Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, muscarinic 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.007 | 0.7335 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.9255 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.5619 | 0.4979 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0071 | 0.7513 | 0.9415 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0071 | 0.7513 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0529 | 0.0242 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0042 | 0.3194 | 0.4252 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0071 | 0.7513 | 0.9415 |
Echinococcus granulosus | zinc finger protein | 0.0023 | 0.0345 | 0.046 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.5619 | 0.6066 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.007 | 0.7335 | 0.9763 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0069 | 0.718 | 0.9557 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.4032 | 0.4348 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.5619 | 0.4979 |
Schistosoma mansoni | jumonji domain containing protein | 0.0069 | 0.718 | 0.8978 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.0862 | 0.1148 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.4364 | 0.4709 |
Brugia malayi | jmjC domain containing protein | 0.0071 | 0.7513 | 0.715 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.5619 | 0.6066 |
Echinococcus multilocularis | zinc finger protein | 0.0023 | 0.0345 | 0.0471 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.2872 | 0.3093 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.0862 | 0.1175 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0069 | 0.718 | 0.9789 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0069 | 0.718 | 0.9789 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0042 | 0.3194 | 0.4355 |
Brugia malayi | Bromodomain containing protein | 0.0045 | 0.3607 | 0.2673 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0071 | 0.7513 | 0.8116 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.0862 | 0.0679 |
Schistosoma mansoni | bromodomain containing protein | 0.0074 | 0.7959 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.2872 | 0.3318 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0024 | 0.0529 | 0.0559 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.2872 | 0.183 |
Brugia malayi | jmjC domain containing protein | 0.0069 | 0.718 | 0.6769 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3619 | 0.3902 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 5 | Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay | ChEMBL. | 20483611 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.