TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 211.261 | Formula: C10H17N3O2
H donors: 1 H acceptors: 2 LogP: -1.4 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CN(CCN1C(=O)[C@@H]2[C@H](C1=O)CNC2)C
InChi: 1S/C10H17N3O2/c1-12(2)3-4-13-9(14)7-5-11-6-8(7)10(13)15/h7-8,11H,3-6H2,1-2H3/t7-,8+
InChiKey: ZOZSDRXQGPJKJR-OCAPTIKFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0019	0.2518	0.2435
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.2518	0.4658
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.2518	0.4658
Echinococcus granulosus	neuropeptides capa receptor	0.0019	0.2518	0.4658
Brugia malayi	Dopamine receptor protein 1	0.0019	0.2518	0.4602
Echinococcus multilocularis	g-protein coupled receptor	0.0019	0.2518	0.4658
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.2518	0.2435
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0019	0.2518	0.4602
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0525	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0019	0.2518	0.2435
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.2518	0.4658
Brugia malayi	Serotonin receptor	0.0019	0.2518	0.4602
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0019	0.2518	0.4658
Schistosoma mansoni	amine GPCR	0.0019	0.2518	0.2435
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0525	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0019	0.2518	0.4658
Schistosoma mansoni	lamin	0.0029	0.4088	0.4023
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.2518	0.4658
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0019	0.2518	0.2435
Brugia malayi	G protein-coupled receptor F59B2.13	0.0019	0.2518	0.4602
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0019	0.2518	0.4571
Echinococcus granulosus	neuropeptide Y receptor	0.0019	0.2518	0.4658
Schistosoma mansoni	neuropeptide receptor	0.0019	0.2518	0.2435
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0939	0.0754
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0058	0.8867	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0019	0.2518	0.4658
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.2518	0.4658
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0019	0.2518	0.4658
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0525	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0019	0.2518	0.2435
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0019	0.2518	0.4658
Brugia malayi	hypothetical protein	0.0019	0.2518	0.4602
Echinococcus granulosus	biogenic amine 5HT receptor	0.0019	0.2518	0.4658
Schistosoma mansoni	amine GPCR	0.0019	0.2518	0.2435
Schistosoma mansoni	hypothetical protein	0.0019	0.2518	0.2435
Brugia malayi	putative neuropeptide receptor NPR1	0.0019	0.2518	0.4602
Echinococcus multilocularis	dro:myosuppressin receptor	0.0019	0.2518	0.4658
Brugia malayi	Dopamine receptor	0.0019	0.2518	0.4602
Onchocerca volvulus		0.0029	0.4088	0.8373
Echinococcus granulosus	neuropeptide receptor	0.0019	0.2518	0.4658
Echinococcus granulosus	biogenic amine 5HT receptor	0.0019	0.2518	0.4658
Echinococcus granulosus	7tm_1 domain containing protein	0.0019	0.2518	0.4658
Echinococcus granulosus	lamin dm0	0.0029	0.4088	0.8541
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Loa Loa (eye worm)	G-protein coupled receptor	0.0019	0.2518	0.4571
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0019	0.2518	0.4658
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0019	0.2518	0.4658
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Echinococcus granulosus	hypothetical protein	0.0019	0.2518	0.4658
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0019	0.2518	0.4658
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0019	0.2518	0.2435
Echinococcus granulosus	g protein coupled receptor	0.0019	0.2518	0.4658
Brugia malayi	follicle stimulating hormone receptor	0.0019	0.2518	0.4602
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.2518	0.4658
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Brugia malayi	hypothetical protein	0.0019	0.2518	0.4602
Echinococcus granulosus	lamin	0.0029	0.4088	0.8541
Echinococcus multilocularis	fmrfamide receptor	0.0019	0.2518	0.4658
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Brugia malayi	Serotonin receptor	0.0019	0.2518	0.4602
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Loa Loa (eye worm)	hypothetical protein	0.0013	0.1572	0.1833
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0019	0.2518	0.4658
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Loa Loa (eye worm)	hypothetical protein	0.0013	0.1572	0.1833
