TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 373.449 | Formula: C17H15N3O3S2
H donors: 1 H acceptors: 3 LogP: 2.5 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Oc1cccc(c1)Cn1ncc2c(c1=O)n(C)c1c2sc(c1)[S+](C)[O-]
InChi: 1S/C17H15N3O3S2/c1-19-13-7-14(25(2)23)24-16(13)12-8-18-20(17(22)15(12)19)9-10-4-3-5-11(21)6-10/h3-8,21H,9H2,1-2H3
InChiKey: PTQIMFRZBDFMMQ-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	pyruvate kinase, liver and RBC	Starlite/ChEMBL	No references
Homo sapiens	pyruvate kinase, muscle	Starlite/ChEMBL	References
Leishmania mexicana	pyruvate kinase, putative	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126685	All targets in OG5_126685
Chlamydia trachomatis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Mycobacterium leprae	Probable pyruvate kinase PykA	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania braziliensis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Giardia lamblia	Pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Candida albicans	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma brucei gambiense	pyruvate kinase 1, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus granulosus	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	pyruvate kinase-PB	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma congolense	pyruvate kinase 1, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania major	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus multilocularis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania major	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Babesia bovis	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania infantum	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Trichomonas vaginalis	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Plasmodium knowlesi	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma brucei gambiense	pyruvate kinase 1, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Schistosoma mansoni	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Toxoplasma gondii	pyruvate kinase PyK1	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania donovani	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Plasmodium falciparum	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Neospora caninum	Pyruvate kinase (EC 2.7.1.40), related	Get druggable targets OG5_126685	All targets in OG5_126685
Theileria parva	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Cryptosporidium hominis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Plasmodium vivax	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Schistosoma japonicum	Pyruvate kinase isozyme R, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Onchocerca volvulus	Pyruvate kinase homolog	Get druggable targets OG5_126685	All targets in OG5_126685
Plasmodium berghei	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania braziliensis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Mycobacterium ulcerans	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus granulosus	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Entamoeba histolytica	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Trichomonas vaginalis	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Schistosoma japonicum	ko:K00873 pyruvate kinase [EC2.7.1.40], putative	Get druggable targets OG5_126685	All targets in OG5_126685
Candida albicans	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	Get druggable targets OG5_126685	All targets in OG5_126685
Cryptosporidium parvum	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania infantum	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma brucei	pyruvate kinase 1	Get druggable targets OG5_126685	All targets in OG5_126685
Brugia malayi	Pyruvate kinase, muscle isozyme	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania mexicana	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma cruzi	pyruvate kinase 2, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma cruzi	pyruvate kinase 2, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma brucei	pyruvate kinase 1, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus multilocularis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Brugia malayi	Pyruvate kinase, M2 isozyme	Get druggable targets OG5_126685	All targets in OG5_126685
Onchocerca volvulus	Pyruvate kinase homolog	Get druggable targets OG5_126685	All targets in OG5_126685
Plasmodium yoelii	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus multilocularis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania braziliensis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania mexicana	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Onchocerca volvulus	Pyruvate kinase homolog	Get druggable targets OG5_126685	All targets in OG5_126685

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	pyruvate kinase	pyruvate kinase, muscle	605 aa	521 aa	34.9 %
Echinococcus granulosus	pyruvate kinase	pyruvate kinase, liver and RBC	574 aa	524 aa	36.3 %
Echinococcus granulosus	pyruvate kinase	pyruvate kinase, putative	498 aa	515 aa	27.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	vivapain-2	0.0016	0.0164	0.0948
Loa Loa (eye worm)	hypothetical protein	0.001	0.0067	0.0182
Brugia malayi	nuclear hormone receptor	0.001	0.0067	0.0182
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0114	0.0622
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0201	0.0548
Leishmania major	DNA polymerase eta, putative	0.0019	0.0201	0.113
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0587	0.0565
