TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 246.305 | Formula: C14H18N2O2
H donors: 1 H acceptors: 2 LogP: 3.56 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCNC(=O)Oc1ccc(cc1)C#N
InChi: 1S/C14H18N2O2/c1-2-3-4-5-10-16-14(17)18-13-8-6-12(11-15)7-9-13/h6-9H,2-5,10H2,1H3,(H,16,17)
InChiKey: CHWMTWLXIPQLLX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	monoglyceride lipase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium ulcerans	lysophospholipase	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	esterase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania mexicana	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	Get druggable targets OG5_127037	All targets in OG5_127037
Candida albicans	similar to YJU3	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	valacyclovir hydrolase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania braziliensis	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium vivax	PST-A protein	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma congolense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma congolense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei gambiense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	lysophospholipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania major	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei gambiense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma congolense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	lysophospholipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania infantum	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium tuberculosis	Possible lysophospholipase	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania donovani	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma cruzi	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	lysophospholipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Candida albicans	similar to YJU3	Get druggable targets OG5_127037	All targets in OG5_127037

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	esterase, putative	monoglyceride lipase	303 aa	254 aa	19.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	0.2242	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0478	0.0577
Onchocerca volvulus		0.004	0.0974	0.1334
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.004	0.0974	0.531
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0838	0.0838
Loa Loa (eye worm)	hypothetical protein	0.0234	0.6493	0.7829
Brugia malayi	Muscleblind-like protein	0.0297	0.8294	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0838	0.3669
Loa Loa (eye worm)	serotonin transporter b	0.0234	0.6493	0.7829
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0039	0.0964	0.1163
Brugia malayi	Carboxylesterase family protein	0.0132	0.3594	0.4334
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0081	0.0081
Brugia malayi	beta-lactamase	0.0035	0.0838	0.1011
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.018	0.018
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0124	0.0124
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.004	0.0974	0.0974
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.3303	0.3983
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0124	0.0149
Plasmodium falciparum	esterase, putative	0.0084	0.2242	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0964	0.4237
Trichomonas vaginalis	alpha-glucosidase, putative	0.0015	0.0262	0.107
Echinococcus multilocularis	para nitrobenzyl esterase	0.0022	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0132	0.3594	0.4334
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0042	0.0042
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0234	0.6493	0.6493
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0427	0.0515
Schistosoma mansoni	alpha glucosidase	0.0039	0.0964	0.0964
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0427	0.0835
Schistosoma mansoni	hypothetical protein	0.0012	0.018	0.018
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0124	0.0124
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0039	0.0964	0.4237
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0838	0.0713
Brugia malayi	MH2 domain containing protein	0.0122	0.3303	0.3983
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.1261	0.1261
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0124	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0478	0.0577
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0042	0.0042
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0838	0.3669
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0177	0.4889	0.4889
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0124	0.0124
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.004	0.0974	0.0974
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0022	0.0478	0.0478
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0124	0.0124
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0838	0.2265
Mycobacterium ulcerans	lipase LipD	0.0035	0.0838	0.2265
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0124	0.0149
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0158	0.4332	0.4332
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0022	0.0478	0.0478
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0124	0.0124
Brugia malayi	Carboxylesterase family protein	0.0022	0.0478	0.0577
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0022	0.0478	0.0478
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0039	0.0964	0.522
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0124	0.0124
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0022	0.0478	0.0478