Schistosoma mansoni	opsin-like receptor	0.0019	0.2518	0.2435
Echinococcus granulosus	dro:myosuppressin receptor	0.0019	0.2518	0.4658
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Schistosoma mansoni	biogenic amine receptor	0.0019	0.2518	0.2435
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.2518	0.4658
Echinococcus granulosus	G protein coupled receptor 139	0.0019	0.2518	0.4658
Brugia malayi	sulfakinin receptor protein	0.0019	0.2518	0.4602
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.2518	0.2435
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.4088	0.9117
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Loa Loa (eye worm)	TYRA-2 protein	0.0019	0.2518	0.4571
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0019	0.2518	0.4658
Echinococcus multilocularis	G protein coupled receptor 139	0.0019	0.2518	0.4658
Schistosoma mansoni	cpg binding protein	0.003	0.4393	0.4331
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.2518	0.4658
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.2518	0.4658
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.4393	1
Brugia malayi	G-protein coupled receptor	0.0019	0.2518	0.4602
Echinococcus granulosus	g protein coupled receptor	0.0019	0.2518	0.4658
Schistosoma mansoni	neuropeptide f receptor 76f	0.0019	0.2518	0.2435
Echinococcus granulosus	sex peptide receptor	0.0019	0.2518	0.4658
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0019	0.2518	0.2435
Trichomonas vaginalis	helicase, putative	0.0007	0.0525	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.1658	0.2082
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0019	0.2518	0.2435
Schistosoma mansoni	biogenic amine receptor	0.0019	0.2518	0.2435
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.2518	0.2435
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.2518	0.4658
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0525	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Loa Loa (eye worm)	neuropeptide F receptor	0.0019	0.2518	0.4571
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Brugia malayi	hypothetical protein	0.0019	0.2518	0.4602
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.2518	0.4658
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0019	0.2518	0.4658
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.2518	0.4658
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0525	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.1908	0.2804
Echinococcus multilocularis	serotonin receptor	0.0019	0.2518	0.4658
Schistosoma mansoni	neuropeptide F-like receptor	0.0019	0.2518	0.2435
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Echinococcus multilocularis	orexin receptor type 2	0.0019	0.2518	0.4658
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0019	0.2518	0.4658
Brugia malayi	hypothetical protein	0.0019	0.2518	0.4602
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0525	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0019	0.2518	0.4602
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.2518	0.4658
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0019	0.2518	0.4571
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0019	0.2518	0.4571
Schistosoma mansoni	opsin-like receptor	0.0019	0.2518	0.2435
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0019	0.2518	0.2435
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0019	0.2518	0.4658
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.1658	0.2532
Onchocerca volvulus		0.0029	0.4088	0.8373
Loa Loa (eye worm)	melatonin receptor type 1A	0.0019	0.2518	0.4571
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0019	0.2518	0.4602
Onchocerca volvulus		0.003	0.4393	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0019	0.2518	0.2435
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Brugia malayi	hypothetical protein	0.0019	0.2518	0.4602
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Schistosoma mansoni	neuropeptide F-like receptor	0.0019	0.2518	0.2435
Schistosoma mansoni	lamin	0.0029	0.4088	0.4023
Echinococcus multilocularis	neuropeptide Y receptor	0.0019	0.2518	0.4658
Schistosoma mansoni	neuropeptide receptor	0.0019	0.2518	0.2435
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Echinococcus granulosus	neuropeptide Y receptor	0.0019	0.2518	0.4658
Echinococcus granulosus	orexin receptor type 2	0.0019	0.2518	0.4658
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0019	0.2518	0.4571
Schistosoma mansoni	histamine h1 receptor	0.0019	0.2518	0.2435
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.2518	0.2435