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0851	0.4909
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0851	0.4909
Trypanosoma cruzi	cysteine proteinase, putative	0.0008	0.0045	0.0261
Schistosoma mansoni	coup transcription factor	0.001	0.0067	0.0067
Echinococcus multilocularis	microtubule associated protein 2	0.0674	1	1
Brugia malayi	nuclear receptor NHR-88	0.001	0.0067	0.0182
Echinococcus granulosus	pyruvate kinase	0.0062	0.0847	0.0826
Giardia lamblia	Pyruvate kinase	0.0062	0.0847	0.4885
Schistosoma mansoni	sodium/dicarboxylate symporter-related	0.0111	0.1581	0.1581
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0164	0.1045
Echinococcus granulosus	excitatory amino acid transporter 3	0.0251	0.3668	0.3653
Schistosoma mansoni	cpg binding protein	0.0028	0.0339	0.0339
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0067	0.0067
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0067	0.0182
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0587	0.1601
Trypanosoma cruzi	DNA damage repair protein, putative	0.0006	0.0007	0.0038
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0067	0.0182
Echinococcus multilocularis	excitatory amino acid transporter 2	0.0251	0.3668	0.3653
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0194	0.1049
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0.0459	0.2599
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0851	0.4909
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0164	0.0446
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.0652	0.3773
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0201	0.113
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0067	0.0182
Onchocerca volvulus		0.0011	0.0083	0.0045
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0121	0.1727	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0067	0.0067
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0067	0.0044
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0067	0.0182
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0164	0.0164
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0067	0.0044
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0067	0.0067
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0851	0.4909
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0201	0.1091
Loa Loa (eye worm)	hypothetical protein	0.001	0.0067	0.0182
Schistosoma mansoni	pyruvate kinase	0.0062	0.0847	0.0847
Echinococcus multilocularis	neutral amino acid transporter A	0.0251	0.3668	0.3653
Leishmania major	pyruvate kinase	0.0121	0.1727	1
Echinococcus multilocularis	Excitatory amino acid transporter	0.0251	0.3668	0.3653
Schistosoma mansoni	solute carrier family 1 (glial high affinity glutamate transporter	0.0251	0.3668	0.3668
Onchocerca volvulus		0.0016	0.0164	0.0269
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0016	0.0164	0.0913
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0164	0.0873
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0067	0.0182
Leishmania major	cathepsin L-like protease	0.0016	0.0164	0.0913
Trypanosoma brucei	pyruvate kinase 1, putative	0.0121	0.1727	1
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0067	0.0067
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0194	0.1123
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0201	0.0201
Schistosoma mansoni	hypothetical protein	0.0399	0.5894	0.5894
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0851	0.4909
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0164	0.0873
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0201	0.0548
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0114	0.0622
Echinococcus granulosus	dna polymerase eta	0.0019	0.0201	0.0178
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0164	0.0873
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0851	0.4909
Mycobacterium tuberculosis	Probable C4-dicarboxylate-transport transmembrane protein DctA	0.0251	0.3668	1
Plasmodium falciparum	pyruvate kinase	0.0121	0.1727	1
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0067	0.0067
Echinococcus multilocularis	pyruvate kinase	0.0121	0.1727	0.1708
Plasmodium vivax	vivapain-3	0.0008	0.0045	0.0261
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0067	0.0182
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0067	0.0067
Trypanosoma cruzi	cysteine protease, putative	0.0008	0.0045	0.0261
Echinococcus granulosus	sodium:dicarboxylate symporter	0.0251	0.3668	0.3653
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0201	0.113
Schistosoma mansoni	ap endonuclease	0.0018	0.0194	0.0194
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.0714	0.4112
Echinococcus multilocularis	neutral amino acid transporter A	0.0251	0.3668	0.3653
Echinococcus granulosus	neutral amino acid transporter	0.0251	0.3668	0.3653
Trypanosoma cruzi	cysteine peptidase, putative	0.0016	0.0164	0.0948
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0067	0.0044
Echinococcus multilocularis	excitatory amino acid transporter 3	0.0251	0.3668	0.3653
Schistosoma mansoni	cpg binding protein	0.003	0.0363	0.0363
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0194	0.1088
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0164	0.0446
Echinococcus multilocularis	cysteine protease	0.0016	0.0164	0.0141
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0194	0.1088
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0067	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0084	0.118	0.3217
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0459	0.0437
Trypanosoma brucei	pyruvate kinase 1	0.0121	0.1727	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0194	0.1123
