Schistosoma mansoni pyruvate kinase 0.0038 0.0366 0.0951
Schistosoma mansoni smad 0.0008 0.0037 0.0095
Echinococcus granulosus neuroligin 0.0046 0.0452 0.1172
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0366 0.249
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.014 0.0364
Loa Loa (eye worm) hypothetical protein 0.0274 0.2904 1
Echinococcus granulosus smad 0.0017 0.014 0.0364
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0046 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.0322
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0366 1
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0012 0.0078 0.0269
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0443 0.0443
Onchocerca volvulus 0.0075 0.076 0.5164
Loa Loa (eye worm) hypothetical protein 0.0233 0.2471 0.8507
Loa Loa (eye worm) hypothetical protein 0.0046 0.0452 0.1555
Loa Loa (eye worm) hypothetical protein 0.0027 0.0241 0.0831
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.1051 0.2729
Schistosoma mansoni BC026374 protein (S09 family) 0.0046 0.0452 0.1172
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0186 0.5078
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0366 0.5344
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0186 0.5078
Echinococcus multilocularis carboxylesterase 5A 0.0274 0.2904 0.2904
Echinococcus multilocularis BC026374 protein (S09 family) 0.0046 0.0452 0.0452
Brugia malayi pyruvate kinase 0.0008 0.004 0.0138
Loa Loa (eye worm) hypothetical protein 0.0093 0.0952 0.3278
Loa Loa (eye worm) hypothetical protein 0.0016 0.013 0.0449
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.0322
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.06 0.1557
Echinococcus granulosus Smad4 0.0017 0.014 0.0364
Schistosoma mansoni Smad4 0.0008 0.0037 0.0095
Onchocerca volvulus 0.0046 0.0452 0.307
Echinococcus multilocularis cpg binding protein 0.003 0.0275 0.0275
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0194 0.2048 0.2048
Schistosoma mansoni pyruvate kinase 0.002 0.0165 0.0429
Echinococcus granulosus carboxylesterase 5A 0.0274 0.2904 0.754
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0148 0.0385
Toxoplasma gondii pyruvate kinase PyKII 0.002 0.0165 0.157
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0148 0.0511
Brugia malayi Pyruvate kinase, muscle isozyme 0.0038 0.0366 0.1261
Brugia malayi Carboxylesterase family protein 0.0046 0.0452 0.1555
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0148 0.0148
Plasmodium falciparum pyruvate kinase 0.0038 0.0366 1
Leishmania major pyruvate kinase 0.0038 0.0366 0.6255
Schistosoma mansoni hypothetical protein 0.0018 0.0148 0.0385
Schistosoma mansoni smad 0.0017 0.014 0.0364
Loa Loa (eye worm) transcription factor SMAD2 0.0255 0.27 0.9297
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0047 0.0123
Loa Loa (eye worm) pyruvate kinase-PB 0.0027 0.0241 0.0831
Echinococcus granulosus geminin 0.0362 0.3852 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0452 0.1172
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.0452 0.7713
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0443 0.1151
Echinococcus multilocularis geminin 0.0362 0.3852 0.3852
Echinococcus multilocularis pyruvate kinase 0.002 0.0165 0.0165
Echinococcus multilocularis neuroligin 0.0046 0.0452 0.0452
Schistosoma mansoni hypothetical protein 0.0041 0.0393 0.102
Entamoeba histolytica pyruvate kinase, putative 0.0027 0.0241 0.6137
Schistosoma mansoni neuroligin 3 (S09 family) 0.0046 0.0452 0.1172
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0046 0.0452 0.0452
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0022 0.0322
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0586 0.152
Schistosoma mansoni hypothetical protein 0.0039 0.0375 0.0974
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0586 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0452 0.1555
Echinococcus granulosus acetylcholinesterase 0.0274 0.2904 0.754
Echinococcus multilocularis acetylcholinesterase 0.0274 0.2904 0.2904
Loa Loa (eye worm) nuclear factor I 0.001 0.0056 0.0194
Echinococcus granulosus mothers against decapentaplegic 2 0.0008 0.0037 0.0095
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0084 0.0854 0.0854
Trichomonas vaginalis spcc417.12 protein, putative 0.0046 0.0452 0.6589
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.0322
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.014 0.014
Brugia malayi MH2 domain containing protein 0.0017 0.014 0.0482
Echinococcus granulosus pyruvate kinase 0.002 0.0165 0.0429
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0443 0.1151
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0258 0.0888
Loa Loa (eye worm) hypothetical protein 0.0274 0.2904 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0186 0.0483
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.013 0.0338
Echinococcus multilocularis pyruvate kinase 0.002 0.0165 0.0165
Echinococcus multilocularis mothers against decapentaplegic 6 0.0008 0.0037 0.0037
Onchocerca volvulus 0.0046 0.0452 0.307
Brugia malayi hypothetical protein 0.0141 0.1471 0.5065
Echinococcus granulosus pyruvate kinase 0.0038 0.0366 0.0951
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0129 0.0876
Brugia malayi MH1 domain containing protein 0.001 0.0056 0.0194
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0186 0.3176
Echinococcus multilocularis pyruvate kinase 0.0038 0.0366 0.0366
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0443 0.1151
Mycobacterium tuberculosis Carboxylesterase LipT 0.0046 0.0452 0.7713
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.014 0.0482
Schistosoma mansoni Smad4 0.0008 0.0037 0.0095
