Detailed information for compound 1109333

Basic information

Technical information
  • TDR Targets ID: 1109333
  • Name: [2-[2-(3-chlorophenyl)tetrazol-5-yl]pyrrolidi n-1-yl]-(5-methylfuran-2-yl)methanone
  • MW: 357.794 | Formula: C17H16ClN5O2
  • H donors: 0 H acceptors: 4 LogP: 3.72 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)n1nnc(n1)C1CCCN1C(=O)c1ccc(o1)C
  • InChi: 1S/C17H16ClN5O2/c1-11-7-8-15(25-11)17(24)22-9-3-6-14(22)16-19-21-23(20-16)13-5-2-4-12(18)10-13/h2,4-5,7-8,10,14H,3,6,9H2,1H3
  • InChiKey: JEPGUCWIUVNQSV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [2-[2-(3-chlorophenyl)tetrazol-5-yl]pyrrolidin-1-yl]-(5-methyl-2-furyl)methanone
  • [2-[2-(3-chlorophenyl)-5-tetrazolyl]-1-pyrrolidinyl]-(5-methyl-2-furyl)methanone
  • [2-[2-(3-chlorophenyl)-1,2,3,4-tetrazol-5-yl]pyrrolidin-1-yl]-(5-methylfuran-2-yl)methanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Metabotropic glutamate receptor 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum Metabotropic glutamate receptor precursor, putative Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi Metabotropic glutamate receptor precursor. Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum ko:K04606 glutamate receptor, metabotropic 3, putative Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0377 0.0377
Schistosoma mansoni cpg binding protein 0.0028 0.3069 0.3696
Schistosoma mansoni cpg binding protein 0.0031 0.3582 0.4313
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0377 0.0377
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.002 0.1951 0.2397
Mycobacterium ulcerans polyketide synthase 0.0024 0.2516 0.3643
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0377 0.0367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0377 0.0314
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0041 0.4992 0.6319
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.186 0.2708
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.2413 0.2992
Schistosoma mansoni zinc finger protein 0.0015 0.1128 0.1358
Loa Loa (eye worm) hypothetical protein 0.0037 0.4465 0.483
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.1473 0.178
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0377 0.0535
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.2413 0.2905
Mycobacterium ulcerans polyketide synthase 0.0026 0.274 0.397
Schistosoma mansoni hypothetical protein 0.002 0.19 0.2287
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0377 0.0367
Loa Loa (eye worm) hypothetical protein 0.002 0.1951 0.2053
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0377 0.0367
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0024 0.2516 0.362
Loa Loa (eye worm) hypothetical protein 0.0014 0.0933 0.0928
Mycobacterium ulcerans polyketide synthase Pks9 0.0016 0.1296 0.1861
Toxoplasma gondii tRNA ligases class I (M) protein 0.002 0.1951 0.1902
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0377 0.0377
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0377 0.0377
Loa Loa (eye worm) PHD-finger family protein 0.002 0.19 0.1996
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0377 0.0367
Schistosoma mansoni hypothetical protein 0.0015 0.1128 0.1358
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.046 0.046
Schistosoma mansoni cpg binding protein 0.0031 0.3582 0.4313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0377 0.0314
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0046 0.574 0.574
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0377 0.0454
Schistosoma mansoni nuclear hormone receptor 0.001 0.0377 0.0454
Loa Loa (eye worm) glutamate receptor 0.0019 0.1769 0.1852
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.7726 0.9303
Schistosoma mansoni zinc finger protein 0.0021 0.1984 0.2388
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.2279 0.3319
Echinococcus multilocularis metabotropic glutamate receptor 5 0.006 0.7846 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0036 0.4297 0.6257
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0377 0.0454
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.7128 1
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.274 0.3948
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0036 0.4297 0.6257
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0008 0.0153 0.0223
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.002 0.1951 0.2397
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.02 0.0139
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.274 0.3948
Mycobacterium ulcerans polyketide synthase Pks13 0.0036 0.4297 0.6244
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.2516 0.3664
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.2406 0.3503
Mycobacterium tuberculosis Probable thioesterase TesA 0.002 0.1916 0.279
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0056 0.7164 0.8626
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.2516 0.3643
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.001 0.0377 0.0314
Schistosoma mansoni metabotropic glutamate receptor 0.0024 0.2451 0.2952
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.274 0.3989
Echinococcus granulosus metabotropic glutamate receptor 2 0.0041 0.4992 0.6319
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0377 0.0377
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.1473 0.178
Giardia lamblia Methionyl-tRNA synthetase 0.0054 0.6868 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0377 0.0367