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0039	0.0964	0.4237
Brugia malayi	hypothetical protein	0.0133	0.3638	0.4386
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0838	0.3669
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0591	0.0903
Brugia malayi	ecdysteroid receptor	0.001	0.0124	0.0149
Loa Loa (eye worm)	hypothetical protein	0.001	0.0124	0.0149
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.004	0.0974	0.1174
Onchocerca volvulus	Huntingtin homolog	0.0133	0.3638	0.5517
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0591	0.1594
Loa Loa (eye worm)	hypothetical protein	0.001	0.0124	0.0149
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0124	0.0124
Loa Loa (eye worm)	hypothetical protein	0.004	0.0974	0.1174
Echinococcus multilocularis	acetylcholinesterase	0.0132	0.3594	0.3594
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0591	0.0713
Schistosoma mansoni	sodium-dependent amino acid transporter	0.004	0.0974	0.0974
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0081	0.0097
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0124	0.0149
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0124	0.0124
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0124	0.0124
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0015	0.0262	0.107
Brugia malayi	nuclear hormone receptor	0.001	0.0124	0.0149
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	0.2242	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.1261	0.1261
Loa Loa (eye worm)	hypothetical protein	0.001	0.0124	0.0149
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0427	0.0835
Plasmodium falciparum	histone acetyltransferase GCN5	0.0043	0.1055	0.3456
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0591	0.0903
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.004	0.0974	0.531
Onchocerca volvulus		0.004	0.0974	0.1334
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.009	0.0109
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0022	0.0478	0.0478
Trypanosoma cruzi	monoglyceride lipase, putative	0.0084	0.2242	1
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0838	0.2265
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0124	0.0149
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0591	0.1663
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0081	0.0097
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0124	0.0124
Schistosoma mansoni	sodium/chloride dependent transporter	0.004	0.0974	0.0974
Toxoplasma gondii	hypothetical protein	0.004	0.0974	0.531
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0838	0.3669
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0042	0.0042
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0022	0.0478	0.0089
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0039	0.0964	0.3546
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0022	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.001	0.0124	0.0149
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0591	0.1663
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0124	0.0149
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0838	0.0713
Loa Loa (eye worm)	hypothetical protein	0.001	0.0124	0.0149
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0081	0.0081
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0177	0.4889	0.4889
Schistosoma mansoni	smad	0.0008	0.0081	0.0081
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0124	0.0124
Brugia malayi	hypothetical protein	0.0026	0.0591	0.0713
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.2242	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0124	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0133	0.3638	0.4386
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0015	0.0262	0.0316
Trichomonas vaginalis	alpha-glucosidase, putative	0.0015	0.0262	0.107
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.004	0.0974	0.0974
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0234	0.6493	0.7829
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0262	0.0316
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.004	0.0974	0.0974
Brugia malayi	beta-lactamase family protein	0.0035	0.0838	0.1011
Echinococcus granulosus	serotonin transporter	0.0234	0.6493	0.6493
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.004	0.0974	0.1174
Schistosoma mansoni	cpg binding protein	0.0029	0.0682	0.0682
Schistosoma mansoni	hypothetical protein	0.0357	1	1
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0084	0.2242	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0838	0.0838
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.1261	0.1261
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0124	0.0149
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0081	0.0081
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0124	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0234	0.6493	0.7829
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0124	0.0149
Brugia malayi	hypothetical protein	0.0022	0.0478	0.0577
Schistosoma mansoni	coup transcription factor	0.001	0.0124	0.0124
Mycobacterium tuberculosis	Possible lysophospholipase	0.0084	0.2242	0.3149
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.018	0.018
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0838	0.1011
Plasmodium vivax	amine transporter, putative	0.004	0.0974	0.301
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0838	0.2911
Brugia malayi	Carboxylesterase family protein	0.0132	0.3594	0.4334
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.009	0.009
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0084	0.2242	1
Schistosoma mansoni	BC026374 protein (S09 family)	0.0022	0.0478	0.0478