Toxoplasma gondii	pyruvate kinase PyK1	0.0121	0.1727	1
Schistosoma mansoni	ap endonuclease	0.0018	0.0194	0.0194
Echinococcus multilocularis	pyruvate kinase	0.0121	0.1727	0.1708
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0067	0.0044
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0201	0.1164
Loa Loa (eye worm)	excitatory amino acid transporter	0.0251	0.3668	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0067	0.0067
Plasmodium vivax	vivapain-2	0.0016	0.0164	0.0948
Leishmania major	cathepsin L-like protease	0.0016	0.0164	0.0913
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0067	0.0067
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0459	0.2632
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0194	0.1123
Trypanosoma brucei	unspecified product	0.0013	0.0114	0.0622
Plasmodium vivax	pyruvate kinase, putative	0.0121	0.1727	1
Echinococcus granulosus	neutral amino acid transporter A	0.0251	0.3668	0.3653
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0164	0.0141
Echinococcus multilocularis	pyruvate kinase	0.0062	0.0847	0.0826
Plasmodium vivax	unspecified product	0.0008	0.0045	0.0261
Brugia malayi	Papain family cysteine protease containing protein	0.0008	0.0045	0.0123
Echinococcus granulosus	pyruvate kinase	0.0121	0.1727	0.1708
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0201	0.113
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0194	0.0529
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0201	0.1091
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0067	0.0182
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0164	0.0873
Trichomonas vaginalis	pyruvate kinase, putative	0.0121	0.1727	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0164	0.0873
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0067	0.0182
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0201	0.113
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0067	0.0182
Leishmania major	cathepsin L-like protease	0.0016	0.0164	0.0913
Schistosoma mansoni	sodium/dicarboxylate symporter-related	0.0111	0.1581	0.1581
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0067	0.0044
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0201	0.0201
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0194	0.0171
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0067	0.0182
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0164	0.0873
Chlamydia trachomatis	glutamate symporter	0.0251	0.3668	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0851	0.4909
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0067	0.0182
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0164	0.0164
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0164	0.0873
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0008	0.0045	0.0045
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0164	0.0446
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0067	0.0044
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0036	0.0459	0.0459
Echinococcus multilocularis	ubiquitin specific protease 41	0.0036	0.0459	0.0437
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0067	0.0067
Echinococcus multilocularis	sodium:dicarboxylate symporter	0.0251	0.3668	0.3653
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0164	0.0873
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0201	0.113
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0459	0.1252
Echinococcus multilocularis	cathepsin L	0.0008	0.0045	0.0022
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0045	0.0224
Treponema pallidum	glutamate/aspartate transporter	0.0111	0.1581	1
Giardia lamblia	Pyruvate kinase	0.0121	0.1727	1
Plasmodium vivax	pyruvate kinase 2, putative	0.0062	0.0847	0.4905
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0164	0.1045
Echinococcus multilocularis	cpg binding protein	0.003	0.0363	0.034
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0851	0.4909
Echinococcus granulosus	neutral amino acid transporter A	0.0251	0.3668	0.3653
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0164	0.0446
Onchocerca volvulus		0.0016	0.0164	0.0269
Plasmodium vivax	vivapain-1	0.0008	0.0045	0.0261
Echinococcus multilocularis	excitatory amino acid transporter 2	0.0251	0.3668	0.3653
Onchocerca volvulus		0.0016	0.0164	0.0269
Echinococcus multilocularis	neutral amino acid transporter A	0.0251	0.3668	0.3653
Onchocerca volvulus	Pyruvate kinase homolog	0.0121	0.1727	0.461
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0083	0.0226
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0587	0.1601
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0587	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0018
Loa Loa (eye worm)	pyruvate kinase	0.0025	0.03	0.0818
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0036	0.0459	0.2632
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0851	0.4909
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0587	0.0587
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0045	0.0181
Brugia malayi	Excitatory amino acid transporter	0.0251	0.3668	1
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0194	0.1311
Loa Loa (eye worm)	hypothetical protein	0.001	0.0067	0.0182
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0201	0.113
Onchocerca volvulus		0.0016	0.0164	0.0269
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0201	0.1164
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0008	0.0045	0.0045
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0067	0.0182
Brugia malayi	steroid hormone receptor	0.001	0.0067	0.0182
