Detailed information for compound 1109409

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 324.761 | Formula: C18H13ClN2O2
  • H donors: 1 H acceptors: 3 LogP: 3.15 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C(Cl)C(N1c1ccc(c2c1cccn2)O)c1ccccc1
  • InChi: 1S/C18H13ClN2O2/c19-15-17(11-5-2-1-3-6-11)21(18(15)23)13-8-9-14(22)16-12(13)7-4-10-20-16/h1-10,15,17,22H
  • InChiKey: MLYZWTJQDFSUHY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Carboxylesterase LipT 0.0235 0.1613 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0071 0.0071
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0071 0.0071
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0368 0.0368
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0235 0.1613 0.1613
Brugia malayi Carboxylesterase family protein 0.0235 0.1613 0.1613
Schistosoma mansoni neuroligin 3 (S09 family) 0.0235 0.1613 0.1613
Trichomonas vaginalis CAMK family protein kinase 0.02 0.1363 0.3596
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0247 0.0339
Schistosoma mansoni tar DNA-binding protein 0.007 0.0419 0.0419
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.036 0.208
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0071 0.0071
Brugia malayi Cytochrome P450 family protein 0.005 0.0273 0.0273
Schistosoma mansoni tar DNA-binding protein 0.007 0.0419 0.0419
Brugia malayi Blistered cuticle protein 3 0.0039 0.0194 0.0194
Onchocerca volvulus Serine\/threonine kinase homolog 0.02 0.1363 0.3832
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.036 0.2044
Echinococcus multilocularis chromobox protein 1 0.0077 0.047 0.047
Brugia malayi Pre-SET motif family protein 0.0441 0.3115 0.3115
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0081 0.0279
Onchocerca volvulus 0.0034 0.0155 0.0435
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0953 0.0953
Loa Loa (eye worm) carboxylesterase 0.0235 0.1613 0.1613
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0071 0.0199
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.005 0.0271 0.1517
Loa Loa (eye worm) hypothetical protein 0.0039 0.0194 0.0194
Trichomonas vaginalis chromobox protein, putative 0.0077 0.047 0.099
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0368 0.0368
Echinococcus multilocularis chromobox protein 1 0.0077 0.047 0.047
Echinococcus multilocularis L aminoadipate semialdehyde 0.0178 0.1198 0.1198
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0081 0.0323
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0081 0.0081
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0071 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0071 0.0071
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0071 0.0071
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0194 0.0194
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.036 0.036
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0022 0.0071 0.0071
Brugia malayi EGF-like domain containing protein 0.0013 0.000000019267 0.000000019267
Echinococcus multilocularis para nitrobenzyl esterase 0.0235 0.1613 0.1613
Echinococcus multilocularis survival motor neuron protein 1 0.0263 0.1817 0.1817
Brugia malayi Heterochromatin protein 1 0.0077 0.047 0.047
Schistosoma mansoni tar DNA-binding protein 0.007 0.0419 0.0419
Loa Loa (eye worm) hypothetical protein 0.0235 0.1613 0.1613
Trypanosoma cruzi polo-like protein kinase, putative 0.02 0.1363 0.5
Echinococcus granulosus tar DNA binding protein 0.007 0.0419 0.0419
Echinococcus multilocularis neuroligin 0.0235 0.1613 0.1613
Giardia lamblia Kinase, PLK 0.02 0.1363 1
Mycobacterium leprae conserved hypothetical protein 0.005 0.0271 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0071 0.0071
Echinococcus granulosus peroxidasin 0.0039 0.0194 0.0194
Loa Loa (eye worm) carboxylesterase 0.0235 0.1613 0.1613
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.02 0.1363 0.1363
Onchocerca volvulus 0.0016 0.0021 0.0059
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0351 0.0351
Echinococcus granulosus acetylcholinesterase 0.1389 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0194 0.0194
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0297 0.0297
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0235 0.1613 0.1613
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0368 0.0368
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0419 0.0419
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0071 0.0071
Echinococcus granulosus neuroligin 0.0235 0.1613 0.1613
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0071 0.0071
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.005 0.0271 0.736
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0081 0.0081
Onchocerca volvulus Peroxidase homolog 0.0039 0.0194 0.0544
Onchocerca volvulus Peroxidasin homolog 0.0039 0.0194 0.0544
Entamoeba histolytica hypothetical protein 0.005 0.0271 0.1475
Trichomonas vaginalis CAMK family protein kinase 0.02 0.1363 0.3596
Loa Loa (eye worm) carboxylesterase 0.1389 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0953 0.0953
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0194 0.0194