Echinococcus granulosus	sodium and chloride dependent glycine	0.004	0.0974	0.0974
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.1261	0.152
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0124	0.0149
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0427	0.1816
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0838	0.1011
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.004	0.0974	0.0974
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0081	0.0081
Plasmodium falciparum	transporter, putative	0.004	0.0974	0.301
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0124	0.0149
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.004	0.0974	0.0974
Echinococcus granulosus	cpg binding protein	0.0029	0.0682	0.0682
Loa Loa (eye worm)	hypothetical protein	0.004	0.0974	0.1174
Onchocerca volvulus		0.0102	0.2762	0.4142
Onchocerca volvulus		0.0035	0.0838	0.1122
Echinococcus granulosus	carboxylesterase 5A	0.0132	0.3594	0.3594
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0427	0.0515
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	0.2242	1
Echinococcus multilocularis	sodium and chloride dependent glycine	0.004	0.0974	0.0974
Mycobacterium ulcerans	carboxylesterase, LipT	0.0022	0.0478	0.0282
Trichomonas vaginalis	spcc417.12 protein, putative	0.0022	0.0478	0.2047
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0234	0.6493	0.7829
Loa Loa (eye worm)	acetylcholinesterase 1	0.0132	0.3594	0.4334
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.2242	1
Loa Loa (eye worm)	hypothetical protein	0.0132	0.3594	0.4334
Onchocerca volvulus		0.0028	0.0637	0.0806
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0124	0.0149
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0124	0.0124
Giardia lamblia	Histone acetyltransferase GCN5	0.0043	0.1055	1
Mycobacterium ulcerans	lysophospholipase	0.0084	0.2242	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0591	0.1663
Echinococcus multilocularis	Smad4	0.0008	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0478	0.0577
Brugia malayi	hypothetical protein	0.0017	0.0327	0.0394
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0838	0.1011
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0124	0.0149
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0974	0.301
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0427	0.0835
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0838	0.3669
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0964	0.4237
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0039	0.0964	0.0964
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0124	0.0124
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0046	0.1164	0.514
Echinococcus multilocularis	muscleblind protein	0.0297	0.8294	0.8294
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0124	0.0124
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0124	0.0124
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0838	0.2911
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.1526	0.1526
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	0.2242	1
Echinococcus granulosus	para nitrobenzyl esterase	0.0022	0.0478	0.0478
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0057	0.1456	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.004	0.0974	0.1174
Schistosoma mansoni	ap endonuclease	0.002	0.0427	0.0427
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.004	0.0974	0.1174
Loa Loa (eye worm)	hypothetical protein	0.004	0.0974	0.1174
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0124	0.0124
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0015	0.0262	0.0217
Brugia malayi	acetyltransferase, GNAT family protein	0.0158	0.4332	0.5223
Echinococcus multilocularis	cpg binding protein	0.0029	0.0682	0.0682
Loa Loa (eye worm)	hypothetical protein	0.004	0.0974	0.1174
Loa Loa (eye worm)	carboxylesterase	0.0022	0.0478	0.0577
Loa Loa (eye worm)	hypothetical protein	0.0133	0.3638	0.4386
Loa Loa (eye worm)	hypothetical protein	0.004	0.0974	0.1174
Schistosoma mansoni	alpha-glucosidase	0.0153	0.4187	0.4187
Schistosoma mansoni	acetylcholinesterase	0.0022	0.0478	0.0478
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0124	0.0124
Loa Loa (eye worm)	hypothetical protein	0.001	0.0124	0.0149
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	0.2242	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0046	0.1164	0.7167
Brugia malayi	MH1 domain containing protein	0.0008	0.0081	0.0097
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0124	0.0124
Echinococcus multilocularis	geminin	0.0357	1	1
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.004	0.0974	0.0974
Onchocerca volvulus		0.0035	0.0838	0.1122
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0838	0.0713
Mycobacterium ulcerans	hypothetical protein	0.0084	0.2242	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0124	0.0149
Echinococcus granulosus	neutral alpha glucosidase AB	0.0039	0.0964	0.0964
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0838	0.1011
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0838	0.0713
Brugia malayi	MH2 domain containing protein	0.0008	0.0081	0.0097
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0838	0.0713
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0427	0.5
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0039	0.0964	0.4237
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0838	0.1011
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0081	0.0081
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0124	0.0124
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0124	0.0124
Onchocerca volvulus		0.0234	0.6493	1
Echinococcus multilocularis	acetylcholinesterase	0.0132	0.3594	0.3594