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0851	0.4909
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0067	0.0044
Brugia malayi	Papain family cysteine protease containing protein	0.0008	0.0045	0.0123
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0164	0.0873
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0201	0.1164
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0083	0.0226
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0587	0.0587
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0164	0.0873
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0164	0.0873
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0067	0.0067
Trypanosoma cruzi	cysteine peptidase, putative	0.0008	0.0045	0.0261
Echinococcus multilocularis	neutral amino acid transporter excitatory amino acid transporter	0.0111	0.1581	0.1561
Brugia malayi	ecdysteroid receptor	0.001	0.0067	0.0182
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0067	0.0182
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0164	0.0873
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0339	0.0923
Onchocerca volvulus	Cathepsin F homolog	0.0016	0.0164	0.0269
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0459	0.266
Echinococcus multilocularis	neutral amino acid transporter excitatory amino acid transporter	0.0251	0.3668	0.3653
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0067	0.0044
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0016	0.0164	0.0141
Echinococcus granulosus	cathepsin l1	0.0016	0.0164	0.0141
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0067	0.0182
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0083	0.0401
Echinococcus granulosus	excitatory amino acid transporter 2	0.0251	0.3668	0.3653
Schistosoma mansoni	DNA polymerase IV / kappa	0.0006	0.0007	0.0007
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0851	0.4928
Entamoeba histolytica	pyruvate kinase, putative	0.0084	0.118	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0006	0.0007	0.0038
Onchocerca volvulus	Excitatory amino acid transporter homolog	0.0251	0.3668	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0587	0.0565
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0194	0.0171
Echinococcus granulosus	Excitatory amino acid transporter	0.0251	0.3668	0.3653
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0194	0.1088
Echinococcus granulosus	cathepsin l1	0.0011	0.0083	0.006
Brugia malayi	polk-prov protein	0.0006	0.0007	0.0018
Toxoplasma gondii	exonuclease III APE	0.0018	0.0194	0.1088
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0201	0.0548
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0201	0.0201
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0067	0.0044
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.0809	0.0809
Loa Loa (eye worm)	hypothetical protein	0.001	0.0067	0.0182
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0049	0.0133
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0201	0.113
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0008	0.0045	0.0261
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0164	0.0873
Echinococcus multilocularis	pyruvate kinase	0.0095	0.1346	0.1326
Echinococcus granulosus	cpg binding protein	0.003	0.0363	0.034
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0201	0.113
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0121	0.1727	1
Chlamydia trachomatis	pyruvate kinase	0.0121	0.1727	0.0701
Loa Loa (eye worm)	hypothetical protein	0.001	0.0067	0.0182
Echinococcus granulosus	dnaJ subfamily B	0.0399	0.5894	0.5885
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0067	0.0044
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0016	0.0164	0.0141
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0047	0.0129
Onchocerca volvulus	Pyruvate kinase homolog	0.0121	0.1727	0.461
Leishmania major	cathepsin L-like protease	0.0016	0.0164	0.0913
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0587	0.0565
Echinococcus multilocularis	dnaJ subfamily B	0.0399	0.5894	0.5885
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0201	0.0178
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0049	0.0026
Echinococcus multilocularis	sodium:dicarboxylate symporter	0.0111	0.1581	0.1561
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0201	0.0021
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0164	0.0873
Leishmania major	cathepsin L-like protease	0.0062	0.0851	0.4909
Leishmania major	cathepsin L-like protease	0.0016	0.0164	0.0913
Trichomonas vaginalis	pyruvate kinase, putative	0.0121	0.1727	1
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1727	0.4708
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0164	0.0141
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0164	0.0446
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0201	0.0178
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0067	0.0067
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0164	0.0873
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0201	0.113
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0194	0.1088
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0067	0.0182
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0067	0.0044
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0114	0.0622
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0339	0.0923
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0201	0.0021
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0201	0.113
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0067	0.0044
Echinococcus granulosus	ubiquitin specific protease 41	0.0036	0.0459	0.0437
