Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.3164 | 0.3831 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.003 | 0.1248 | 0.1511 |
Schistosoma mansoni | thyroid hormone receptor | 0.0145 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.1605 | 0.1944 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1871 | 0.1871 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0942 | 0.114 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0178 | 0.0215 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.9179 | 0.9179 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1605 | 0.1605 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.2835 | 0.3433 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 0.5177 | 0.5177 |
Onchocerca volvulus | 0.0056 | 0.3242 | 1 | |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0134 | 0.9179 | 0.9179 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.1871 | 0.1871 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0942 | 0.114 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1871 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0056 | 0.3242 | 0.3926 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0178 | 0.0215 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.5177 | 0.6269 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.5177 | 0.5177 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.5177 | 0.564 |
Schistosoma mansoni | lamin | 0.0056 | 0.3242 | 0.3242 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.5177 | 0.5177 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0178 | 0.0178 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0027 | 0.102 | 0.102 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.2835 | 0.3433 |
Loa Loa (eye worm) | intermediate filament protein | 0.0056 | 0.3242 | 0.3926 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.102 | 0.1235 |
Onchocerca volvulus | 0.0056 | 0.3242 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.5177 | 0.6269 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.1871 | 0.2039 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0027 | 0.102 | 0.1111 |
Schistosoma mansoni | lamin | 0.0056 | 0.3242 | 0.3242 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0014 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1871 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0178 | 0.0215 |
Echinococcus granulosus | lamin dm0 | 0.0056 | 0.3242 | 0.3532 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0178 | 0.0178 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1871 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0056 | 0.3242 | 0.3532 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0178 | 0.0215 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1871 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.2835 | 0.3433 |
Echinococcus multilocularis | lamin | 0.0056 | 0.3242 | 0.3242 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 0.5177 | 0.564 |
Schistosoma mansoni | intermediate filament proteins | 0.0056 | 0.3242 | 0.3242 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.8259 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.8259 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.8259 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0134 | 0.9179 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.5177 | 0.6269 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.003 | 0.1248 | 0.1511 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0178 | 0.0194 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 0.5177 | 0.6269 |
Echinococcus multilocularis | musashi | 0.0056 | 0.3242 | 0.3242 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0178 | 0.0194 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0014 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0038 | 0.1871 | 0.2266 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.5177 | 0.564 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1605 | 0.1944 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0178 | 0.0178 |
Echinococcus multilocularis | lamin dm0 | 0.0056 | 0.3242 | 0.3242 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0178 | 0.0194 |
Schistosoma mansoni | thyroid hormone receptor | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.5177 | 0.6269 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.1871 | 0.1871 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.2835 | 0.3433 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.3242 | 0.3926 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0178 | 0.0178 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 0.5177 | 0.5177 |
Echinococcus granulosus | lamin | 0.0056 | 0.3242 | 0.3532 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0178 | 0.0178 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 0.5177 | 0.6269 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0178 | 0.0178 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0178 | 0.0178 |
Brugia malayi | intermediate filament protein | 0.0056 | 0.3242 | 0.3926 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0056 | 0.3242 | 0.3926 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 33 nM | Inhibition of AChE | ChEMBL. | 20053484 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.