Brugia malayi	Dopamine receptor protein 2	0.0019	0.2518	0.4602
Echinococcus granulosus	allatostatin A receptor	0.0019	0.2518	0.4658
Brugia malayi	GnHR receptor homolog	0.0019	0.2518	0.4602
Brugia malayi	intermediate filament protein	0.0029	0.4088	0.9122
Brugia malayi	G protein-coupled receptor	0.0019	0.2518	0.4602
Echinococcus granulosus	intermediate filament protein	0.0029	0.4088	0.8541
Schistosoma mansoni	cpg binding protein	0.0032	0.4678	0.4619
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.2518	0.4658
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.2518	0.4658
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0939	0.0754
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.4088	0.9117
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.2518	0.2435
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.2518	0.4658
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0019	0.2518	0.2435
Schistosoma mansoni	hypothetical protein	0.0019	0.2518	0.2435
Brugia malayi	larval opioid receptor	0.0019	0.2518	0.4602
Echinococcus multilocularis	serotonin receptor	0.0019	0.2518	0.4658
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0019	0.2518	0.4658
Echinococcus multilocularis	neuropeptide receptor A26	0.0019	0.2518	0.4658
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0019	0.2518	0.2435
Echinococcus multilocularis	neuropeptide receptor	0.0019	0.2518	0.4658
Echinococcus multilocularis	neuropeptides capa receptor	0.0019	0.2518	0.4658
Brugia malayi	AKH receptor	0.0019	0.2518	0.4602
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Echinococcus granulosus	cpg binding protein	0.0032	0.4678	1
Schistosoma mansoni	intermediate filament proteins	0.0029	0.4088	0.4023
Brugia malayi	CXXC zinc finger family protein	0.003	0.4393	1
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.1908	0.2845
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.2518	0.4658
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Echinococcus multilocularis	neuropeptide Y receptor	0.0019	0.2518	0.4658
Echinococcus granulosus	neuropeptide receptor A26	0.0019	0.2518	0.4658
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0019	0.2518	0.4658
Echinococcus multilocularis	cpg binding protein	0.0032	0.4678	1
Schistosoma mansoni	amine GPCR	0.0019	0.2518	0.2435
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Schistosoma mansoni	hypothetical protein	0.0019	0.2518	0.2435
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0019	0.2518	0.4602
Echinococcus granulosus	neuropeptide FF receptor 2	0.0019	0.2518	0.4658
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0019	0.2518	0.4658
Echinococcus granulosus	somatostatin receptor	0.0019	0.2518	0.4658
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0634	0.0531
Schistosoma mansoni	opsin-like receptor	0.0019	0.2518	0.2435
Brugia malayi	RE15519p	0.0019	0.2518	0.4602
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.1658	0.2532
Schistosoma mansoni	hypothetical protein	0.0019	0.2518	0.2435
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.2518	0.2435
Echinococcus multilocularis	neuropeptide receptor	0.0019	0.2518	0.4658
Brugia malayi	hypothetical protein	0.0019	0.2518	0.4602
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.2518	0.2435
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0019	0.2518	0.4658
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.2518	0.2435
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.2518	0.2435
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0525	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0019	0.2518	0.4602
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0019	0.2518	0.4658
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Brugia malayi	G-protein coupled receptor	0.0019	0.2518	0.4602
Echinococcus multilocularis	neuropeptides capa receptor	0.0019	0.2518	0.4658
Schistosoma mansoni	amine GPCR	0.0019	0.2518	0.2435
Loa Loa (eye worm)	hypothetical protein	0.0029	0.4088	0.9117
Echinococcus granulosus	neuropeptide s receptor	0.0019	0.2518	0.4658
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0019	0.2518	0.4658
Echinococcus granulosus	g protein coupled receptor	0.0019	0.2518	0.4658
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Brugia malayi	neuropeptide F receptor	0.0019	0.2518	0.4602
Brugia malayi	hypothetical protein	0.0019	0.2518	0.4602
Echinococcus multilocularis	musashi	0.0029	0.4088	0.8541
Echinococcus multilocularis	lamin dm0	0.0029	0.4088	0.8541
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0019	0.2518	0.4658
