TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 454.916 | Formula: C22H26ClF3N4O
H donors: 0 H acceptors: 1 LogP: 6.31 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCCN(Cc1n2cc(n(c2nc1C(F)(F)F)c1ccc(cc1C)OC)Cl)CC1CC1
InChi: 1S/C22H26ClF3N4O/c1-4-9-28(11-15-5-6-15)12-18-20(22(24,25)26)27-21-29(18)13-19(23)30(21)17-8-7-16(31-3)10-14(17)2/h7-8,10,13,15H,4-6,9,11-12H2,1-3H3
InChiKey: GXOIKFZNFZSRBD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	corticotropin releasing hormone receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130760	All targets in OG5_130760
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	Get druggable targets OG5_130760	All targets in OG5_130760
Schistosoma japonicum	IPR001879,Hormone receptor, extracellular,domain-containing	Get druggable targets OG5_130760	All targets in OG5_130760
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	Get druggable targets OG5_130760	All targets in OG5_130760
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	Get druggable targets OG5_130760	All targets in OG5_130760

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	corticotropin releasing hormone receptor 1	444 aa	445 aa	25.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	DNA polymerase eta, putative	0.0021	0.0246	0.3858
Loa Loa (eye worm)	RNA binding protein	0.0146	0.3847	0.3846
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0309	0.0308
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0246	0.0245
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0381	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0537	0.0537
Echinococcus granulosus	smad	0.0019	0.0194	0.0213
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0305	0.4711
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0021	0.0246	0.027
Brugia malayi	MH2 domain containing protein	0.0019	0.0194	0.0193
Brugia malayi	MH2 domain containing protein	0.0275	0.7554	0.7554
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0381	0.038
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0023	0.0309	0.8117
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0246	0.3858
Brugia malayi	RNA binding protein	0.0146	0.3847	0.3846
Schistosoma mansoni	tar DNA-binding protein	0.0146	0.3847	0.4241
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0023	0.0309	0.034
Echinococcus multilocularis	Smad4	0.0019	0.0194	0.0213
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0175	0.4683	0.4682
Brugia malayi	latrophilin 2 splice variant baaae	0.012	0.3092	0.3091
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0021	0.0246	0.0245
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0381	1
Echinococcus granulosus	FTZ F1 alpha	0.0023	0.0309	0.034
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0023	0.0305	0.0304
Echinococcus granulosus	dna polymerase eta	0.0021	0.0246	0.027
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0021	0.0246	0.027
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0309	0.034
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0023	0.0309	0.0308
Schistosoma mansoni	hypothetical protein	0.0055	0.1246	0.1373
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0023	0.0309	0.034
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0023	0.0309	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0309	0.0308
Echinococcus granulosus	ecdysone induced protein 78C	0.0023	0.0309	0.034
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0371	0.9258
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0381	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0381	0.038
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0381	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0023	0.0309	0.0308
Brugia malayi	Steroid receptor seven-up type 2	0.0023	0.0309	0.0308
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0023	0.0309	0.0308
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0023	0.0305	0.5097
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0023	0.0305	0.3154
Brugia malayi	RNA, U transporter 1	0.0087	0.2163	0.2162
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0197	0.0197
Echinococcus granulosus	Smad4	0.0019	0.0194	0.0213
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0023	0.0305	0.0335
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0246	0.0245
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0309	0.0308
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0309	0.034
Schistosoma mansoni	hypothetical protein	0.0055	0.1246	0.1373
Plasmodium vivax	importin-beta 2, putative	0.0031	0.0537	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0175	0.4683	0.4682
Echinococcus multilocularis	snurportin 1	0.0328	0.9069	1
Echinococcus granulosus	tar DNA binding protein	0.0146	0.3847	0.4241
Schistosoma mansoni	hypothetical protein	0.0055	0.1246	0.1373
Echinococcus granulosus	mothers against decapentaplegic 5	0.0019	0.0194	0.0213
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0381	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0371	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0309	0.034
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0023	0.0309	0.0308
Schistosoma mansoni	hypothetical protein	0.0328	0.9069	1
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.0246	0.2642
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.0309	0.034
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0381	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0246	0.3858
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0021	0.0246	0.027
