Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 603 aa | 548 aa | 28.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.2953 | 0.2953 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.2953 | 0.2953 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.7675 | 0.7675 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.7675 | 0.7675 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0489 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0489 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0489 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0489 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.7675 | 0.7675 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0489 | 0.0489 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.7675 | 0.7675 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.7675 | 0.7675 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.5498 | 0.5498 |
Brugia malayi | RNA binding protein | 0.0067 | 0.7675 | 0.7675 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.7675 | 0.7675 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0489 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.7675 | 0.7675 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0489 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.7675 | 0.7675 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0489 | 0.0489 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0489 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0489 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0489 | 0.0489 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.5498 | 0.5498 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.7675 | 0.7675 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5498 | 0.5498 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.7675 | 0.7675 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.2953 | 0.2953 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.7675 | 0.7675 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0489 | 0.0489 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0489 | 0.0489 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0489 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0489 | 0.0489 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.5498 | 0.5498 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.7675 | 0.7675 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0489 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0489 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0489 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0489 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0489 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0489 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1100 nM | Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric method | ChEMBL. | 20137941 |
IC50 (binding) | > 100000 nM | Inhibition of mouse brain AChE after 1 hr by modified Ellman's colorimetric method | ChEMBL. | 20137941 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.