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0019	0.2518	0.4602
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Schistosoma mansoni	biogenic amine receptor	0.0019	0.2518	0.2435
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.2518	0.2435
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0019	0.2518	0.2435
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Brugia malayi	hypothetical protein	0.0019	0.2518	0.4602
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0019	0.2518	0.4571
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0019	0.2518	0.4571
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Echinococcus multilocularis	somatostatin receptor	0.0019	0.2518	0.4658
Echinococcus granulosus	neuropeptides capa receptor	0.0019	0.2518	0.4658
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4002	0.8868
Echinococcus granulosus	7TM GPCR rhodopsin	0.0019	0.2518	0.4658
Echinococcus granulosus	fmrfamide receptor	0.0019	0.2518	0.4658
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0019	0.2518	0.4658
Echinococcus multilocularis	neuropeptide s receptor	0.0019	0.2518	0.4658
Loa Loa (eye worm)	neuropeptide F receptor	0.0019	0.2518	0.4571
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.2518	0.4658
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.2518	0.4658
Brugia malayi	neuropeptide F receptor	0.0019	0.2518	0.4602
Schistosoma mansoni	amine GPCR	0.0019	0.2518	0.2435
Schistosoma mansoni	neuropeptide receptor	0.0019	0.2518	0.2435
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.2518	0.4658
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0019	0.2518	0.4658
Echinococcus granulosus	serotonin receptor	0.0019	0.2518	0.4658
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.2518	0.4658
Echinococcus multilocularis	fmrfamide receptor	0.0019	0.2518	0.4658
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.2518	0.4658
Echinococcus multilocularis	sex peptide receptor	0.0019	0.2518	0.4658
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.4088	0.9122
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.2518	0.4658
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0525	1
Brugia malayi	hypothetical protein	0.0019	0.2518	0.4602
Schistosoma mansoni	myosin xvIII	0.0019	0.2518	0.2435
Echinococcus granulosus	g-protein coupled receptor	0.0019	0.2518	0.4658
Schistosoma mansoni	adenoreceptor	0.0019	0.2518	0.2435
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Schistosoma mansoni	cpg binding protein	0.0032	0.4678	0.4619
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.2518	0.2435
Brugia malayi	putative neuropeptide receptor	0.0019	0.2518	0.4602
Echinococcus granulosus	neuropeptide receptor	0.0019	0.2518	0.4658
Brugia malayi	ORL1-like opioid receptor	0.0019	0.2518	0.4602
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.2518	0.2435
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.2518	0.4658
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0019	0.2518	0.4658
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Schistosoma mansoni	neuropeptide receptor	0.0019	0.2518	0.2435
Echinococcus multilocularis	lamin	0.0029	0.4088	0.8541
Brugia malayi	hypothetical protein	0.0019	0.2518	0.4602
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0019	0.2518	0.2435
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Brugia malayi	Melatonin receptor type 1A	0.0019	0.2518	0.4602
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2518	0.4571
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0019	0.2518	0.2435

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	< 10 %	Cytotoxicity against human SW480 cells at 100 uM after 72 hrs by MTT assay	ChEMBL.	20153915
Inhibition (functional)	< 10 %	Cytotoxicity against human DU145 cells at 100 uM after 72 hrs by MTT assay	ChEMBL.	20153915
Inhibition (functional)	= 11 %	Cytotoxicity against human H460 cells at 100 uM after 72 hrs by MTT assay	ChEMBL.	20153915
Inhibition (functional)	= 12 %	Cytotoxicity against human A2780 cells at 100 uM after 72 hrs by MTT assay	ChEMBL.	20153915
Inhibition (functional)	= 13 %	Cytotoxicity against human MCF7 cells at 100 uM after 72 hrs by MTT assay	ChEMBL.	20153915
Inhibition (functional)	= 13 %	Cytotoxicity against human A431 cells at 100 uM after 72 hrs by MTT assay	ChEMBL.	20153915
Inhibition (functional)	= 14 %	Cytotoxicity against human HT-29 cells at 100 uM after 72 hrs by MTT assay	ChEMBL.	20153915

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1087321

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1109364