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0023	0.0309	0.034
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0381	1
Echinococcus granulosus	GPCR family 2	0.0055	0.1246	0.1373
Echinococcus multilocularis	dna polymerase kappa	0.0021	0.0246	0.027
Schistosoma mansoni	ran	0.0023	0.0305	0.0335
Echinococcus granulosus	dna polymerase kappa	0.0021	0.0246	0.027
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0146	0.3847	0.3846
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0021	0.0246	0.027
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0023	0.0309	0.034
Echinococcus multilocularis	FTZ F1 alpha	0.0023	0.0309	0.034
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0246	0.3858
Schistosoma mansoni	hypothetical protein	0.0055	0.1246	0.1373
Trichomonas vaginalis	ran, putative	0.0023	0.0305	0.4711
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0381	1
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0019	0.0194	0.0213
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0246	0.3858
Schistosoma mansoni	hypothetical protein	0.012	0.3092	0.3409
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0246	0.3858
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0023	0.0309	0.0308
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0023	0.0309	0.034
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.0309	0.034
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0309	0.0308
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0381	1
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0371	1
Onchocerca volvulus		0.0025	0.0381	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0197	0.139
Onchocerca volvulus		0.0023	0.0309	0.8117
Brugia malayi	nuclear hormone receptor	0.0023	0.0309	0.0308
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.0246	0.2642
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0023	0.0309	0.034
Trypanosoma brucei	unspecified product	0.0021	0.0246	0.3858
Brugia malayi	MH1 domain containing protein	0.0019	0.0194	0.0193
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0246	0.3858
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0055	0.1246	0.1373
Schistosoma mansoni	retinoic acid receptor RXR	0.0023	0.0309	0.034
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0023	0.0309	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1246	0.1245
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0023	0.0309	0.034
Loa Loa (eye worm)	MH2 domain-containing protein	0.0019	0.0194	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0309	0.0308
Loa Loa (eye worm)	TAR-binding protein	0.0146	0.3847	0.3846
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0246	0.3858
Echinococcus multilocularis	smad	0.0019	0.0194	0.0213
Brugia malayi	steroid hormone receptor	0.0023	0.0309	0.0308
Loa Loa (eye worm)	hypothetical protein	0.036	1	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0023	0.0309	0.034
Brugia malayi	Latrophilin receptor protein 2	0.0055	0.1246	0.1245
Schistosoma mansoni	tar DNA-binding protein	0.0146	0.3847	0.4241
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0023	0.0309	0.034
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0309	0.0308
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0246	0.3858
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0019	0.0194	0.0213
Schistosoma mansoni	importin beta-1	0.0031	0.0537	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0309	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0309	0.0308
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0305	0.4711
Loa Loa (eye worm)	MH1 domain-containing protein	0.0019	0.0194	0.0193
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.0381	1
Echinococcus granulosus	snurportin 1	0.0328	0.9069	1
Brugia malayi	MH1 domain containing protein	0.0019	0.0194	0.0193
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0023	0.0309	0.034
Brugia malayi	nuclear receptor NHR-88	0.0023	0.0309	0.0308
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0537	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0197	0.0197
Entamoeba histolytica	Ran family GTPase	0.0023	0.0305	0.4361
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0381	0.5
Loa Loa (eye worm)	MH2 domain-containing protein	0.0275	0.7554	0.7554
Schistosoma mansoni	tar DNA-binding protein	0.0146	0.3847	0.4241
Schistosoma mansoni	ran	0.0023	0.0305	0.0335
Brugia malayi	TAR-binding protein	0.0146	0.3847	0.3846
Schistosoma mansoni	smad1 5 8 and	0.0019	0.0194	0.0213
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0381	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0023	0.0309	0.8117
Schistosoma mansoni	smad1 5 8 and	0.0019	0.0194	0.0213
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0023	0.0309	0.0308
Echinococcus multilocularis	dna polymerase eta	0.0021	0.0246	0.027
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0381	0.038
Brugia malayi	photoreceptor-specific nuclear receptor	0.0023	0.0309	0.0308
Brugia malayi	Importin beta-1 subunit	0.0031	0.0537	0.0537
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0023	0.0309	0.0308
Echinococcus multilocularis	tar DNA binding protein	0.0146	0.3847	0.4241
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0246	0.3858
Loa Loa (eye worm)	steroid hormone receptor	0.0023	0.0309	0.0308
Loa Loa (eye worm)	Smad1	0.0019	0.0194	0.0193
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0381	0.038
Brugia malayi	MH2 domain containing protein	0.0019	0.0194	0.0193
