Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.0361 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0361 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0361 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0361 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0361 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0361 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0361 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0361 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0361 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0361 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0361 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0361 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 38 % | Percentage of inhibition of noradrenaline-induced contractions in rat portal vein at 10 microM (in vitro) | ChEMBL. | 8340916 |
Max fall in blood pressure (functional) | = 29 mmHg | Change in systolic blood pressure at intervals of 1 hr after oral administration of 1 mg/kg of compound in spontaneously hypertensive rats (in vitro) | ChEMBL. | 8340916 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.