Loa Loa (eye worm)	hypothetical protein	0.001	0.0067	0.0182
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0036	0.0459	0.365
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0459	0.266
Trypanosoma brucei	unspecified product	0.0019	0.0201	0.113
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0201	0.113
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0587	0.0565
Echinococcus multilocularis	Excitatory amino acid transporter	0.0251	0.3668	0.3653
Onchocerca volvulus		0.0016	0.0164	0.0269
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0016	0.0164	0.0913
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.0164	0.0446
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0067	0.0044
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0045	0.0224
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0201	0.113
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0164	0.0873
Brugia malayi	cathepsin L-like precursor	0.0011	0.0083	0.0226
Echinococcus multilocularis	cysteine protease	0.0016	0.0164	0.0141
Echinococcus granulosus	pyruvate kinase	0.0121	0.1727	0.1708
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0164	0.0269
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0164	0.0873
Trypanosoma cruzi	DNA polymerase eta, putative	0.0006	0.0007	0.0038
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0851	0.4928
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0201	0.0178
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0067	0.0182
Onchocerca volvulus		0.0016	0.0164	0.0269
Loa Loa (eye worm)	hypothetical protein	0.001	0.0067	0.0182
Schistosoma mansoni	microtubule-associated protein tau	0.0674	1	1
Loa Loa (eye worm)	pyruvate kinase-PB	0.0084	0.118	0.3217
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0164	0.1045
Echinococcus multilocularis	pyruvate kinase	0.0062	0.0847	0.0826
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0083	0.0226
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0201	0.1164
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0164	0.0446
Mycobacterium ulcerans	pyruvate kinase	0.0121	0.1727	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0067	0.0044
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0164	0.0141
Echinococcus granulosus	cathepsin L cysteine protease	0.0008	0.0045	0.0022
Echinococcus granulosus	pyruvate kinase	0.0062	0.0847	0.0826
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0008	0.0045	0.0045
Trypanosoma brucei	unspecified product	0.0013	0.0114	0.0622
Wolbachia endosymbiont of Brugia malayi	Na+/H+-dicarboxylate symporter	0.0251	0.3668	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0067	0.0182
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0459	0.0437
Treponema pallidum	glutamate transporter	0.0111	0.1581	1
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0036	0.0459	0.1252
Echinococcus granulosus	Excitatory amino acid transporter	0.0251	0.3668	0.3653
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0194	0.0529
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0067	0.0182
Brugia malayi	Pyruvate kinase, alpha/beta domain containing protein	0.0037	0.0466	0.1271
Schistosoma mansoni	pyruvate kinase	0.0121	0.1727	0.1727
Trypanosoma cruzi	cysteine proteinase, putative	0.0008	0.0045	0.0261
Schistosoma mansoni	pyruvate kinase	0.0121	0.1727	0.1727
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0164	0.0873
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0049	0.0026
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0016	0.0164	0.0913
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0201	0.113
Trypanosoma cruzi	hypothetical protein, conserved	0.0006	0.0007	0.0038
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0067	0.0182
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0164	0.0873
Loa Loa (eye worm)	hypothetical protein	0.001	0.0067	0.0182
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0201	0.113
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0.0459	0.2599
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0067	0.0044
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0201	0.113
Leishmania major	pyruvate kinase	0.0121	0.1727	1
Echinococcus granulosus	cathepsin L	0.0008	0.0045	0.0022
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0067	0.0067
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0036	0.0459	0.2632
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0083	0.0401
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0201	0.113
Trypanosoma cruzi	DNA damage repair protein, putative	0.0006	0.0007	0.0038
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0201	0.1374
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0164	0.0873
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0164	0.0446
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0016	0.0164	0.0446
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0201	0.113
Loa Loa (eye worm)	pyruvate kinase	0.0121	0.1727	0.4708
Echinococcus granulosus	pyruvate kinase	0.0062	0.0847	0.0826
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0164	0.0873
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0201	0.113
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0008	0.0045	0.0224
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0201	0.1164
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0057	0.077	0.446
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0067	0.0044
Echinococcus granulosus	cysteine protease	0.0008	0.0045	0.0022
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0036	0.0459	0.0459
