Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | gamma-aminobutyric acid (GABA) A receptor, alpha 2 | Starlite/ChEMBL | References |
Rattus norvegicus | GABA-A receptor; anion channel | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0657 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0657 | 1 | 1 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Brugia malayi | Dihydrofolate reductase | 0.0657 | 1 | 1 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Chlamydia trachomatis | dihydrofolate reductase | 0.0657 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0657 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0251 | 0.3448 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0251 | 0.3448 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0657 | 1 | 0.5 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0251 | 0.3448 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0657 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0251 | 0.3448 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0657 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0657 | 1 | 1 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0251 | 0.3448 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0251 | 0.3448 | 0.5 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Onchocerca volvulus | Putative nachr subunit | 0.0038 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = -3.964 | Binding affinity for rat benzodiazepine receptor inverse agonist site | ChEMBL. | 8667357 |
IC50 (binding) | = -3.964 | Binding affinity towards benzodiazepine receptor inverse agonist site by the displacement of [3H]-Diazepam in rat cerebral cortical membranes. | ChEMBL. | 8411009 |
IC50 (binding) | = 5.07 | Inhibition of the compound was determined on Benzodiazepine receptor | ChEMBL. | 9435905 |
IC50 (binding) | = 9200 nM | In vitro inhibition of 3[H]Diazepam binding to Benzodiazepine receptor from rat cerebral cortical membranes | ChEMBL. | 2167977 |
IC50 (binding) | = 9200 nM | In vitro inhibition of 3[H]Diazepam binding to Benzodiazepine receptor from rat cerebral cortical membranes | ChEMBL. | 2167977 |
Log 1/IC50 (binding) | = -3.964 | Binding affinity for rat benzodiazepine receptor inverse agonist site | ChEMBL. | 8667357 |
Log 1/IC50 (binding) | = -3.964 | Binding affinity towards benzodiazepine receptor inverse agonist site by the displacement of [3H]-Diazepam in rat cerebral cortical membranes. | ChEMBL. | 8411009 |
Log IC50 (binding) | = 5.07 | Inhibition of the compound was determined on Benzodiazepine receptor | ChEMBL. | 9435905 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
4 literature references were collected for this gene.