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0368 0.0368
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.036 0.036
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0024 0.0081 0.0081
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0223 0.0627
Brugia malayi hypothetical protein 0.0263 0.1817 0.1817
Brugia malayi nuclear hormone receptor 0.0022 0.0071 0.0071
Loa Loa (eye worm) heterochromatin protein 1 0.0077 0.047 0.047
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0953 0.0953
Loa Loa (eye worm) acetylcholinesterase 1 0.1389 1 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0235 0.1613 0.1613
Onchocerca volvulus Peroxidase homolog 0.0039 0.0194 0.0544
Loa Loa (eye worm) hypothetical protein 0.1389 1 1
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0194 0.0194
Echinococcus multilocularis peroxidasin 0.0039 0.0194 0.0194
Onchocerca volvulus Dual oxidase homolog 0.0039 0.0194 0.0544
Schistosoma mansoni hypothetical protein 0.0054 0.0297 0.0297
Trichomonas vaginalis chromobox protein, putative 0.0077 0.047 0.099
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0235 0.1613 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0071 0.0071
Brugia malayi Pre-SET motif family protein 0.0063 0.0368 0.0368
Loa Loa (eye worm) hypothetical protein 0.0235 0.1613 0.1613
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0178 0.1198 0.1198
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0071 0.0071
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1389 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0514 0.3642 0.3642
Echinococcus multilocularis tar DNA binding protein 0.007 0.0419 0.0419
Echinococcus granulosus carboxylesterase 5A 0.1389 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0144 0.0953 0.0953
Brugia malayi Peroxidasin 0.0039 0.0194 0.0194
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0368 0.0368
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0223 0.0269
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0144 0.0953 0.0953
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0071 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0071 0.0071
Onchocerca volvulus Peroxidasin homolog 0.0039 0.0194 0.0544
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0235 0.1613 0.1613
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0953 0.0953
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.005 0.0271 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0071 0.0071
Loa Loa (eye worm) blistered cuticle protein 3 0.0039 0.0194 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0038
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.005 0.0271 0.1479
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0235 0.1613 0.1613
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0071 0.0071
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0178 0.1198 0.1198
Loa Loa (eye worm) hypothetical protein 0.0024 0.0081 0.0081
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0081 0.0279
Loa Loa (eye worm) hypothetical protein 0.0039 0.0194 0.0194
Brugia malayi chromobox protein homolog 3 0.0043 0.0223 0.0223
Loa Loa (eye worm) RNA binding protein 0.007 0.0419 0.0419
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.1389 1 1
Onchocerca volvulus 0.0502 0.3558 1
Schistosoma mansoni peroxidasin 0.0039 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0039 0.0194 0.0194
Trichomonas vaginalis CAMK family protein kinase 0.02 0.1363 0.3596
Loa Loa (eye worm) hypothetical protein 0.0024 0.0081 0.0081
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0039 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0013 0.000000019267 0.000000019267
Echinococcus granulosus acetylcholinesterase 0.1389 1 1
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.005 0.0271 0.1479
Brugia malayi TAR-binding protein 0.007 0.0419 0.0419
Loa Loa (eye worm) hypothetical protein 0.0039 0.0194 0.0194
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0076 0.046 0.046
Loa Loa (eye worm) TAR-binding protein 0.007 0.0419 0.0419
Schistosoma mansoni chromobox protein 0.0077 0.047 0.047
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0071 0.0199
Loa Loa (eye worm) hypothetical protein 0.0022 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0038
Schistosoma mansoni survival motor neuron protein 0.0054 0.0297 0.0297
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0273 0.0273
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0235 0.1613 0.4325
Schistosoma mansoni chromobox protein 0.0077 0.047 0.047
Brugia malayi Carboxylesterase family protein 0.0235 0.1613 0.1613
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0071 0.0071
Onchocerca volvulus 0.0178 0.1198 0.3367
Echinococcus multilocularis acetylcholinesterase 0.1389 1 1
Onchocerca volvulus Chorion peroxidase homolog 0.0039 0.0194 0.0544
Echinococcus multilocularis neurogenic locus notch protein 0.0013 0.000000019267 0.000000019267
Onchocerca volvulus 0.0235 0.1613 0.4534
Schistosoma mansoni acetylcholinesterase 0.0235 0.1613 0.1613
Echinococcus multilocularis neuropeptide receptor A26 0.0514 0.3642 0.3642