Leishmania major	hypothetical protein, conserved	0.0035	0.0838	0.2911
Loa Loa (eye worm)	hypothetical protein	0.0297	0.8294	1
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0637	0.0768
Plasmodium falciparum	lysophospholipase, putative	0.0084	0.2242	1
Onchocerca volvulus		0.004	0.0974	0.1334
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0838	0.2265
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0081	0.0081
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0964	0.3546
Leishmania major	hypothetical protein, conserved	0.0026	0.0591	0.1663
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0223	0.6191	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0177	0.4889	0.5895
Echinococcus multilocularis	serotonin transporter	0.0234	0.6493	0.6493
Leishmania major	alpha glucosidase II subunit, putative	0.0039	0.0964	0.3546
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0838	0.2265
Trypanosoma brucei	monoglyceride lipase, putative	0.0084	0.2242	1
Trypanosoma brucei	glucosidase, putative	0.0039	0.0964	0.3546
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.004	0.0974	0.531
Echinococcus granulosus	neuroligin	0.0022	0.0478	0.0478
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0124	0.0124
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0046	0.1164	0.4062
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0046	0.1164	0.7167
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.004	0.0974	0.0974
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0427	0.0427
Brugia malayi	Carboxylesterase family protein	0.0022	0.0478	0.0577
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0838	0.0713
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0427	0.1816
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0124	0.0124
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0158	0.4332	0.4332
Brugia malayi	hypothetical protein	0.004	0.0974	0.1174
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.004	0.0974	0.0974
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.004	0.0974	0.0974
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0838	0.2265
Schistosoma mansoni	sodium/chloride dependent transporter	0.0234	0.6493	0.6493
Loa Loa (eye worm)	Smad1	0.0008	0.0081	0.0097
Trichomonas vaginalis	alpha-glucosidase, putative	0.0015	0.0262	0.107
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0042	0.0042
Brugia malayi	steroid hormone receptor	0.001	0.0124	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0478	0.0577
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0124	0.0124
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0838	0.2911
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0022	0.0478	0.2047
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.004	0.0974	0.5
Schistosoma mansoni	hypothetical protein	0.0357	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0478	0.0577
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0124	0.0149
Treponema pallidum	sodium- and chloride- dependent transporter	0.0234	0.6493	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.004	0.0974	0.1174
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0427	0.0427
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0124	0.0124
Schistosoma mansoni	sodium/chloride dependent transporter	0.004	0.0974	0.0974
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0838	0.1011
Trichomonas vaginalis	alpha-glucosidase, putative	0.0015	0.0262	0.107
Brugia malayi	Carboxylesterase family protein	0.0022	0.0478	0.0577
Plasmodium falciparum	amino acid transporter, putative	0.004	0.0974	0.301
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.004	0.0974	0.0974
Schistosoma mansoni	alpha-glucosidase	0.0153	0.4187	0.4187
Onchocerca volvulus		0.0035	0.0838	0.1122
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0637	0.0768
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0022	0.0478	0.0089
Brugia malayi	nuclear receptor NHR-88	0.001	0.0124	0.0149
Onchocerca volvulus		0.0022	0.0478	0.0557
Trichomonas vaginalis	esterase, putative	0.0035	0.0838	0.3669
Echinococcus granulosus	lysosomal alpha glucosidase	0.0177	0.4889	0.4889
Schistosoma mansoni	Smad4	0.0008	0.0081	0.0081
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0838	0.0713
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.004	0.0974	0.0974
Echinococcus multilocularis	smad	0.0008	0.0081	0.0081
Plasmodium falciparum	lysophospholipase, putative	0.0084	0.2242	1
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0015	0.0262	0.107
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0124	0.0149
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0084	0.2242	1
Onchocerca volvulus		0.0022	0.0478	0.0557
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.004	0.0974	0.0974
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0039	0.0964	0.1163
Trichomonas vaginalis	alpha-glucosidase, putative	0.0015	0.0262	0.107
Loa Loa (eye worm)	hypothetical protein	0.001	0.0124	0.0149
Schistosoma mansoni	cpg binding protein	0.0029	0.0682	0.0682
Echinococcus granulosus	acetylcholinesterase	0.0132	0.3594	0.3594
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0838	0.0713
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0124	0.0124
Brugia malayi	Carboxylesterase family protein	0.0022	0.0478	0.0577
Loa Loa (eye worm)	carboxylesterase	0.0132	0.3594	0.4334
Echinococcus granulosus	sodium and chloride dependent glycine	0.004	0.0974	0.0974
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0964	0.4237
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0124	0.0124
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0177	0.4889	0.5895
Echinococcus multilocularis	neuroligin	0.0022	0.0478	0.0478