Giardia lamblia Leucyl-tRNA synthetase 0.002 0.1951 0.2841
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.2516 0.3643
Mycobacterium ulcerans thioesterase 0.002 0.1916 0.2766
Echinococcus multilocularis methionine tRNA synthetase 0.0054 0.6868 0.8738
Loa Loa (eye worm) hypothetical protein 0.001 0.0377 0.0314
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.4112 0.5185
Loa Loa (eye worm) hypothetical protein 0.002 0.1951 0.2053
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0377 0.0377
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0008 0.0093 0.0093
Echinococcus granulosus cpg binding protein 0.0031 0.3582 0.4501
Schistosoma mansoni coup transcription factor 0.001 0.0377 0.0454
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0377 0.0367
Plasmodium falciparum methionine--tRNA ligase 0.0054 0.6868 1
Mycobacterium ulcerans fatty acid synthase Fas 0.0008 0.0046 0.0035
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0054 0.6868 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0377 0.0377
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0024 0.2516 0.362
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.2279 0.2416
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.001 0.0371 0.0541
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0377 0.0454
Plasmodium vivax methionine--tRNA ligase, putative 0.0054 0.6868 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0016 0.1296 0.1833
Echinococcus granulosus methionine tRNA synthetase 0.0054 0.6868 0.8738
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0377 0.0367
Leishmania major leucyl-tRNA synthetase, putative 0.002 0.1951 0.2841
Leishmania major hypothetical protein, conserved 0.0015 0.1128 0.1643
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0377 0.0377
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0377 0.0314
Brugia malayi Receptor family ligand binding region containing protein 0.0013 0.0775 0.0775
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.274 0.3948
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.4112 0.5185
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0377 0.0367
Loa Loa (eye worm) hypothetical protein 0.0013 0.0775 0.0754
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0033 0.3832 0.4131
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0377 0.0367
Onchocerca volvulus 0.0023 0.2279 0.4115
Echinococcus granulosus FTZ F1 alpha 0.001 0.0377 0.0367
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.274 0.3136
Schistosoma mansoni bromodomain containing protein 0.0063 0.8305 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0377 0.0314
Loa Loa (eye worm) hypothetical protein 0.006 0.7846 0.8566
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0054 0.6868 1
Onchocerca volvulus 0.0028 0.3069 0.5602
Loa Loa (eye worm) hypothetical protein 0.0041 0.4964 0.5382
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0054 0.6868 0.7485
Schistosoma mansoni hypothetical protein 0.0008 0.0093 0.0112
Loa Loa (eye worm) hypothetical protein 0.0069 0.9144 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0377 0.0314
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.1812 0.2615
Mycobacterium ulcerans thioesterase TesA 0.002 0.1916 0.2766
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.1812 0.2589
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0016 0.1296 0.1861
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.1382 0.1663
Loa Loa (eye worm) hypothetical protein 0.002 0.1951 0.2053
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0008 0.0046 0.0067
Brugia malayi nuclear hormone receptor 0.001 0.0377 0.0377
Onchocerca volvulus 0.0033 0.3832 0.7038
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.002 0.1951 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0377 0.0454
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0377 0.0367
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0054 0.6868 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.004 0.4808 0.5209
Onchocerca volvulus Fatty acid synthase homolog 0.0044 0.5406 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.1473 0.1773
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0377 0.0377
Treponema pallidum methionyl-tRNA synthetase 0.002 0.1951 0.5
Loa Loa (eye worm) histone methyltransferase 0.0009 0.02 0.0119
Echinococcus multilocularis leucyl tRNA synthetase 0.002 0.1951 0.2397
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0024 0.2516 0.3664
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.274 0.3989
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.274 0.397
Schistosoma mansoni thyroid hormone receptor 0.001 0.0377 0.0454
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.1382 0.1664
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.1473 0.1773
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.1382 0.1664
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0013 0.0775 0.0754
Mycobacterium ulcerans leucyl-tRNA synthetase 0.002 0.1951 0.2817
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0377 0.0535
Loa Loa (eye worm) hypothetical protein 0.001 0.0377 0.0314
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0022 0.0022
Brugia malayi protein ZK524.3 0.002 0.1951 0.1951
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0377 0.0367
Onchocerca volvulus 0.0042 0.5182 0.9579
Brugia malayi methionyl-tRNA synthetase 0.002 0.1951 0.1951
Leishmania major methionyl-tRNA synthetase, putative 0.0054 0.6868 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0377 0.0367
