Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.067 | 0.4852 | 0.4852 |
Brugia malayi | FAD binding domain containing protein | 0.133 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.133 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0616 | 0.4433 | 0.4433 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0616 | 0.4433 | 1 |
Giardia lamblia | Hypothetical protein | 0.1179 | 0.8821 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0236 | 0.1464 | 0.0716 |
Schistosoma mansoni | NADH-cytochrome B5 reductase | 0.0151 | 0.0805 | 0.0805 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0236 | 0.1464 | 0.0716 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0616 | 0.4433 | 0.3946 |
Echinococcus multilocularis | NADH cytochrome b5 reductase 3 | 0.0151 | 0.0805 | 0.0805 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0071 | 0.0176 | 0.0176 |
Plasmodium vivax | hypothetical protein, conserved | 0.0509 | 0.3594 | 0.3033 |
Onchocerca volvulus | 0.0151 | 0.0805 | 0.5 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0236 | 0.1464 | 0.0716 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0509 | 0.3594 | 0.3033 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0821 | 0.6032 | 0.6032 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.133 | 1 | 1 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0509 | 0.3594 | 0.3033 |
Brugia malayi | diaphorase | 0.0151 | 0.0805 | 0.0777 |
Schistosoma mansoni | cytochrome P450 reductase | 0.133 | 1 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.0821 | 0.6032 | 0.6032 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0616 | 0.4433 | 0.6941 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0509 | 0.3594 | 0.5 |
Schistosoma mansoni | diflavin oxidoreductase | 0.066 | 0.4773 | 0.4773 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0509 | 0.3594 | 0.3033 |
Loa Loa (eye worm) | hypothetical protein | 0.133 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0065 | 0.0134 | 0.0134 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.133 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.066 | 0.4773 | 1 |
Echinococcus granulosus | NADH cytochrome b5 reductase 3 | 0.0151 | 0.0805 | 0.0805 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0616 | 0.4433 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0509 | 0.3594 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0509 | 0.3594 | 0.5 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0509 | 0.3594 | 0.3033 |
Trypanosoma cruzi | p450 reductase, putative | 0.133 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0509 | 0.3594 | 0.5 |
Schistosoma mansoni | cytochrome B5 | 0.0151 | 0.0805 | 0.0805 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0057 | 0.0073 | 0.0042 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.133 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.133 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0509 | 0.3594 | 0.5 |
Echinococcus granulosus | methionine synthase reductase | 0.0821 | 0.6032 | 0.6032 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.133 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.133 | 1 | 1 |
Loa Loa (eye worm) | cytochrome b5 reductase 4 | 0.0151 | 0.0805 | 0.0738 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.133 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.1179 | 0.8821 | 1 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0509 | 0.3594 | 0.3547 |
Leishmania major | cytochrome P450 reductase, putative | 0.1179 | 0.8821 | 0.8717 |
Brugia malayi | Cytochrome b5-like Heme/Steroid binding domain containing protein | 0.0151 | 0.0805 | 0.0777 |
Chlamydia trachomatis | sulfite reductase | 0.0821 | 0.6032 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.133 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.133 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0616 | 0.4433 | 0.4416 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0236 | 0.1464 | 0.0716 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0821 | 0.6032 | 0.6003 |
Brugia malayi | dihydrofolate reductase family protein | 0.0616 | 0.4433 | 0.4416 |
Loa Loa (eye worm) | diaphorase | 0.0151 | 0.0805 | 0.0738 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0509 | 0.3594 | 0.3033 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0071 | 0.0176 | 0.0176 |
Treponema pallidum | flavodoxin | 0.0509 | 0.3594 | 1 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0509 | 0.3594 | 0.3033 |
Plasmodium vivax | flavodoxin domain containing protein | 0.1179 | 0.8821 | 0.8717 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.1179 | 0.8821 | 0.8159 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0151 | 0.0805 | 0.0805 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.133 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.133 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.066 | 0.4773 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.133 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0616 | 0.4433 | 0.4433 |
Brugia malayi | FAD binding domain containing protein | 0.0821 | 0.6032 | 0.6019 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0151 | 0.0805 | 0.0805 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0236 | 0.1464 | 0.0716 |
Trichomonas vaginalis | sulfite reductase, putative | 0.133 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.133 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0236 | 0.1464 | 0.166 |
Echinococcus multilocularis | cytochrome b5 reductase 4 | 0.0151 | 0.0805 | 0.0805 |
Leishmania major | hypothetical protein, conserved | 0.0509 | 0.3594 | 0.3033 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0616 | 0.4433 | 0.4392 |
Brugia malayi | flavodoxin family protein | 0.0509 | 0.3594 | 0.3574 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.133 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.133 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0616 | 0.4433 | 0.4433 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.133 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0176 | 0.0104 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 2088 uM | Inhibition of angiotensin I phosphorylation catalyzed by the protein-tyrosine kinase p56 lck partially purified from bovine thymus. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.