Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.000894353 | 0.00905607 | 0.5 |
Onchocerca volvulus | 0.000894353 | 0.00905607 | 1 | |
Leishmania major | oxidoreductase-like protein | 0.000894353 | 0.00905607 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.000894353 | 0.00905607 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0182554 | 1 | 1 |
Trypanosoma brucei | oxidoreductase-like protein | 0.000894353 | 0.00905607 | 0.5 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.000894353 | 0.00905607 | 0.5 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.000894353 | 0.00905607 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.000894353 | 0.00905607 | 1 |
Leishmania major | pteridine reductase 1 | 0.000894353 | 0.00905607 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0182554 | 1 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0182554 | 1 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0182554 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0182554 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0182554 | 1 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0182554 | 1 | 1 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.000894353 | 0.00905607 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0182554 | 1 | 1 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.000894353 | 0.00905607 | 0.5 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.000894353 | 0.00905607 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.000894353 | 0.00905607 | 0.5 |
Trypanosoma brucei | pteridine reductase 1 | 0.000894353 | 0.00905607 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.000894353 | 0.00905607 | 0.5 |
Schistosoma mansoni | dihydropteridine reductase | 0.000894353 | 0.00905607 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.000894353 | 0.00905607 | 0.5 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.000894353 | 0.00905607 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0182554 | 1 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.000894353 | 0.00905607 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.000894353 | 0.00905607 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.000894353 | 0.00905607 | 1 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.000894353 | 0.00905607 | 1 |
Onchocerca volvulus | 0.000894353 | 0.00905607 | 1 | |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.000894353 | 0.00905607 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 7.8 uM | Antiparasitic activity against Trypanosoma cruzi Tulahuen C2C4 amastigotes | ChEMBL. | 20185305 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma cruzi | ChEMBL23 | 20185305 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.