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0124	0.0124
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0838	0.0713
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0084	0.2242	1
Echinococcus granulosus	smad	0.0008	0.0081	0.0081
Plasmodium falciparum	lysophospholipase, putative	0.0084	0.2242	1
Echinococcus granulosus	muscleblind protein	0.0297	0.8294	0.8294
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0838	0.1011
Loa Loa (eye worm)	hypothetical protein	0.001	0.0124	0.0149
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0022	0.0478	0.0478
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.1261	0.1261
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0039	0.0964	0.3546
Brugia malayi	MH1 domain containing protein	0.0008	0.0081	0.0097
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0838	0.0713
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0124	0.0124
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0964	0.4237
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0427	0.0835
Echinococcus granulosus	acetylcholinesterase	0.0132	0.3594	0.3594
Toxoplasma gondii	hypothetical protein	0.004	0.0974	0.531
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.3303	0.3983
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0478	0.0577
Echinococcus granulosus	Smad4	0.0008	0.0081	0.0081
Loa Loa (eye worm)	norepinephrine transporter	0.0234	0.6493	0.7829
Echinococcus multilocularis	muscleblind protein 1	0.0297	0.8294	0.8294
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0081	0.0081
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0838	0.0838
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0964	0.4237
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.1261	0.1261
Loa Loa (eye worm)	carboxylesterase	0.0022	0.0478	0.0577
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0124	0.0149
Schistosoma mansoni	gliotactin	0.0022	0.0478	0.0478
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0124	0.0149
Loa Loa (eye worm)	hypothetical protein	0.004	0.0974	0.1174
Echinococcus multilocularis	sodium and chloride dependent glycine	0.004	0.0974	0.0974
Loa Loa (eye worm)	hypothetical protein	0.0234	0.6493	0.7829
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0838	0.1011
Entamoeba histolytica	acetyltransferase, GNAT family	0.0043	0.1055	0.4003
Onchocerca volvulus		0.0022	0.0478	0.0557
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0039	0.0964	0.4237
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0081	0.0081
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0427	0.0835
Brugia malayi	beta-lactamase family protein	0.0035	0.0838	0.1011
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0124	0.0149
Leishmania major	monoglyceride lipase, putative	0.0084	0.2242	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0838	0.0838
Plasmodium vivax	PST-A protein	0.0084	0.2242	1
Brugia malayi	Smad1	0.0008	0.0081	0.0097
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.004	0.0974	0.0974
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0124	0.0149
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.004	0.0974	0.0974
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.1261	0.1261
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0964	0.3546
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0838	0.1011
Onchocerca volvulus		0.0022	0.0478	0.0557
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0124	0.0124
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.004	0.0974	0.1174
Onchocerca volvulus	Huntingtin homolog	0.0133	0.3638	0.5517
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0478	0.0577
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0153	0.4206	0.4206
Schistosoma mansoni	cpg binding protein	0.0028	0.0637	0.0637
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0046	0.1164	0.1164
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0015	0.0262	0.107
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0591	0.0903
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.1261	0.1261
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0124	0.0149
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0087	0.0105
Toxoplasma gondii	ABC1 family protein	0.0035	0.0838	0.3996
Loa Loa (eye worm)	hypothetical protein	0.0297	0.8294	1
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0022	0.0478	0.0089
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.1261	0.152
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.009	0.009
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0132	0.3594	0.3594
Trypanosoma brucei	monoglyceride lipase, putative	0.0084	0.2242	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0046	0.1164	0.514
Echinococcus granulosus	BC026374 protein S09 family	0.0022	0.0478	0.0478
Onchocerca volvulus		0.0022	0.0478	0.0557
Brugia malayi	MH2 domain containing protein	0.0008	0.0081	0.0097
Loa Loa (eye worm)	hypothetical protein	0.004	0.0974	0.1174
Loa Loa (eye worm)	acetyltransferase	0.0158	0.4332	0.5223
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0124	0.0149
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0124	0.0124
Echinococcus multilocularis	carboxylesterase 5A	0.0132	0.3594	0.3594
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0124	0.0149
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0042	0.0042
Schistosoma mansoni	ap endonuclease	0.002	0.0427	0.0427

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 12 uM	Inhibition of human recombinant MGL by liquid scintillation counting	ChEMBL.	19232787

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL541001

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1109901