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0309	0.034
Schistosoma mansoni	Smad4	0.0019	0.0194	0.0213
Echinococcus multilocularis	importin subunit beta 1	0.0031	0.0537	0.0592
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0023	0.0309	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0197	0.0197
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0023	0.0309	0.034
Schistosoma mansoni	tar DNA-binding protein	0.0146	0.3847	0.4241
Loa Loa (eye worm)	hypothetical protein	0.012	0.3092	0.3091
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0197	0.5
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0371	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0371	1
Echinococcus multilocularis	GPCR, family 2	0.0055	0.1246	0.1373
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0241	0.6564	0.7237
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0381	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0246	0.3858
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0309	0.034
Brugia malayi	ecdysteroid receptor	0.0023	0.0309	0.0308
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0023	0.0309	0.034
Schistosoma mansoni	tar DNA-binding protein	0.0146	0.3847	0.4241
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0023	0.0305	0.0335
Schistosoma mansoni	RAR-like nuclear receptor	0.0023	0.0309	0.034
Schistosoma mansoni	DNA polymerase eta	0.0021	0.0246	0.027
Brugia malayi	RNA recognition motif domain containing protein	0.0146	0.3847	0.3846
Onchocerca volvulus	Bile acid receptor homolog	0.0023	0.0309	0.8117
Echinococcus granulosus	importin subunit beta 1	0.0031	0.0537	0.0592
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0328	0.9069	0.9069
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0019	0.0194	0.0213
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0241	0.6564	0.7237
Schistosoma mansoni	smad1 5 8 and	0.0019	0.0194	0.0213
Plasmodium falciparum	importin beta, putative	0.0031	0.0537	1
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0381	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0381	1
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0023	0.0305	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0309	0.0308
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0381	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0197	0.0197
Toxoplasma gondii	HEAT repeat-containing protein	0.0031	0.0537	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0023	0.0309	0.0308
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0246	0.3858
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0246	0.3858
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0309	0.0308
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0055	0.1246	0.1245
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0023	0.0309	0.034
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.0309	0.0308
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0023	0.0309	0.034
Loa Loa (eye worm)	transcription factor SMAD2	0.0275	0.7554	0.7554
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0023	0.0309	0.034
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0537	1
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0019	0.0194	0.0213
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0023	0.0309	0.034
Schistosoma mansoni	coup transcription factor	0.0023	0.0309	0.034
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0.0246	0.3665
Echinococcus multilocularis	ecdysone induced protein 78C	0.0023	0.0309	0.034
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0381	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0309	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0197	0.0197
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0023	0.0309	0.0308
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0.0246	0.3665
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0023	0.0309	0.0308
Brugia malayi	Smad1	0.0019	0.0194	0.0193
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0381	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0309	0.0308
Leishmania major	GTP-binding protein, putative	0.0023	0.0305	0.4361
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0023	0.0309	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0309	0.0308
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0309	0.0308
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0246	0.3858
Entamoeba histolytica	hypothetical protein	0.0025	0.0371	0.9258
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0381	0.038
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0246	0.0245
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0381	0.038
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0055	0.1246	0.1373
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0023	0.0305	0.3154
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0023	0.0305	0.0304
Schistosoma mansoni	smad	0.0019	0.0194	0.0213
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0055	0.1246	0.1245
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0309	0.034

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)		Antagonist activity at human CRF1 receptor expressed in human IMR-32 cells assessed as inhibition of CRF-stimulated cAMP production	ChEMBL.	20471832
Ki (binding)	= 13 nM	Displacement of [125I] Tyr-o-CRF from human CRF[125I]receptor expressed in human IMR-3[125I]cells after 100 mins	ChEMBL.	20471832

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1083922

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1109945