Plasmodium vivax pyruvate kinase, putative 0.0038 0.0366 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0586 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0038 0.0366 0.6255
Echinococcus granulosus acetylcholinesterase 0.0274 0.2904 0.754
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0186 0.3176
Loa Loa (eye worm) hypothetical protein 0.0018 0.0148 0.0511
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0531 0.5048
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0148 0.0511
Echinococcus granulosus Ankyrin 0.0016 0.013 0.0338
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.014 0.0364
Echinococcus multilocularis acetylcholinesterase 0.0274 0.2904 0.2904
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0393 0.0393
Schistosoma mansoni ap endonuclease 0.0022 0.0186 0.0483
Trypanosoma brucei pyruvate kinase 1 0.0038 0.0366 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0443 0.1151
Schistosoma mansoni cpg binding protein 0.003 0.0275 0.0715
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0366 1
Brugia malayi Protein kinase domain containing protein 0.0016 0.0129 0.0444
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0443 0.0443
Toxoplasma gondii exonuclease III APE 0.0022 0.0186 0.1769
Schistosoma mansoni acetylcholinesterase 0.0046 0.0452 0.1172
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0366 0.1261
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0266 0.2823 0.9719
Brugia malayi Carboxylesterase family protein 0.0046 0.0452 0.1555
Echinococcus multilocularis Ankyrin 0.0016 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0129 0.0444
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0194 0.2048 0.5318
Brugia malayi hypothetical protein 0.0075 0.076 0.2616
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0375 0.1292
Echinococcus multilocularis jun protein 0.0095 0.098 0.098
Entamoeba histolytica hypothetical protein 0.0041 0.0393 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0258 0.0888
Mycobacterium ulcerans carboxylesterase, LipT 0.0046 0.0452 0.6649
Onchocerca volvulus Huntingtin homolog 0.0141 0.1471 1
Loa Loa (eye worm) carboxylesterase 0.0046 0.0452 0.1555
Schistosoma mansoni smad1 5 8 and 0.0017 0.014 0.0364
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.014 0.0364
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0148 0.0511
Schistosoma mansoni hypothetical protein 0.0018 0.0148 0.0385
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0452 0.1172
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0129 0.0444
Echinococcus granulosus cpg binding protein 0.003 0.0275 0.0715
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0095 0.098 0.2545
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0186 0.5078
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.0452 0.7713
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0366 0.5344
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0443 0.1527
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0685 0.1779
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0233 0.2471 0.8507
Brugia malayi hypothetical protein 0.0046 0.0452 0.1555
Entamoeba histolytica hypothetical protein 0.0041 0.0393 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0046 0.0452 0.0452
Entamoeba histolytica hypothetical protein 0.0041 0.0393 1
Schistosoma mansoni hypothetical protein 0.0077 0.0788 0.2045
Brugia malayi bZIP transcription factor family protein 0.0095 0.098 0.3375
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0037 0.0126
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0129 0.0334
Toxoplasma gondii Alpha-galactosidase 0.0014 0.0108 0.1031
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0366 0.249
Plasmodium vivax pyruvate kinase 2, putative 0.002 0.0165 0.4508
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0008 0.0037 0.0249
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0029 0.0075
Trichomonas vaginalis helicase, putative 0.0006 0.0022 0.0322
Brugia malayi hypothetical protein 0.0041 0.0393 0.1353
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.0322
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0102 0.1051 0.1051
Echinococcus granulosus pyruvate kinase 0.0038 0.0366 0.0951
Brugia malayi MH1 domain containing protein 0.0017 0.014 0.0482
Schistosoma mansoni ap endonuclease 0.0022 0.0186 0.0483
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0186 1
Schistosoma mansoni gliotactin 0.0046 0.0452 0.1172
Schistosoma mansoni pyruvate kinase 0.0038 0.0366 0.0951
Schistosoma mansoni hypothetical protein 0.0362 0.3852 1
Echinococcus granulosus pyruvate kinase 0.002 0.0165 0.0429
Echinococcus granulosus mothers against decapentaplegic 6 0.0008 0.0037 0.0095
Echinococcus multilocularis pyruvate kinase 0.003 0.0279 0.0279
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0571 0.1965
Schistosoma mansoni jun-related protein 0.0077 0.0788 0.2045
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0586 1
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0366 0.1261
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.1051 0.2729
Brugia malayi Carboxylesterase family protein 0.0274 0.2904 1
Mycobacterium ulcerans pyruvate kinase 0.0038 0.0366 0.4512
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0186 0.5078
Loa Loa (eye worm) hypothetical protein 0.0039 0.0375 0.1292

Activities

Activity type Activity value Assay description Source Reference
MIC90 (functional) = 128 ug ml-1 Antifungal activity against Candida albicans by NCCLS broth microdilution method ChEMBL. 20138517
MIC90 (functional) = 128 ug ml-1 Antifungal activity against Cryptococcus neoformans by NCCLS broth microdilution method ChEMBL. 20138517

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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