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0377 0.0367
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0007 0.0022 0.0033
Schistosoma mansoni methionine-tRNA synthetase 0.002 0.1951 0.2349
Brugia malayi AMP-binding enzyme family protein 0.0023 0.2279 0.2279
Loa Loa (eye worm) hypothetical protein 0.001 0.0377 0.0314
Loa Loa (eye worm) fatty acid synthase 0.0024 0.2468 0.2624
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.7787 0.9924
Brugia malayi steroid hormone receptor 0.001 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0017 0.1473 0.1524
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.2406 0.3503
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0377 0.0535
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0377 0.0377
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0377 0.0454
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.274 0.3989
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.3069 0.3288
Chlamydia trachomatis leucine--tRNA ligase 0.002 0.1951 0.5
Echinococcus multilocularis zinc finger protein 0.0021 0.1984 0.2439
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.001 0.0377 0.0314
Toxoplasma gondii methionyl-tRNA synthetase 0.0054 0.6868 0.9594
Loa Loa (eye worm) hypothetical protein 0.001 0.0377 0.0314
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0377 0.0367
Brugia malayi Bromodomain containing protein 0.0037 0.4455 0.4455
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0377 0.0314
Schistosoma mansoni leucyl-tRNA synthetase 0.002 0.1951 0.2349
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.1471 0.1522
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0014 0.0962 0.1401
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0017 0.1502 0.2187
Loa Loa (eye worm) glutamate receptor 0.0049 0.617 0.6714
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.2516 0.3643
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.274 0.397
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.2413 0.2992
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.1382 0.1663
Brugia malayi PHD-finger family protein 0.0026 0.2755 0.2755
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0377 0.0454
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0024 0.2516 0.2516
Loa Loa (eye worm) hypothetical protein 0.001 0.0377 0.0314
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0377 0.0367
Treponema pallidum leucyl-tRNA synthetase 0.002 0.1951 0.5
Brugia malayi methionyl-tRNA synthetase 0.0054 0.6868 0.6868
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0377 0.0367
Loa Loa (eye worm) hypothetical protein 0.0043 0.5321 0.5776
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0377 0.0377
Mycobacterium leprae Polyketide synthase Pks13 0.0036 0.4297 0.6231
Toxoplasma gondii type I fatty acid synthase, putative 0.0017 0.1478 0.1163
Echinococcus granulosus metabotropic glutamate receptor 5 0.006 0.7846 1
Schistosoma mansoni methionine-tRNA synthetase 0.0054 0.6868 0.8269
Schistosoma mansoni metabotropic glutamate receptor 0.0041 0.4992 0.6011
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0044 0.5488 0.5488
Brugia malayi ecdysteroid receptor 0.001 0.0377 0.0377
Brugia malayi nuclear receptor NHR-88 0.001 0.0377 0.0377
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0377 0.0454
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0013 0.0775 0.0754
Onchocerca volvulus 0.001 0.0377 0.0535
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.1812 0.2615
Echinococcus granulosus zinc finger protein 0.0021 0.1984 0.2439
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.002 0.1916 0.2741
Brugia malayi CXXC zinc finger family protein 0.0028 0.3069 0.3069
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0377 0.0314
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0377 0.0454
Echinococcus multilocularis cpg binding protein 0.0031 0.3582 0.4501
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0016 0.1251 0.0807
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0377 0.0314
Brugia malayi metabotropic glutamate receptor type 2 0.0024 0.2451 0.2451
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.2516 0.3643
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0377 0.0367
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.7787 0.9924
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0377 0.0314
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0054 0.6868 1
Loa Loa (eye worm) acyl carrier protein 0.0011 0.0571 0.0528
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0054 0.6868 1
Brugia malayi Metabotropic glutamate receptor precursor. 0.0049 0.617 0.617
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.2516 0.3664
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0377 0.0377
Schistosoma mansoni thyroid hormone receptor 0.001 0.0377 0.0454
Chlamydia trachomatis methionine--tRNA ligase 0.002 0.1951 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0377 0.0377
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0054 0.6868 1
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0054 0.6868 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.02 0.0139
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0377 0.0454

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 6.98 Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranes ChEMBL. 20483612

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.