Schistosoma mansoni coup transcription factor 0.0022 0.0071 0.0071
Brugia malayi ecdysteroid receptor 0.0022 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0039 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0235 0.1613 0.1613
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0043 0.0223 0.0223
Trypanosoma cruzi polo-like protein kinase, putative 0.02 0.1363 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.0071 0.0071
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0071 0.0071
Onchocerca volvulus 0.0039 0.0194 0.0544
Brugia malayi Carboxylesterase family protein 0.0235 0.1613 0.1613
Schistosoma mansoni tar DNA-binding protein 0.007 0.0419 0.0419
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0235 0.1613 0.1613
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0071 0.0071
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.036 0.2044
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0953 0.0953
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.005 0.0271 0.5
Onchocerca volvulus 0.0022 0.0071 0.0199
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0071 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0071 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0071 0.0071
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0071 0.0071
Onchocerca volvulus 0.0039 0.0194 0.0544
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0071 0.0071
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.036 0.2044
Brugia malayi Carboxylesterase family protein 0.1389 1 1
Echinococcus granulosus neuropeptide s receptor 0.0514 0.3642 0.3642
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0071 0.0071
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0081 0.0279
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0038 0.0045
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.036 0.036
Loa Loa (eye worm) hypothetical protein 0.0235 0.1613 0.1613
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0071 0.0071
Onchocerca volvulus 0.0076 0.046 0.1292
Trichomonas vaginalis spcc417.12 protein, putative 0.0235 0.1613 0.4325
Schistosoma mansoni kinase 0.0102 0.0647 0.0647
Loa Loa (eye worm) hypothetical protein 0.0039 0.0194 0.0194
Brugia malayi steroid hormone receptor 0.0022 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0039 0.0194 0.0194
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0071 0.0071
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0628 0.1451
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.005 0.0271 0.736
Trypanosoma brucei polo-like protein kinase 0.02 0.1363 1
Schistosoma mansoni serine/threonine protein kinase 0.02 0.1363 0.1363
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0071 0.0071
Schistosoma mansoni gliotactin 0.0235 0.1613 0.1613
Loa Loa (eye worm) hypothetical protein 0.0022 0.0071 0.0071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0953 0.0953
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0368 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0081 0.0323
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0071 0.0071
Onchocerca volvulus 0.0235 0.1613 0.4534
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0071 0.0071
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0071 0.0071
Mycobacterium ulcerans carboxylesterase, LipT 0.0235 0.1613 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0081 0.0279
Loa Loa (eye worm) hypothetical protein 0.0022 0.0071 0.0071
Leishmania major phosphopantetheinyl transferase-like protein 0.005 0.0271 0.1475
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0628 0.1451
Loa Loa (eye worm) hypothetical protein 0.0263 0.1817 0.1817
Echinococcus granulosus BC026374 protein S09 family 0.0235 0.1613 0.1613
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0223 0.0269
Trichomonas vaginalis CAMK family protein kinase 0.02 0.1363 0.3596
Loa Loa (eye worm) hypothetical protein 0.0039 0.0194 0.0194
Trichomonas vaginalis CAMK family protein kinase 0.02 0.1363 0.3596
Echinococcus granulosus neurogenic locus notch protein 0.0013 0.000000019267 0.000000019267
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.005 0.0271 0.7059
Echinococcus multilocularis carboxylesterase 5A 0.1389 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0194 0.0194
Trichomonas vaginalis CAMK family protein kinase 0.02 0.1363 0.3596
Loa Loa (eye worm) hypothetical protein 0.0039 0.0194 0.0194
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0071 0.0071
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.005 0.0271 1
Echinococcus granulosus survival motor neuron protein 1 0.0263 0.1817 0.1817
Echinococcus granulosus chromobox protein 1 0.0077 0.047 0.047
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0013 0.000000019267 0.000000054157
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0071 0.0071
Echinococcus granulosus L aminoadipate semialdehyde 0.0178 0.1198 0.1198
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.036 0.9782
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0235 0.1613 0.1613
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0071 0.0071