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0164	0.0873
Leishmania major	cysteine peptidase A (CPA)	0.0016	0.0164	0.0913
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0201	0.0178
Schistosoma mansoni	cathepsin F (C01 family)	0.0011	0.0083	0.0083
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0164	0.0873
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0164	0.0269
Plasmodium falciparum	pyruvate kinase 2	0.0062	0.0847	0.4885
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0164	0.0873
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0083	0.0226
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0164	0.0141
Brugia malayi	pyruvate kinase	0.0025	0.03	0.0818
Schistosoma mansoni	cpg binding protein	0.003	0.0363	0.0363
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0045	0.0181
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0067	0.0182
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0851	0.4909
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0201	0.0178
Loa Loa (eye worm)	pyruvate kinase	0.0121	0.1727	0.4708
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0083	0.0226
Loa Loa (eye worm)	ctsf protein	0.0016	0.0164	0.0446
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0121	0.1727	0.4708
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0121	0.1727	0.4413
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0194	0.1088
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0201	0.0548
Leishmania major	cathepsin L-like protease	0.0062	0.0851	0.4909
Onchocerca volvulus		0.0028	0.0339	0.0755
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0459	0.0437
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0121	0.1727	0.4708
Toxoplasma gondii	pyruvate kinase PyKII	0.0062	0.0847	0.4885
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0164	0.0873
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0164	0.0446
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0067	0.0044
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0067	0.0182
Echinococcus granulosus	excitatory amino acid transporter 2	0.0251	0.3668	0.3653
Loa Loa (eye worm)	pyruvate kinase	0.0121	0.1727	0.4708
Loa Loa (eye worm)	cysteine protease	0.0016	0.0164	0.0446
Loa Loa (eye worm)	fibroinase	0.0016	0.0164	0.0446
Toxoplasma gondii	cathepsin CPL	0.0016	0.0164	0.0913
Onchocerca volvulus		0.0016	0.0164	0.0269
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0459	0.0437
Onchocerca volvulus	Pyruvate kinase homolog	0.0121	0.1727	0.461
Entamoeba histolytica	cysteine proteinase, putative	0.0011	0.0083	0.0333
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0023	0.0023
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0121	0.1727	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0067	0.0182
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0067	0.0044
Plasmodium vivax	DNA repair protein REV1, putative	0.0006	0.0007	0.0038
Leishmania major	cathepsin L-like protease	0.0062	0.0851	0.4909
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0459	0.2599
Brugia malayi	pyruvate kinase, muscle isozyme	0.0025	0.03	0.0818
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.0851	0.4928
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0851	0.4928
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0067	0.0182
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0011	0.0083	0.0226
Echinococcus multilocularis	pyruvate kinase	0.0062	0.0847	0.0826
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0194	0.1049
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0201	0.113

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (binding)	= 0.13 uM	Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assay	ChEMBL.	20451379
Activity (binding)		Activation of PKL assessed as pyruvate formation by fluorescent pyruvate kinase-lactate dehydrogenase coupled assay	ChEMBL.	20451379
Activity (binding)		Activation of PKR assessed as pyruvate formation by fluorescent pyruvate kinase-lactate dehydrogenase coupled assay	ChEMBL.	20451379
Activity (binding)		Activation of PKL assessed as ATP product formation by luminescent pyruvate kinase-luciferase coupled assay	ChEMBL.	20451379
Activity (binding)		Activation of PKR assessed as ATP product formation by luminescent pyruvate kinase-luciferase coupled assay	ChEMBL.	20451379
Activity (binding)	= 102 %	Maximum activation of human PKM2 assessed as ATP product formation at 57 uM after 1 hr by luminescent pyruvate kinase-luciferase coupled assay relative to fructose-1,6-bis-phosphate	ChEMBL.	20451379
Potency (functional)	0.1298 uM	PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase: for Probe SAR. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.1495 uM	PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK): for Probe SAR. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1379, AID1721, AID2266]	ChEMBL.	No reference
Potency (functional)	= 0.4606 um	PUBCHEM_BIOASSAY: Secondary assay for Activators of Human Pyruvate Kinase M2 isoform. (Class of assay: confirmatory) [Related pubchem assays: 1634, 1631 ]	ChEMBL.	No reference
Potency (functional)	1.0312 uM	PUBCHEM_BIOASSAY: Secondary LDH Assay for Activators of Human Pyruvate Kinase M2 isoform: for Probe SAR. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 3.2609 um	PUBCHEM_BIOASSAY: Secondary LDH Assay for Activators of Human Reticulocyte Pyruvate Kinase: for Probe SAR. (Class of assay: confirmatory) [Related pubchem assays: 2095, 1631 ]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1082815

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1110085