Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0202 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0202 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0202 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0202 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0202 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0202 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0202 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0202 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0202 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0202 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antimicrobial activity against Escherichia coli at 1000 ug after 24 to 48 hrs by well diffusion method | ChEMBL. | 19427713 | |
Activity (functional) | = 70.75 % | Analgesic activity against Swiss albino mouse assessed as increase in paw licking or jump response at 10 mg/kg, po after 1.5 hrs by hot plate method | ChEMBL. | 19427713 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.