Echinococcus multilocularis BC026374 protein (S09 family) 0.0235 0.1613 0.1613
Loa Loa (eye worm) hypothetical protein 0.0022 0.0071 0.0071
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0194 0.0194
Brugia malayi hypothetical protein 0.0235 0.1613 0.1613
Onchocerca volvulus 0.0054 0.0297 0.0835
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0038
Echinococcus granulosus chromobox protein 1 0.0077 0.047 0.047
Schistosoma mansoni peroxidasin 0.0039 0.0194 0.0194
Onchocerca volvulus Neurogenic locus notch homolog 0.0013 0.000000019267 0.000000054157
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0081 0.0279
Loa Loa (eye worm) hypothetical protein 0.0034 0.0155 0.0155
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0247 0.0694
Echinococcus granulosus para nitrobenzyl esterase 0.0235 0.1613 0.1613
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0441 0.3115 0.3115
Brugia malayi hypothetical protein 0.0039 0.0194 0.0194
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0368 0.0368
Onchocerca volvulus 0.0039 0.0194 0.0544
Brugia malayi SET domain containing protein 0.0015 0.0017 0.0017
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.036 0.036
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0071 0.0071
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0071 0.0071
Mycobacterium ulcerans hypothetical protein 0.0024 0.0081 0.0279
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0178 0.1198 0.1198
Treponema pallidum 4'-phosphopantetheinyl transferase 0.005 0.0271 0.5
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0235 0.1613 0.1613
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0071 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0071 0.0071
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0235 0.1613 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0038
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0081 0.0279
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0071 0.0071
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.036 0.217
Echinococcus multilocularis acetylcholinesterase 0.1389 1 1
Brugia malayi nuclear receptor NHR-88 0.0022 0.0071 0.0071
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0071 0.0071
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0071 0.0071
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0071 0.0071
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0419 0.0419
Onchocerca volvulus 0.0024 0.0081 0.0229
Brugia malayi notch-like transmembrane receptor 0.0013 0.000000019267 0.000000019267
Loa Loa (eye worm) hypothetical protein 0.0022 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0039 0.0194 0.0194
Brugia malayi serine/threonine-protein kinase plk-2 0.02 0.1363 0.1363
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0247 0.0339
Plasmodium vivax SET domain protein, putative 0.0063 0.0368 1
Onchocerca volvulus 0.0235 0.1613 0.4534
Loa Loa (eye worm) hypothetical protein 0.0022 0.0071 0.0071
Onchocerca volvulus 0.0235 0.1613 0.4534
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0071 0.0071
Brugia malayi RNA binding protein 0.007 0.0419 0.0419
Schistosoma mansoni tar DNA-binding protein 0.007 0.0419 0.0419
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0081 0.0081
Onchocerca volvulus 0.0235 0.1613 0.4534
Echinococcus multilocularis neuropeptide s receptor 0.0514 0.3642 0.3642
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0071 0.0071
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0081 0.0279
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0071 0.0071
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0071 0.0199
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0071 0.0071
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0071 0.0071
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0071 0.0071
Brugia malayi Carboxylesterase family protein 0.0235 0.1613 0.1613
Trichomonas vaginalis CAMK family protein kinase 0.02 0.1363 0.3596
Entamoeba histolytica serine/threonine protein kinase, putative 0.02 0.1363 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0953 0.0953
Schistosoma mansoni BC026374 protein (S09 family) 0.0235 0.1613 0.1613
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.02 0.1363 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0071 0.0071
Echinococcus granulosus serine:threonine protein kinase PLK1 0.02 0.1363 0.1363
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0194 0.0194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0063 0.0368 0.0368
Loa Loa (eye worm) hypothetical protein 0.0039 0.0194 0.0194
Trichomonas vaginalis set domain proteins, putative 0.0502 0.3558 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.02 0.1363 0.1363

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 2 % Antifilarial activity against Brugia malayi assessed as loss of motility at 80 ng/ml after 48 hrs by MTT assay ChEMBL. 20483610
Activity (functional) = 2 % Antifilarial activity against Brugia malayi assessed as loss of motility at 100 ng/ml after 48 hrs by MTT assay ChEMBL. 20483610

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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